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Items: 43


A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery.

Sjögren AK, Breitholtz K, Ahlberg E, Milton L, Forsgard M, Persson M, Stahl SH, Wilmer MJ, Hornberg JJ.

Arch Toxicol. 2018 Oct;92(10):3175-3190. doi: 10.1007/s00204-018-2284-y. Epub 2018 Aug 24.


Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip.

Vriend J, Nieskens TTG, Vormann MK, van den Berge BT, van den Heuvel A, Russel FGM, Suter-Dick L, Lanz HL, Vulto P, Masereeuw R, Wilmer MJ.

AAPS J. 2018 Jul 26;20(5):87. doi: 10.1208/s12248-018-0247-0.


Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study.

Suter-Dick L, Mauch L, Ramp D, Caj M, Vormann MK, Hutter S, Lanz HL, Vriend J, Masereeuw R, Wilmer MJ.

AAPS J. 2018 Jul 23;20(5):86. doi: 10.1208/s12248-018-0245-2.


Recellularized Native Kidney Scaffolds as a Novel Tool in Nephrotoxicity Screening.

Fedecostante M, Westphal KGC, Buono MF, Sanchez Romero N, Wilmer MJ, Kerkering J, Baptista PM, Hoenderop JG, Masereeuw R.

Drug Metab Dispos. 2018 Sep;46(9):1338-1350. doi: 10.1124/dmd.118.080721. Epub 2018 Jul 6.


Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.

Nieskens TTG, Peters JGP, Dabaghie D, Korte D, Jansen K, Van Asbeck AH, Tavraz NN, Friedrich T, Russel FGM, Masereeuw R, Wilmer MJ.

Drug Metab Dispos. 2018 May;46(5):592-599. doi: 10.1124/dmd.117.079384. Epub 2018 Mar 7.


Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.

Mihajlovic M, van den Heuvel LP, Hoenderop JG, Jansen J, Wilmer MJ, Westheim AJF, Allebes WA, Stamatialis D, Hilbrands LB, Masereeuw R.

Sci Rep. 2017 Aug 2;7(1):7103. doi: 10.1038/s41598-017-07582-1.


Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters.

Caetano-Pinto P, Jamalpoor A, Ham J, Goumenou A, Mommersteeg M, Pijnenburg D, Ruijtenbeek R, Sanchez-Romero N, van Zelst B, Heil SG, Jansen J, Wilmer MJ, van Herpen CML, Masereeuw R.

Mol Pharm. 2017 Jun 5;14(6):2147-2157. doi: 10.1021/acs.molpharmaceut.7b00308. Epub 2017 May 24.


Kidney-on-a-chip technology for renal proximal tubule tissue reconstruction.

Nieskens TT, Wilmer MJ.

Eur J Pharmacol. 2016 Nov 5;790:46-56. doi: 10.1016/j.ejphar.2016.07.018. Epub 2016 Jul 9. Review.


Bioengineered kidney tubules efficiently excrete uremic toxins.

Jansen J, Fedecostante M, Wilmer MJ, Peters JG, Kreuser UM, van den Broek PH, Mensink RA, Boltje TJ, Stamatialis D, Wetzels JF, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Sci Rep. 2016 May 31;6:26715. doi: 10.1038/srep26715.


Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line.

Caetano-Pinto P, Janssen MJ, Gijzen L, Verscheijden L, Wilmer MJ, Masereeuw R.

Mol Pharm. 2016 Mar 7;13(3):933-44. doi: 10.1021/acs.molpharmaceut.5b00821. Epub 2016 Feb 23.


A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.

Nieskens TT, Peters JG, Schreurs MJ, Smits N, Woestenenk R, Jansen K, van der Made TK, Röring M, Hilgendorf C, Wilmer MJ, Masereeuw R.

AAPS J. 2016 Mar;18(2):465-75. doi: 10.1208/s12248-016-9871-8. Epub 2016 Jan 28.


Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening.

Wilmer MJ, Ng CP, Lanz HL, Vulto P, Suter-Dick L, Masereeuw R.

Trends Biotechnol. 2016 Feb;34(2):156-170. doi: 10.1016/j.tibtech.2015.11.001. Epub 2015 Dec 18. Review.


Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

Gozalpour E, Wilmer MJ, Bilos A, Masereeuw R, Russel FG, Koenderink JB.

Toxicol In Vitro. 2016 Apr;32:138-45. doi: 10.1016/j.tiv.2015.12.009. Epub 2015 Dec 17.


Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.

Jansen J, De Napoli IE, Fedecostante M, Schophuizen CM, Chevtchik NV, Wilmer MJ, van Asbeck AH, Croes HJ, Pertijs JC, Wetzels JF, Hilbrands LB, van den Heuvel LP, Hoenderop JG, Stamatialis D, Masereeuw R.

Sci Rep. 2015 Nov 16;5:16702. doi: 10.1038/srep16702.


Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate.

Peters E, Geraci S, Heemskerk S, Wilmer MJ, Bilos A, Kraenzlin B, Gretz N, Pickkers P, Masereeuw R.

Br J Pharmacol. 2015 Oct;172(20):4932-45. doi: 10.1111/bph.13261. Epub 2015 Sep 22.


Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology.

Mutsaers HA, Caetano-Pinto P, Seegers AE, Dankers AC, van den Broek PH, Wetzels JF, van den Brand JA, van den Heuvel LP, Hoenderop JG, Wilmer MJ, Masereeuw R.

Toxicol In Vitro. 2015 Oct;29(7):1868-77. doi: 10.1016/j.tiv.2015.07.020. Epub 2015 Jul 26.


Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane.

Schophuizen CM, De Napoli IE, Jansen J, Teixeira S, Wilmer MJ, Hoenderop JG, Van den Heuvel LP, Masereeuw R, Stamatialis D.

Acta Biomater. 2015 Mar;14:22-32. doi: 10.1016/j.actbio.2014.12.002. Epub 2014 Dec 17.


Biotechnological challenges of bioartificial kidney engineering.

Jansen J, Fedecostante M, Wilmer MJ, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Biotechnol Adv. 2014 Nov 15;32(7):1317-1327. doi: 10.1016/j.biotechadv.2014.08.001. Epub 2014 Aug 16. Review.


A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue.

Jansen J, Schophuizen CM, Wilmer MJ, Lahham SH, Mutsaers HA, Wetzels JF, Bank RA, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Exp Cell Res. 2014 Apr 15;323(1):87-99. doi: 10.1016/j.yexcr.2014.02.011. Epub 2014 Feb 18.


Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.

Mekahli D, Decuypere JP, Sammels E, Welkenhuyzen K, Schoeber J, Audrezet MP, Corvelyn A, Dechênes G, Ong AC, Wilmer MJ, van den Heuvel L, Bultynck G, Parys JB, Missiaen L, Levtchenko E, De Smedt H.

Pflugers Arch. 2014 Aug;466(8):1591-604. doi: 10.1007/s00424-013-1394-x. Epub 2013 Nov 6.


Optimized metabolomic approach to identify uremic solutes in plasma of stage 3-4 chronic kidney disease patients.

Mutsaers HA, Engelke UF, Wilmer MJ, Wetzels JF, Wevers RA, van den Heuvel LP, Hoenderop JG, Masereeuw R.

PLoS One. 2013 Aug 2;8(8):e71199. doi: 10.1371/journal.pone.0071199. Print 2013.


Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition.

Hosper NA, van den Berg PP, de Rond S, Popa ER, Wilmer MJ, Masereeuw R, Bank RA.

Exp Cell Res. 2013 Nov 15;319(19):3000-9. doi: 10.1016/j.yexcr.2013.07.014. Epub 2013 Jul 29.


Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter.

Schophuizen CM, Wilmer MJ, Jansen J, Gustavsson L, Hilgendorf C, Hoenderop JG, van den Heuvel LP, Masereeuw R.

Pflugers Arch. 2013 Dec;465(12):1701-14. doi: 10.1007/s00424-013-1307-z. Epub 2013 Jun 29.


Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients.

Gorvin CM, Wilmer MJ, Piret SE, Harding B, van den Heuvel LP, Wrong O, Jat PS, Lippiat JD, Levtchenko EN, Thakker RV.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7014-9. doi: 10.1073/pnas.1302063110. Epub 2013 Apr 9.


Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration.

Mutsaers HA, Wilmer MJ, Reijnders D, Jansen J, van den Broek PH, Forkink M, Schepers E, Glorieux G, Vanholder R, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Biochim Biophys Acta. 2013 Jan;1832(1):142-50. doi: 10.1016/j.bbadis.2012.09.006. Epub 2012 Sep 24.


Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity.

Moghadasali R, Mutsaers HA, Azarnia M, Aghdami N, Baharvand H, Torensma R, Wilmer MJ, Masereeuw R.

Exp Toxicol Pathol. 2013 Jul;65(5):595-600. doi: 10.1016/j.etp.2012.06.002. Epub 2012 Jun 21.


Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters?

Mutsaers HA, Wilmer MJ, van den Heuvel LP, Hoenderop JG, Masereeuw R.

Nephrol Dial Transplant. 2011 Dec;26(12):4149. doi: 10.1093/ndt/gfr562. Epub 2011 Oct 24. No abstract available.


Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells.

Wilmer MJ, Kluijtmans LA, van der Velden TJ, Willems PH, Scheffer PG, Masereeuw R, Monnens LA, van den Heuvel LP, Levtchenko EN.

Biochim Biophys Acta. 2011 Jun;1812(6):643-51. doi: 10.1016/j.bbadis.2011.02.010. Epub 2011 Feb 28.


Role of p-glycoprotein expression and function in cystinotic renal proximal tubular cells.

Peeters K, Wilmer MJ, Schoeber JP, Reijnders D, Heuvel LP, Masereeuw R, Levtchenko E.

Pharmaceutics. 2011 Oct 27;3(4):782-92. doi: 10.3390/pharmaceutics3040782.


The pathogenesis of cystinosis: mechanisms beyond cystine accumulation.

Wilmer MJ, Emma F, Levtchenko EN.

Am J Physiol Renal Physiol. 2010 Nov;299(5):F905-16. doi: 10.1152/ajprenal.00318.2010. Epub 2010 Sep 8. Review.


Cystinosis: practical tools for diagnosis and treatment.

Wilmer MJ, Schoeber JP, van den Heuvel LP, Levtchenko EN.

Pediatr Nephrol. 2011 Feb;26(2):205-15. doi: 10.1007/s00467-010-1627-6. Epub 2010 Aug 24. Review.


Analysis of CTNS gene transcripts in nephropathic cystinosis.

Taranta A, Wilmer MJ, van den Heuvel LP, Bencivenga P, Bellomo F, Levtchenko EN, Emma F.

Pediatr Nephrol. 2010 Jul;25(7):1263-7. doi: 10.1007/s00467-010-1502-5. Epub 2010 Mar 30.


Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters.

Wilmer MJ, Saleem MA, Masereeuw R, Ni L, van der Velden TJ, Russel FG, Mathieson PW, Monnens LA, van den Heuvel LP, Levtchenko EN.

Cell Tissue Res. 2010 Feb;339(2):449-57. doi: 10.1007/s00441-009-0882-y. Epub 2009 Nov 10.


FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia?

Cairo ER, Swarts HG, Wilmer MJ, Willems PH, Levtchenko EN, De Pont JJ, Koenderink JB.

J Membr Biol. 2009 Oct;231(2-3):117-24. doi: 10.1007/s00232-009-9210-4. Epub 2009 Oct 29.


Mitochondrial complex V expression and activity in cystinotic fibroblasts.

Wilmer MJ, van den Heuvel LP, Rodenburg RJ, Vogel RO, Nijtmans LG, Monnens LA, Levtchenko EN.

Pediatr Res. 2008 Nov;64(5):495-7. doi: 10.1203/PDR.0b013e318183fd67.


Urinary protein excretion pattern and renal expression of megalin and cubilin in nephropathic cystinosis.

Wilmer MJ, Christensen EI, van den Heuvel LP, Monnens LA, Levtchenko EN.

Am J Kidney Dis. 2008 Jun;51(6):893-903. doi: 10.1053/j.ajkd.2008.03.010. Epub 2008 May 2.


The use of CDME in cystinosis research.

Wilmer MJ, van den Heuvel LP, Levtchenko EN.

Neurochem Res. 2008 Nov;33(11):2373-4. doi: 10.1007/s11064-008-9709-6. Epub 2008 Apr 22. No abstract available.


Identification and subcellular localization of a new cystinosin isoform.

Taranta A, Petrini S, Palma A, Mannucci L, Wilmer MJ, De Luca V, Diomedi-Camassei F, Corallini S, Bellomo F, van den Heuvel LP, Levtchenko EN, Emma F.

Am J Physiol Renal Physiol. 2008 May;294(5):F1101-8. doi: 10.1152/ajprenal.00413.2007. Epub 2008 Mar 12.


P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury.

Huls M, Kramers C, Levtchenko EN, Wilmer MJ, Dijkman HB, Kluijtmans LA, van der Hoorn JW, Russel FG, Masereeuw R.

Kidney Int. 2007 Nov;72(10):1233-41. Epub 2007 Sep 12.


Cystine dimethylester model of cystinosis: still reliable?

Wilmer MJ, Willems PH, Verkaart S, Visch HJ, de Graaf-Hess A, Blom HJ, Monnens LA, van den Heuvel LP, Levtchenko EN.

Pediatr Res. 2007 Aug;62(2):151-5.


Decreased intracellular ATP content and intact mitochondrial energy generating capacity in human cystinotic fibroblasts.

Levtchenko EN, Wilmer MJ, Janssen AJ, Koenderink JB, Visch HJ, Willems PH, de Graaf-Hess A, Blom HJ, van den Heuvel LP, Monnens LA.

Pediatr Res. 2006 Feb;59(2):287-92.


Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis.

Levtchenko EN, van Dael CM, de Graaf-Hess AC, Wilmer MJ, van den Heuvel LP, Monnens LA, Blom HJ.

Pediatr Nephrol. 2006 Jan;21(1):110-3. Epub 2005 Oct 27.


Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells.

Wilmer MJ, de Graaf-Hess A, Blom HJ, Dijkman HB, Monnens LA, van den Heuvel LP, Levtchenko EN.

Biochem Biophys Res Commun. 2005 Nov 18;337(2):610-4. Epub 2005 Sep 23.


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