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Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis.

Ilaiwy A, Ten Have GAM, Bain JR, Muehlbauer MJ, O'Neal SK, Berthiaume JM, Parry TL, Deutz NE, Willis MS.

Am J Pathol. 2019 Sep;189(9):1797-1813. doi: 10.1016/j.ajpath.2019.05.021.


Walk the Line: The Role of Ubiquitin in Regulating Transcription in Myocytes.

Suryadevara V, Willis MS.

Physiology (Bethesda). 2019 Sep 1;34(5):327-340. doi: 10.1152/physiol.00055.2018.


Clinical Development of Therapeutic Agents for Hospitalized Patients With Influenza: Challenges and Innovations.

King JC, Beigel JH, Ison MG, Rothman RE, Uyeki TM, Walker RE, Neaton JD, Tegeris JS, Zhou JA, Armstrong KL, Carter W, Miele PS, Willis MS, Dugas AF, Tracy LA, Vock DM, Bright RA.

Open Forum Infect Dis. 2019 Mar 14;6(4):ofz137. doi: 10.1093/ofid/ofz137. eCollection 2019 Apr.


Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice.

Oakley RH, Cruz-Topete D, He B, Foley JF, Myers PH, Xu X, Gomez-Sanchez CE, Chambon P, Willis MS, Cidlowski JA.

Sci Signal. 2019 Apr 16;12(577). pii: eaau9685. doi: 10.1126/scisignal.aau9685.


Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1.

Willis MS, Parry TL, Brown DI, Mota RI, Huang W, Beak JY, Sola M, Zhou C, Hicks ST, Caughey MC, D'Agostino RB Jr, Jordan J, Hundley WG, Jensen BC.

Circ Heart Fail. 2019 Mar;12(3):e005234. doi: 10.1161/CIRCHEARTFAILURE.118.005234.


F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria.

Ling TY, Yi F, Lu T, Wang XL, Sun X, Willis MS, Wu LQ, Shen WK, Adelman JP, Lee HC.

J Biol Chem. 2019 Mar 15;294(11):4160-4168. doi: 10.1074/jbc.RA118.003837. Epub 2019 Jan 11.


Primary diffuse large B cell lymphoma of the vulva-Two new cases of a rare entity and review of the literature.

Ye AL, Willis MS, Link BK, Naridze RL, Syrbu SI, Liu V.

JAAD Case Rep. 2018 Oct 16;4(9):962-967. doi: 10.1016/j.jdcr.2018.06.023. eCollection 2018 Oct. No abstract available.


The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability.

Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O.

Acta Physiol (Oxf). 2019 Mar;225(3):e13195. doi: 10.1111/apha.13195. Epub 2018 Oct 22.


Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.

Oakley RH, Campen MJ, Paffett ML, Chen X, Wang Z, Parry TL, Hillhouse C, Cidlowski JA, Willis MS.

BMC Med Genet. 2018 Sep 21;19(1):175. doi: 10.1186/s12881-018-0670-1.


Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16.

Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC.

PLoS Genet. 2018 Sep 17;14(9):e1007664. doi: 10.1371/journal.pgen.1007664. eCollection 2018 Sep.


Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP.

Ravi S, Parry TL, Willis MS, Lockyer P, Patterson C, Bain JR, Stevens RD, Ilkayeva OR, Newgard CB, Schisler JC.

J Cardiovasc Dev Dis. 2018 Aug 15;5(3). pii: E43. doi: 10.3390/jcdd5030043.


Untargeted metabolomics analysis of ischemia-reperfusion-injured hearts ex vivo from sedentary and exercise-trained rats.

Parry TL, Starnes JW, O'Neal SK, Bain JR, Muehlbauer MJ, Honcoop A, Ilaiwy A, Christopher P, Patterson C, Willis MS.

Metabolomics. 2018 Jan;14(1):8. doi: 10.1007/s11306-017-1303-y. Epub 2017 Dec 4.


Image-Based Methods for Phase Estimation, Gating, and Temporal Superresolution of Cardiac Ultrasound.

Chittajallu DR, McCormick M, Gerber S, Czernuszewicz TJ, Gessner R, Willis MS, Niethammer M, Kwitt R, Aylward SR.

IEEE Trans Biomed Eng. 2019 Jan;66(1):72-79. doi: 10.1109/TBME.2018.2823279. Epub 2018 Apr 24.


Computer Modeling of Diabetes and Its Transparency: A Report on the Eighth Mount Hood Challenge.

Palmer AJ, Si L, Tew M, Hua X, Willis MS, Asseburg C, McEwan P, Leal J, Gray A, Foos V, Lamotte M, Feenstra T, O'Connor PJ, Brandle M, Smolen HJ, Gahn JC, Valentine WJ, Pollock RF, Breeze P, Brennan A, Pollard D, Ye W, Herman WH, Isaman DJ, Kuo S, Laiteerapong N, Tran-Duy A, Clarke PM.

Value Health. 2018 Jun;21(6):724-731. doi: 10.1016/j.jval.2018.02.002. Epub 2018 Apr 9.


Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates.

Pascal KE, Dudgeon D, Trefry JC, Anantpadma M, Sakurai Y, Murin CD, Turner HL, Fairhurst J, Torres M, Rafique A, Yan Y, Badithe A, Yu K, Potocky T, Bixler SL, Chance TB, Pratt WD, Rossi FD, Shamblin JD, Wollen SE, Zelko JM, Carrion R Jr, Worwa G, Staples HM, Burakov D, Babb R, Chen G, Martin J, Huang TT, Erlandson K, Willis MS, Armstrong K, Dreier TM, Ward AB, Davey RA, Pitt MLM, Lipsich L, Mason P, Olson W, Stahl N, Kyratsous CA.

J Infect Dis. 2018 Nov 22;218(suppl_5):S612-S626. doi: 10.1093/infdis/jiy285.


Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo.

Mota R, Parry TL, Yates CC, Qiang Z, Eaton SC, Mwiza JM, Tulasi D, Schisler JC, Patterson C, Zaglia T, Sandri M, Willis MS.

Am J Pathol. 2018 Jul;188(7):1676-1692. doi: 10.1016/j.ajpath.2018.04.007. Epub 2018 May 23.


Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations.

Halladay JR, Lenhart KC, Robasky K, Jones W, Homan WF, Cummings DM, Cené CW, Hinderliter AL, Miller CL, Donahue KE, Garcia BA, Keyserling TC, Ammerman AS, Patterson C, DeWalt DA, Johnston LF, Willis MS, Schisler JC.

J Pers Med. 2018 Apr 30;8(2). pii: E16. doi: 10.3390/jpm8020016.


Modeling the Transition From Decompensated to Pathological Hypertrophy.

Pascual F, Schisler JC, Grevengoed TJ, Willis MS, Coleman RA.

J Am Heart Assoc. 2018 Apr 5;7(8). pii: e008293. doi: 10.1161/JAHA.117.008293.


Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study.

Raffield LM, Ellis J, Olson NC, Duan Q, Li J, Durda P, Pankratz N, Keating BJ, Wassel CL, Cushman M, Wilson JG, Gross MD, Tracy RP, Rich SS, Reiner AP, Li Y, Willis MS, Lange EM, Lange LA.

J Hum Genet. 2018 Mar;63(3):327-337. doi: 10.1038/s10038-017-0384-9. Epub 2018 Jan 10.


Septolobular panniculitis in disseminated Lyme borreliosis.

Dittmer MR, Willis MS, Selby JC, Liu V.

J Cutan Pathol. 2018 Apr;45(4):274-277. doi: 10.1111/cup.13100. Epub 2018 Feb 9.


The role of heat shock proteins and co-chaperones in heart failure.

Ranek MJ, Stachowski MJ, Kirk JA, Willis MS.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738). pii: 20160530. doi: 10.1098/rstb.2016.0530. Review.


Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all.

Abdullah M, Berthiaume JM, Willis MS.

Transl Res. 2018 May;195:48-61. doi: 10.1016/j.trsl.2017.10.012. Epub 2017 Nov 7. Review.


Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

Ravi S, Schuck RN, Hilliard E, Lee CR, Dai X, Lenhart K, Willis MS, Jensen BC, Stouffer GA, Patterson C, Schisler JC.

Am J Pathol. 2017 Dec;187(12):2895-2911. doi: 10.1016/j.ajpath.2017.08.006. Epub 2017 Nov 16.


Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Transducer and Activator of Transcription and Epidermal Growth Factor Receptor Inhibition.

Stuhlmiller TJ, Zawistowski JS, Chen X, Sciaky N, Angus SP, Hicks ST, Parry TL, Huang W, Beak JY, Willis MS, Johnson GL, Jensen BC.

J Am Heart Assoc. 2017 Oct 19;6(10). pii: e006635. doi: 10.1161/JAHA.117.006635.


Nebulized Delivery of the MAPKAP Kinase 2 Peptide Inhibitor MMI-0100 Protects Against Ischemia-Induced Systolic Dysfunction.

Brown DI, Cooley BC, Quintana MT, Lander C, Willis MS.

Int J Pept Res Ther. 2016 Sep;22(3):317-324. doi: 10.1007/s10989-015-9507-3. Epub 2016 Jan 9.


Post-translationally modified muscle-specific ubiquitin ligases as circulating biomarkers in experimental cancer cachexia.

Mota R, Rodríguez JE, Bonetto A, O'Connell TM, Asher SA, Parry TL, Lockyer P, McCudden CR, Couch ME, Willis MS.

Am J Cancer Res. 2017 Sep 1;7(9):1948-1958. eCollection 2017.


Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.

Jensen BC, Parry TL, Huang W, Beak JY, Ilaiwy A, Bain JR, Newgard CB, Muehlbauer MJ, Patterson C, Johnson GL, Willis MS.

Br J Pharmacol. 2017 Dec;174(24):4797-4811. doi: 10.1111/bph.14062. Epub 2017 Nov 24.


Evidence that endogenous formaldehyde produces immunogenic and atherogenic adduct epitopes.

Nakamura J, Shimomoto T, Collins LB, Holley DW, Zhang Z, Barbee JM, Sharma V, Tian X, Kondo T, Uchida K, Yi X, Perkins DO, Willis MS, Gold A, Bultman SJ.

Sci Rep. 2017 Sep 7;7(1):10787. doi: 10.1038/s41598-017-11289-8.


MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C.

Meng Q, Bhandary B, Osinska H, James J, Xu N, Shay-Winkler K, Gulick J, Willis MS, Lander C, Robbins J.

J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006590. doi: 10.1161/JAHA.117.006590.


Upregulation of autophagy genes and the unfolded protein response in human heart failure.

Jensen BC, Bultman SJ, Holley D, Tang W, de Ridder G, Pizzo S, Bowles D, Willis MS.

Int J Clin Exp Med. 2017;10(1):1051-1058. Epub 2017 Jan 30.


Exercise-Induced Alterations in Skeletal Muscle, Heart, Liver, and Serum Metabolome Identified by Non-Targeted Metabolomics Analysis.

Starnes JW, Parry TL, O'Neal SK, Bain JR, Muehlbauer MJ, Honcoop A, Ilaiwy A, Christopher PM, Patterson C, Willis MS.

Metabolites. 2017 Aug 8;7(3). pii: E40. doi: 10.3390/metabo7030040.


Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo.

Abdullah M, Kornegay JN, Honcoop A, Parry TL, Balog-Alvarez CJ, O'Neal SK, Bain JR, Muehlbauer MJ, Newgard CB, Patterson C, Willis MS.

Metabolites. 2017 Jul 29;7(3). pii: E38. doi: 10.3390/metabo7030038.


Ubiquitin Ligases and Posttranslational Regulation of Energy in the Heart: The Hand that Feeds.

Brown DI, Parry TL, Willis MS.

Compr Physiol. 2017 Jun 18;7(3):841-862. doi: 10.1002/cphy.c160024. Review.


Non-Targeted Metabolomics Analysis of the Effects of Tyrosine Kinase Inhibitors Sunitinib and Erlotinib on Heart, Muscle, Liver and Serum Metabolism In Vivo.

Jensen BC, Parry TL, Huang W, Ilaiwy A, Bain JR, Muehlbauer MJ, O'Neal SK, Patterson C, Johnson GL, Willis MS.

Metabolites. 2017 Jun 22;7(3). pii: E31. doi: 10.3390/metabo7030031.


The alpha-1A adrenergic receptor agonist A61603 reduces cardiac polyunsaturated fatty acid and endocannabinoid metabolites associated with inflammation in vivo.

Willis MS, Ilaiwy A, Montgomery MD, Simpson PC, Jensen BC.

Metabolomics. 2016 Oct;12(10). pii: 155. doi: 10.1007/s11306-016-1097-3. Epub 2016 Sep 15.


Erratum to 'Cessation of biomechanical stretch model of C2C12 cells modelsmyocyte atrophy and anaplerotic changes in metabolism usingnon-targeted metabolomics analysisAmro' [Int. J. Biochem. Cell Biol. (2016) 80-92].

Ilaiwy A, Quintana MT, Bain JR, Muehlbauer MJ, Brown DI, Stansfield WE, Willis MS.

Int J Biochem Cell Biol. 2017 Jul;88:238-240. doi: 10.1016/j.biocel.2017.02.010. Epub 2017 Mar 19. No abstract available.


BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

Willis MS, Holley DW, Wang Z, Chen X, Quintana M, Jensen BC, Tannu M, Parker J, Jeyaraj D, Jain MK, Wolfram JA, Lee HG, Bultman SJ.

J Mol Cell Cardiol. 2017 Apr;105:99-109. doi: 10.1016/j.yjmcc.2017.02.003. Epub 2017 Feb 21.


A purified MAA-based ELISA is a useful tool for determining anti-MAA antibody titer with high sensitivity.

Shimomoto T, Collins LB, Yi X, Holley DW, Zhang Z, Tian X, Uchida K, Wang C, Hörkkö S, Willis MS, Gold A, Bultman SJ, Nakamura J.

PLoS One. 2017 Feb 21;12(2):e0172172. doi: 10.1371/journal.pone.0172172. eCollection 2017.


Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.

Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS.

Metabolomics. 2016 Aug;12(8). pii: 134. doi: 10.1007/s11306-016-1079-5. Epub 2016 Jul 26.


The Head and the Heart: The Alzheimer's Connection.

Jensen BC, Willis MS.

J Am Coll Cardiol. 2016 Dec 6;68(22):2408-2411. doi: 10.1016/j.jacc.2016.09.934. No abstract available.


Diffuse Vesicular Eruption.

Sidey KA, Willis MSJ, Wanat KA.

JAMA Dermatol. 2017 Feb 1;153(2):219-220. doi: 10.1001/jamadermatol.2016.3751. No abstract available.


Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis.

Ilaiwy A, Quintana MT, Bain JR, Muehlbauer MJ, Brown DI, Stansfield WE, Willis MS.

Int J Biochem Cell Biol. 2016 Oct;79:80-92. doi: 10.1016/j.biocel.2016.08.012. Epub 2016 Aug 8. Erratum in: Int J Biochem Cell Biol. 2017 Jul;88:238-240.


Cardiac ubiquitin ligases: Their role in cardiac metabolism, autophagy, cardioprotection and therapeutic potential.

Parry TL, Willis MS.

Biochim Biophys Acta. 2016 Dec;1862(12):2259-2269. doi: 10.1016/j.bbadis.2016.07.002. Epub 2016 Jul 13. Review.


Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.

Quintana MT, Parry TL, He J, Yates CC, Sidorova TN, Murray KT, Bain JR, Newgard CB, Muehlbauer MJ, Eaton SC, Hishiya A, Takayama S, Willis MS.

Am J Pathol. 2016 Aug;186(8):1989-2007. doi: 10.1016/j.ajpath.2016.03.017. Epub 2016 Jun 17.


Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice.

Cruz-Topete D, Myers PH, Foley JF, Willis MS, Cidlowski JA.

Endocrinology. 2016 Jul;157(7):2759-71. doi: 10.1210/en.2015-1604. Epub 2016 May 24.


"Are you eating healthy?" Nutrition discourse in Midwestern clinics for the underserved.

Curtis SM, Willis MS.

Patient Educ Couns. 2016 Oct;99(10):1641-6. doi: 10.1016/j.pec.2016.04.011. Epub 2016 Apr 20.


Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo.

Ilaiwy A, Liu M, Parry TL, Bain JR, Newgard CB, Schisler JC, Muehlbauer MJ, Despa F, Willis MS.

Metabolomics. 2016 May;12(5). pii: 95. doi: 10.1007/s11306-016-1022-9. Epub 2016 Apr 23.


Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

Kornegay JN, Bogan DJ, Bogan JR, Dow JL, Wang J, Fan Z, Liu N, Warsing LC, Grange RW, Ahn M, Balog-Alvarez CJ, Cotten SW, Willis MS, Brinkmeyer-Langford C, Zhu H, Palandra J, Morris CA, Styner MA, Wagner KR.

Skelet Muscle. 2016 Apr 4;6:14. doi: 10.1186/s13395-016-0085-7. eCollection 2016.


BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

Bultman SJ, Holley DW, G de Ridder G, Pizzo SV, Sidorova TN, Murray KT, Jensen BC, Wang Z, Bevilacqua A, Chen X, Quintana MT, Tannu M, Rosson GB, Pandya K, Willis MS.

Cardiovasc Pathol. 2016 May-Jun;25(3):258-269. doi: 10.1016/j.carpath.2016.02.004. Epub 2016 Mar 4.


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