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Items: 1 to 50 of 181

1.

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.

Jakobi AJ, Huber ST, Mortensen SA, Schultz SW, Palara A, Kuhm T, Shrestha BK, Lamark T, Hagen WJH, Wilmanns M, Johansen T, Brech A, Sachse C.

Nat Commun. 2020 Jan 23;11(1):440. doi: 10.1038/s41467-020-14343-8.

2.

Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment.

Chatziefthimiou SD, Hornburg P, Sauer F, Mueller S, Ugurlar D, Xu ER, Wilmanns M.

PLoS One. 2019 Dec 19;14(12):e0226693. doi: 10.1371/journal.pone.0226693. eCollection 2019.

3.

Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif.

Pogenberg V, Ballesteros-Álvarez J, Schober R, Sigvaldadóttir I, Obarska-Kosinska A, Milewski M, Schindl R, Ögmundsdóttir MH, Steingrímsson E, Wilmanns M.

Nucleic Acids Res. 2020 Jan 24;48(2):934-948. doi: 10.1093/nar/gkz1104.

4.

The ATPases of the mycobacterial type VII secretion system: Structural and mechanistic insights into secretion.

Crosskey TD, Beckham KSH, Wilmanns M.

Prog Biophys Mol Biol. 2019 Nov 22. pii: S0079-6107(19)30212-3. doi: 10.1016/j.pbiomolbio.2019.11.008. [Epub ahead of print] Review.

5.

An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.

Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O.

Mol Cell. 2019 Mar 21;73(6):1282-1291.e8. doi: 10.1016/j.molcel.2019.01.028. Epub 2019 Feb 18.

6.

MITF has a central role in regulating starvation-induced autophagy in melanoma.

Möller K, Sigurbjornsdottir S, Arnthorsson AO, Pogenberg V, Dilshat R, Fock V, Brynjolfsdottir SH, Bindesboll C, Bessadottir M, Ogmundsdottir HM, Simonsen A, Larue L, Wilmanns M, Thorsson V, Steingrimsson E, Ogmundsdottir MH.

Sci Rep. 2019 Jan 31;9(1):1055. doi: 10.1038/s41598-018-37522-6.

7.

Publisher Correction: A short isoform of ATG7 fails to lipidate LC3/GABARAP.

Ogmundsdottir MH, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, Ogmundsdottir HM, Simonsen A, Wilmanns M, Steingrimsson E.

Sci Rep. 2018 Nov 16;8(1):17194. doi: 10.1038/s41598-018-35540-y.

8.

Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems.

Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciutė G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV.

J Mol Biol. 2019 Jan 18;431(2):289-307. doi: 10.1016/j.jmb.2018.11.003. Epub 2018 Nov 10.

9.

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction.

Schneppenheim R, Hellermann N, Brehm MA, Klemm U, Obser T, Huck V, Schneider SW, Denis CV, Tischer A, Auton M, März W, Xu ER, Wilmanns M, Zotz RB.

Blood. 2019 Jan 24;133(4):356-365. doi: 10.1182/blood-2018-04-843425. Epub 2018 Oct 26.

10.

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor.

Xu ER, von Bülow S, Chen PC, Lenting PJ, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis CV, Wilmanns M, Hennig J.

Blood. 2019 Jan 24;133(4):366-376. doi: 10.1182/blood-2018-04-843615. Epub 2018 Oct 10.

11.

A short isoform of ATG7 fails to lipidate LC3/GABARAP.

Ogmundsdottir MH, Fock V, Sooman L, Pogenberg V, Dilshat R, Bindesbøll C, Ogmundsdottir HM, Simonsen A, Wilmanns M, Steingrimsson E.

Sci Rep. 2018 Sep 26;8(1):14391. doi: 10.1038/s41598-018-32694-7. Erratum in: Sci Rep. 2018 Nov 16;8(1):17194.

12.

Subcellular localization and stability of MITF are modulated by the bHLH-Zip domain.

Fock V, Gudmundsson SR, Gunnlaugsson HO, Stefansson JA, Ionasz V, Schepsky A, Viarigi J, Reynisson IE, Pogenberg V, Wilmanns M, Ogmundsdottir MH, Steingrimsson E.

Pigment Cell Melanoma Res. 2019 Jan;32(1):41-54. doi: 10.1111/pcmr.12721. Epub 2018 Jul 20.

PMID:
29938923
13.

Model-based local density sharpening of cryo-EM maps.

Jakobi AJ, Wilmanns M, Sachse C.

Elife. 2017 Oct 23;6. pii: e27131. doi: 10.7554/eLife.27131.

14.

Evolution of catalytic centers of antibodies by virtual screening of broad repertoire of mutants using supercomputer.

Golovin AV, Smirnov IV, Stepanova AV, Zalevskiy AO, Zlobin AS, Ponomarenko NA, Belogurov AA, Knorre VD, Hurs EN, Chatziefthimiou SD, Wilmanns M, Blackburn GM, Khomutov RM, Gabibov AG.

Dokl Biochem Biophys. 2017 Jul;475(1):245-249. doi: 10.1134/S1607672917040019. Epub 2017 Sep 2.

PMID:
28864894
15.

Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq.

Schulz EC, Seiler M, Zuliani C, Voigt F, Rybin V, Pogenberg V, Mücke N, Wilmanns M, Gibson TJ, Barabas O.

Sci Rep. 2017 Aug 29;7(1):9903. doi: 10.1038/s41598-017-10085-8.

16.

Crystallographic insights into a cobalt (III) sepulchrate based alternative cofactor system of P450 BM3 monooxygenase.

Panneerselvam S, Shehzad A, Mueller-Dieckmann J, Wilmanns M, Bocola M, Davari MD, Schwaneberg U.

Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):134-140. doi: 10.1016/j.bbapap.2017.07.010. Epub 2017 Jul 22.

PMID:
28739446
17.

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis.

Beckham KS, Ciccarelli L, Bunduc CM, Mertens HD, Ummels R, Lugmayr W, Mayr J, Rettel M, Savitski MM, Svergun DI, Bitter W, Wilmanns M, Marlovits TC, Parret AH, Houben EN.

Nat Microbiol. 2017 Apr 10;2:17047. doi: 10.1038/nmicrobiol.2017.47.

PMID:
28394313
18.

Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells.

Costello JL, Castro IG, Camões F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp NA, Ribeiro D, Wilmanns M, Jedd G, Islinger M, Schrader M.

J Cell Sci. 2017 May 1;130(9):1675-1687. doi: 10.1242/jcs.200204. Epub 2017 Mar 21.

19.

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M.

Nat Commun. 2017 Mar 10;8:14635. doi: 10.1038/ncomms14635.

20.

Robotic QM/MM-driven maturation of antibody combining sites.

Smirnov IV, Golovin AV, Chatziefthimiou SD, Stepanova AV, Peng Y, Zolotareva OI, Belogurov AA Jr, Kurkova IN, Ponomarenko NA, Wilmanns M, Blackburn GM, Gabibov AG, Lerner RA.

Sci Adv. 2016 Oct 19;2(10):e1501695. eCollection 2016 Oct.

21.

Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction.

Hastings R, de Villiers CP, Hooper C, Ormondroyd L, Pagnamenta A, Lise S, Salatino S, Knight SJ, Taylor JC, Thomson KL, Arnold L, Chatziefthimiou SD, Konarev PV, Wilmanns M, Ehler E, Ghisleni A, Gautel M, Blair E, Watkins H, Gehmlich K.

Circ Cardiovasc Genet. 2016 Oct;9(5):426-435. Epub 2016 Sep 13.

22.

Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli.

Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP.

Data Brief. 2016 Jun 29;8:733-40. doi: 10.1016/j.dib.2016.06.033. eCollection 2016 Sep.

23.

A standardized production pipeline for high profile targets from Mycobacterium tuberculosis.

Milewski MC, Broger T, Kirkpatrick J, Filomena A, Komadina D, Schneiderhan-Marra N, Wilmanns M, Parret AH.

Proteomics Clin Appl. 2016 Oct;10(9-10):1049-1057. doi: 10.1002/prca.201600033. Epub 2016 Aug 3.

24.

Higher-order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle.

Bertipaglia C, Schneider S, Jakobi AJ, Tarafder AK, Bykov YS, Picco A, Kukulski W, Kosinski J, Hagen WJ, Ravichandran AC, Wilmanns M, Kaksonen M, Briggs JA, Sachse C.

EMBO Rep. 2016 Jul;17(7):1044-60. doi: 10.15252/embr.201541960. Epub 2016 Jun 6.

25.

Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2.

Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP.

Biochem Biophys Res Commun. 2016 Jul 22;476(2):102-7. doi: 10.1016/j.bbrc.2016.05.045. Epub 2016 May 11.

PMID:
27178209
26.

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites.

Simon B, Huart AS, Temmerman K, Vahokoski J, Mertens HD, Komadina D, Hoffmann JE, Yumerefendi H, Svergun DI, Kursula P, Schultz C, McCarthy AA, Hart DJ, Wilmanns M.

Structure. 2016 Jun 7;24(6):851-61. doi: 10.1016/j.str.2016.03.020. Epub 2016 Apr 28.

27.

In cellulo serial crystallography of alcohol oxidase crystals inside yeast cells.

Jakobi AJ, Passon DM, Knoops K, Stellato F, Liang M, White TA, Seine T, Messerschmidt M, Chapman HN, Wilmanns M.

IUCrJ. 2016 Jan 12;3(Pt 2):88-95. doi: 10.1107/S2052252515022927. eCollection 2016 Mar 1.

28.

Structural biology of the import pathways of peroxisomal matrix proteins.

Emmanouilidis L, Gopalswamy M, Passon DM, Wilmanns M, Sattler M.

Biochim Biophys Acta. 2016 May;1863(5):804-13. doi: 10.1016/j.bbamcr.2015.09.034. Epub 2015 Oct 9. Review.

29.

Towards the molecular mechanism of the integration of peroxisomal membrane proteins.

Giannopoulou EA, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M.

Biochim Biophys Acta. 2016 May;1863(5):863-9. doi: 10.1016/j.bbamcr.2015.09.031. Epub 2015 Oct 3. Review.

30.

Structural insights into cargo recognition by the yeast PTS1 receptor.

Hagen S, Drepper F, Fischer S, Fodor K, Passon D, Platta HW, Zenn M, Schliebs W, Girzalsky W, Wilmanns M, Warscheid B, Erdmann R.

J Biol Chem. 2015 Oct 30;290(44):26610-26. doi: 10.1074/jbc.M115.657973. Epub 2015 Sep 10.

31.

Molecular mechanisms of protein kinase regulation by calcium/calmodulin.

Simon B, Huart AS, Wilmanns M.

Bioorg Med Chem. 2015 Jun 15;23(12):2749-60. doi: 10.1016/j.bmc.2015.04.051. Epub 2015 Apr 24. Review.

PMID:
25963826
32.

Refined requirements for protein regions important for activity of the TALE AvrBs3.

Schreiber T, Sorgatz A, List F, Blüher D, Thieme S, Wilmanns M, Bonas U.

PLoS One. 2015 Mar 17;10(3):e0120214. doi: 10.1371/journal.pone.0120214. eCollection 2015.

33.

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

Werner S, Brors B, Eick J, Marques E, Pogenberg V, Parret A, Kemming D, Wood AW, Edgren H, Neubauer H, Streichert T, Riethdorf S, Bedi U, Baccelli I, Jücker M, Eils R, Fehm T, Trumpp A, Johnsen SA, Klefström J, Wilmanns M, Müller V, Pantel K, Wikman H.

Cancer Discov. 2015 May;5(5):506-19. doi: 10.1158/2159-8290.CD-14-1042. Epub 2015 Feb 25.

34.

Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism.

Ehebauer MT, Zimmermann M, Jakobi AJ, Noens EE, Laubitz D, Cichocki B, Marrakchi H, Lanéelle MA, Daffé M, Sachse C, Dziembowski A, Sauer U, Wilmanns M.

PLoS Pathog. 2015 Feb 19;11(2):e1004623. doi: 10.1371/journal.ppat.1004623. eCollection 2015 Feb.

35.

Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly.

Das U, Pogenberg V, Subhramanyam UK, Wilmanns M, Gourinath S, Srinivasan A.

J Struct Biol. 2014 Dec;188(3):249-58. doi: 10.1016/j.jsb.2014.10.002. Epub 2014 Oct 22.

PMID:
25450593
36.

Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes.

Fodor K, Wolf J, Reglinski K, Passon DM, Lou Y, Schliebs W, Erdmann R, Wilmanns M.

Traffic. 2015 Jan;16(1):85-98. doi: 10.1111/tra.12238. Epub 2014 Dec 2.

37.

Structure of the Mycobacterium tuberculosis type VII secretion system chaperone EspG5 in complex with PE25-PPE41 dimer.

Korotkova N, Freire D, Phan TH, Ummels R, Creekmore CC, Evans TJ, Wilmanns M, Bitter W, Parret AH, Houben EN, Korotkov KV.

Mol Microbiol. 2014 Oct;94(2):367-82. doi: 10.1111/mmi.12770. Epub 2014 Sep 15.

38.

Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins.

Kravchenko IV, Furalyov VA, Chatziefthimiou S, Wilmanns M, Popov VO.

Mol Cell Endocrinol. 2015 Jan 5;399:69-77. doi: 10.1016/j.mce.2014.08.010. Epub 2014 Aug 22.

PMID:
25152160
39.

Active site conformational changes upon reaction intermediate biotinyl-5'-AMP binding in biotin protein ligase from Mycobacterium tuberculosis.

Ma Q, Akhter Y, Wilmanns M, Ehebauer MT.

Protein Sci. 2014 Jul;23(7):932-9. doi: 10.1002/pro.2475. Epub 2014 Apr 22.

40.

Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody.

Ponomarenko N, Chatziefthimiou SD, Kurkova I, Mokrushina Y, Mokrushina Y, Stepanova A, Smirnov I, Avakyan M, Bobik T, Mamedov A, Mitkevich V, Belogurov A Jr, Fedorova OS, Dubina M, Golovin A, Lamzin V, Friboulet A, Makarov AA, Wilmanns M, Gabibov A.

Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):708-19. doi: 10.1107/S1399004713032446. Epub 2014 Feb 15.

41.

WXG100 protein superfamily consists of three subfamilies and exhibits an α-helical C-terminal conserved residue pattern.

Poulsen C, Panjikar S, Holton SJ, Wilmanns M, Song YH.

PLoS One. 2014 Feb 26;9(2):e89313. doi: 10.1371/journal.pone.0089313. eCollection 2014.

42.

Design of a bZip transcription factor with homo/heterodimer-induced DNA-binding preference.

Pogenberg V, Consani Textor L, Vanhille L, Holton SJ, Sieweke MH, Wilmanns M.

Structure. 2014 Mar 4;22(3):466-77. doi: 10.1016/j.str.2013.12.017. Epub 2014 Feb 13.

43.

A PEF/Y substrate recognition and signature motif plays a critical role in DAPK-related kinase activity.

Temmerman K, de Diego I, Pogenberg V, Simon B, Jonko W, Li X, Wilmanns M.

Chem Biol. 2014 Feb 20;21(2):264-73. doi: 10.1016/j.chembiol.2013.12.008. Epub 2014 Jan 16.

44.

Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells.

Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M.

ACS Chem Biol. 2014 Mar 21;9(3):769-76. doi: 10.1021/cb400903u. Epub 2014 Jan 15.

PMID:
24387659
45.

The 11th International Conference on Biology and Synchrotron Radiation.

Wilmanns M, Svergun DI.

J Synchrotron Radiat. 2014 Jan;21(Pt 1):280-2. doi: 10.1107/S1600577513030609. Epub 2013 Dec 3.

PMID:
24365950
46.

Group III alcohol dehydrogenase from Pectobacterium atrosepticum: insights into enzymatic activity and organization of the metal ion-containing region.

Elleuche S, Fodor K, von der Heyde A, Klippel B, Wilmanns M, Antranikian G.

Appl Microbiol Biotechnol. 2014 May;98(9):4041-51. doi: 10.1007/s00253-013-5374-z. Epub 2013 Nov 22.

PMID:
24265029
47.

Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.

Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Fürst DO.

Mol Biol Cell. 2013 Oct;24(20):3215-26. doi: 10.1091/mbc.E13-04-0202. Epub 2013 Aug 28.

48.

Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, 31P-NMR spectroscopy and reaction path modelling.

Barabás O, Németh V, Bodor A, Perczel A, Rosta E, Kele Z, Zagyva I, Szabadka Z, Grolmusz VI, Wilmanns M, Vértessy BG.

Nucleic Acids Res. 2013 Dec;41(22):10542-55. doi: 10.1093/nar/gkt756. Epub 2013 Aug 27.

49.

Structural and biochemical characterization of Rv2140c, a phosphatidylethanolamine-binding protein from Mycobacterium tuberculosis.

Eulenburg G, Higman VA, Diehl A, Wilmanns M, Holton SJ.

FEBS Lett. 2013 Sep 17;587(18):2936-42. doi: 10.1016/j.febslet.2013.07.038. Epub 2013 Jul 29.

50.

A disulphide bond in the E2 enzyme Pex4p modulates ubiquitin-conjugating activity.

Williams C, van den Berg M, Stanley WA, Wilmanns M, Distel B.

Sci Rep. 2013;3:2212. doi: 10.1038/srep02212.

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