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Cytosine-5 RNA methylation links protein synthesis to cell metabolism.

Gkatza NA, Castro C, Harvey RF, Heiß M, Popis MC, Blanco S, Bornelöv S, Sajini AA, Gleeson JG, Griffin JL, West JA, Kellner S, Willis AE, Dietmann S, Frye M.

PLoS Biol. 2019 Jun 14;17(6):e3000297. doi: 10.1371/journal.pbio.3000297. [Epub ahead of print]


Author Correction: Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS).

Queiroz RML, Smith T, Villanueva E, Marti-Solano M, Monti M, Pizzinga M, Mirea DM, Ramakrishna M, Harvey RF, Dezi V, Thomas GH, Willis AE, Lilley KS.

Nat Biotechnol. 2019 Jun;37(6):692. doi: 10.1038/s41587-019-0161-8.


Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.

Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ.

Cell Death Differ. 2019 Mar 11. doi: 10.1038/s41418-019-0316-7. [Epub ahead of print]


Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS).

Queiroz RML, Smith T, Villanueva E, Marti-Solano M, Monti M, Pizzinga M, Mirea DM, Ramakrishna M, Harvey RF, Dezi V, Thomas GH, Willis AE, Lilley KS.

Nat Biotechnol. 2019 Feb;37(2):169-178. doi: 10.1038/s41587-018-0001-2. Epub 2019 Jan 3. Erratum in: Nat Biotechnol. 2019 Jun;37(6):692.


Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism.

Rotblat B, Agostini M, Niklison-Chirou MV, Amelio I, Willis AE, Melino G.

Cell Cycle. 2018;17(23):2637-2643. doi: 10.1080/15384101.2018.1553341. Epub 2018 Dec 4.


Identification of the RNA polymerase I-RNA interactome.

Piñeiro D, Stoneley M, Ramakrishna M, Alexandrova J, Dezi V, Juke-Jones R, Lilley KS, Cain K, Willis AE.

Nucleic Acids Res. 2018 Nov 16;46(20):11002-11013. doi: 10.1093/nar/gky779.


CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM.

Lezina L, Spriggs RV, Beck D, Jones C, Dudek KM, Bzura A, Jones GDD, Packham G, Willis AE, Wagner SD.

Blood Adv. 2018 Aug 14;2(15):1869-1881. doi: 10.1182/bloodadvances.2017015560.


TAp73 contributes to the oxidative stress response by regulating protein synthesis.

Marini A, Rotblat B, Sbarrato T, Niklison-Chirou MV, Knight JRP, Dudek K, Jones C, Bushell M, Knight RA, Amelio I, Willis AE, Melino G.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6219-6224. doi: 10.1073/pnas.1718531115. Epub 2018 May 29.


Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE.

Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y.


Trans-acting translational regulatory RNA binding proteins.

Harvey RF, Smith TS, Mulroney T, Queiroz RML, Pizzinga M, Dezi V, Villenueva E, Ramakrishna M, Lilley KS, Willis AE.

Wiley Interdiscip Rev RNA. 2018 May;9(3):e1465. doi: 10.1002/wrna.1465. Epub 2018 Jan 17. Review.


Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf).

Chernova T, Murphy FA, Galavotti S, Sun XM, Powley IR, Grosso S, Schinwald A, Zacarias-Cabeza J, Dudek KM, Dinsdale D, Le Quesne J, Bennett J, Nakas A, Greaves P, Poland CA, Donaldson K, Bushell M, Willis AE, MacFarlane M.

Curr Biol. 2017 Nov 6;27(21):3302-3314.e6. doi: 10.1016/j.cub.2017.09.007.


Post-transcriptional control of stress responses in cancer.

Harvey RF, Willis AE.

Curr Opin Genet Dev. 2018 Feb;48:30-35. doi: 10.1016/j.gde.2017.10.006. Epub 2017 Nov 5. Review.


An improved analysis methodology for translational profiling by microarray.

Sbarrato T, Spriggs RV, Wilson L, Jones C, Dudek K, Bastide A, Pichon X, Pöyry T, Willis AE.

RNA. 2017 Nov;23(11):1601-1613. doi: 10.1261/rna.060525.116. Epub 2017 Aug 25.


Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins.

Harvey R, Dezi V, Pizzinga M, Willis AE.

Biochem Soc Trans. 2017 Aug 15;45(4):1007-14. doi: 10.1042/BST20160364. Epub 2017 Jul 14. Review.


Suboptimal T-cell receptor signaling compromises protein translation, ribosome biogenesis, and proliferation of mouse CD8 T cells.

Tan TCJ, Knight J, Sbarrato T, Dudek K, Willis AE, Zamoyska R.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6117-E6126. doi: 10.1073/pnas.1700939114. Epub 2017 Jul 10.


Till stress do us ataRT: a novel toxin-antitoxin system targeting translation initiation.

Pizzinga M, Harvey RF, Willis AE.

Cell Death Differ. 2017 Jun;24(6):951-952. doi: 10.1038/cdd.2017.66. Epub 2017 May 12. No abstract available.


RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.

Bastide A, Peretti D, Knight JR, Grosso S, Spriggs RV, Pichon X, Sbarrato T, Roobol A, Roobol J, Vito D, Bushell M, von der Haar T, Smales CM, Mallucci GR, Willis AE.

Curr Biol. 2017 Mar 6;27(5):638-650. doi: 10.1016/j.cub.2017.01.047. Epub 2017 Feb 23.


Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.

Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR.

Genes Dev. 2017 Jan 1;31(1):18-33. doi: 10.1101/gad.290940.116. Epub 2017 Jan 17.


Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.

Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P.

J Exp Med. 2016 Oct 17;213(11):2503-2523. Epub 2016 Oct 10.


Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.

Soukarieh F, Nowicki MW, Bastide A, Pöyry T, Jones C, Dudek K, Patwardhan G, Meullenet F, Oldham NJ, Walkinshaw MD, Willis AE, Fischer PM.

Eur J Med Chem. 2016 Nov 29;124:200-217. doi: 10.1016/j.ejmech.2016.08.047. Epub 2016 Aug 24.


PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ, Packham G.

Oncotarget. 2016 Nov 15;7(46):74807-74819. doi: 10.18632/oncotarget.11655.


A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.

Sbarrato T, Horvilleur E, Pöyry T, Hill K, Chaplin LC, Spriggs RV, Stoneley M, Wilson L, Jayne S, Vulliamy T, Beck D, Dokal I, Dyer MJ, Yeomans AM, Packham G, Bushell M, Wagner SD, Willis AE.

Cell Death Dis. 2016 Jun 2;7(6):e2249. doi: 10.1038/cddis.2016.148.


Translational Control: Selective Upregulation of ECM Components Drives Tumour Growth.

Willis AE.

Curr Biol. 2016 Mar 21;26(6):R241-3. doi: 10.1016/j.cub.2016.01.053.


Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.

Chernova T, Sun XM, Powley IR, Galavotti S, Grosso S, Murphy FA, Miles GJ, Cresswell L, Antonov AV, Bennett J, Nakas A, Dinsdale D, Cain K, Bushell M, Willis AE, MacFarlane M.

Cell Death Differ. 2016 Jul;23(7):1152-64. doi: 10.1038/cdd.2015.165. Epub 2016 Feb 19.


Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.

Knight JR, Bastide A, Peretti D, Roobol A, Roobol J, Mallucci GR, Smales CM, Willis AE.

RNA. 2016 Apr;22(4):623-35. doi: 10.1261/rna.054411.115. Epub 2016 Feb 8.


Temporal Regulation of Distinct Internal Ribosome Entry Sites of the Dicistroviridae Cricket Paralysis Virus.

Khong A, Bonderoff JM, Spriggs RV, Tammpere E, Kerr CH, Jackson TJ, Willis AE, Jan E.

Viruses. 2016 Jan 19;8(1). pii: E25. doi: 10.3390/v8010025.


Cap-Independent Translation in Hematological Malignancies.

Horvilleur E, Wilson LA, Bastide A, Piñeiro D, Pöyry TA, Willis AE.

Front Oncol. 2015 Dec 21;5:293. doi: 10.3389/fonc.2015.00293. eCollection 2015. Review.


Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.

Blood. 2016 Jan 28;127(4):449-57. doi: 10.1182/blood-2015-07-660969. Epub 2015 Oct 21.


A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.

Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE.

Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115. Epub 2015 Sep 3.


Control of translation in the cold: implications for therapeutic hypothermia.

Knight JR, Willis AE.

Biochem Soc Trans. 2015 Jun;43(3):333-7. doi: 10.1042/BST20150052. Review.


eIF4A1 is a promising new therapeutic target in ER-negative breast cancer.

Stoneley M, Willis AE.

Cell Death Differ. 2015 Apr;22(4):524-5. doi: 10.1038/cdd.2014.210. Epub 2015 Jan 23. No abstract available.


RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.

Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin MG, Moreno JA, Steinert JR, Smith T, Dinsdale D, Willis AE, Mallucci GR.

Nature. 2015 Feb 12;518(7538):236-9. doi: 10.1038/nature14142. Epub 2015 Jan 14.


LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.

Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, Mauri F, Jameson C, Sturge J, Gabra H, Bushell M, Willis AE, Curry E, Blagden SP.

Oncogene. 2015 Sep 24;34(39):5025-36. doi: 10.1038/onc.2014.428. Epub 2014 Dec 22.


mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.

Nature. 2015 Jan 22;517(7535):497-500. doi: 10.1038/nature13896. Epub 2014 Nov 5.


Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

Knight JR, Bastide A, Roobol A, Roobol J, Jackson TJ, Utami W, Barrett DA, Smales CM, Willis AE.

Biochem J. 2015 Jan 15;465(2):227-38. doi: 10.1042/BJ20141014.


p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.

Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM.

Biochem J. 2015 Jan 15;465(2):213-25. doi: 10.1042/BJ20140852.


TRANS PROF DB: A new resource for sharing translational profiles.

Spriggs RV, Willis AE.

Translation (Austin). 2014 Oct 30;2(2):e965615. doi: 10.4161/2169074X.2014.965615. eCollection 2014 Sep 1.


Evaluating bias-reducing protocols for RNA sequencing library preparation.

Jackson TJ, Spriggs RV, Burgoyne NJ, Jones C, Willis AE.

BMC Genomics. 2014 Jul 7;15:569. doi: 10.1186/1471-2164-15-569.


The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE.

PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr.


DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information.

Amelio I, Gostev M, Knight RA, Willis AE, Melino G, Antonov AV.

Cell Death Dis. 2014 Feb 6;5:e1051. doi: 10.1038/cddis.2014.9.


Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease.

Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.

Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.


The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.

Roobol A, Roobol J, Carden MJ, Smith ME, Hershey JW, Bastide A, Knight JR, Willis AE, Smales CM.

Biochem J. 2014 Mar 1;458(2):213-24. doi: 10.1042/BJ20130979.


Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.

King HA, Cobbold LC, Pichon X, Pöyry T, Wilson LA, Booden H, Jukes-Jones R, Cain K, Lilley KS, Bushell M, Willis AE.

Cell Death Differ. 2014 Jan;21(1):161-71. doi: 10.1038/cdd.2013.135. Epub 2013 Oct 18.


A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

Horvilleur E, Sbarrato T, Hill K, Spriggs RV, Screen M, Goodrem PJ, Sawicka K, Chaplin LC, Touriol C, Packham G, Potter KN, Dirnhofer S, Tzankov A, Dyer MJ, Bushell M, MacFarlane M, Willis AE.

Leukemia. 2014 May;28(5):1092-102. doi: 10.1038/leu.2013.295. Epub 2013 Oct 18.


Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.

Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR.

Sci Transl Med. 2013 Oct 9;5(206):206ra138. doi: 10.1126/scitranslmed.3006767.


Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-α infliximab.

Chimenti MS, Tucci P, Candi E, Perricone R, Melino G, Willis AE.

Cell Cycle. 2013 Sep 15;12(18):3025-36. doi: 10.4161/cc.26067. Epub 2013 Aug 19.


Rapamycin regulates biochemical metabolites.

Tucci P, Porta G, Agostini M, Antonov A, Garabadgiu AV, Melino G, Willis AE.

Cell Cycle. 2013 Aug 1;12(15):2454-67. doi: 10.4161/cc.25450. Epub 2013 Jun 28.


A perspective on mammalian upstream open reading frame function.

Somers J, Pöyry T, Willis AE.

Int J Biochem Cell Biol. 2013 Aug;45(8):1690-700. doi: 10.1016/j.biocel.2013.04.020. Epub 2013 Apr 25. Review.


Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.

Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M.

Science. 2013 Apr 5;340(6128):82-5. doi: 10.1126/science.1231197.

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