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Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.

Affronti HC, Rowsam AM, Pellerite AJ, Rosario SR, Long MD, Jacobi JJ, Bianchi-Smiraglia A, Boerlin CS, Gillard BM, Karasik E, Foster BA, Moser M, Wilton JH, Attwood K, Nikiforov MA, Azabdaftari G, Pili R, Phillips JG, Casero RA Jr, Smiraglia DJ.

Nat Commun. 2020 Jan 7;11(1):52. doi: 10.1038/s41467-019-13950-4.


Reply to: "Pitfalls in measuring temporal trends for late diagnosis of viral hepatitis".

Wilton J, Samji H, Yu A, Krajden M, Janjua NZ; BC Hepatitis Testers Cohort team.

J Hepatol. 2019 Dec;71(6):1256-1258. doi: 10.1016/j.jhep.2019.09.015. Epub 2019 Oct 23. No abstract available.


Cohort profile: Development and profile of a population-based, retrospective cohort of diagnosed people living with HIV in Ontario, Canada (Ontario HIV Laboratory Cohort).

Liu J, Wilton J, Sullivan A, Marchand-Austin A, Rachlis B, Giles M, Light L, Sider D, Kroch AE, Gilbert M; Ontario HIV Epidemiology and Surveillance Initiative.

BMJ Open. 2019 May 27;9(5):e027325. doi: 10.1136/bmjopen-2018-027325.


Diet and lupus: what do the patients think?

Robinson GA, Mcdonnell T, Wincup C, Martin-Gutierrez L, Wilton J, Kalea AZ, Ciurtin C, Pineda-Torra I, Jury EC.

Lupus. 2019 May;28(6):755-763. doi: 10.1177/0961203319845473. Epub 2019 Apr 26.


Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models.

Kamoun WS, Kirpotin DB, Huang ZR, Tipparaju SK, Noble CO, Hayes ME, Luus L, Koshkaryev A, Kim J, Olivier K, Kornaga T, Oyama S, Askoxylakis V, Pien C, Kuesters G, Dumont N, Lugovskoy AA, Schihl SA, Wilton JH, Geddie ML, Suchy J, Grabow S, Kohli N, Reynolds CP, Blaydes R, Zhou Y, Sawyer AJ, Marks JD, Drummond DC.

Nat Biomed Eng. 2019 Apr;3(4):264-280. doi: 10.1038/s41551-019-0385-4. Epub 2019 Apr 5.


Trends in HIV care cascade engagement among diagnosed people living with HIV in Ontario, Canada: A retrospective, population-based cohort study.

Wilton J, Liu J, Sullivan A, Rachlis B, Marchand-Austin A, Giles M, Light L, Rank C, Burchell AN, Gardner S, Sider D, Gilbert M, Kroch AE; Ontario HIV Epidemiology and Surveillance Initiative.

PLoS One. 2019 Jan 4;14(1):e0210096. doi: 10.1371/journal.pone.0210096. eCollection 2019.


Towards viscoelastic characterisation of the human ulnar nerve: An early assessment using embalmed cadavers.

Barberio CG, Chaudhry T, Power DM, Tan S, Lawless BM, Espino DM, Wilton JC.

Med Eng Phys. 2019 Feb;64:15-22. doi: 10.1016/j.medengphy.2018.12.009. Epub 2018 Dec 13.


Acceptability and tolerability of and adherence to HIV preexposure prophylaxis among Toronto gay and bisexual men: a pilot study.

Tan DHS, Schnubb A, Lawless J, Szadkowski L, Grennan T, Wilton J, Fowler S, Hart TA, Maxwell J, Raboud JM.

CMAJ Open. 2018 Dec 10;6(4):E611-E617. doi: 10.9778/cmajo.20180068. Print 2018 Oct-Dec.


Late diagnosis, delayed presentation and late presentation among persons enrolled in a clinical HIV cohort in Ontario, Canada (1999-2013).

Wilton J, Light L, Gardner S, Rachlis B, Conway T, Cooper C, Cupido P, Kendall CE, Loutfy M, McGee F, Murray J, Lush J, Rachlis A, Wobeser W, Bacon J, Kroch AE, Gilbert M, Rourke SB, Burchell AN; Ontario HIV Treatment Network (OHTN) Cohort Study Team.

HIV Med. 2019 Feb;20(2):110-120. doi: 10.1111/hiv.12686. Epub 2018 Nov 14.


A Phase Ib Study of the FGFR/VEGFR Inhibitor Dovitinib With Gemcitabine and Capecitabine in Advanced Solid Tumor and Pancreatic Cancer Patients.

Ma WW, Xie H, Fetterly G, Pitzonka L, Whitworth A, LeVea C, Wilton J, Mantione K, Schihl S, Dy GK, Boland P, Iyer R, Tan W, Brady W, Straubinger RM, Adjei AA.

Am J Clin Oncol. 2019 Feb;42(2):184-189. doi: 10.1097/COC.0000000000000492.


Outcome measures of disease activity for rare autoimmune rheumatic diseases.

Jones A, Cotton A, Guinto J, Wilton J, Ciurtin C.

Br J Hosp Med (Lond). 2018 Jul 2;79(7):396-401. doi: 10.12968/hmed.2018.79.7.396. Review.


Awareness of, interest in, and willingness to pay for HIV pre-exposure prophylaxis among Canadian gay, bisexual, and other men who have sex with men.

Morgan J, Ferlatte O, Salway T, Wilton J, Hull M.

Can J Public Health. 2018 Dec;109(5-6):791-799. doi: 10.17269/s41997-018-0090-1. Epub 2018 Jun 5.


Trends in the awareness, acceptability, and usage of HIV pre-exposure prophylaxis among at-risk men who have sex with men in Toronto.

Rana J, Wilton J, Fowler S, Hart TA, Bayoumi AM, Tan DHS.

Can J Public Health. 2018 Jun;109(3):342-352. doi: 10.17269/s41997-018-0064-3. Epub 2018 Apr 26.


Decentralizing the delivery of HIV pre-exposure prophylaxis (PrEP) through family physicians and sexual health clinic nurses: a dissemination and implementation study protocol.

Sharma M, Chris A, Chan A, Knox DC, Wilton J, McEwen O, Mishra S, Grace D, Rogers T, Bayoumi AM, Maxwell J, Shahin R, Bogoch I, Gilbert M, Tan DHS.

BMC Health Serv Res. 2018 Jul 3;18(1):513. doi: 10.1186/s12913-018-3324-2.


Guided self-help to manage binge eating in a dietetic-led community weight management service.

Traviss-Turner GD, Philpot U, Wilton J, Green K, Heywood-Everett S, Hill AJ.

Clin Obes. 2018 Aug;8(4):250-257. doi: 10.1111/cob.12259. Epub 2018 Jun 14.


Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade.

Fiandalo MV, Stocking JJ, Pop EA, Wilton JH, Mantione KM, Li Y, Attwood KM, Azabdaftari G, Wu Y, Watt DS, Wilson EM, Mohler JL.

Oncotarget. 2018 Jan 10;9(13):11227-11242. doi: 10.18632/oncotarget.24107. eCollection 2018 Feb 16.


High HIV risk and syndemic burden regardless of referral source among MSM screening for a PrEP demonstration project in Toronto, Canada.

Wilton J, Noor SW, Schnubb A, Lawless J, Hart TA, Grennan T, Fowler S, Maxwell J, Tan DHS.

BMC Public Health. 2018 Feb 27;18(1):292. doi: 10.1186/s12889-018-5180-8.


Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.

Affronti HC, Long MD, Rosario SR, Gillard BM, Karasik E, Boerlin CS, Pellerite AJ, Foster BA, Attwood K, Pili R, Wilton JH, Campbell MJ, Smiraglia DJ.

Oncotarget. 2017 Oct 20;8(61):103758-103774. doi: 10.18632/oncotarget.21911. eCollection 2017 Nov 28.


Serum-free complete medium, an alternative medium to mimic androgen deprivation in human prostate cancer cell line models.

Fiandalo MV, Wilton JH, Mantione KM, Wrzosek C, Attwood KM, Wu Y, Mohler JL.

Prostate. 2018 Feb;78(3):213-221. doi: 10.1002/pros.23459. Epub 2017 Dec 1.


Considerations for Using the HIRI-MSM Screening Tool to Identify MSM Who Would Benefit Most From PrEP.

Wilton J, Mishra S, Tan DHS.

J Acquir Immune Defic Syndr. 2017 Oct 1;76(2):e58-e61. doi: 10.1097/QAI.0000000000001472. No abstract available.


Graphite design.

Wilton J.

Lancet Respir Med. 2016 Sep;4(9):698. doi: 10.1016/S2213-2600(16)30229-6. Epub 2016 Aug 31. No abstract available.


Can intra-operative fluorescence play a significant role in hepatobiliary surgery?

Jones AD, Wilton JC.

Eur J Surg Oncol. 2017 Sep;43(9):1622-1627. doi: 10.1016/j.ejso.2017.02.015. Epub 2017 Mar 6. Review.


Absence of tmRNA Has a Protective Effect against Fluoroquinolones in Streptococcus pneumoniae.

Brito L, Wilton J, Ferrándiz MJ, Gómez-Sanz A, de la Campa AG, Amblar M.

Front Microbiol. 2017 Jan 10;7:2164. doi: 10.3389/fmicb.2016.02164. eCollection 2016.


Cacophony of colour.

Wilton J.

Lancet Respir Med. 2016 Nov;4(11):872. doi: 10.1016/S2213-2600(16)30336-8. No abstract available.


Focusing on breath.

Wilton J.

Lancet Respir Med. 2016 Oct;4(10):780. doi: 10.1016/S2213-2600(16)30096-0. No abstract available.


Characterization of Prostate Cancer in a Functional Eunuch.

Stocking JJ, Fiandalo MV, Pop EA, Wilton JH, Azabdaftari G, Mohler JL.

J Natl Compr Canc Netw. 2016 Sep;14(9):1054-60.


Breathing fire.

Wilton J.

Lancet Respir Med. 2016 Jun;4(6):444. doi: 10.1016/S2213-2600(16)30086-8. Epub 2016 May 31. No abstract available.


Conversation piece (happen).

Wilton J.

Lancet Respir Med. 2016 May;4(5):360. doi: 10.1016/S2213-2600(16)30016-9. Epub 2016 Apr 25. No abstract available.



Wilton J.

Lancet Respir Med. 2016 Apr;4(4):258. doi: 10.1016/S2213-2600(15)00372-0. Epub 2016 Apr 4. No abstract available.


Smoke without fire.

Wilton J.

Lancet Respir Med. 2016 Mar;4(3):184. doi: 10.1016/S2213-2600(16)00051-5. Epub 2016 Mar 2. No abstract available.


Use of an HIV-risk screening tool to identify optimal candidates for PrEP scale-up among men who have sex with men in Toronto, Canada: disconnect between objective and subjective HIV risk.

Wilton J, Kain T, Fowler S, Hart TA, Grennan T, Maxwell J, Tan DH.

J Int AIDS Soc. 2016 Jun 3;19(1):20777. doi: 10.7448/IAS.19.1.20777. eCollection 2016.


Lower Extremity Focused Neurologic Examination.

Wilton JP.

Clin Podiatr Med Surg. 2016 Apr;33(2):191-202. doi: 10.1016/j.cpm.2015.12.008. Epub 2016 Jan 28. Review.


Take a deep breath in.

Wilton J.

Lancet Respir Med. 2016 Feb;4(2):106. doi: 10.1016/S2213-2600(16)00016-3. Epub 2016 Feb 2. No abstract available.


The Anatomical Society core regional anatomy syllabus for undergraduate medicine.

Smith CF, Finn GM, Stewart J, Atkinson MA, Davies DC, Dyball R, Morris J, Ockleford C, Parkin I, Standring S, Whiten S, Wilton J, McHanwell S.

J Anat. 2016 Jan;228(1):15-23. doi: 10.1111/joa.12405. Epub 2015 Nov 27. Review.


Preparing for pre-exposure prophylaxis: perceptions and readiness of Canadian pharmacists for the implementation of HIV pre-exposure prophylaxis.

Yoong D, Naccarato M, Sharma M, Wilton J, Senn H, Tan DH.

Int J STD AIDS. 2016 Jul;27(8):608-16. doi: 10.1177/0956462415589896. Epub 2015 May 29.


Pre-exposure prophylaxis for sexually-acquired HIV risk management: a review.

Wilton J, Senn H, Sharma M, Tan DH.

HIV AIDS (Auckl). 2015 Apr 28;7:125-36. doi: 10.2147/HIV.S50025. eCollection 2015. Review.


Small regulatory RNAs in Streptococcus pneumoniae: discovery and biological functions.

Wilton J, Acebo P, Herranz C, Gómez A, Amblar M.

Front Genet. 2015 Apr 7;6:126. doi: 10.3389/fgene.2015.00126. eCollection 2015.


The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy.

Chittaranjan S, Xu J, Kuzyk M, Dullat HK, Wilton J, DeVorkin L, Lebovitz C, Morin GB, Marra MA, Gorski SM.

Biol Open. 2015 Apr 2;4(5):672-84. doi: 10.1242/bio.20148417.


Entrapment neuropathy about the foot and ankle: an update.

Pomeroy G, Wilton J, Anthony S.

J Am Acad Orthop Surg. 2015 Jan;23(1):58-66. doi: 10.5435/JAAOS-23-01-58. Review.


A phase IB clinical trial with Dekavil (F8-IL10), an immunoregulatory 'armed antibody' for the treatment of rheumatoid arthritis, used in combination wiIh methotrexate.

Galeazzi M, Bazzichi L, Sebastiani GD, Neri D, Garcia E, Ravenni N, Giovannoni L, Wilton J, Bardelli M, Baldi C, Selvi E, Iuliano A, Minisola G, Caporali R, Prisco E, Bombardieri S.

Isr Med Assoc J. 2014 Oct;16(10):666. No abstract available.


Pharmacokinetic analysis of the FAK scaffold inhibitor C4 in dogs.

Wilton J, Kurenova E, Pitzonka L, Gaudy A, Curtin L, Sexton S, Cance W, Fetterly G.

Eur J Drug Metab Pharmacokinet. 2016 Feb;41(1):55-67. doi: 10.1007/s13318-014-0233-6. Epub 2014 Nov 7.


Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens.

Kim W, Zhang L, Wilton JH, Fetterly G, Mohler JL, Weinberg V, Morse A, Szmulewitz RZ, Friedlander TW, Fong L, Lin AM, Harzstark AL, Molina A, Small EJ, Ryan CJ.

Clin Cancer Res. 2014 Dec 15;20(24):6269-76. doi: 10.1158/1078-0432.CCR-14-1595. Epub 2014 Oct 21.


The Neurological Hand Deformity Classification for children with cerebral palsy.

Georgiades M, Elliott C, Wilton J, Blair E, Blackmore M, Garbellini S.

Aust Occup Ther J. 2014 Dec;61(6):394-402. doi: 10.1111/1440-1630.12150. Epub 2014 Aug 29.


Preparing for PrEP: perceptions and readiness of canadian physicians for the implementation of HIV pre-exposure prophylaxis.

Sharma M, Wilton J, Senn H, Fowler S, Tan DH.

PLoS One. 2014 Aug 18;9(8):e105283. doi: 10.1371/journal.pone.0105283. eCollection 2014.


Roles for the backdoor pathway of androgen metabolism in prostate cancer response to castration and drug treatment.

Fiandalo MV, Wilton J, Mohler JL.

Int J Biol Sci. 2014 Jun 3;10(6):596-601. doi: 10.7150/ijbs.8780. eCollection 2014. Review.


A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers.

McCann SE, Edge SB, Hicks DG, Thompson LU, Morrison CD, Fetterly G, Andrews C, Clark K, Wilton J, Kulkarni S.

Nutr Cancer. 2014;66(4):566-75. doi: 10.1080/01635581.2014.894097. Epub 2014 Mar 26.


Continence and micturition: an anatomical basis.

Shah AP, Mevcha A, Wilby D, Alatsatianos A, Hardman JC, Jacques S, Wilton JC.

Clin Anat. 2014 Nov;27(8):1275-83. doi: 10.1002/ca.22388. Epub 2014 Mar 10. Review.


Outcomes after cardiac arrest in an adult burn center.

Wilton JC, Hardin MO, Ritchie JD, Chung KK, Aden JK, Cancio LC, Wolf SE, White CE.

Burns. 2013 Dec;39(8):1541-6. doi: 10.1016/j.burns.2013.08.005. Epub 2013 Sep 3.


Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors.

Wu Y, Godoy A, Azzouni F, Wilton JH, Ip C, Mohler JL.

Prostate. 2013 Sep;73(13):1470-82. doi: 10.1002/pros.22694. Epub 2013 Jun 27.

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