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A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling.

Kasari V, Pochopien AA, Margus T, Murina V, Turnbull K, Zhou Y, Nissan T, Graf M, Nováček J, Atkinson GC, Johansson MJO, Wilson DN, Hauryliuk V.

Nucleic Acids Res. 2019 Jul 12. pii: gkz600. doi: 10.1093/nar/gkz600. [Epub ahead of print]


Intracellular Antimicrobial Peptides Targeting the Protein Synthesis Machinery.

Graf M, Wilson DN.

Adv Exp Med Biol. 2019;1117:73-89. doi: 10.1007/978-981-13-3588-4_6. Review.


The Natural Product Elegaphenone Potentiates Antibiotic Effects against Pseudomonas aeruginosa.

Zhao W, Cross AR, Crowe-McAuliffe C, Weigert-Munoz A, Csatary EE, Solinski AE, Krysiak J, Goldberg JB, Wilson DN, Medina E, Wuest WM, Sieber SA.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8581-8584. doi: 10.1002/anie.201903472. Epub 2019 May 16.


Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA.

Pausch P, Steinchen W, Wieland M, Klaus T, Freibert SA, Altegoer F, Wilson DN, Bange G.

J Biol Chem. 2018 Dec 21;293(51):19699-19709. doi: 10.1074/jbc.RA118.003070. Epub 2018 Oct 26.


Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.

Beckert B, Turk M, Czech A, Berninghausen O, Beckmann R, Ignatova Z, Plitzko JM, Wilson DN.

Nat Microbiol. 2018 Oct;3(10):1115-1121. doi: 10.1038/s41564-018-0237-0. Epub 2018 Sep 3.


Structural basis for antibiotic resistance mediated by the Bacillus subtilis ABCF ATPase VmlR.

Crowe-McAuliffe C, Graf M, Huter P, Takada H, Abdelshahid M, Nováček J, Murina V, Atkinson GC, Hauryliuk V, Wilson DN.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8978-8983. doi: 10.1073/pnas.1808535115. Epub 2018 Aug 20.


Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1.

Graf M, Huter P, Maracci C, Peterek M, Rodnina MV, Wilson DN.

Nat Commun. 2018 Aug 3;9(1):3053. doi: 10.1038/s41467-018-05465-1.


Total Synthesis and Structural Revision of the Antibiotic Tetrapeptide GE81112A.

Jürjens G, Schuler SMM, Kurz M, Petit S, Couturier C, Jeannot F, Nguyen F, Wende RC, Hammann PE, Wilson DN, Bacqué E, Pöverlein C, Bauer A.

Angew Chem Int Ed Engl. 2018 Sep 10;57(37):12157-12161. doi: 10.1002/anie.201805901. Epub 2018 Aug 13.


The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics.

Polikanov YS, Aleksashin NA, Beckert B, Wilson DN.

Front Mol Biosci. 2018 May 14;5:48. doi: 10.3389/fmolb.2018.00048. eCollection 2018. Review.


Fragments of the Nonlytic Proline-Rich Antimicrobial Peptide Bac5 Kill Escherichia coli Cells by Inhibiting Protein Synthesis.

Mardirossian M, Barrière Q, Timchenko T, Müller C, Pacor S, Mergaert P, Scocchi M, Wilson DN.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00534-18. doi: 10.1128/AAC.00534-18. Print 2018 Aug.


The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome.

Mardirossian M, Pérébaskine N, Benincasa M, Gambato S, Hofmann S, Huter P, Müller C, Hilpert K, Innis CA, Tossi A, Wilson DN.

Cell Chem Biol. 2018 May 17;25(5):530-539.e7. doi: 10.1016/j.chembiol.2018.02.004. Epub 2018 Mar 8.


Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P.

Huter P, Arenz S, Bock LV, Graf M, Frister JO, Heuer A, Peil L, Starosta AL, Wohlgemuth I, Peske F, Nováček J, Berninghausen O, Grubmüller H, Tenson T, Beckmann R, Rodnina MV, Vaiana AC, Wilson DN.

Mol Cell. 2017 Nov 2;68(3):515-527.e6. doi: 10.1016/j.molcel.2017.10.014.


Myticalins: A Novel Multigenic Family of Linear, Cationic Antimicrobial Peptides from Marine Mussels (Mytilus spp.).

Leoni G, De Poli A, Mardirossian M, Gambato S, Florian F, Venier P, Wilson DN, Tossi A, Pallavicini A, Gerdol M.

Mar Drugs. 2017 Aug 22;15(8). pii: E261. doi: 10.3390/md15080261.


An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.

Florin T, Maracci C, Graf M, Karki P, Klepacki D, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN, Rodnina MV, Mankin AS.

Nat Struct Mol Biol. 2017 Sep;24(9):752-757. doi: 10.1038/nsmb.3439. Epub 2017 Jul 24.


Structural Basis for Ribosome Rescue in Bacteria.

Huter P, Müller C, Arenz S, Beckert B, Wilson DN.

Trends Biochem Sci. 2017 Aug;42(8):669-680. doi: 10.1016/j.tibs.2017.05.009. Epub 2017 Jun 16. Review.


The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.

Su T, Cheng J, Sohmen D, Hedman R, Berninghausen O, von Heijne G, Wilson DN, Beckmann R.

Elife. 2017 May 30;6. pii: e25642. doi: 10.7554/eLife.25642.


Proline-rich antimicrobial peptides targeting protein synthesis.

Graf M, Mardirossian M, Nguyen F, Seefeldt AC, Guichard G, Scocchi M, Innis CA, Wilson DN.

Nat Prod Rep. 2017 Jul 1;34(7):702-711. doi: 10.1039/c7np00020k. Epub 2017 May 24. Review.


Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.

Beckert B, Abdelshahid M, Schäfer H, Steinchen W, Arenz S, Berninghausen O, Beckmann R, Bange G, Turgay K, Wilson DN.

EMBO J. 2017 Jul 14;36(14):2061-2072. doi: 10.15252/embj.201696189. Epub 2017 May 3.


Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea.

Prunetti L, Graf M, Blaby IK, Peil L, Makkay AM, Starosta AL, Papke RT, Oshima T, Wilson DN, de Crécy-Lagard V.

Archaea. 2016 Dec 8;2016:7316725. doi: 10.1155/2016/7316725. eCollection 2016.


Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions.

Graf M, Arenz S, Huter P, Dönhöfer A, Novácek J, Wilson DN.

Nucleic Acids Res. 2017 Mar 17;45(5):2887-2896. doi: 10.1093/nar/gkw1272.


Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons.

Huter P, Müller C, Beckert B, Arenz S, Berninghausen O, Beckmann R, Wilson DN.

Nature. 2017 Jan 26;541(7638):546-549. doi: 10.1038/nature20821. Epub 2016 Dec 1.


Climbing to the peak of nascent-chain knowledge.

Wilson DN, Clark PL.

Nat Struct Mol Biol. 2016 Nov 4;23(11):949-951. doi: 10.1038/nsmb.3314. No abstract available.


Bacterial Protein Synthesis as a Target for Antibiotic Inhibition.

Arenz S, Wilson DN.

Cold Spring Harb Perspect Med. 2016 Sep 1;6(9). pii: a025361. doi: 10.1101/cshperspect.a025361. Review.


A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.

Arenz S, Bock LV, Graf M, Innis CA, Beckmann R, Grubmüller H, Vaiana AC, Wilson DN.

Nat Commun. 2016 Jul 6;7:12026. doi: 10.1038/ncomms12026.


Resveratrol prevents pulmonary trunk remodeling but not right ventricular hypertrophy in monocrotaline-induced pulmonary hypertension.

Wilson DN, Schacht SE, Al-Nakkash L, Babu JR, Broderick TL.

Pathophysiology. 2016 Dec;23(4):243-250. doi: 10.1016/j.pathophys.2016.05.004. Epub 2016 May 27.


Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.

Arenz S, Juette MF, Graf M, Nguyen F, Huter P, Polikanov YS, Blanchard SC, Wilson DN.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7527-32. doi: 10.1073/pnas.1604790113. Epub 2016 Jun 21.


Knud Hermann Nierhaus 1941-2016.

Wilson DN, Spahn CM.

Nat Struct Mol Biol. 2016 Jun 7;23(6):503-4. doi: 10.1038/nsmb.3239. No abstract available.


The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

Arenz S, Abdelshahid M, Sohmen D, Payoe R, Starosta AL, Berninghausen O, Hauryliuk V, Beckmann R, Wilson DN.

Nucleic Acids Res. 2016 Jul 27;44(13):6471-81. doi: 10.1093/nar/gkw470. Epub 2016 May 25.


The ABC of Ribosome-Related Antibiotic Resistance.

Wilson DN.

MBio. 2016 May 3;7(3). pii: e00598-16. doi: 10.1128/mBio.00598-16.


Translation regulation via nascent polypeptide-mediated ribosome stalling.

Wilson DN, Arenz S, Beckmann R.

Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/ Epub 2016 Feb 7. Review.


Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.

Seefeldt AC, Graf M, Pérébaskine N, Nguyen F, Arenz S, Mardirossian M, Scocchi M, Wilson DN, Innis CA.

Nucleic Acids Res. 2016 Mar 18;44(5):2429-38. doi: 10.1093/nar/gkv1545. Epub 2016 Jan 20.


Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.

Schmidt C, Becker T, Heuer A, Braunger K, Shanmuganathan V, Pech M, Berninghausen O, Wilson DN, Beckmann R.

Nucleic Acids Res. 2016 Feb 29;44(4):1944-51. doi: 10.1093/nar/gkv1517. Epub 2015 Dec 28.


Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development.

Arenz S, Wilson DN.

Mol Cell. 2016 Jan 7;61(1):3-14. doi: 10.1016/j.molcel.2015.10.019. Epub 2015 Nov 12. Review.


Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A.

Lassak J, Wilson DN, Jung K.

Mol Microbiol. 2016 Jan;99(2):219-35. doi: 10.1111/mmi.13233. Epub 2015 Nov 5. Review.


Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome.

Doerfel LK, Wohlgemuth I, Kubyshkin V, Starosta AL, Wilson DN, Budisa N, Rodnina MV.

J Am Chem Soc. 2015 Oct 14;137(40):12997-3006. doi: 10.1021/jacs.5b07427. Epub 2015 Oct 5.


Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions.

Beckert B, Kedrov A, Sohmen D, Kempf G, Wild K, Sinning I, Stahlberg H, Wilson DN, Beckmann R.

Nat Struct Mol Biol. 2015 Oct;22(10):767-73. doi: 10.1038/nsmb.3086. Epub 2015 Sep 7.


Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA.

Antimicrob Agents Chemother. 2015 Sep;59(9):5870. doi: 10.1128/AAC.01551-15. No abstract available.


Antimicrobial peptides target ribosomes.

Wilson DN, Guichard G, Innis CA.

Oncotarget. 2015 Jul 10;6(19):16826-7. No abstract available.


Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.


The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.

Seefeldt AC, Nguyen F, Antunes S, Pérébaskine N, Graf M, Arenz S, Inampudi KK, Douat C, Guichard G, Wilson DN, Innis CA.

Nat Struct Mol Biol. 2015 Jun;22(6):470-5. doi: 10.1038/nsmb.3034. Epub 2015 May 18.


Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.

Sohmen D, Chiba S, Shimokawa-Chiba N, Innis CA, Berninghausen O, Beckmann R, Ito K, Wilson DN.

Nat Commun. 2015 Apr 23;6:6941. doi: 10.1038/ncomms7941.


Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution.

Arenz S, Nguyen F, Beckmann R, Wilson DN.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5401-6. doi: 10.1073/pnas.1501775112. Epub 2015 Apr 13.


Corrigendum: Arginine-rhamnosylation as new strategy to activate translation elongation factor P.

Lassak J, Keilhauer EC, Fürst M, Wuichet K, Gödeke J, Starosta AL, Chen JM, Søgaard-Andersen L, Rohr J, Wilson DN, Häussler S, Mann M, Jung K.

Nat Chem Biol. 2015 Apr;11(4):299. doi: 10.1038/nchembio0415-299d. No abstract available.


Arginine-rhamnosylation as new strategy to activate translation elongation factor P.

Lassak J, Keilhauer EC, Fürst M, Wuichet K, Gödeke J, Starosta AL, Chen JM, Søgaard-Andersen L, Rohr J, Wilson DN, Häussler S, Mann M, Jung K.

Nat Chem Biol. 2015 Apr;11(4):266-70. doi: 10.1038/nchembio.1751. Epub 2015 Feb 16. Erratum in: Nat Chem Biol. 2015 Apr;11(4):299.


Structural basis for the interaction of protein S1 with the Escherichia coli ribosome.

Byrgazov K, Grishkovskaya I, Arenz S, Coudevylle N, Temmel H, Wilson DN, Djinovic-Carugo K, Moll I.

Nucleic Acids Res. 2015 Jan;43(1):661-73. doi: 10.1093/nar/gku1314. Epub 2014 Dec 15.


A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P.

Starosta AL, Lassak J, Peil L, Atkinson GC, Woolstenhulme CJ, Virumäe K, Buskirk A, Tenson T, Remme J, Jung K, Wilson DN.

Cell Rep. 2014 Oct 23;9(2):476-83. doi: 10.1016/j.celrep.2014.09.008. Epub 2014 Oct 9.


Drug sensing by the ribosome induces translational arrest via active site perturbation.

Arenz S, Meydan S, Starosta AL, Berninghausen O, Beckmann R, Vázquez-Laslop N, Wilson DN.

Mol Cell. 2014 Nov 6;56(3):446-52. doi: 10.1016/j.molcel.2014.09.014. Epub 2014 Oct 8.


Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site.

Starosta AL, Lassak J, Peil L, Atkinson GC, Virumäe K, Tenson T, Remme J, Jung K, Wilson DN.

Nucleic Acids Res. 2014;42(16):10711-9. doi: 10.1093/nar/gku768. Epub 2014 Aug 20.


The bacterial translation stress response.

Starosta AL, Lassak J, Jung K, Wilson DN.

FEMS Microbiol Rev. 2014 Nov;38(6):1172-201. doi: 10.1111/1574-6976.12083. Epub 2014 Sep 26. Review.


Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein.

Ghalei H, von Moeller H, Eppers D, Sohmen D, Wilson DN, Loll B, Wahl MC.

Nucleic Acids Res. 2014 Jun;42(10):6698-708. doi: 10.1093/nar/gku259. Epub 2014 Apr 17.

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