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Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance.

McNeill DR, Whitaker AM, Stark WJ, Illuzzi JL, McKinnon PJ, Freudenthal BD, Wilson DM.

Mutagenesis. 2019 Dec 9. pii: gez046. doi: 10.1093/mutage/gez046. [Epub ahead of print]


The psychological impact of Stevens-Johnson syndrome and toxic epidermal necrolysis on patients' lives: a Critically Appraised Topic.

O'Reilly P, Kennedy C, Meskell P, Coffey A, Delaunois I, Dore L, Howard S, Ramsay B, Scanlon C, Wilson DM, Whelan B, Ryan S.

Br J Dermatol. 2019 Dec 2. doi: 10.1111/bjd.18746. [Epub ahead of print]


EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

Hsu JH, Rasmusson T, Robinson J, Pachl F, Read J, Kawatkar S, O' Donovan DH, Bagal S, Code E, Rawlins P, Argyrou A, Tomlinson R, Gao N, Zhu X, Chiarparin E, Jacques K, Shen M, Woods H, Bednarski E, Wilson DM, Drew L, Castaldi MP, Fawell S, Bloecher A.

Cell Chem Biol. 2020 Jan 16;27(1):41-46.e17. doi: 10.1016/j.chembiol.2019.11.004. Epub 2019 Nov 27.


The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

Jacobsen LM, Bocchino L, Evans-Molina C, DiMeglio L, Goland R, Wilson DM, Atkinson MA, Aye T, Russell WE, Wentworth JM, Boulware D, Geyer S, Sosenko JM.

Diabetologia. 2019 Nov 25. doi: 10.1007/s00125-019-05047-w. [Epub ahead of print]


High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.

Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM.

ACS Infect Dis. 2020 Jan 10;6(1):43-49. doi: 10.1021/acsinfecdis.9b00196. Epub 2019 Nov 21.


Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.

Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR.

Oncotarget. 2019 Oct 22;10(58):6096-6110. doi: 10.18632/oncotarget.27225. eCollection 2019 Oct 22.


The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS.

Zhou D, Sun L, Nguyen M, Yeh LT, Wilson DM.

Drug Metab Lett. 2019;13(2):111-122. doi: 10.2174/1872312813666191015162634.


One Year Clinical Experience of the First Commercial Hybrid Closed-Loop System.

Lal RA, Basina M, Maahs DM, Hood K, Buckingham B, Wilson DM.

Diabetes Care. 2019 Dec;42(12):2190-2196. doi: 10.2337/dc19-0855. Epub 2019 Sep 23.


Mentoring in research-focused doctoral nursing programs and student perceptions of career readiness in the United States.

Nersesian PV, Starbird LE, Wilson DM, Marea CX, Uveges MK, Choi SSW, Szanton SL, Cajita MI.

J Prof Nurs. 2019 Sep - Oct;35(5):358-364. doi: 10.1016/j.profnurs.2019.04.005. Epub 2019 Apr 15.


Is the bereavement grief intensity of survivors linked with their perception of death quality?

Wilson DM, Cohen J, Eliason C, Deliens L, Macleod R, Hewitt JA, Houttekier D.

Int J Palliat Nurs. 2019 Aug 2;25(8):398-405. doi: 10.12968/ijpn.2019.25.8.398.


A Research Literature Review to Determine How Bereavement Programs Are Evaluated.

Wilson DM, Errasti-Ibarrondo B, Rodríguez-Prat A.

Omega (Westport). 2019 Aug 20:30222819869492. doi: 10.1177/0030222819869492. [Epub ahead of print] No abstract available.


Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.

Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR.

Mol Pharm. 2019 Sep 3;16(9):3831-3841. doi: 10.1021/acs.molpharmaceut.9b00464. Epub 2019 Aug 16.


DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging.

Tiwari V, Wilson DM 3rd.

Am J Hum Genet. 2019 Aug 1;105(2):237-257. doi: 10.1016/j.ajhg.2019.06.005. Review.


Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.

Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR.

Chemistry. 2019 Sep 12;25(51):11842-11846. doi: 10.1002/chem.201902771. Epub 2019 Aug 20.


Funeral and interment practices of rural residents: A mixed methods study.

Rainsford S, Phillips CB, MacLeod RD, Wilson DM.

Death Stud. 2019 May 31:1-9. doi: 10.1080/07481187.2019.1616853. [Epub ahead of print]


Educational needs of healthcare professionals and members of the general public in Alberta Canada, 2 years after the implementation of medical assistance in dying.

Wilson DM, Triscott JAC, Cohen J, MacLeod R.

Health Soc Care Community. 2019 Sep;27(5):1295-1302. doi: 10.1111/hsc.12766. Epub 2019 May 31.


Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.

Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR.

Magn Reson Med. 2019 Sep;82(3):959-972. doi: 10.1002/mrm.27780. Epub 2019 May 3.


A Study to Understand the Impact of Bereavement Grief on the Workplace.

Wilson DM, Punjani S, Song Q, Low G.

Omega (Westport). 2019 Apr 25:30222819846419. doi: 10.1177/0030222819846419. [Epub ahead of print]


Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data.

Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. Epub 2019 Apr 9.


Where are we now in relation to determining the prevalence of ageism in this era of escalating population ageing?

Wilson DM, Errasti-Ibarrondo B, Low G.

Ageing Res Rev. 2019 May;51:78-84. doi: 10.1016/j.arr.2019.03.001. Epub 2019 Mar 9. Review.


Who Are High Users of Hospitals in Canada? Findings From a Population-Based Study.

Wilson DM, Shen Y, Birch S.

Can J Nurs Res. 2019 Dec;51(4):245-254. doi: 10.1177/0844562119833584. Epub 2019 Mar 7. No abstract available.


A Feasibility Study to Detect Neonatal Hypoglycemia in Infants of Diabetic Mothers Using Real-Time Continuous Glucose Monitoring.

Nally LM, Bondy N, Doiev J, Buckingham BA, Wilson DM.

Diabetes Technol Ther. 2019 Apr;21(4):170-176. doi: 10.1089/dia.2018.0337. Epub 2019 Mar 6.


Understanding ambivalence toward organ donation and transplantation: An exploratory study of nursing students.

Contiero PP, Wilson DM.

Nurse Educ Today. 2019 May;76:191-195. doi: 10.1016/j.nedt.2019.02.008. Epub 2019 Feb 22.


Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.

Shen Z, Lee CA, Wallach K, Valdez S, Wilson DM, Kerr B, Gillen M.

Clin Pharmacol Drug Dev. 2019 Jul;8(5):657-663. doi: 10.1002/cpdd.662. Epub 2019 Feb 13.


Rehabilitation After Hip Fracture for Nursing Home Residents: A Controlled Feasibility Trial.

Beaupre LA, Magaziner JS, Jones CA, Jhangri GS, Johnston DWC, Wilson DM, Majumdar SR.

J Gerontol A Biol Sci Med Sci. 2019 Aug 16;74(9):1518-1525. doi: 10.1093/gerona/glz031.


Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.

Shen Z, Lee CA, Valdez S, Yang X, Wilson DM, Flanagan T, Gillen M.

Clin Pharmacol Drug Dev. 2019 Jul;8(5):647-656. doi: 10.1002/cpdd.663. Epub 2019 Feb 12.


Experimental free ligand conformations: a missing link in structure-based drug discovery.

Chiarparin E, Packer MJ, Wilson DM.

Future Med Chem. 2019 Jan;11(2):79-82. doi: 10.4155/fmc-2018-0339. Epub 2019 Jan 16. No abstract available.


Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

Tron AE, Belmonte MA, Adam A, Aquila BM, Boise LH, Chiarparin E, Cidado J, Embrey KJ, Gangl E, Gibbons FD, Gregory GP, Hargreaves D, Hendricks JA, Johannes JW, Johnstone RW, Kazmirski SL, Kettle JG, Lamb ML, Matulis SM, Nooka AK, Packer MJ, Peng B, Rawlins PB, Robbins DW, Schuller AG, Su N, Yang W, Ye Q, Zheng X, Secrist JP, Clark EA, Wilson DM, Fawell SE, Hird AW.

Nat Commun. 2018 Dec 17;9(1):5341. doi: 10.1038/s41467-018-07551-w.


Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.

Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294. doi: 10.1073/pnas.1809682115. Epub 2018 Dec 11.


Imaging-Based Approach to Extradural Infections of the Spine.

Talbott JF, Shah VN, Uzelac A, Narvid J, Dumont RA, Chin CT, Wilson DM.

Semin Ultrasound CT MR. 2018 Dec;39(6):570-586. doi: 10.1053/j.sult.2018.09.003. Epub 2018 Sep 26. Review. No abstract available.


Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins.

Iyama T, Okur MN, Golato T, McNeill DR, Lu H, Hamilton R, Raja A, Bohr VA, Wilson DM 3rd.

Sci Rep. 2018 Nov 30;8(1):17490. doi: 10.1038/s41598-018-36027-6.


Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.

Yang C, Zhou D, Shen Z, Wilson DM, Renner M, Miner JN, Girardet JL, Lee CA.

Drug Metab Dispos. 2019 Feb;47(2):104-113. doi: 10.1124/dmd.118.080549. Epub 2018 Nov 15.


A study of nurse-based Injury Units in Ireland: An emergency care development for consideration worldwide.

Wilson DM, Devkota R.

Int J Health Plann Manage. 2019 Jan;34(1):e72-e84. doi: 10.1002/hpm.2700. Epub 2018 Nov 8.


Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR.

Behr SC, Villanueva-Meyer JE, Li Y, Wang YH, Wei J, Moroz A, Lee JK, Hsiao JC, Gao KT, Ma W, Cha S, Wilson DM, Seo Y, Nelson SJ, Chang SM, Evans MJ.

JCI Insight. 2018 Nov 2;3(21). pii: 93999. doi: 10.1172/jci.insight.93999.


Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.

McCoull W, Cheung T, Anderson E, Barton P, Burgess J, Byth K, Cao Q, Castaldi MP, Chen H, Chiarparin E, Carbajo RJ, Code E, Cowan S, Davey PR, Ferguson AD, Fillery S, Fuller NO, Gao N, Hargreaves D, Howard MR, Hu J, Kawatkar A, Kemmitt PD, Leo E, Molina DM, O'Connell N, Petteruti P, Rasmusson T, Raubo P, Rawlins PB, Ricchiuto P, Robb GR, Schenone M, Waring MJ, Zinda M, Fawell S, Wilson DM.

ACS Chem Biol. 2018 Nov 16;13(11):3131-3141. doi: 10.1021/acschembio.8b00698. Epub 2018 Oct 17.


Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.

Barker MD, Liddle J, Atkinson FL, Wilson DM, Dickson MC, Ramirez-Molina C, Lewis H, Davis RP, Somers DO, Neu M, Jones E, Watson R.

Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-3462. doi: 10.1016/j.bmcl.2018.09.022. Epub 2018 Sep 18.


Hippocampal Engagement During Recall Depends on Memory Content.

Ross DA, Sadil P, Wilson DM, Cowell RA.

Cereb Cortex. 2019 Apr 1;29(4):1699. doi: 10.1093/cercor/bhy182. No abstract available.


DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.

Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW.

Oncotarget. 2018 Aug 3;9(60):31719-31743. doi: 10.18632/oncotarget.25859. eCollection 2018 Aug 3.


Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans.

Shah V, Yang C, Shen Z, Kerr BM, Tieu K, Wilson DM, Hall J, Gillen M, Lee CA.

Xenobiotica. 2019 Jul;49(7):811-822. doi: 10.1080/00498254.2018.1504257. Epub 2018 Sep 12.


A scoping review of research to assess the frequency, types, and reasons for end-of-life care setting transitions.

Wilson DM, Birch S.

Scand J Public Health. 2018 Aug 13:1403494818785042. doi: 10.1177/1403494818785042. [Epub ahead of print]


Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.

Lee JS, Adler L, Karathia H, Carmel N, Rabinovich S, Auslander N, Keshet R, Stettner N, Silberman A, Agemy L, Helbling D, Eilam R, Sun Q, Brandis A, Malitsky S, Itkin M, Weiss H, Pinto S, Kalaora S, Levy R, Barnea E, Admon A, Dimmock D, Stern-Ginossar N, Scherz A, Nagamani SCS, Unda M, Wilson DM 3rd, Elhasid R, Carracedo A, Samuels Y, Hannenhalli S, Ruppin E, Erez A.

Cell. 2018 Sep 6;174(6):1559-1570.e22. doi: 10.1016/j.cell.2018.07.019. Epub 2018 Aug 9.


Recognition memory shielded from semantic but not perceptual interference in normal aging.

Wilson DM, Potter KW, Cowell RA.

Neuropsychologia. 2018 Oct;119:448-463. doi: 10.1016/j.neuropsychologia.2018.07.031. Epub 2018 Jul 30.


Sustained Continuous Glucose Monitor Use in Low-Income Youth with Type 1 Diabetes Following Insurance Coverage Supports Expansion of Continuous Glucose Monitor Coverage for All.

Prahalad P, Addala A, Buckingham BA, Wilson DM, Maahs DM.

Diabetes Technol Ther. 2018 Sep;20(9):632-634. doi: 10.1089/dia.2018.0204. Epub 2018 Jul 18. No abstract available.


Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes.

Haller MJ, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Miller JL, Atkinson MA, Becker DJ, Baidal D, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell W, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group.

Diabetes Care. 2018 Sep;41(9):1917-1925. doi: 10.2337/dc18-0494. Epub 2018 Jul 16.


Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Verinurad, a Selective Uric Acid Reabsorption Inhibitor.

Smith WB, Hall J, Berg JK, Kazimir M, Yamamoto A, Walker S, Lee CA, Shen Z, Wilson DM, Zhou D, Gillen M, Marbury TC.

Clin Drug Investig. 2018 Aug;38(8):703-713. doi: 10.1007/s40261-018-0652-2.


Use of Hospitals by Older versus Younger Canadians: Myths and Misconceptions.

Wilson DM, Shen Y, Low G.

Can J Aging. 2018 Sep;37(3):309-317. doi: 10.1017/S0714980818000235. Epub 2018 Jun 22.


Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.

Clippinger AJ, Allen D, Behrsing H, BéruBé KA, Bolger MB, Casey W, DeLorme M, Gaça M, Gehen SC, Glover K, Hayden P, Hinderliter P, Hotchkiss JA, Iskandar A, Keyser B, Luettich K, Ma-Hock L, Maione AG, Makena P, Melbourne J, Milchak L, Ng SP, Paini A, Page K, Patlewicz G, Prieto P, Raabe H, Reinke EN, Roper C, Rose J, Sharma M, Spoo W, Thorne PS, Wilson DM, Jarabek AM.

Toxicol In Vitro. 2018 Oct;52:131-145. doi: 10.1016/j.tiv.2018.06.009. Epub 2018 Jun 20. Review.


Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.

Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM.

Sci Rep. 2018 May 21;8(1):7928. doi: 10.1038/s41598-018-26296-6.


Measuring glucocorticoid receptor expression in vivo with PET.

Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson DM, Kurhanewicz J, Evans MJ.

Oncotarget. 2018 Apr 17;9(29):20399-20408. doi: 10.18632/oncotarget.24911. eCollection 2018 Apr 17.


APE1 deficiency promotes cellular senescence and premature aging features.

Li M, Yang X, Lu X, Dai N, Zhang S, Cheng Y, Zhang L, Yang Y, Liu Y, Yang Z, Wang D, Wilson DM 3rd.

Nucleic Acids Res. 2018 Jun 20;46(11):5664-5677. doi: 10.1093/nar/gky326.

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