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Items: 14

1.

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.

Lee W, Windley MJ, Perry MD, Vandenberg JI, Hill AP.

Mol Pharmacol. 2019 May;95(5):537-550. doi: 10.1124/mol.118.115220. Epub 2019 Feb 15.

PMID:
30770456
2.

Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.

Munawar S, Windley MJ, Tse EG, Todd MH, Hill AP, Vandenberg JI, Jabeen I.

Front Pharmacol. 2018 Sep 19;9:1035. doi: 10.3389/fphar.2018.01035. eCollection 2018.

3.

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF.

Biomedicines. 2018 Aug 28;6(3). pii: E90. doi: 10.3390/biomedicines6030090.

4.

The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction.

Windley MJ, Lee W, Vandenberg JI, Hill AP.

Mol Pharmacol. 2018 Jul;94(1):760-769. doi: 10.1124/mol.117.111534. Epub 2018 May 4.

PMID:
29728448
5.

In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.

Lee W, Windley MJ, Vandenberg JI, Hill AP.

Front Physiol. 2017 Nov 16;8:934. doi: 10.3389/fphys.2017.00934. eCollection 2017. Review.

6.

Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.

Windley MJ, Vetter I, Lewis RJ, Nicholson GM.

Neuropharmacology. 2017 Dec;127:224-242. doi: 10.1016/j.neuropharm.2017.04.008. Epub 2017 Apr 8.

PMID:
28396143
7.

Measuring kinetics and potency of hERG block for CiPA.

Windley MJ, Abi-Gerges N, Fermini B, Hancox JC, Vandenberg JI, Hill AP.

J Pharmacol Toxicol Methods. 2017 Sep;87:99-107. doi: 10.1016/j.vascn.2017.02.017. Epub 2017 Feb 10.

PMID:
28192183
8.

Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.

Windley MJ, Mann SA, Vandenberg JI, Hill AP.

Mol Pharmacol. 2016 Jul;90(1):1-11. doi: 10.1124/mol.115.103127. Epub 2016 May 12.

PMID:
27190211
9.

In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS.

Lee W, Mann SA, Windley MJ, Imtiaz MS, Vandenberg JI, Hill AP.

Prog Biophys Mol Biol. 2016 Jan;120(1-3):89-99. doi: 10.1016/j.pbiomolbio.2015.12.005. Epub 2015 Dec 20.

PMID:
26713558
10.

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

de Araujo AD, Herzig V, Windley MJ, Dziemborowicz S, Mobli M, Nicholson GM, Alewood PF, King GF.

Antioxid Redox Signal. 2013 Dec 1;19(16):1976-80. doi: 10.1089/ars.2013.5365. Epub 2013 Jun 19.

11.

Spider-venom peptides as bioinsecticides.

Windley MJ, Herzig V, Dziemborowicz SA, Hardy MC, King GF, Nicholson GM.

Toxins (Basel). 2012 Mar;4(3):191-227. doi: 10.3390/toxins4030191. Epub 2012 Mar 22. Review.

12.

A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus.

Windley MJ, Escoubas P, Valenzuela SM, Nicholson GM.

Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.

PMID:
21447641
13.

Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy.

Mobli M, de Araújo AD, Lambert LK, Pierens GK, Windley MJ, Nicholson GM, Alewood PF, King GF.

Angew Chem Int Ed Engl. 2009;48(49):9312-4. doi: 10.1002/anie.200905206. No abstract available.

PMID:
19890933
14.

The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels.

Gunning SJ, Maggio F, Windley MJ, Valenzuela SM, King GF, Nicholson GM.

FEBS J. 2008 Aug;275(16):4045-59. doi: 10.1111/j.1742-4658.2008.06545.x. Epub 2008 Jul 9.

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