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The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.

Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire MJ, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier MS, Coulombe B, Brais B.

Mol Brain. 2019 Jun 20;12(1):59. doi: 10.1186/s13041-019-0479-7.


Metabolic programming a lean phenotype by deregulation of RNA polymerase III.

Willis IM, Moir RD, Hernandez N.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12182-12187. doi: 10.1073/pnas.1815590115. Epub 2018 Nov 14.


Enhanced Isotopic Ratio Outlier Analysis (IROA) Peak Detection and Identification with Ultra-High Resolution GC-Orbitrap/MS: Potential Application for Investigation of Model Organism Metabolomes.

Qiu Y, Moir RD, Willis IM, Seethapathy S, Biniakewitz RC, Kurland IJ.

Metabolites. 2018 Jan 18;8(1). pii: E9. doi: 10.3390/metabo8010009.


Signaling to and from the RNA Polymerase III Transcription and Processing Machinery.

Willis IM, Moir RD.

Annu Rev Biochem. 2018 Jun 20;87:75-100. doi: 10.1146/annurev-biochem-062917-012624. Epub 2018 Jan 12. Review.


Maf1 phenotypes and cell physiology.

Willis IM.

Biochim Biophys Acta Gene Regul Mech. 2018 Apr;1861(4):330-337. doi: 10.1016/j.bbagrm.2017.11.009. Epub 2017 Dec 15. Review.


Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13. doi: 10.1186/s13041-017-0294-y.


Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock.

Mange F, Praz V, Migliavacca E, Willis IM, Schütz F, Hernandez N; CycliX Consortium.

Genome Res. 2017 Jun;27(6):973-984. doi: 10.1101/gr.217521.116. Epub 2017 Mar 24.


Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Dasgupta S, Yang C, Castro LM, Tashima AK, Ferro ES, Moir RD, Willis IM, Fricker LD.

PLoS One. 2016 Sep 29;11(9):e0163312. doi: 10.1371/journal.pone.0163312. eCollection 2016.


Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae.

Lee J, Moir RD, Willis IM.

PLoS One. 2015 May 13;10(5):e0127225. doi: 10.1371/journal.pone.0127225. eCollection 2015.


Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM.

Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.


Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of rapamycin complex 1 signaling and the Cdc-like kinase Kns1.

Sanchez-Casalongue ME, Lee J, Diamond A, Shuldiner S, Moir RD, Willis IM.

J Biol Chem. 2015 Mar 13;290(11):7221-33. doi: 10.1074/jbc.M114.626523. Epub 2015 Jan 28.


Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.

Frame IJ, Deniskin R, Rinderspacher A, Katz F, Deng SX, Moir RD, Adjalley SH, Coburn-Flynn O, Fidock DA, Willis IM, Landry DW, Akabas MH.

ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30.


Regulating maf1 expression and its expanding biological functions.

Moir RD, Willis IM.

PLoS Genet. 2015 Jan 8;11(1):e1004896. doi: 10.1371/journal.pgen.1004896. eCollection 2015 Jan. No abstract available.


Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization.

Bonhoure N, Bounova G, Bernasconi D, Praz V, Lammers F, Canella D, Willis IM, Herr W, Hernandez N, Delorenzi M; CycliX Consortium.

Genome Res. 2014 Jul;24(7):1157-68. doi: 10.1101/gr.168260.113. Epub 2014 Apr 7.


The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization.

Atencio D, Barnes C, Duncan TM, Willis IM, Hanes SD.

G3 (Bethesda). 2014 Mar 20;4(3):523-37. doi: 10.1534/g3.113.008763.


Regulation of pol III transcription by nutrient and stress signaling pathways.

Moir RD, Willis IM.

Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):361-75. doi: 10.1016/j.bbagrm.2012.11.001. Epub 2012 Nov 16. Review.


Phosphopeptide characterization by mass spectrometry using reversed-phase supports for solid-phase β-elimination/Michael addition.

Nika H, Lee J, Willis IM, Angeletti RH, Hawke DH.

J Biomol Tech. 2012 Jul;23(2):51-68. doi: 10.7171/jbt.2012-2302-002.


SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR.

Moir RD, Gross DA, Silver DL, Willis IM.

PLoS Genet. 2012 Aug;8(8):e1002890. doi: 10.1371/journal.pgen.1002890. Epub 2012 Aug 23.


Recovery of RNA polymerase III transcription from the glycerol-repressed state: revisiting the role of protein kinase CK2 in Maf1 phosphoregulation.

Moir RD, Lee J, Willis IM.

J Biol Chem. 2012 Aug 31;287(36):30833-41. doi: 10.1074/jbc.M112.378828. Epub 2012 Jul 18.


The yeast magmas ortholog pam16 has an essential function in fermentative growth that involves sphingolipid metabolism.

Short MK, Hallett JP, Tar K, Dange T, Schmidt M, Moir R, Willis IM, Jubinsky PT.

PLoS One. 2012;7(7):e39428. doi: 10.1371/journal.pone.0039428. Epub 2012 Jul 10.


Two new kinases in the TOR signaling network regulate ribosome and tRNA synthesis.

Willis IM, Lee J.

Cell Cycle. 2012 Aug 1;11(15):2769-70. doi: 10.4161/cc.21257. Epub 2012 Aug 1. No abstract available.


TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases.

Lee J, Moir RD, McIntosh KB, Willis IM.

Mol Cell. 2012 Mar 30;45(6):836-43. doi: 10.1016/j.molcel.2012.01.018. Epub 2012 Feb 23.


Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells.

Lajoie P, Moir RD, Willis IM, Snapp EL.

Mol Biol Cell. 2012 Mar;23(5):955-64. doi: 10.1091/mbc.E11-12-0995. Epub 2012 Jan 4.


Eukaryotic cells producing ribosomes deficient in Rpl1 are hypersensitive to defects in the ubiquitin-proteasome system.

McIntosh KB, Bhattacharya A, Willis IM, Warner JR.

PLoS One. 2011;6(8):e23579. doi: 10.1371/journal.pone.0023579. Epub 2011 Aug 12.


Does casein kinase II phosphorylation of Maf1 trigger RNA polymerase III activation?

Willis IM, Moir RD, Lee J.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):E300; author reply E301. doi: 10.1073/pnas.1107306108. Epub 2011 Jul 6. No abstract available.


Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.

Rana T, Misra S, Mittal MK, Farrow AL, Wilson KT, Linton MF, Fazio S, Willis IM, Chaudhuri G.

J Biol Chem. 2011 Feb 25;286(8):6614-26. doi: 10.1074/jbc.M110.181735. Epub 2010 Dec 13.


Why Dom34 stimulates growth of cells with defects of 40S ribosomal subunit biosynthesis.

Bhattacharya A, McIntosh KB, Willis IM, Warner JR.

Mol Cell Biol. 2010 Dec;30(23):5562-71. doi: 10.1128/MCB.00618-10. Epub 2010 Sep 27.


Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway.

Lee J, Moir RD, Willis IM.

J Biol Chem. 2009 May 8;284(19):12604-8. doi: 10.1074/jbc.C900020200. Epub 2009 Mar 19.


Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III.

Rosonina E, Willis IM, Manley JL.

Mol Cell Biol. 2009 Apr;29(8):2308-21. doi: 10.1128/MCB.01841-08. Epub 2009 Feb 9.


Facilitated recycling protects human RNA polymerase III from repression by Maf1 in vitro.

Cabart P, Lee J, Willis IM.

J Biol Chem. 2008 Dec 26;283(52):36108-17. doi: 10.1074/jbc.M807538200. Epub 2008 Oct 29.


Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes.

Willis IM, Chua G, Tong AH, Brost RL, Hughes TR, Boone C, Moir RD.

PLoS Genet. 2008 Jul 4;4(7):e1000112. doi: 10.1371/journal.pgen.1000112.


Multiple kinases and system robustness: a link between Cdc37 and genome integrity.

Caplan AJ, Ma'ayan A, Willis IM.

Cell Cycle. 2007 Dec 15;6(24):3145-7. Epub 2007 Oct 3.


Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.

Johnson SS, Zhang C, Fromm J, Willis IM, Johnson DL.

Mol Cell. 2007 May 11;26(3):367-79.


Integration of nutritional and stress signaling pathways by Maf1.

Willis IM, Moir RD.

Trends Biochem Sci. 2007 Feb;32(2):51-3. Epub 2006 Dec 14. Review.


Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1.

Moir RD, Lee J, Haeusler RA, Desai N, Engelke DR, Willis IM.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15044-9. Epub 2006 Sep 27.


Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

Sauve AA, Moir RD, Schramm VL, Willis IM.

Mol Cell. 2005 Feb 18;17(4):595-601.


Two steps in Maf1-dependent repression of transcription by RNA polymerase III.

Desai N, Lee J, Upadhya R, Chu Y, Moir RD, Willis IM.

J Biol Chem. 2005 Feb 25;280(8):6455-62. Epub 2004 Dec 8.


Signaling repression of transcription by RNA polymerase III in yeast.

Willis IM, Desai N, Upadhya R.

Prog Nucleic Acid Res Mol Biol. 2004;77:323-53. Review. No abstract available.


Tetratricopeptide repeats of Tfc4 and a limiting step in the assembly of the initiation factor TFIIIB.

Moir RD, Willis IM.

Adv Protein Chem. 2004;67:93-121. Review. No abstract available.


The Brf1 and Bdp1 subunits of transcription factor TFIIIB bind to overlapping sites in the tetratricopeptide repeats of Tfc4.

Liao Y, Willis IM, Moir RD.

J Biol Chem. 2003 Nov 7;278(45):44467-74. Epub 2003 Aug 20.


Novel small-molecule inhibitors of RNA polymerase III.

Wu L, Pan J, Thoroddsen V, Wysong DR, Blackman RK, Bulawa CE, Gould AE, Ocain TD, Dick LR, Errada P, Dorr PK, Parkinson T, Wood T, Kornitzer D, Weissman Z, Willis IM, McGovern K.

Eukaryot Cell. 2003 Apr;2(2):256-64.


Autoinhibition of TFIIIB70 binding by the tetratricopeptide repeat-containing subunit of TFIIIC.

Moir RD, Puglia KV, Willis IM.

J Biol Chem. 2002 Jan 4;277(1):694-701. Epub 2001 Oct 29.


Kinetic trapping of DNA by transcription factor IIIB.

Cloutier TE, Librizzi MD, Mollah AK, Brenowitz M, Willis IM.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9581-6. Epub 2001 Jul 31.


Nhp6, an HMG1 protein, functions in SNR6 transcription by RNA polymerase III in S. cerevisiae.

Kruppa M, Moir RD, Kolodrubetz D, Willis IM.

Mol Cell. 2001 Feb;7(2):309-18. Erratum in: Mol Cell 2001 Sep;8(3):727.


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