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Characterization of a smart pH-cleavable PEG polymer towards the development of dual pH-sensitive liposomes.

Kanamala M, Palmer BD, Wilson WR, Wu Z.

Int J Pharm. 2018 Sep 5;548(1):288-296. doi: 10.1016/j.ijpharm.2018.07.009. Epub 2018 Jul 4.


Comparison of Dual β-Lactam therapy to penicillin-aminoglycoside combination in treatment of Enterococcus faecalis infective endocarditis.

El Rafei A, DeSimone DC, Narichania AD, Sohail MR, Vikram HR, Li Z, Steckelberg JM, Wilson WR, Baddour LM.

J Infect. 2018 Jun 30. pii: S0163-4453(18)30191-9. doi: 10.1016/j.jinf.2018.06.013. [Epub ahead of print]


PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation.

Kanamala M, Palmer BD, Ghandehari H, Wilson WR, Wu Z.

Pharm Res. 2018 May 31;35(8):154. doi: 10.1007/s11095-018-2429-y.


Diagnostic evaluation and management of culture-negative cardiovascular implantable electronic device infections.

Esquer Garrigos Z, George MP, Farid S, Abu Saleh OM, Vijayvargiya P, Mahmood M, Friedman PA, Steckelberg JM, DeSimone DC, Wilson WR, Baddour LM, Sohail MR.

Pacing Clin Electrophysiol. 2018 May 31. doi: 10.1111/pace.13397. [Epub ahead of print]


Drug-DNA adducts as biomarkers for metabolic activation of the nitro-aromatic nitrogen mustard prodrug PR-104A.

Stornetta A, Deng KK, Danielli S, Liyanage HDS, Sturla SJ, Wilson WR, Gu Y.

Biochem Pharmacol. 2018 Aug;154:64-74. doi: 10.1016/j.bcp.2018.04.004. Epub 2018 Apr 7.


Utility of cardiac computed tomography scanning in the diagnosis and pre-operative evaluation of patients with infective endocarditis.

Sims JR, Anavekar NS, Chandrasekaran K, Steckelberg JM, Wilson WR, Gersh BJ, Baddour LM, DeSimone DC.

Int J Cardiovasc Imaging. 2018 Jul;34(7):1155-1163. doi: 10.1007/s10554-018-1318-0. Epub 2018 Feb 15.


Clinical, Radiographic, and Microbiologic Features of Infective Endocarditis in Patients With Hypertrophic Cardiomyopathy.

Sims JR, Anavekar NS, Bhatia S, O'Horo JC, Geske JB, Chandrasekaran K, Wilson WR, Baddour LM, Gersh BJ, DeSimone DC.

Am J Cardiol. 2018 Feb 15;121(4):480-484. doi: 10.1016/j.amjcard.2017.11.010. Epub 2017 Nov 23.


Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides.

Bonnet M, Hong CR, Wong WW, Liew LP, Shome A, Wang J, Gu Y, Stevenson RJ, Qi W, Anderson RF, Pruijn FB, Wilson WR, Jamieson SMF, Hicks KO, Hay MP.

J Med Chem. 2018 Feb 8;61(3):1241-1254. doi: 10.1021/acs.jmedchem.7b01678. Epub 2018 Jan 11.


Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Gu Y, Chang TT, Wang J, Jaiswal JK, Edwards D, Downes NJ, Liyanage HDS, Lynch CRH, Pruijn FB, Hickey AJR, Hay MP, Wilson WR, Hicks KO.

Front Pharmacol. 2017 Aug 11;8:531. doi: 10.3389/fphar.2017.00531. eCollection 2017.


Impacts of a care process model and inpatient electrophysiology service on cardiovascular implantable electronic device infections: a preliminary evaluation.

Tan EM, Nagpal A, DeSimone DC, Anderson B, Linderbaum J, De Ziel T, Li Z, Sohail MR, Cha YM, Loomis E, Espinosa R, Friedman PA, Greason K, Schiller H, Virk A, Wilson WR, Steckelberg JM, Baddour LM.

J Interv Card Electrophysiol. 2017 Oct;50(1):117-124. doi: 10.1007/s10840-017-0282-2. Epub 2017 Aug 26.


Effect of the American Heart Association 2007 Guidelines on the Practice of Dental Prophylaxis for the Prevention of Infective Endocarditis in Olmsted County, Minnesota.

DeSimone DC, El Rafei A, Challener DW, Carr AB, Kelly JA, Rocca WA, St Sauver JL, Bock-Goodner CM, Lahr BD, Steckelberg JM, Wilson WR, Baddour LM.

Mayo Clin Proc. 2017 May 10. pii: S0025-6196(17)30238-0. doi: 10.1016/j.mayocp.2017.03.013. [Epub ahead of print]


Outcomes in Patients With Cardiovascular Implantable Electronic Device Infection Managed With Chronic Antibiotic Suppression.

Tan EM, DeSimone DC, Sohail MR, Baddour LM, Wilson WR, Steckelberg JM, Virk A.

Clin Infect Dis. 2017 Jun 1;64(11):1516-1521. doi: 10.1093/cid/cix181.


International experts' practice in the antibiotic therapy of infective endocarditis is not following the guidelines.

Tissot-Dupont H, Casalta JP, Gouriet F, Hubert S, Salaun E, Habib G, Fernandez-Gerlinger MP, Mainardi JL, Tattevin P, Revest M, Lucht F, Botelho-Nevers E, Gagneux-Brunon A, Snygg-Martin U, Chan KL, Bishara J, Vilacosta I, Olmos C, San Román JA, López J, Tornos P, Fernández-Hidalgo N, Durante-Mangoni E, Utili R, Paul M, Baddour LM, DeSimone DC, Sohail MR, Steckelberg JM, Wilson WR, Raoult D.

Clin Microbiol Infect. 2017 Oct;23(10):736-739. doi: 10.1016/j.cmi.2017.03.007. Epub 2017 Mar 18.


DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.

Stornetta A, Villalta PW, Gossner F, Wilson WR, Balbo S, Sturla SJ.

Chem Res Toxicol. 2017 Mar 20;30(3):830-839. doi: 10.1021/acs.chemrestox.6b00412. Epub 2017 Feb 19.


pH-Sensitive PEGylated liposomes for delivery of an acidic dinitrobenzamide mustard prodrug: Pathways of internalization, cellular trafficking and cytotoxicity to cancer cells.

Yang MM, Wilson WR, Wu Z.

Int J Pharm. 2017 Jan 10;516(1-2):323-333. doi: 10.1016/j.ijpharm.2016.11.041. Epub 2016 Nov 18.


Vascular Graft Infections, Mycotic Aneurysms, and Endovascular Infections: A Scientific Statement From the American Heart Association.

Wilson WR, Bower TC, Creager MA, Amin-Hanjani S, O'Gara PT, Lockhart PB, Darouiche RO, Ramlawi B, Derdeyn CP, Bolger AF, Levison ME, Taubert KA, Baltimore RS, Baddour LM; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; Council on Peripheral Vascular Disease; and Stroke Council.

Circulation. 2016 Nov 15;134(20):e412-e460. Epub 2016 Oct 13. No abstract available.


Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.

Anderson RF, Yadav P, Shinde SS, Hong CR, Pullen SM, Reynisson J, Wilson WR, Hay MP.

Chem Res Toxicol. 2016 Aug 15;29(8):1310-24. doi: 10.1021/acs.chemrestox.6b00133. Epub 2016 Jul 29.


Growth hormone receptor antagonism suppresses tumour regrowth after radiotherapy in an endometrial cancer xenograft model.

Evans A, Jamieson SM, Liu DX, Wilson WR, Perry JK.

Cancer Lett. 2016 Aug 28;379(1):117-23. doi: 10.1016/j.canlet.2016.05.031. Epub 2016 May 27.


Prosthetic pulmonary valve and pulmonary conduit endocarditis: clinical, microbiological and echocardiographic features in adults.

Miranda WR, Connolly HM, Bonnichsen CR, DeSimone DC, Dearani JA, Maleszewski JJ, Greason KL, Wilson WR, Baddour LM.

Eur Heart J Cardiovasc Imaging. 2016 Aug;17(8):936-43. doi: 10.1093/ehjci/jew086. Epub 2016 May 8.


Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.

Hunter FW, Wouters BG, Wilson WR.

Br J Cancer. 2016 May 10;114(10):1071-7. doi: 10.1038/bjc.2016.79. Epub 2016 Apr 12. Review.


Cardiovascular Implantable Electronic Device Infections due to Propionibacterium Species.

El Rafei A, Desimone DC, Sohail MR, Desimone CV, Steckelberg JM, Wilson WR, Baddour LM.

Pacing Clin Electrophysiol. 2016 Jun;39(6):522-30. doi: 10.1111/pace.12845. Epub 2016 Apr 22.


Beta-haemolytic streptococcal endocarditis: clinical presentation, management and outcomes.

El Rafei A, DeSimone DC, DeSimone CV, Lahr BD, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM.

Infect Dis (Lond). 2016;48(5):373-8. doi: 10.3109/23744235.2015.1129672. Epub 2016 Jan 14.


Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review.

Kanamala M, Wilson WR, Yang M, Palmer BD, Wu Z.

Biomaterials. 2016 Apr;85:152-67. doi: 10.1016/j.biomaterials.2016.01.061. Epub 2016 Jan 29. Review.


Infective Endocarditis Involving the Pulmonary Valve.

Miranda WR, Connolly HM, DeSimone DC, Phillips SD, Wilson WR, Sohail MR, Steckelberg JM, Baddour LM.

Am J Cardiol. 2015 Dec 15;116(12):1928-31. doi: 10.1016/j.amjcard.2015.09.038. Epub 2015 Oct 9.


Clinical Presentation, Risk Factors, and Outcomes of Hematogenous Prosthetic Joint Infection in Patients with Staphylococcus aureus Bacteremia.

Tande AJ, Palraj BR, Osmon DR, Berbari EF, Baddour LM, Lohse CM, Steckelberg JM, Wilson WR, Sohail MR.

Am J Med. 2016 Feb;129(2):221.e11-20. doi: 10.1016/j.amjmed.2015.09.006. Epub 2015 Oct 8.


Temporal trends in infective endocarditis epidemiology from 2007 to 2013 in Olmsted County, MN.

DeSimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR, Steckelberg JM, Wilson WR, Baddour LM.

Am Heart J. 2015 Oct;170(4):830-6. doi: 10.1016/j.ahj.2015.07.007. Epub 2015 Jul 17.


Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association.

Baddour LM, Wilson WR, Bayer AS, Fowler VG Jr, Tleyjeh IM, Rybak MJ, Barsic B, Lockhart PB, Gewitz MH, Levison ME, Bolger AF, Steckelberg JM, Baltimore RS, Fink AM, O'Gara P, Taubert KA; American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council.

Circulation. 2015 Oct 13;132(15):1435-86. doi: 10.1161/CIR.0000000000000296. Epub 2015 Sep 15. Review. Erratum in: Circulation. 2015 Oct 27;132(17):e215. Circulation. 2016 Aug 23;134(8):e113.


Trends in Infective Endocarditis Incidence, Microbiology, and Valve Replacement in the United States From 2000 to 2011: The Devil Is in the Details.

DeSimone DC, Wilson WR, Baddour LM.

J Am Coll Cardiol. 2015 Sep 8;66(10):1201-2. doi: 10.1016/j.jacc.2015.05.079. No abstract available.


Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, Rischin D, Wilson WR, Wouters BG.

Cancer Res. 2015 Oct 1;75(19):4211-23. doi: 10.1158/0008-5472.CAN-15-1107. Epub 2015 Aug 21.


Genitourinary Procedures as Risk Factors for Prosthetic Hip or Knee Infection: A Hospital-Based Prospective Case-Control Study.

Gupta A, Osmon DR, Hanssen AD, Lightner DJ, Wilson WR, Steckelberg JM, Baddour LM, Harmsen WS, Mandrekar JN, Berbari EF.

Open Forum Infect Dis. 2015 Jun 30;2(3):ofv097. doi: 10.1093/ofid/ofv097. eCollection 2015 Sep.


Incidence of Infective Endocarditis Due to Viridans Group Streptococci Before and After the 2007 American Heart Association's Prevention Guidelines: An Extended Evaluation of the Olmsted County, Minnesota, Population and Nationwide Inpatient Sample.

DeSimone DC, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR, Steckelberg JM, Wilson WR, Baddour LM; Mayo Cardiovascular Infections Study Group.

Mayo Clin Proc. 2015 Jul;90(7):874-81. doi: 10.1016/j.mayocp.2015.04.019.


AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.

Moradi Manesh D, El-Hoss J, Evans K, Richmond J, Toscan CE, Bracken LS, Hedrick A, Sutton R, Marshall GM, Wilson WR, Kurmasheva RT, Billups C, Houghton PJ, Smith MA, Carol H, Lock RB.

Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.


Association of Mitral Valve Prolapse With Infective Endocarditis Due to Viridans Group Streptococci.

DeSimone DC, DeSimone CV, Tleyjeh IM, Correa de Sa DD, Anavekar NS, Lahr BD, Sohail MR, Steckelberg JM, Wilson WR, Baddour LM.

Clin Infect Dis. 2015 Aug 15;61(4):623-5. doi: 10.1093/cid/civ375. Epub 2015 May 11.


Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.

Abbattista MR, Jamieson SM, Gu Y, Nickel JE, Pullen SM, Patterson AV, Wilson WR, Guise CP.

Cancer Biol Ther. 2015;16(4):610-22. doi: 10.1080/15384047.2015.1017171. Epub 2015 Apr 14.


Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guide Use of Echocardiography in the Management of Staphylococcus aureus Bacteremia.

Palraj BR, Baddour LM, Hess EP, Steckelberg JM, Wilson WR, Lahr BD, Sohail MR.

Clin Infect Dis. 2015 Jul 1;61(1):18-28. doi: 10.1093/cid/civ235. Epub 2015 Mar 25.


Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.

Konopleva M, Thall PF, Yi CA, Borthakur G, Coveler A, Bueso-Ramos C, Benito J, Konoplev S, Gu Y, Ravandi F, Jabbour E, Faderl S, Thomas D, Cortes J, Kadia T, Kornblau S, Daver N, Pemmaraju N, Nguyen HQ, Feliu J, Lu H, Wei C, Wilson WR, Melink TJ, Gutheil JC, Andreeff M, Estey EH, Kantarjian H.

Haematologica. 2015 Jul;100(7):927-34. doi: 10.3324/haematol.2014.118455. Epub 2015 Feb 14.


Predicting risk of endovascular device infection in patients with Staphylococcus aureus bacteremia (PREDICT-SAB).

Sohail MR, Palraj BR, Khalid S, Uslan DZ, Al-Saffar F, Friedman PA, Hayes DL, Lohse CM, Wilson WR, Steckelberg JM, Baddour LM.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):137-44. doi: 10.1161/CIRCEP.114.002199. Epub 2014 Dec 12.


Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution.

Gu Y, Jaiswal JK, Wang J, Hicks KO, Hay MP, Wilson WR.

J Pharm Sci. 2014 Nov;103(11):3464-3472. doi: 10.1002/jps.24099. Epub 2014 Sep 11.


Dual targeting of hypoxia and homologous recombination repair dysfunction in triple-negative breast cancer.

Hunter FW, Hsu HL, Su J, Pullen SM, Wilson WR, Wang J.

Mol Cancer Ther. 2014 Nov;13(11):2501-14. doi: 10.1158/1535-7163.MCT-14-0476. Epub 2014 Sep 5.


Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5.

Wang J, Guise CP, Dachs GU, Phung Y, Hsu AH, Lambie NK, Patterson AV, Wilson WR.

Biochem Pharmacol. 2014 Oct 15;91(4):436-46. doi: 10.1016/j.bcp.2014.08.003. Epub 2014 Aug 15.


Pregnancy and postpartum infective endocarditis: a systematic review.

Kebed KY, Bishu K, Al Adham RI, Baddour LM, Connolly HM, Sohail MR, Steckelberg JM, Wilson WR, Murad MH, Anavekar NS.

Mayo Clin Proc. 2014 Aug;89(8):1143-52. doi: 10.1016/j.mayocp.2014.04.024. Epub 2014 Jul 1. Review.


Desulfovibrio legallii prosthetic shoulder joint infection and review of antimicrobial susceptibility and clinical characteristics of Desulfovibrio infections.

Vasoo S, Mason EL, Gustafson DR, Cunningham SA, Cole NC, Vetter EA, Steinmann SP, Wilson WR, Patel R, Berbari EF, Henry NK.

J Clin Microbiol. 2014 Aug;52(8):3105-10. doi: 10.1128/JCM.00083-14. Epub 2014 May 21.


Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.

Bonnet M, Hong CR, Gu Y, Anderson RF, Wilson WR, Pruijn FB, Wang J, Hicks KO, Hay MP.

Bioorg Med Chem. 2014 Apr 1;22(7):2123-32. doi: 10.1016/j.bmc.2014.02.039. Epub 2014 Mar 3.


The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs.

Hunter FW, Jaiswal JK, Hurley DG, Liyanage HD, McManaway SP, Gu Y, Richter S, Wang J, Tercel M, Print CG, Wilson WR, Pruijn FB.

Biochem Pharmacol. 2014 May 15;89(2):224-35. doi: 10.1016/j.bcp.2014.03.001. Epub 2014 Mar 13.


Targeting hypoxia in the leukemia microenvironment.

Benito J, Zeng Z, Konopleva M, Wilson WR.

Int J Hematol Oncol. 2013 Aug 1;2(4):279-288.


A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Jamieson SM, Gu Y, Manesh DM, El-Hoss J, Jing D, Mackenzie KL, Guise CP, Foehrenbacher A, Pullen SM, Benito J, Smaill JB, Patterson AV, Mulaw MA, Konopleva M, Bohlander SK, Lock RB, Wilson WR.

Biochem Pharmacol. 2014 Mar 1;88(1):36-45. doi: 10.1016/j.bcp.2013.12.019. Epub 2014 Jan 13.


Design of optimized hypoxia-activated prodrugs using pharmacokinetic/pharmacodynamic modeling.

Foehrenbacher A, Secomb TW, Wilson WR, Hicks KO.

Front Oncol. 2013 Dec 27;3:314. doi: 10.3389/fonc.2013.00314. Review.


Clinical presentation and outcomes of cardiovascular implantable electronic device infections in hemodialysis patients.

Hickson LJ, Gooden JY, Le KY, Baddour LM, Friedman PA, Hayes DL, Wilson WR, Steckelberg JM, Sohail MR.

Am J Kidney Dis. 2014 Jul;64(1):104-10. doi: 10.1053/j.ajkd.2013.11.018. Epub 2014 Jan 3.


Euthermic endocarditis.

DeSimone DC, Baddour LM, Lahr BD, Chung HH, Wilson WR, Steckelberg JM; Mayo Cardiovascular Infections Study Group.

PLoS One. 2013 Nov 11;8(11):e80144. doi: 10.1371/journal.pone.0080144. eCollection 2013.


Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.

Su J, Gu Y, Pruijn FB, Smaill JB, Patterson AV, Guise CP, Wilson WR.

J Biol Chem. 2013 Dec 27;288(52):37138-53. doi: 10.1074/jbc.M113.505222. Epub 2013 Nov 6.

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