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A validated UPLC-MS/MS assay for the quantification of amino acids and biogenic amines in rat urine.

Gray N, Plumb RS, Wilson ID, Nicholson JK.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Dec 29;1106-1107:50-57. doi: 10.1016/j.jchromb.2018.12.028. [Epub ahead of print]


The Metabolic Fate and Effects of 2-Bromophenol in Male Sprague-Dawley Rats.

Adesina-Georgiadis KN, Gray N, Plumb RS, Thompson DF, Holmes E, Nicholson JK, Wilson ID.

Xenobiotica. 2018 Dec 17:1-22. doi: 10.1080/00498254.2018.1559376. [Epub ahead of print]


The Evolutionarily Conserved Cassette Exon 7b Drives ERG's Oncogenic Properties.

Jumbe SL, Porazinski SR, Oltean S, Mansell JP, Vahabi B, Wilson ID, Ladomery MR.

Transl Oncol. 2019 Jan;12(1):134-142. doi: 10.1016/j.tranon.2018.09.001. Epub 2018 Oct 5.


The metabolic fate of fenclozic acid in chimeric mice with a humanized liver.

Ekdahl A, Weidolf L, Baginski M, Morikawa Y, Thompson RA, Wilson ID.

Arch Toxicol. 2018 Sep;92(9):2819-2828. doi: 10.1007/s00204-018-2274-0. Epub 2018 Aug 9.


Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective.

Athersuch TJ, Antoine DJ, Boobis AR, Coen M, Daly AK, Possamai L, Nicholson JK, Wilson ID.

Toxicol Res (Camb). 2018 Mar 6;7(3):347-357. doi: 10.1039/c7tx00340d. eCollection 2018 May 8. Review.


Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies.

Broadhurst D, Goodacre R, Reinke SN, Kuligowski J, Wilson ID, Lewis MR, Dunn WB.

Metabolomics. 2018;14(6):72. doi: 10.1007/s11306-018-1367-3. Epub 2018 May 18. Review.


Capillary ultra performance liquid chromatography-tandem mass spectrometry analysis of tienilic acid metabolites in urine following intravenous administration to the rat.

King AM, Grant I, Rainville PD, Isaac G, Coen M, Wilson ID, Plumb RS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 15;1087-1088:142-148. doi: 10.1016/j.jchromb.2018.04.034. Epub 2018 Apr 26.


The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice.

Wilson CE, Dickie AP, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ.

Arch Toxicol. 2018 Jun;92(6):1953-1967. doi: 10.1007/s00204-018-2212-1. Epub 2018 May 2.


Quality Control and Validation Issues in LC-MS Metabolomics.

Begou O, Gika HG, Theodoridis GA, Wilson ID.

Methods Mol Biol. 2018;1738:15-26. doi: 10.1007/978-1-4939-7643-0_2.


Metabolic Profiling: Status, Challenges, and Perspective.

Gika HG, Theodoridis GA, Wilson ID.

Methods Mol Biol. 2018;1738:3-13. doi: 10.1007/978-1-4939-7643-0_1.


Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems.

Bradshaw PR, Wilson ID, Gill RU, Butler PJ, Dilworth C, Athersuch TJ.

Sci Rep. 2018 Feb 5;8(1):2405. doi: 10.1038/s41598-018-20464-4.


Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation.

Glymenaki M, Barnes A, Hagan SO, Warhurst G, McBain AJ, Wilson ID, Kell DB, Else KJ, Cruickshank SM.

Sci Rep. 2017 Aug 18;7(1):8836. doi: 10.1038/s41598-017-08732-1.


Hyphenated MS-based targeted approaches in metabolomics.

Begou O, Gika HG, Wilson ID, Theodoridis G.

Analyst. 2017 Aug 21;142(17):3079-3100. doi: 10.1039/c7an00812k. Review.


Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection.

Rainville PD, Wilson ID, Nicholson JK, Isaac G, Mullin L, Langridge JI, Plumb RS.

Anal Chim Acta. 2017 Aug 22;982:1-8. doi: 10.1016/j.aca.2017.06.020. Epub 2017 Jun 19.


Residual ground-water levels of the neonicotinoid thiacloprid perturb chemosensing of Caenorhabditis elegans.

Hopewell H, Floyd KG, Burnell D, Hancock JT, Allainguillaume J, Ladomery MR, Wilson ID.

Ecotoxicology. 2017 Sep;26(7):981-990. doi: 10.1007/s10646-017-1826-z. Epub 2017 Jun 22.


Application of 1H NMR spectroscopy to the metabolic phenotyping of rodent brain extracts: A metabonomic study of gut microbial influence on host brain metabolism.

Swann JR, Garcia-Perez I, Braniste V, Wilson ID, Sidaway JE, Nicholson JK, Pettersson S, Holmes E.

J Pharm Biomed Anal. 2017 Sep 5;143:141-146. doi: 10.1016/j.jpba.2017.05.040. Epub 2017 May 31.


MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure.

Triantafyllou E, Pop OT, Possamai LA, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies SP, Tickle J, Yuksel M, Patel VC, Abeles RD, Stamataki Z, Curbishley SM, Ma Y, Wilson ID, Coen M, Woollard KJ, Quaglia A, Wendon J, Thursz MR, Adams DH, Weston CJ, Antoniades CG.

Gut. 2018 Feb;67(2):333-347. doi: 10.1136/gutjnl-2016-313615. Epub 2017 Apr 27.


The pharmacokinetics and metabolism of lumiracoxib in chimeric humanized and murinized FRG mice.

Dickie AP, Wilson CE, Schreiter K, Wehr R, Wilson EM, Bial J, Scheer N, Wilson ID, Riley RJ.

Biochem Pharmacol. 2017 Jul 1;135:139-150. doi: 10.1016/j.bcp.2017.03.015. Epub 2017 Mar 27.


Gut microbiota modulation of chemotherapy efficacy and toxicity.

Alexander JL, Wilson ID, Teare J, Marchesi JR, Nicholson JK, Kinross JM.

Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):356-365. doi: 10.1038/nrgastro.2017.20. Epub 2017 Mar 8. Review.


High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure.

Gray N, Zia R, King A, Patel VC, Wendon J, McPhail MJ, Coen M, Plumb RS, Wilson ID, Nicholson JK.

Anal Chem. 2017 Feb 21;89(4):2478-2487. doi: 10.1021/acs.analchem.6b04623. Epub 2017 Feb 7.


Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice.

Pickup K, Martin S, Partridge EA, Jones HB, Wills J, Schulz-Utermoehl T, McCarthy A, Rodrigues A, Page C, Ratcliffe K, Sarda S, Wilson ID.

Arch Toxicol. 2017 Jul;91(7):2643-2653. doi: 10.1007/s00204-016-1894-5. Epub 2016 Nov 28.


Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Akingbasote JA, Foster AJ, Jones HB, David R, Gooderham NJ, Wilson ID, Kenna JG.

Toxicol Res (Camb). 2016 Nov 9;6(1):81-88. doi: 10.1039/c6tx00376a. eCollection 2017 Jan 1.


Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis.

Michopoulos F, Karagianni N, Whalley NM, Firth MA, Nikolaou C, Wilson ID, Critchlow SE, Kollias G, Theodoridis GA.

J Proteome Res. 2016 Dec 2;15(12):4579-4590. Epub 2016 Oct 28.


Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities.

Goveia J, Pircher A, Conradi LC, Kalucka J, Lagani V, Dewerchin M, Eelen G, DeBerardinis RJ, Wilson ID, Carmeliet P.

EMBO Mol Med. 2016 Oct 4;8(10):1134-1142. doi: 10.15252/emmm.201606798. Print 2016 Oct.


Gut microbiome interactions with drug metabolism, efficacy, and toxicity.

Wilson ID, Nicholson JK.

Transl Res. 2017 Jan;179:204-222. doi: 10.1016/j.trsl.2016.08.002. Epub 2016 Aug 13. Review.


The 44th annual open meeting of the Drug Metabolism Discussion Group (DMDG) at Robinson College, Cambridge, UK, September 16th-18th, 2015.

Wilson ID.

Xenobiotica. 2016 Jul;46(7):664-666. doi: 10.3109/00498254.2016.1164798. No abstract available.


Analysis of polar urinary metabolites for metabolic phenotyping using supercritical fluid chromatography and mass spectrometry.

Sen A, Knappy C, Lewis MR, Plumb RS, Wilson ID, Nicholson JK, Smith NW.

J Chromatogr A. 2016 Jun 3;1449:141-55. doi: 10.1016/j.chroma.2016.04.040. Epub 2016 Apr 19.


Development of a Rapid Microbore Metabolic Profiling Ultraperformance Liquid Chromatography-Mass Spectrometry Approach for High-Throughput Phenotyping Studies.

Gray N, Adesina-Georgiadis K, Chekmeneva E, Plumb RS, Wilson ID, Nicholson JK.

Anal Chem. 2016 Jun 7;88(11):5742-51. doi: 10.1021/acs.analchem.6b00038. Epub 2016 May 9.


Corrigendum to "Protocol for quality control in metabolic profiling of biological fluids by U(H)PLC-MS" [J. Chromatogr. B 1008 (2016) 15-25].

Gika HG, Zisi C, Theodoridis G, Wilson ID.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:214. doi: 10.1016/j.jchromb.2016.02.026. Epub 2016 Feb 26. No abstract available.


Advances in Mass Spectrometry Within Drug Discovery.

Wingfield J, Wilson ID.

J Biomol Screen. 2016 Feb;21(2):109-10. doi: 10.1177/1087057115623454. No abstract available.


Comparative metabonomic analysis of hepatotoxicity induced by acetaminophen and its less toxic meta-isomer.

Kyriakides M, Maitre L, Stamper BD, Mohar I, Kavanagh TJ, Foster J, Wilson ID, Holmes E, Nelson SD, Coen M.

Arch Toxicol. 2016 Dec;90(12):3073-3085. Epub 2016 Jan 9.


Protocol for quality control in metabolic profiling of biological fluids by U(H)PLC-MS.

Gika HG, Zisi C, Theodoridis G, Wilson ID.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:15-25. doi: 10.1016/j.jchromb.2015.10.045. Epub 2015 Nov 10. Erratum in: J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:214.


Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Stahl SH, Yates JW, Nicholls AW, Kenna JG, Coen M, Ortega F, Nicholson JK, Wilson ID.

Drug Discov Today Technol. 2015 Aug;15:9-14. doi: 10.1016/j.ddtec.2015.06.003. Epub 2015 Jul 16. Review.


A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.

Scheer N, Wilson ID.

Drug Discov Today. 2016 Feb;21(2):250-63. doi: 10.1016/j.drudis.2015.09.002. Epub 2015 Sep 7. Review.


An integrated ceramic, micro-fluidic device for the LC/MS/MS analysis of pharmaceuticals in plasma.

Rainville PD, Murphy JP, Tomany M, Wilson ID, Smith NW, Evans C, Kheler J, Bowen C, Plumb RS, Nicholson JK.

Analyst. 2015 Aug 21;140(16):5546-56. doi: 10.1039/c5an00646e.


Integration of microfluidic LC with HRMS for the analysis of analytes in biofluids: past, present and future.

Rainville PD, Langridge JI, Wrona MD, Wilson ID, Plumb RS.

Bioanalysis. 2015;7(11):1397-411. doi: 10.4155/bio.15.68.


Solid phase extraction methodology for UPLC-MS based metabolic profiling of urine samples.

Michopoulos F, Gika H, Palachanis D, Theodoridis G, Wilson ID.

Electrophoresis. 2015 Sep;36(18):2170-2178. doi: 10.1002/elps.201500101. Epub 2015 Jul 6.


High-Throughput Microbore UPLC-MS Metabolic Phenotyping of Urine for Large-Scale Epidemiology Studies.

Gray N, Lewis MR, Plumb RS, Wilson ID, Nicholson JK.

J Proteome Res. 2015 Jun 5;14(6):2714-21. doi: 10.1021/acs.jproteome.5b00203. Epub 2015 May 11.


Predicting drug metabolism: experiment and/or computation?

Kirchmair J, Göller AH, Lang D, Kunze J, Testa B, Wilson ID, Glen RC, Schneider G.

Nat Rev Drug Discov. 2015 Jun;14(6):387-404. doi: 10.1038/nrd4581. Epub 2015 Apr 24. Review.


Identification of a novel human circulating metabolite of tenofovir disoproxil fumarate with LC-MS/MS.

Nye LC, Gray N, McClure M, Boffit M, Holmes E, Plumb RS, Wilson ID.

Bioanalysis. 2015;7(6):643-52. doi: 10.4155/bio.14.300.


The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS ((79/81)Br), HPLC-ICPMS & HPLC-oaTOFMS.

Duckett C, McCullagh M, Smith C, Wilson ID.

Xenobiotica. 2015;45(8):672-80. doi: 10.3109/00498254.2015.1007491. Epub 2015 Apr 2.


An overview of fecal sample preparation for global metabolic profiling.

Deda O, Gika HG, Wilson ID, Theodoridis GA.

J Pharm Biomed Anal. 2015 Sep 10;113:137-50. doi: 10.1016/j.jpba.2015.02.006. Epub 2015 Feb 14. Review.


Detection of thiol modifications by hydrogen sulfide.

Williams E, Pead S, Whiteman M, Wood ME, Wilson ID, Ladomery MR, Teklic T, Lisjak M, Hancock JT.

Methods Enzymol. 2015;555:233-51. doi: 10.1016/bs.mie.2014.11.026. Epub 2015 Jan 8.


Metabolic phenotyping by liquid chromatography-mass spectrometry to study human health and disease.

Wilson ID.

Anal Chem. 2015 Mar 3;87(5):2519. doi: 10.1021/acs.analchem.5b00409. Epub 2015 Feb 19. No abstract available.


A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

Rainville PD, Simeone JL, Root DS, Mallet CR, Wilson ID, Plumb RS.

Analyst. 2015 Mar 21;140(6):1921-31. doi: 10.1039/c4an02090a.


Molecular phenotyping of a UK population: defining the human serum metabolome.

Dunn WB, Lin W, Broadhurst D, Begley P, Brown M, Zelena E, Vaughan AA, Halsall A, Harding N, Knowles JD, Francis-McIntyre S, Tseng A, Ellis DI, O'Hagan S, Aarons G, Benjamin B, Chew-Graham S, Moseley C, Potter P, Winder CL, Potts C, Thornton P, McWhirter C, Zubair M, Pan M, Burns A, Cruickshank JK, Jayson GC, Purandare N, Wu FC, Finn JD, Haselden JN, Nicholls AW, Wilson ID, Goodacre R, Kell DB.

Metabolomics. 2015;11:9-26. Epub 2014 Jul 25.


A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.

Grimsley A, Foster A, Gallagher R, Hutchison M, Lundqvist A, Pickup K, Wilson ID, Samuelsson K.

Biochem Pharmacol. 2014 Dec 15;92(4):701-11. doi: 10.1016/j.bcp.2014.10.004. Epub 2014 Oct 22.


Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey.

Yu H, Barrass N, Gales S, Lenz E, Parry T, Powell H, Thurman D, Hutchison M, Wilson ID, Bi L, Qiao J, Qin Q, Ren J.

Xenobiotica. 2015 Mar;45(3):270-7. doi: 10.3109/00498254.2014.973000. Epub 2014 Oct 22.


Age and microenvironment outweigh genetic influence on the Zucker rat microbiome.

Lees H, Swann J, Poucher SM, Nicholson JK, Holmes E, Wilson ID, Marchesi JR.

PLoS One. 2014 Sep 18;9(9):e100916. doi: 10.1371/journal.pone.0100916. eCollection 2014.


Ethyl sulphate, a chemically reactive human metabolite of ethanol?

Mitchell SC, Waring RH, Wilson ID.

Xenobiotica. 2014 Nov;44(11):957-60. doi: 10.3109/00498254.2014.941045. Epub 2014 Jul 18.


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