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Items: 28


Evidence for distinct forms of compulsivity in the SAPAP3 mutant-mouse model for obsessive-compulsive disorder.

Ehmer I, Crown L, van Leeuwen W, Feenstra M, Willuhn I, Denys D.

eNeuro. 2020 Mar 25. pii: ENEURO.0245-19.2020. doi: 10.1523/ENEURO.0245-19.2020. [Epub ahead of print]


NINscope, a versatile miniscope for multi-region circuit investigations.

de Groot A, van den Boom BJ, van Genderen RM, Coppens J, van Veldhuijzen J, Bos J, Hoedemaker H, Negrello M, Willuhn I, De Zeeuw CI, Hoogland TM.

Elife. 2020 Jan 14;9. pii: e49987. doi: 10.7554/eLife.49987.


Instrumental learning in a mouse model for obsessive-compulsive disorder: Impaired habit formation in Sapap3 mutants.

Ehmer I, Feenstra M, Willuhn I, Denys D.

Neurobiol Learn Mem. 2020 Feb;168:107162. doi: 10.1016/j.nlm.2020.107162. Epub 2020 Jan 9.


Monitoring deep brain stimulation by measuring regional brain oxygen responses in freely moving mice.

Bazzu G, Serra PA, Hamelink R, Feenstra MGP, Willuhn I, Denys D.

J Neurosci Methods. 2019 Apr 1;317:20-28. doi: 10.1016/j.jneumeth.2019.01.012. Epub 2019 Feb 1.


Behavioral flexibility in a mouse model for obsessive-compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants.

van den Boom BJG, Mooij AH, Misevičiūtė I, Denys D, Willuhn I.

Genes Brain Behav. 2019 Apr;18(4):e12557. doi: 10.1111/gbb.12557. Epub 2019 Feb 27.


Differential Effects of Deep Brain Stimulation of the Internal Capsule and the Striatum on Excessive Grooming in Sapap3 Mutant Mice.

Pinhal CM, van den Boom BJG, Santana-Kragelund F, Fellinger L, Bech P, Hamelink R, Feng G, Willuhn I, Feenstra MGP, Denys D.

Biol Psychiatry. 2018 Dec 15;84(12):917-925. doi: 10.1016/j.biopsych.2018.05.011. Epub 2018 May 23.


A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states.

Verharen JPH, de Jong JW, Roelofs TJM, Huffels CFM, van Zessen R, Luijendijk MCM, Hamelink R, Willuhn I, den Ouden HEM, van der Plasse G, Adan RAH, Vanderschuren LJMJ.

Nat Commun. 2018 Feb 21;9(1):731. doi: 10.1038/s41467-018-03087-1.


Deep brain stimulation of the medial forebrain bundle elevates striatal dopamine concentration without affecting spontaneous or reward-induced phasic release.

Klanker M, Feenstra M, Willuhn I, Denys D.

Neuroscience. 2017 Nov 19;364:82-92. doi: 10.1016/j.neuroscience.2017.09.012. Epub 2017 Sep 14.


Automated classification of self-grooming in mice using open-source software.

van den Boom BJG, Pavlidi P, Wolf CJH, Mooij AH, Willuhn I.

J Neurosci Methods. 2017 Sep 1;289:48-56. doi: 10.1016/j.jneumeth.2017.05.026. Epub 2017 Jun 23.


Regionally distinct phasic dopamine release patterns in the striatum during reversal learning.

Klanker M, Fellinger L, Feenstra M, Willuhn I, Denys D.

Neuroscience. 2017 Mar 14;345:110-123. doi: 10.1016/j.neuroscience.2016.05.011. Epub 2016 May 13.


Compulsivity in obsessive-compulsive disorder and addictions.

Figee M, Pattij T, Willuhn I, Luigjes J, van den Brink W, Goudriaan A, Potenza MN, Robbins TW, Denys D.

Eur Neuropsychopharmacol. 2016 May;26(5):856-68. doi: 10.1016/j.euroneuro.2015.12.003. Epub 2015 Dec 11. Review.


Phasic dopamine release induced by positive feedback predicts individual differences in reversal learning.

Klanker M, Sandberg T, Joosten R, Willuhn I, Feenstra M, Denys D.

Neurobiol Learn Mem. 2015 Nov;125:135-45. doi: 10.1016/j.nlm.2015.08.011. Epub 2015 Sep 5.


Phasic dopamine release in the nucleus accumbens in response to pro-social 50 kHz ultrasonic vocalizations in rats.

Willuhn I, Tose A, Wanat MJ, Hart AS, Hollon NG, Phillips PE, Schwarting RK, Wöhr M.

J Neurosci. 2014 Aug 6;34(32):10616-23. doi: 10.1523/JNEUROSCI.1060-14.2014.


Repeated stress exposure causes strain-dependent shifts in the behavioral economics of cocaine in rats.

Groblewski PA, Zietz C, Willuhn I, Phillips PE, Chavkin C.

Addict Biol. 2015 Mar;20(2):297-301. doi: 10.1111/adb.12123. Epub 2014 Feb 15.


Excessive cocaine use results from decreased phasic dopamine signaling in the striatum.

Willuhn I, Burgeno LM, Groblewski PA, Phillips PE.

Nat Neurosci. 2014 May;17(5):704-9. doi: 10.1038/nn.3694. Epub 2014 Apr 6.


Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use.

Willuhn I, Burgeno LM, Everitt BJ, Phillips PE.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20703-8. doi: 10.1073/pnas.1213460109. Epub 2012 Nov 26.


Interactions between Procedural Learning and Cocaine Exposure Alter Spontaneous and Cortically Evoked Spike Activity in the Dorsal Striatum.

Ondracek JM, Willuhn I, Steiner H, West AR.

Front Neurosci. 2010 Dec 29;4:206. doi: 10.3389/fnins.2010.00206. eCollection 2010.


Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse.

Willuhn I, Wanat MJ, Clark JJ, Phillips PE.

Curr Top Behav Neurosci. 2010;3:29-71. doi: 10.1007/7854_2009_27. Review.


A selective role for dopamine in stimulus-reward learning.

Flagel SB, Clark JJ, Robinson TE, Mayo L, Czuj A, Willuhn I, Akers CA, Clinton SM, Phillips PE, Akil H.

Nature. 2011 Jan 6;469(7328):53-7. doi: 10.1038/nature09588. Epub 2010 Dec 8.


Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals.

Clark JJ, Sandberg SG, Wanat MJ, Gan JO, Horne EA, Hart AS, Akers CA, Parker JG, Willuhn I, Martinez V, Evans SB, Stella N, Phillips PE.

Nat Methods. 2010 Feb;7(2):126-9. doi: 10.1038/nmeth.1412. Epub 2009 Dec 27.


Phasic dopamine release in appetitive behaviors and drug addiction.

Wanat MJ, Willuhn I, Clark JJ, Phillips PE.

Curr Drug Abuse Rev. 2009 May;2(2):195-213. Review.


Long-lasting dysregulation of gene expression in corticostriatal circuits after repeated cocaine treatment in adult rats: effects on zif 268 and homer 1a.

Unal CT, Beverley JA, Willuhn I, Steiner H.

Eur J Neurosci. 2009 Apr;29(8):1615-26. doi: 10.1111/j.1460-9568.2009.06691.x.


Skill-memory consolidation in the striatum: critical for late but not early long-term memory and stabilized by cocaine.

Willuhn I, Steiner H.

Behav Brain Res. 2009 Apr 12;199(1):103-7. doi: 10.1016/j.bbr.2008.07.010. Epub 2008 Jul 18.


Motor-skill learning in a novel running-wheel task is dependent on D1 dopamine receptors in the striatum.

Willuhn I, Steiner H.

Neuroscience. 2008 Apr 22;153(1):249-58. doi: 10.1016/j.neuroscience.2008.01.041. Epub 2008 Feb 6.


Augmented D1 dopamine receptor signaling and immediate-early gene induction in adult striatum after prenatal cocaine.

Tropea TF, Guerriero RM, Willuhn I, Unterwald EM, Ehrlich ME, Steiner H, Kosofsky BE.

Biol Psychiatry. 2008 Jun 1;63(11):1066-74. doi: 10.1016/j.biopsych.2007.12.002. Epub 2008 Feb 13.


Impaired maze performance in aged rats is accompanied by increased density of NMDA, 5-HT1A, and alpha-adrenoceptor binding in hippocampus.

Topic B, Willuhn I, Palomero-Gallagher N, Zilles K, Huston JP, Hasenöhrl RU.

Hippocampus. 2007;17(1):68-77.


Motor-skill learning-associated gene regulation in the striatum: effects of cocaine.

Willuhn I, Steiner H.

Neuropsychopharmacology. 2006 Dec;31(12):2669-82. Epub 2006 Jan 4.


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