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Items: 13

1.

Solute Carrier Transporters as Potential Targets for the Treatment of Metabolic Disease.

Schumann T, König J, Henke C, Willmes DM, Bornstein SR, Jordan J, Fromm MF, Birkenfeld AL.

Pharmacol Rev. 2020 Jan;72(1):343-379. doi: 10.1124/pr.118.015735. Review.

PMID:
31882442
2.

Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.

Binger KJ, Neukam M, Tattikota SG, Qadri F, Puchkov D, Willmes DM, Wurmsee S, Geisberger S, Dechend R, Raile K, Kurth T, Nguyen G, Poy MN, Solimena M, Muller DN, Birkenfeld AL.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19983-19988. doi: 10.1073/pnas.1903678116. Epub 2019 Sep 16.

3.

The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target.

Willmes DM, Kurzbach A, Henke C, Schumann T, Zahn G, Heifetz A, Jordan J, Helfand SL, Birkenfeld AL.

Pharmacol Ther. 2018 May;185:1-11. doi: 10.1016/j.pharmthera.2017.10.003. Epub 2017 Oct 5. Review.

4.

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism.

von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, Jordan J, Pfeiffer AFH, Mingrone G, Bornstein SR, Stroehle P, Harms C, Wunderlich FT, Helfand SL, Bernier M, de Cabo R, Shulman GI, Chavakis T, Püschel GP, Birkenfeld AL.

Hepatology. 2017 Aug;66(2):616-630. doi: 10.1002/hep.29089. Epub 2017 Jun 26.

5.

Pharmacogenomics in type 2 diabetes: oral antidiabetic drugs.

Daniels MA, Kan C, Willmes DM, Ismail K, Pistrosch F, Hopkins D, Mingrone G, Bornstein SR, Birkenfeld AL.

Pharmacogenomics J. 2016 Oct;16(5):399-410. doi: 10.1038/tpj.2016.54. Epub 2016 Jul 19. Review.

PMID:
27432533
6.

The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance.

Willmes DM, Helfand SL, Birkenfeld AL.

Aging (Albany NY). 2016 Feb;8(2):208-9. No abstract available.

7.

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).

Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL.

Aging (Albany NY). 2015 Dec;7(12):1086-93.

8.

Knockdown of Indy/CeNac2 extends Caenorhabditis elegans life span by inducing AMPK/aak-2.

Schwarz F, Karadeniz Z, Fischer-Rosinsky A, Willmes DM, Spranger J, Birkenfeld AL.

Aging (Albany NY). 2015 Aug;7(8):553-67.

9.

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC.

Cell Metab. 2014 Oct 7;20(4):678-86. doi: 10.1016/j.cmet.2014.08.002.

10.

Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome.

Schlueter N, de Sterke A, Willmes DM, Spranger J, Jordan J, Birkenfeld AL.

Pharmacol Ther. 2014 Oct;144(1):12-27. doi: 10.1016/j.pharmthera.2014.04.007. Epub 2014 Apr 27. Review.

11.

The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.

Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, Püschel GP, Birkenfeld AL.

Diabetes. 2014 Mar;63(3):1048-57. doi: 10.2337/db13-0749. Epub 2013 Nov 12.

12.

The Role of INDY in Metabolic Regulation.

Willmes DM, Birkenfeld AL.

Comput Struct Biotechnol J. 2013 Dec 8;6:e201303020. doi: 10.5936/csbj.201303020. eCollection 2013. Review.

13.

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.

Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27.

PMID:
21441927

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