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Items: 1 to 50 of 108

1.

DIRS retrotransposons amplify via linear, single-stranded cDNA intermediates.

Malicki M, Spaller T, Winckler T, Hammann C.

Nucleic Acids Res. 2020 Mar 14. pii: gkaa160. doi: 10.1093/nar/gkaa160. [Epub ahead of print]

PMID:
32170321
2.

Migraine in 746 patients with multiple sclerosis.

Fragoso YD, Adoni T, Alves-Leon SV, Apostolos-Pereira SL, Carneiro MAD, Chikota EM, Diniz DS, Eboni ACB, Gomes S, Gonçalves MVM, Goncalves RP, Inojosa JL, Junqueira TF, Machado SC, Malfetano FR, Mansur LF, Mendes MF, Muniz A, Nobrega Junior AW, Olival GSD, Parolin MF, Pimentel MLV, Rocha CF, Ruocco HH, Santos GC, Siquineli F, Soares JOD, Sousa NAC, Tauil CB, Winckler TCA.

Arq Neuropsiquiatr. 2019 Sep 23;77(9):617-621. doi: 10.1590/0004-282X20190100. eCollection 2019.

3.

Dermatoses in parkinsonism: the importance of multidisciplinary follow-up.

Antunes I, Purim KSM, Grande LL, Alberton NC, Navarro TFR, Winckler TCD.

Rev Assoc Med Bras (1992). 2019 Jul 22;65(6):791-795. doi: 10.1590/1806-9282.65.6.791.

4.

Clinical Characteristics of Patients With Neuromyelitis Optica Spectrum Disorders With Early Onset.

Fragoso YD, Sousa NAC, Saad T, Alves-Leon SV, Pimentel MLV, Goncalves MVM, Stella CV, Diniz DS, Santos GC, Gomes S, Adoni T, Anacleto A, Claudino R, Malfetano FR, Winckler TCD, Damasceno A, Eboni ACB, Farinhas JGD, Mota RSS.

J Child Neurol. 2019 Aug;34(9):487-490. doi: 10.1177/0883073819842421. Epub 2019 Apr 23.

PMID:
31012355
5.

Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.

Branco LP, Adoni T, Apostolos-Pereira SL, Brooks JBB, Correa EC, Damasceno CA, Eboni ACB, Fezer L, Gama PDD, Goncalves MVM, Gomes S, Grzesiuk AK, Mendes MF, Morales RR, Muniz A, Parolin MFK, Pimentel MLV, Ribeiro MC, Santos GACD, Sato HK, Scherpenhuijzen SB, Scorcine C, Siquineli F, Sousa NAC, Varela DL, Winckler TCA, Fragoso YD.

Arq Neuropsiquiatr. 2018 Sep;76(9):588-591. doi: 10.1590/0004-282X20180083.

6.

Convergent evolution of integration site selection upstream of tRNA genes by yeast and amoeba retrotransposons.

Kling E, Spaller T, Schiefner J, Bönisch D, Winckler T.

Nucleic Acids Res. 2018 Aug 21;46(14):7250-7260. doi: 10.1093/nar/gky582.

7.

The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum.

Heinrich D, Barnett R, Tweedy L, Insall R, Stallforth P, Winckler T.

ACS Chem Biol. 2018 Jun 15;13(6):1506-1513. doi: 10.1021/acschembio.8b00046. Epub 2018 May 24.

PMID:
29792671
8.

Multiple Roots of Fruiting Body Formation in Amoebozoa.

Hillmann F, Forbes G, Novohradská S, Ferling I, Riege K, Groth M, Westermann M, Marz M, Spaller T, Winckler T, Schaap P, Glöckner G.

Genome Biol Evol. 2018 Feb 1;10(2):591-606. doi: 10.1093/gbe/evy011.

9.

TRE5-A retrotransposition profiling reveals putative RNA polymerase III transcription complex binding sites on the Dictyostelium extrachromosomal rDNA element.

Spaller T, Groth M, Glöckner G, Winckler T.

PLoS One. 2017 Apr 13;12(4):e0175729. doi: 10.1371/journal.pone.0175729. eCollection 2017.

10.

Versatile synthesis of the signaling peptide glorin.

Barnett R, Raszkowski D, Winckler T, Stallforth P.

Beilstein J Org Chem. 2017 Feb 8;13:247-250. doi: 10.3762/bjoc.13.27. eCollection 2017.

11.

A cell-based biosensor for nanomaterials cytotoxicity assessment in three dimensional cell culture.

Dubiak-Szepietowska M, Karczmarczyk A, Winckler T, Feller KH.

Toxicology. 2016 Aug 31;370:60-69. doi: 10.1016/j.tox.2016.09.012. Epub 2016 Sep 28.

PMID:
27693313
12.

Convergent evolution of tRNA gene targeting preferences in compact genomes.

Spaller T, Kling E, Glöckner G, Hillmann F, Winckler T.

Mob DNA. 2016 Aug 31;7(1):17. doi: 10.1186/s13100-016-0073-9. eCollection 2016.

13.

Safety of switching from natalizumab straight into fingolimod in a group of JCV-positive patients with multiple sclerosis.

Fragoso YD, Alves-Leon SV, Becker J, Brooks JB, Correa EC, Damasceno A, Gama PD, Gama RA, Matta AP, Maciel EP, Winckler TC.

Arq Neuropsiquiatr. 2016 Aug;74(8):650-2. doi: 10.1590/0004-282X20160090.

14.

Real-life experience with fampridine (Fampyra®) for patients with multiple sclerosis and gait disorders.

Fragoso YD, Adoni T, Alves-Leon SV, Apostolos-Pereira SL, Barreira AA, Brooks JB, Claudino R, Correa EC, Ferreira ML, Finkelsztejn A, Finkelsztejn J, da Gama PD, Goncalves MV, Guerreiro CT, da Cunha Matta AP, Marques VD, Rizo Morales R, Parolin MF, de Castro Ribeiro M, Ribeiro TA, Ruocco HH, Sato H, Scherpenhuijzen S, Siquineli F, de Carvalho Sousa NA, Varela DL, Tauil CB, Winckler TC.

NeuroRehabilitation. 2016 Jun 30;39(2):301-4. doi: 10.3233/NRE-161361.

PMID:
27372365
15.

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro.

Dubiak-Szepietowska M, Karczmarczyk A, Jönsson-Niedziółka M, Winckler T, Feller KH.

Toxicol Appl Pharmacol. 2016 Mar 1;294:78-85. doi: 10.1016/j.taap.2016.01.016. Epub 2016 Jan 26.

PMID:
26825373
16.

The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.

Schaap P, Barrantes I, Minx P, Sasaki N, Anderson RW, Bénard M, Biggar KK, Buchler NE, Bundschuh R, Chen X, Fronick C, Fulton L, Golderer G, Jahn N, Knoop V, Landweber LF, Maric C, Miller D, Noegel AA, Peace R, Pierron G, Sasaki T, Schallenberg-Rüdinger M, Schleicher M, Singh R, Spaller T, Storey KB, Suzuki T, Tomlinson C, Tyson JJ, Warren WC, Werner ER, Werner-Felmayer G, Wilson RK, Winckler T, Gott JM, Glöckner G, Marwan W.

Genome Biol Evol. 2015 Nov 27;8(1):109-25. doi: 10.1093/gbe/evv237.

17.

A host factor supports retrotransposition of the TRE5-A population in Dictyostelium cells by suppressing an Argonaute protein.

Schmith A, Spaller T, Gaube F, Fransson Å, Boesler B, Ojha S, Nellen W, Hammann C, Söderbom F, Winckler T.

Mob DNA. 2015 Sep 3;6:14. doi: 10.1186/s13100-015-0045-5. eCollection 2015.

18.

Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.

Otto R, Penzis R, Gaube F, Adolph O, Föhr KJ, Warncke P, Robaa D, Appenroth D, Fleck C, Enzensperger C, Lehmann J, Winckler T.

J Med Chem. 2015 Aug 27;58(16):6710-5. doi: 10.1021/acs.jmedchem.5b00958. Epub 2015 Aug 17.

PMID:
26278660
19.

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.

Tewes B, Frehland B, Schepmann D, Robaa D, Uengwetwanit T, Gaube F, Winckler T, Sippl W, Wünsch B.

J Med Chem. 2015 Aug 13;58(15):6293-305. doi: 10.1021/acs.jmedchem.5b00897. Epub 2015 Jul 30.

PMID:
26186074
20.

Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation.

Hillmann F, Novohradská S, Mattern DJ, Forberger T, Heinekamp T, Westermann M, Winckler T, Brakhage AA.

Environ Microbiol. 2015 Aug;17(8):2858-69. doi: 10.1111/1462-2920.12808. Epub 2015 Mar 27.

PMID:
25684622
21.

Beta and gamma carboline derivatives as potential anti-Alzheimer agents: A comparison.

Otto R, Penzis R, Gaube F, Winckler T, Appenroth D, Fleck C, Tränkle C, Lehmann J, Enzensperger C.

Eur J Med Chem. 2014 Nov 24;87:63-70. doi: 10.1016/j.ejmech.2014.09.048. Epub 2014 Sep 16.

PMID:
25240096
22.

A sensitive sensor cell line for the detection of oxidative stress responses in cultured human keratinocytes.

Hofmann U, Priem M, Bartzsch C, Winckler T, Feller KH.

Sensors (Basel). 2014 Jun 25;14(7):11293-307. doi: 10.3390/s140711293.

23.

The Dictyostelium discoideum RNA-dependent RNA polymerase RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for the spreading of RNA silencing signals.

Wiegand S, Meier D, Seehafer C, Malicki M, Hofmann P, Schmith A, Winckler T, Földesi B, Boesler B, Nellen W, Reimegård J, Käller M, Hällman J, Emanuelsson O, Avesson L, Söderbom F, Hammann C.

Nucleic Acids Res. 2014 Mar;42(5):3330-45. doi: 10.1093/nar/gkt1337. Epub 2013 Dec 24.

24.

Selfish DNA: a pharmaceutical perspective.

Winckler T.

Pharmazie. 2013 Jul;68(7):467-73. Review.

PMID:
23923624
25.

Conserved gene regulatory function of the carboxy-terminal domain of dictyostelid C-module-binding factor.

Schmith A, Groth M, Ratka J, Gatz S, Spaller T, Siol O, Glöckner G, Winckler T.

Eukaryot Cell. 2013 Mar;12(3):460-8. doi: 10.1128/EC.00329-12. Epub 2013 Jan 25.

26.

A whole-cell biosensor as in vitro alternative to skin irritation tests.

Hofmann U, Michaelis S, Winckler T, Wegener J, Feller KH.

Biosens Bioelectron. 2013 Jan 15;39(1):156-62. doi: 10.1016/j.bios.2012.07.075. Epub 2012 Aug 8.

PMID:
22917920
27.

[Experimental vaccination against tuberculosis].

Winckler T.

Pharm Unserer Zeit. 2012 Jan;41(1):7-8. German. No abstract available.

PMID:
22470912
28.

[Fight against malaria with genetically modified mosquitoes].

Winckler T.

Pharm Unserer Zeit. 2011 Sep;40(5):374-5. German. No abstract available.

PMID:
22299152
29.

1-Benzyl-1,2,3,4-tetrahydro-β-carboline as channel blocker of N-methyl-D-aspartate receptors.

Espinoza-Moraga M, Caballero J, Gaube F, Winckler T, Santos LS.

Chem Biol Drug Des. 2012 Apr;79(4):594-9. doi: 10.1111/j.1747-0285.2012.01317.x. Epub 2012 Feb 1.

PMID:
22226015
30.

Dictyostelium transfer RNA gene-targeting retrotransposons: Studying mobile element-host interactions in a compact genome.

Winckler T, Schiefner J, Spaller T, Siol O.

Mob Genet Elements. 2011 Jul;1(2):145-150. Epub 2011 Jul 1.

31.

[What is HUSEC041 MLST ST678?].

Winckler T, Dingermann T, Zündorf I.

Pharm Unserer Zeit. 2011 Jul;40(4):355-6. doi: 10.1002/pauz.201190043. German. No abstract available.

PMID:
21698638
32.

[Programmed cell death in bacteria].

Winckler T.

Pharm Unserer Zeit. 2011 Jul;40(4):296-7. doi: 10.1002/pauz.201190038. German. No abstract available.

PMID:
21698625
33.

[Viral gene transfer medicinal products. Therapy with "disarmed" human pathogens].

Winckler T.

Pharm Unserer Zeit. 2011 May;40(3):202-11. doi: 10.1002/pauz.201100415. Review. German. No abstract available.

PMID:
21698609
34.

[Personalized therapy for HIV infection].

Winckler T.

Pharm Unserer Zeit. 2011 May;40(3):188-9. doi: 10.1002/pauz.201190019. German. No abstract available.

PMID:
21698605
35.

[ Editorial: Pharmazie in unserer Zeit 3/2011].

Büning H, Fischer D, Winckler T.

Pharm Unserer Zeit. 2011 May;40(3):185. doi: 10.1002/pauz.201190017. German. No abstract available.

PMID:
21538373
36.

Genetically tagged TRE5-A retrotransposons reveal high amplification rates and authentic target site preference in the Dictyostelium discoideum genome.

Siol O, Spaller T, Schiefner J, Winckler T.

Nucleic Acids Res. 2011 Aug;39(15):6608-19. doi: 10.1093/nar/gkr261. Epub 2011 Apr 27.

37.

Developmental gene regulation by an ancient intercellular communication system in social amoebae.

Asghar A, Groth M, Siol O, Gaube F, Enzensperger C, Glöckner G, Winckler T.

Protist. 2012 Jan;163(1):25-37. doi: 10.1016/j.protis.2010.12.002. Epub 2011 Mar 2.

PMID:
21371934
38.

[Systematics and biology of the hepatitis viruses. Like disease - different viruses].

Winckler T.

Pharm Unserer Zeit. 2011 Jan;40(1):14-24. doi: 10.1002/pauz.201100395. Review. German. No abstract available.

PMID:
21194077
39.

The C-module-binding factor supports amplification of TRE5-A retrotransposons in the Dictyostelium discoideum genome.

Bilzer A, Dölz H, Reinhardt A, Schmith A, Siol O, Winckler T.

Eukaryot Cell. 2011 Jan;10(1):81-6. doi: 10.1128/EC.00205-10. Epub 2010 Nov 12.

40.

[Treatment of Ebola infection with siRNA.].

Winckler T.

Pharm Unserer Zeit. 2010 Nov;39(6):427-8. doi: 10.1002/pauz.201090092. German. No abstract available.

PMID:
20967928
41.

Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.

Tewes B, Frehland B, Schepmann D, Schmidtke KU, Winckler T, Wünsch B.

Bioorg Med Chem. 2010 Nov 15;18(22):8005-15. doi: 10.1016/j.bmc.2010.09.026. Epub 2010 Sep 24.

PMID:
20965739
42.

[Gene therapy for hemophilia B].

Winckler T.

Pharm Unserer Zeit. 2010 Jul;39(4):258-9. doi: 10.1002/pauz.201090048. German. No abstract available.

PMID:
20589790
43.

[The deciphering of the fifth DNA base. The human methylome].

Winckler T, Zündorf I, Dingermann T.

Pharm Unserer Zeit. 2010 May;39(3):210-6. doi: 10.1002/pauz.201000368. Review. German. No abstract available.

PMID:
20425775
44.

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.

Rook Y, Schmidtke KU, Gaube F, Schepmann D, Wünsch B, Heilmann J, Lehmann J, Winckler T.

J Med Chem. 2010 May 13;53(9):3611-7. doi: 10.1021/jm1000024.

PMID:
20361801
45.

Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists.

Tewes B, Frehland B, Schepmann D, Schmidtke KU, Winckler T, Wünsch B.

ChemMedChem. 2010 May 3;5(5):687-95. doi: 10.1002/cmdc.201000005.

PMID:
20340125
46.

[What is special about the new swine flu virus?].

Winckler T.

Pharm Unserer Zeit. 2009;38(6):488-90. doi: 10.1002/pauz.200990092. Review. German. No abstract available.

PMID:
19862710
47.

[Final IQWiG to Ginkgo biloba].

Winckler T.

Pharm Unserer Zeit. 2009;38(5):454-61. doi: 10.1002/pauz.200900334. Review. German. No abstract available.

PMID:
19711323
48.

[Dual-specificity therapeutic antibodies].

Winckler T.

Pharm Unserer Zeit. 2009;38(5):395-6. doi: 10.1002/pauz.200990068. German. No abstract available.

PMID:
19711313
49.

[Nucleic acids can be administered orally for infections].

Winckler T.

Pharm Unserer Zeit. 2009;38(5):394-5. doi: 10.1002/pauz.200990067. German. No abstract available.

PMID:
19711309
50.

[The current status of gene therapy in severe immunodeficiency].

Winckler T.

Pharm Unserer Zeit. 2009;38(3):204-6. doi: 10.1002/pauz.200990023. Review. German. No abstract available.

PMID:
19396911

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