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Items: 1 to 50 of 64

1.

Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer.

Blum AE, Venkitachalam S, Ravillah D, Chelluboyina AK, Kieber-Emmons AM, Ravi L, Kresak A, Chandar AK, Markowitz SD, Canto MI, Wang JS, Shaheen NJ, Guo Y, Shyr Y, Willis JE, Chak A, Varadan V, Guda K.

Gastroenterology. 2019 May;156(6):1761-1774. doi: 10.1053/j.gastro.2019.01.263. Epub 2019 Feb 12.

PMID:
30768984
2.

Clinical utility of reflex testing using focused next-generation sequencing for management of patients with advanced lung adenocarcinoma.

Miller TE, Yang M, Bajor D, Friedman JD, Chang RYC, Dowlati A, Willis JE, Sadri N.

J Clin Pathol. 2018 Dec;71(12):1108-1115. doi: 10.1136/jclinpath-2018-205396. Epub 2018 Sep 18.

PMID:
30228211
3.

Performance of multitarget stool DNA testing in African American patients.

Cooper GS, Markowitz SD, Chen Z, Tuck M, Willis JE, Berger BM, Brenner DE, Li L.

Cancer. 2018 Oct 1;124(19):3876-3880. doi: 10.1002/cncr.31660. Epub 2018 Sep 7.

4.

Subtypes of Barrett's oesophagus and oesophageal adenocarcinoma based on genome-wide methylation analysis.

Yu M, Maden SK, Stachler M, Kaz AM, Ayers J, Guo Y, Carter KT, Willbanks A, Heinzerling TJ, O'Leary RM, Xu X, Bass A, Chandar AK, Chak A, Elliott R, Willis JE, Markowitz SD, Grady WM.

Gut. 2018 Jun 8. pii: gutjnl-2017-314544. doi: 10.1136/gutjnl-2017-314544. [Epub ahead of print]

PMID:
29884612
5.

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R; Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW.

Cancer Cell. 2018 Apr 9;33(4):721-735.e8. doi: 10.1016/j.ccell.2018.03.010. Epub 2018 Apr 2.

6.

Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing.

Cooper GS, Markowitz SD, Chen Z, Tuck M, Willis JE, Berger BM, Brenner DE, Li L.

Dig Dis Sci. 2018 Jun;63(6):1449-1453. doi: 10.1007/s10620-018-5001-z. Epub 2018 Mar 7.

7.

Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus.

Moinova HR, LaFramboise T, Lutterbaugh JD, Chandar AK, Dumot J, Faulx A, Brock W, De la Cruz Cabrera O, Guda K, Barnholtz-Sloan JS, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Thota PN, Willis JE, Chak A, Markowitz SD.

Sci Transl Med. 2018 Jan 17;10(424). pii: eaao5848. doi: 10.1126/scitranslmed.aao5848.

8.

Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma.

Luebeck EG, Curtius K, Hazelton WD, Maden S, Yu M, Thota PN, Patil DT, Chak A, Willis JE, Grady WM.

Clin Epigenetics. 2017 Oct 16;9:113. doi: 10.1186/s13148-017-0409-4. eCollection 2017.

9.

A nonrandomized trial of vitamin D supplementation for Barrett's esophagus.

Cummings LC, Thota PN, Willis JE, Chen Y, Cooper GS, Furey N, Bednarchik B, Alashkar BM, Dumot J, Faulx AL, Fink SP, Kresak AM, Abusneineh B, Barnholtz-Sloan J, Leahy P, Veigl ML, Chak A, Markowitz SD.

PLoS One. 2017 Sep 18;12(9):e0184928. doi: 10.1371/journal.pone.0184928. eCollection 2017.

10.

Erratum to: Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use.

Kaz AM, Wong CJ, Varadan V, Willis JE, Chak A, Grady WM.

Clin Epigenetics. 2017 Mar 1;9:23. doi: 10.1186/s13148-017-0324-8. eCollection 2017.

11.
12.

RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas.

Blum AE, Venkitachalam S, Guo Y, Kieber-Emmons AM, Ravi L, Chandar AK, Iyer PG, Canto MI, Wang JS, Shaheen NJ, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Shyr Y, Chak A, Varadan V, Guda K.

Cancer Res. 2016 Oct 1;76(19):5628-5633. Epub 2016 Aug 8.

13.

Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas.

Sun X, Elston R, Falk GW, Grady WM, Faulx A, Mittal SK, Canto MI, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Willis JE, Guda K, Markowitz S, Barnholtz-Sloan JS, Chandar A, Brock W, Chak A.

Mol Genet Genomic Med. 2016 Mar 14;4(4):407-19. doi: 10.1002/mgg3.211. eCollection 2016 Jul.

14.

Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia.

Fecteau RE, Kong J, Kresak A, Brock W, Song Y, Fujioka H, Elston R, Willis JE, Lynch JP, Markowitz SD, Guda K, Chak A.

JAMA Oncol. 2016 Oct 1;2(10):1333-1339. doi: 10.1001/jamaoncol.2016.2054.

15.

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z.

Nat Commun. 2016 Jun 20;7:11971. doi: 10.1038/ncomms11971.

16.

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.

Curtius K, Wong CJ, Hazelton WD, Kaz AM, Chak A, Willis JE, Grady WM, Luebeck EG.

PLoS Comput Biol. 2016 May 11;12(5):e1004919. doi: 10.1371/journal.pcbi.1004919. eCollection 2016 May. Erratum in: PLoS Comput Biol. 2017 Mar 17;13(3):e1005439.

17.

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Venkitachalam S, Revoredo L, Varadan V, Fecteau RE, Ravi L, Lutterbaugh J, Markowitz SD, Willis JE, Gerken TA, Guda K.

Sci Rep. 2016 Mar 23;6:23642. doi: 10.1038/srep23642.

18.

Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Sun X, Elston RC, Barnholtz-Sloan JS, Falk GW, Grady WM, Faulx A, Mittal SK, Canto M, Shaheen NJ, Wang JS, Iyer PG, Abrams JA, Tian YD, Willis JE, Guda K, Markowitz SD, Chandar A, Warfe JM, Brock W, Chak A.

Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):727-35. doi: 10.1158/1055-9965.EPI-15-0832. Epub 2016 Feb 29.

19.

A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis.

Markowitz SD, Nock NL, Schmit SL, Stadler ZK, Joseph V, Zhang L, Willis JE, Scacheri P, Veigl M, Adams MD, Raskin L, Sullivan JF, Stratton K, Shia J, Ellis N, Rennert HS, Manschreck C, Li L, Offit K, Elston RC, Rennert G, Gruber SB.

PLoS One. 2016 Jan 11;11(1):e0146435. doi: 10.1371/journal.pone.0146435. eCollection 2016.

20.

Magnetic resonance enterography/enteroclysis in acquired small bowel diverticulitis and small bowel diverticulosis.

Mansoori B, Delaney CP, Willis JE, Paspulati RM, Ros PR, Schmid-Tannwald C, Herrmann KA.

Eur Radiol. 2016 Sep;26(9):2881-91. doi: 10.1007/s00330-015-4098-0. Epub 2015 Nov 23.

PMID:
26597545
21.

Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.

Yu M, O'Leary RM, Kaz AM, Morris SM, Carter KT, Chak A, Chandar A, Willis JE, Moinova HR, Markowitz SD, Brenner DE, Anandabapasathy S, Westerhoff M, Wong CJ, Shaheen NJ, Chen Y, Barnholtz-Sloan JS, Grady WM.

Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1890-7. doi: 10.1158/1055-9965.EPI-15-0370. Epub 2015 Nov 6.

22.

ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.

Varadan V, Singh S, Nosrati A, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Markowitz SD, Willis JE, Guda K.

Genome Med. 2015 Jul 20;7:69. doi: 10.1186/s13073-015-0192-9. eCollection 2015.

23.

TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.

Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD.

Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340.

24.

Reply to Ashktorab et al.: Mutational landscape of colon cancers in African Americans.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2853. doi: 10.1073/pnas.1505059112. Epub 2015 May 4. No abstract available.

25.

Novel recurrently mutated genes in African American colon cancers.

Guda K, Veigl ML, Varadan V, Nosrati A, Ravi L, Lutterbaugh J, Beard L, Willson JK, Sedwick WD, Wang ZJ, Molyneaux N, Miron A, Adams MD, Elston RC, Markowitz SD, Willis JE.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1149-54. doi: 10.1073/pnas.1417064112. Epub 2015 Jan 12.

26.

Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs.

Fink SP, Dawson DM, Zhang Y, Kresak A, Lawrence EG, Yang P, Chen Y, Barnholtz-Sloan JS, Willis JE, Kopelovich L, Markowitz SD.

Carcinogenesis. 2015 Feb;36(2):291-8. doi: 10.1093/carcin/bgu241. Epub 2014 Dec 10.

27.

The Cancer Genomics Resource List 2014.

Zutter MM, Bloom KJ, Cheng L, Hagemann IS, Kaufman JH, Krasinskas AM, Lazar AJ, Leonard DG, Lindeman NI, Moyer AM, Nikiforova MN, Nowak JA, Pfeifer JD, Sepulveda AR, Willis JE, Yohe SL.

Arch Pathol Lab Med. 2015 Aug;139(8):989-1008. doi: 10.5858/arpa.2014-0330-CP. Epub 2014 Dec 1.

28.

Static tank depuration and chronic short-term experimental contamination of Eastern oysters (Crassostrea virginica) with Giardia duodenalis cysts.

Willis JE, McClure JT, McClure C, Spears J, Davidson J, Greenwood SJ.

Int J Food Microbiol. 2015 Jan 2;192:13-9. doi: 10.1016/j.ijfoodmicro.2014.08.027. Epub 2014 Aug 28.

PMID:
25305439
29.

Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.

Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, Lutterbaugh JD, Shrubsole MJ, Zheng W, Markowitz SD, Grady WM.

Gastroenterology. 2014 Aug;147(2):418-29.e8. doi: 10.1053/j.gastro.2014.04.039. Epub 2014 Apr 30.

30.

Bioaccumulation and elimination of Cryptosporidium parvum oocysts in experimentally exposed Eastern oysters (Crassostrea virginica) held in static tank aquaria.

Willis JE, McClure JT, McClure C, Spears J, Davidson J, Greenwood SJ.

Int J Food Microbiol. 2014 Mar 3;173:72-80. doi: 10.1016/j.ijfoodmicro.2013.11.033. Epub 2013 Dec 13.

PMID:
24412961
31.

A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer.

Chan J, Kinsella MT, Willis JE, Hu H, Reynolds H Jr, Delaney C, McCulla A, Deharo S, Ahdesmäki M, Allen WL, Johnston PG, Kinsella TJ.

Front Oncol. 2013 Nov 25;3:288. doi: 10.3389/fonc.2013.00288. eCollection 2013.

32.

Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies.

Moinova H, Leidner RS, Ravi L, Lutterbaugh J, Barnholtz-Sloan JS, Chen Y, Chak A, Markowitz SD, Willis JE.

Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):594-600. doi: 10.1158/1055-9965.EPI-11-1060. Epub 2012 Feb 7.

33.

Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus.

Chak A, Chen Y, Vengoechea J, Canto MI, Elston R, Falk GW, Grady WM, Guda K, Kinnard M, Markowitz S, Mittal S, Prasad G, Shaheen N, Willis JE, Barnholtz-Sloan JS.

Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):376-83. doi: 10.1158/1055-9965.EPI-11-0927. Epub 2011 Dec 16.

34.

Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.

Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM.

Genes Chromosomes Cancer. 2012 Apr;51(4):384-93. doi: 10.1002/gcc.21923. Epub 2011 Dec 14.

35.

DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses.

Kaz AM, Wong CJ, Luo Y, Virgin JB, Washington MK, Willis JE, Leidner RS, Chak A, Grady WM.

Epigenetics. 2011 Dec;6(12):1403-12. doi: 10.4161/epi.6.12.18199.

36.

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, Avruch J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1312-20. doi: 10.1073/pnas.1110428108. Epub 2011 Oct 31.

37.

The four hydrophobic residues on the Hsp70 inter-domain linker have two distinct roles.

Kumar DP, Vorvis C, Sarbeng EB, Cabra Ledesma VC, Willis JE, Liu Q.

J Mol Biol. 2011 Sep 2;411(5):1099-113. doi: 10.1016/j.jmb.2011.07.001. Epub 2011 Jul 7.

38.

Image analysis for classification of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography.

Qi X, Pan Y, Sivak MV, Willis JE, Isenberg G, Rollins AM.

Biomed Opt Express. 2010 Sep 9;1(3):825-847.

39.

A feasibility and dosimetric evaluation of endoscopic radiofrequency ablation for human colonic and rectal epithelium in a treat and resect trial.

Trunzo JA, McGee MF, Poulose BK, Willis JE, Ermlich B, Laughinghouse M, Champagne BJ, Delaney CP, Marks JM.

Surg Endosc. 2011 Feb;25(2):491-6. doi: 10.1007/s00464-010-1199-3. Epub 2010 Jul 22.

PMID:
20652324
40.

A segregation analysis of Barrett's esophagus and associated adenocarcinomas.

Sun X, Elston R, Barnholtz-Sloan J, Falk G, Grady WM, Kinnard M, Mittal SK, Willis JE, Markowitz S, Brock W, Chak A.

Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):666-74. doi: 10.1158/1055-9965.EPI-09-1136. Epub 2010 Mar 3.

41.

Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction.

Chak A, Falk G, Grady WM, Kinnard M, Elston R, Mittal S, King JF, Willis JE, Kondru A, Brock W, Barnholtz-Sloan J.

Am J Gastroenterol. 2009 Aug;104(8):1913-21. doi: 10.1038/ajg.2009.241. Epub 2009 Jun 2.

42.

Automated quantification of colonic crypt morphology using integrated microscopy and optical coherence tomography.

Qi X, Pan Y, Hu Z, Kang W, Willis JE, Olowe K, Sivak MV Jr, Rollins AM.

J Biomed Opt. 2008 Sep-Oct;13(5):054055. doi: 10.1117/1.2993323.

43.

The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.

Rojas A, Meherem S, Kim YH, Washington MK, Willis JE, Markowitz SD, Grady WM.

Int J Cancer. 2008 Jul 1;123(1):14-21. doi: 10.1002/ijc.23608.

44.

The pathologist's role in rectal cancer patient assessments.

Willis JE.

Clin Colon Rectal Surg. 2007 Aug;20(3):158-66. doi: 10.1055/s-2007-984860.

45.

Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.

Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C.

Gastroenterology. 2007 Jan;132(1):154-65. Epub 2006 Oct 12.

PMID:
17241868
46.

Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction.

Chak A, Ochs-Balcom H, Falk G, Grady WM, Kinnard M, Willis JE, Elston R, Eng C.

Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1668-73.

47.

Computer-aided diagnosis of dysplasia in Barrett's esophagus using endoscopic optical coherence tomography.

Qi X, Sivak MV, Isenberg G, Willis JE, Rollins AM.

J Biomed Opt. 2006 Jul-Aug;11(4):044010.

48.

In vivo optical coherence tomography imaging of the pancreatic and biliary ductal system.

Singh P, Chak A, Willis JE, Rollins A, Sivak MV Jr.

Gastrointest Endosc. 2005 Dec;62(6):970-4.

PMID:
16301046
49.

Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett's esophagus: a prospective, double-blinded study.

Isenberg G, Sivak MV Jr, Chak A, Wong RC, Willis JE, Wolf B, Rowland DY, Das A, Rollins A.

Gastrointest Endosc. 2005 Dec;62(6):825-31.

PMID:
16301020
50.

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.

Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Gautam S, Markowitz SD.

Int J Cancer. 2006 Feb 1;118(3):600-8.

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