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Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines.

Roell KR, Havener TM, Reif DM, Jack J, McLeod HL, Wiltshire T, Motsinger-Reif AA.

Front Genet. 2019 Oct 15;10:829. doi: 10.3389/fgene.2019.00829. eCollection 2019.


Functional characterization of 84 PALB2 variants of uncertain significance.

Wiltshire T, Ducy M, Foo TK, Hu C, Lee KY, Belur Nagaraj A, Rodrigue A, Gomes TT, Simard J, Monteiro ANA, Xia B, Carvalho MA, Masson JY, Couch FJ.

Genet Med. 2019 Oct 21. doi: 10.1038/s41436-019-0682-z. [Epub ahead of print]


Characterizing the pharmacogenome using molecular inversion probes for targeted next-generation sequencing.

Suzuki O, Dong OM, Howard RM, Wiltshire T.

Pharmacogenomics. 2019 Sep;20(14):1005-1020. doi: 10.2217/pgs-2019-0057.


Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.

Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18.


Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma.

Keatley K, Stromei-Cleroux S, Wiltshire T, Rajala N, Burton G, Holt WV, Littlewood DTJ, Briscoe AG, Jung J, Ashkan K, Heales SJ, Pilkington GJ, Meunier B, McGeehan JE, Hargreaves IP, McGeehan RE.

Int J Mol Sci. 2019 Jul 9;20(13). pii: E3364. doi: 10.3390/ijms20133364.


The influence of Neanderthal alleles on cytotoxic response.

Akhtari FS, Havener TM, Fukudo M, Jack JR, McLeod HL, Wiltshire T, Motsinger-Reif AA.

PeerJ. 2018 Oct 23;6:e5691. doi: 10.7717/peerj.5691. eCollection 2018.


Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping.

Frick A, Benton C, Suzuki O, Dong O, Howard R, El-Sabae H, Wiltshire T.

Pharmacy (Basel). 2018 Oct 23;6(4). pii: E115. doi: 10.3390/pharmacy6040115.


Challenges and Solutions for Future Pharmacy Practice in the Era of Precision Medicine.

Dong OM, Howard RM, Church R, Cottrell M, Forrest A, Innocenti F, Mosedale M, Kashuba A, Gonzalez D, Wiltshire T.

Am J Pharm Educ. 2018 Aug;82(6):6652. doi: 10.5688/ajpe6652.


Multiscale movement coordination dynamics in collaborative team problem solving.

Wiltshire TJ, Steffensen SV, Fiore SM.

Appl Ergon. 2019 Sep;79:143-151. doi: 10.1016/j.apergo.2018.07.007. Epub 2018 Aug 10.


Projected impact of a multigene pharmacogenetic test to optimize medication prescribing in cardiovascular patients.

Dong OM, Li A, Suzuki O, Oni-Orisan A, Gonzalez R, Stouffer GA, Lee CR, Wiltshire T.

Pharmacogenomics. 2018 Jun 1;19(9):771-782. doi: 10.2217/pgs-2018-0049. Epub 2018 May 25.


Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice.

Zhuang GZ, Upadhyay U, Tong X, Kang Y, Erasso DM, Fu ES, Sarantopoulos KD, Martin ER, Wiltshire T, Diatchenko L, Smith SB, Maixner W, Levitt RC.

Gene Ther. 2018 Jul;25(4):297-311. doi: 10.1038/s41434-018-0018-7. Epub 2018 Apr 24.


Clinical pharmacogenetics: how do we ensure a favorable future for patients?

Wiltshire T, Dong OM.

Pharmacogenomics. 2018 Apr;19(6):553-562. doi: 10.2217/pgs-2017-0192. Epub 2018 Apr 5.


The NIEHS TaRGET II Consortium and environmental epigenomics.

Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA; TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL.

Nat Biotechnol. 2018 Mar 6;36(3):225-227. doi: 10.1038/nbt.4099. No abstract available.


Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

Chen J, Akhtari FS, Wagner MJ, Suzuki O, Wiltshire T, Motsinger-Reif AA, Dumond JB.

Clin Transl Sci. 2018 Mar;11(2):226-236. doi: 10.1111/cts.12525. Epub 2017 Dec 3.


Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action.

Quayle LA, Pereira MG, Scheper G, Wiltshire T, Peake RE, Hussain I, Rea CA, Bates TE.

Oncotarget. 2017 Sep 13;8(51):88670-88688. doi: 10.18632/oncotarget.20858. eCollection 2017 Oct 24.


A multivariate dynamic systems model for psychotherapy with more than one client.

Butner JE, Deits-Lebehn C, Crenshaw AO, Wiltshire TJ, Perry NS, Kent de Grey RG, Hogan JN, Smith TW, Baucom KJW, Baucom BRW.

J Couns Psychol. 2017 Nov;64(6):616-625. doi: 10.1037/cou0000238.


Evaluating Emotional and Biological Sensitivity to Maternal Behavior among Self-injuring and Depressed Adolescent Girls Using Nonlinear Dynamics.

Crowell SE, Butner JE, Wiltshire TJ, Munion AK, Yaptangco M, Beauchaine TP.

Clin Psychol Sci. 2017 Mar 1;5(2):272-285. doi: 10.1177/2167702617692861. Epub 2017 Mar 13.


Changes in Dimensionality and Fractal Scaling Suggest Soft-Assembled Dynamics in Human EEG.

Wiltshire TJ, Euler MJ, McKinney TL, Butner JE.

Front Physiol. 2017 Sep 1;8:633. doi: 10.3389/fphys.2017.00633. eCollection 2017.


Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice.

Fu ES, Erasso DM, Zhuang GZ, Upadhyay U, Ozdemir M, Wiltshire T, Sarantopoulos KD, Smith SB, Maixner W, Martin ER, Levitt RC.

Neuroreport. 2017 Dec 13;28(18):1215-1220. doi: 10.1097/WNR.0000000000000872.


Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact.

Gonzalez D, Rao GG, Bailey SC, Brouwer KLR, Cao Y, Crona DJ, Kashuba ADM, Lee CR, Morbitzer K, Patterson JH, Wiltshire T, Easter J, Savage SW, Powell JR.

Clin Transl Sci. 2017 Nov;10(6):443-454. doi: 10.1111/cts.12490. Epub 2017 Aug 10. Review. No abstract available.


Modeling Change in Project Duration and Completion: Scheduling Dynamics of NASA's Exploration Flight Test 1 (EFT-1) Activities.

Wiltshire TJ, Butner JE, Pirtle Z.

Nonlinear Dynamics Psychol Life Sci. 2017 Jul;21(3):335-358.


Advancing precision medicine in healthcare: addressing implementation challenges to increase pharmacogenetic testing in the clinical setting.

Dong OM, Wiltshire T.

Physiol Genomics. 2017 Jul 1;49(7):346-354. doi: 10.1152/physiolgenomics.00029.2017. Epub 2017 May 26.


Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice.

Levitt RC, Zhuang GY, Kang Y, Erasso DM, Upadhyay U, Ozdemir M, Fu ES, Sarantopoulos KD, Smith SB, Maixner W, Diatchenko L, Martin ER, Wiltshire T.

Mamm Genome. 2017 Oct;28(9-10):407-415. doi: 10.1007/s00335-017-9694-7. Epub 2017 May 25.


Modeling Multi-Agent Self-Organization through the Lens of Higher Order Attractor Dynamics.

Butner JE, Wiltshire TJ, Munion AK.

Front Psychol. 2017 Mar 20;8:380. doi: 10.3389/fpsyg.2017.00380. eCollection 2017.


Graphic methods for interpreting longitudinal dyadic patterns from repeated-measures actor-partner interdependence models.

Perry NS, Baucom KJW, Bourne S, Butner J, Crenshaw AO, Hogan JN, Imel ZE, Wiltshire TJ, Baucom BRW.

J Fam Psychol. 2017 Aug;31(5):592-603. doi: 10.1037/fam0000293. Epub 2017 Feb 27.


Problem-Solving Phase Transitions During Team Collaboration.

Wiltshire TJ, Butner JE, Fiore SM.

Cogn Sci. 2018 Jan;42(1):129-167. doi: 10.1111/cogs.12482. Epub 2017 Feb 18.


Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.

Mosedale M, Kim Y, Brock WJ, Roth SE, Wiltshire T, Eaddy JS, Keele GR, Corty RW, Xie Y, Valdar W, Watkins PB.

Toxicol Sci. 2017 Apr 1;156(2):438-454. doi: 10.1093/toxsci/kfw269.


Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, Acosta PL, Ciencewicki J, McCaw ZR, Kobzik L, Miller-DeGraff L, Gladwell W, Peden DB, Serra ME, Shi M, Weinberg C, Suzuki O, Wang X, Bell DA, Polack FP, Kleeberger SR.

EBioMedicine. 2016 Sep;11:73-84. doi: 10.1016/j.ebiom.2016.08.011. Epub 2016 Aug 6.


Transitioning Pharmacogenomics into the Clinical Setting: Training Future Pharmacists.

Frick A, Benton CS, Scolaro KL, McLaughlin JE, Bradley CL, Suzuki OT, Wang N, Wiltshire T.

Front Pharmacol. 2016 Aug 8;7:241. doi: 10.3389/fphar.2016.00241. eCollection 2016.


Gulp1 is associated with the pharmacokinetics of PEGylated liposomal doxorubicin (PLD) in inbred mouse strains.

Song G, Suzuki OT, Santos CM, Lucas AT, Wiltshire T, Zamboni WC.

Nanomedicine. 2016 Oct;12(7):2007-2017. doi: 10.1016/j.nano.2016.05.019. Epub 2016 Jun 9.


Working memory performance inversely predicts spontaneous delta and theta-band scaling relations.

Euler MJ, Wiltshire TJ, Niermeyer MA, Butner JE.

Brain Res. 2016 Apr 15;1637:22-33. doi: 10.1016/j.brainres.2016.02.008. Epub 2016 Feb 10.


Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease.

Murphy SJ, Hart SN, Halling GC, Johnson SH, Smadbeck JB, Drucker T, Lima JF, Rohakhtar FR, Harris FR, Kosari F, Subramanian S, Petersen GM, Wiltshire TD, Kipp BR, Truty MJ, McWilliams RR, Couch FJ, Vasmatzis G.

Cancer Res. 2016 Feb 1;76(3):749-61. doi: 10.1158/0008-5472.CAN-15-2198. Epub 2015 Dec 16.


Molecular genetic mechanisms of allelic specific regulation of murine Comt expression.

Segall SK, Shabalina SA, Meloto CB, Wen X, Cunningham D, Tarantino LM, Wiltshire T, Gauthier J, Tohyama S, Martin LJ, Mogil JS, Diatchenko L.

Pain. 2015 Oct;156(10):1965-77. doi: 10.1097/j.pain.0000000000000258.


Identifying genes that mediate anthracyline toxicity in immune cells.

Frick A, Suzuki OT, Benton C, Parks B, Fedoriw Y, Richards KL, Thomas RS, Wiltshire T.

Front Pharmacol. 2015 Apr 15;6:62. doi: 10.3389/fphar.2015.00062. eCollection 2015.


Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics.

Frick A, Fedoriw Y, Richards K, Damania B, Parks B, Suzuki O, Benton CS, Chan E, Thomas RS, Wiltshire T.

Pharmgenomics Pers Med. 2015 Feb 26;8:81-98. doi: 10.2147/PGPM.S73312. eCollection 2015.


Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway.

Zhuang GZ, Keeler B, Grant J, Bianchi L, Fu ES, Zhang YP, Erasso DM, Cui JG, Wiltshire T, Li Q, Hao S, Sarantopoulos KD, Candiotti K, Wishnek SM, Smith SB, Maixner W, Diatchenko L, Martin ER, Levitt RC.

PLoS One. 2015 Mar 3;10(3):e0118273. doi: 10.1371/journal.pone.0118273. eCollection 2015.


Initial locomotor sensitivity to cocaine varies widely among inbred mouse strains.

Wiltshire T, Ervin RB, Duan H, Bogue MA, Zamboni WC, Cook S, Chung W, Zou F, Tarantino LM.

Genes Brain Behav. 2015 Mar;14(3):271-80. doi: 10.1111/gbb.12209.


Prospects for direct social perception: a multi-theoretical integration to further the science of social cognition.

Wiltshire TJ, Lobato EJ, McConnell DS, Fiore SM.

Front Hum Neurosci. 2015 Jan 7;8:1007. doi: 10.3389/fnhum.2014.01007. eCollection 2014.


A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes.

Suzuki OT, Frick A, Parks BB, Trask OJ Jr, Butz N, Steffy B, Chan E, Scoville DK, Healy E, Benton C, McQuaid PE, Thomas RS, Wiltshire T.

Front Genet. 2014 Aug 29;5:272. doi: 10.3389/fgene.2014.00272. eCollection 2014.


Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.

Xu X, Jaeger ER, Wang X, Lagler-Ferrez E, Batalov S, Mathis NL, Wiltshire T, Walker JR, Cooke MP, Sauer K, Huang YH.

PLoS One. 2014 Aug 18;9(8):e105561. doi: 10.1371/journal.pone.0105561. eCollection 2014.


Shifting the paradigm of music instruction: implications of embodiment stemming from an augmented reality guitar learning system.

Keebler JR, Wiltshire TJ, Smith DC, Fiore SM, Bedwell JS.

Front Psychol. 2014 May 27;5:471. doi: 10.3389/fpsyg.2014.00471. eCollection 2014.


Complex collaborative problem-solving processes in mission control.

Fiore SM, Wiltshire TJ, Oglesby JM, O'Keefe WS, Salas E.

Aviat Space Environ Med. 2014 Apr;85(4):456-61.


Genome-wide association mapping of acute lung injury in neonatal inbred mice.

Nichols JL, Gladwell W, Verhein KC, Cho HY, Wess J, Suzuki O, Wiltshire T, Kleeberger SR.

FASEB J. 2014 Jun;28(6):2538-50. doi: 10.1096/fj.13-247221. Epub 2014 Feb 26.


Toward understanding social cues and signals in human-robot interaction: effects of robot gaze and proxemic behavior.

Fiore SM, Wiltshire TJ, Lobato EJ, Jentsch FG, Huang WH, Axelrod B.

Front Psychol. 2013 Nov 27;4:859. doi: 10.3389/fpsyg.2013.00859. eCollection 2013.


In vitro and in vivo mouse models for pharmacogenetic studies.

Frick A, Suzuki O, Butz N, Chan E, Wiltshire T.

Methods Mol Biol. 2013;1015:263-78. doi: 10.1007/978-1-62703-435-7_17.


Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.

Shimomura K, Kumar V, Koike N, Kim TK, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo SH, Hong HK, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, Takahashi JS.

Elife. 2013 Apr 9;2:e00426. doi: 10.7554/eLife.00426.


The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain.

Beisner DR, Langerak P, Parker AE, Dahlberg C, Otero FJ, Sutton SE, Poirot L, Barnes W, Young MA, Niessen S, Wiltshire T, Bodendorf U, Martoglio B, Cravatt B, Cooke MP.

J Exp Med. 2013 Jan 14;210(1):23-30. doi: 10.1084/jem.20121072. Epub 2012 Dec 24.


Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses.

Eisener-Dorman AF, Bailey JS, Grabowski-Boase L, Huitron-Resendiz S, Roberts AJ, Wiltshire T, Tarantino LM.

Psychopharmacology (Berl). 2013 Jan;225(2):407-19. doi: 10.1007/s00213-012-2827-5. Epub 2012 Sep 5.


Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.

Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14381-6. doi: 10.1073/pnas.1212366109. Epub 2012 Aug 20.

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