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Where next for inhaled corticosteroids in childhood asthma?

Sinha IP, Dodd SR, Grime C, Hawcutt DB, Fernandes RM, Roberts MR, Simba JM, Williamson PR.

Lancet Respir Med. 2020 Jan 20. pii: S2213-2600(20)30013-8. doi: 10.1016/S2213-2600(20)30013-8. [Epub ahead of print] No abstract available.


PIV Analysis of Stented Haemodynamics in the Descending Aorta.

Williamson P, Docherty PD, Yazdi SG, Jermy M, Khanafer A, Kabaliuk N, Geoghegan PH.

Conf Proc IEEE Eng Med Biol Soc. 2019 Jul;2019:4737-4740. doi: 10.1109/EMBC.2019.8856823.


Cauda Equina Syndrome Core Outcome Set (CESCOS): An international patient and healthcare professional consensus for research studies.

Srikandarajah N, Noble A, Clark S, Wilby M, Freeman BJC, Fehlings MG, Williamson PR, Marson T.

PLoS One. 2020 Jan 10;15(1):e0225907. doi: 10.1371/journal.pone.0225907. eCollection 2020.


Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed.

Treweek S, Bevan S, Bower P, Briel M, Campbell M, Christie J, Collett C, Cotton S, Devane D, El Feky A, Galvin S, Gardner H, Gillies K, Hood K, Jansen J, Littleford R, Parker A, Ramsay C, Restrup L, Sullivan F, Torgerson D, Tremain L, von Elm E, Westmore M, Williams H, Williamson PR, Clarke M.

Trials. 2020 Jan 7;21(1):33. doi: 10.1186/s13063-019-3980-5.


Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 diabetes (SCORE-IT): a patient and healthcare professional consensus on a core outcome set for type 2 diabetes.

Harman NL, Wilding JPH, Curry D, Harris J, Logue J, Pemberton RJ, Perreault L, Thompson G, Tunis S, Williamson PR; SCORE-IT Study Team .

BMJ Open Diabetes Res Care. 2019 Dec 29;7(1):e000700. doi: 10.1136/bmjdrc-2019-000700. eCollection 2019.


Transcription-mediated amplification blood donation screening for Babesia.

Tonnetti L, Young C, Kessler DA, Williamson PC, Reik R, Proctor MC, Brès V, Deisting B, Bakkour S, Schneider W, Diner S, Busch MP, Stramer SL, Linnen JM.

Transfusion. 2020 Feb;60(2):317-325. doi: 10.1111/trf.15630. Epub 2019 Dec 29.


A Systematic Review of Core Outcomes for Hypospadias Surgery.

Leunbach TL, O'Toole S, Springer A, Williamson PR, Ahmed SF.

Sex Dev. 2019 Dec 20. doi: 10.1159/000504973. [Epub ahead of print]


Quantifications of CSF Apoptotic Bodies Do Not Provide Clinical Value in Multiple Sclerosis.

Masvekar R, Mizrahi J, Park J, Williamson PR, Bielekova B.

Front Neurol. 2019 Nov 26;10:1241. doi: 10.3389/fneur.2019.01241. eCollection 2019.


PPI in research: a reflection from early stage researchers.

Biggane AM, Olsen M, Williamson PR.

Res Involv Engagem. 2019 Nov 19;5:35. doi: 10.1186/s40900-019-0170-2. eCollection 2019.


Choosing important health outcomes for comparative effectiveness research: 5th annual update to a systematic review of core outcome sets for research.

Gargon E, Gorst SL, Williamson PR.

PLoS One. 2019 Dec 12;14(12):e0225980. doi: 10.1371/journal.pone.0225980. eCollection 2019.


HIV-Negative Cryptococcal Meningoencephalitis Results in a Persistent Frontal-Subcortical Syndrome.

Traino K, Snow J, Ham L, Summers A, Segalà L, Shirazi T, Biassou N, Panackal A, Anjum S, Marr KA, Kreisl WC, Bennett JE, Williamson PR.

Sci Rep. 2019 Dec 5;9(1):18442. doi: 10.1038/s41598-019-54876-7.


Allergies and Eosinophilic Esophagitis-Current Updates for the Pediatric Gastroenterologist.

Williamson P, Aceves S.

Curr Gastroenterol Rep. 2019 Nov 20;21(11):56. doi: 10.1007/s11894-019-0729-y. Review.


Participating in core outcome set development via Delphi surveys: qualitative interviews provide pointers to inform guidance.

Biggane AM, Williamson PR, Ravaud P, Young B.

BMJ Open. 2019 Nov 14;9(11):e032338. doi: 10.1136/bmjopen-2019-032338.


Evaluation of an automatic article selection method for timelier updates of the Comet Core Outcome Set database.

Norman CR, Gargon E, Leeflang MMG, Névéol A, Williamson PR.

Database (Oxford). 2019 Jan 1;2019. pii: baz109. doi: 10.1093/database/baz109.


Tendon lengthening after achilles tendon rupture-passive effects on the ankle joint in a cadaveric pilot study simulating weight bearing.

Williamson PM, Pennings JP, Harlow E, Hanna P, Lechtig A, Okajima S, Biggane P, Nasr M, Zurakowski D, Duggal N, Nazarian A.

Injury. 2020 Feb;51(2):532-536. doi: 10.1016/j.injury.2019.10.024. Epub 2019 Oct 14.


One-step pentaplex real-time polymerase chain reaction assay for detection of zika, dengue, chikungunya, West nile viruses and a human housekeeping gene.

Mishra N, Ng J, Rakeman JL, Perry MJ, Centurioni DA, Dean AB, Price A, Thakkar R, Angus AG, Williamson P, Delwart E, Carrington C, Sahadeo N, Che X, Briese T, Tokarz R, Lipkin WI.

J Clin Virol. 2019 Nov;120:44-50. doi: 10.1016/j.jcv.2019.08.011. Epub 2019 Sep 16.


A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials.

Rosala-Hallas A, Gamble C, Blazeby J, Williamson PR.

Trials. 2019 Sep 18;20(1):571. doi: 10.1186/s13063-019-3669-9.


Assessing the impact of a research funder's recommendation to consider core outcome sets.

Hughes KL, Kirkham JJ, Clarke M, Williamson PR.

PLoS One. 2019 Sep 13;14(9):e0222418. doi: 10.1371/journal.pone.0222418. eCollection 2019.


Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with genes encoding their enzymes.

Soh PXY, Marin Cely JM, Mortlock SA, Jara CJ, Booth R, Natera S, Roessner U, Crossett B, Cordwell S, Singh Khatkar M, Williamson P.

Metabolomics. 2019 Sep 6;15(9):123. doi: 10.1007/s11306-019-1586-2.


Protocols for the Analysis of microRNA Expression, Biogenesis, and Function in Immune Cells.

Zhang N, Hu G, Myers TG, Williamson PR.

Curr Protoc Immunol. 2019 Sep;126(1):e78. doi: 10.1002/cpim.78.


Intradural cauda equina Candida abscess presenting with hydrocephalus: case report.

Argersinger DP, Natkha VP, Shepard MJ, Thomas AA, Oler AJ, Williamson PR, Chittiboina P, Heiss JD.

J Neurosurg Spine. 2019 Aug 30:1-4. doi: 10.3171/2019.6.SPINE19271. [Epub ahead of print]


Improving therapy of severe infections through drug repurposing of synergistic combinations.

Cheng YS, Williamson PR, Zheng W.

Curr Opin Pharmacol. 2019 Oct;48:92-98. doi: 10.1016/j.coph.2019.07.006. Epub 2019 Aug 24. Review.


TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy.

Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, García-Fiñana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M; TAILoR Study Group .

Clin Infect Dis. 2019 Jul 3. pii: ciz589. doi: 10.1093/cid/ciz589. [Epub ahead of print]


Cognitive and behavioral therapy for insomnia increases the use of continuous positive airway pressure therapy in obstructive sleep apnea participants with comorbid insomnia: a randomized clinical trial.

Sweetman A, Lack L, Catcheside PG, Antic NA, Smith S, Chai-Coetzer CL, Douglas J, O'grady A, Dunn N, Robinson J, Paul D, Williamson P, McEvoy RD.

Sleep. 2019 Dec 24;42(12). pii: zsz178. doi: 10.1093/sleep/zsz178.


Industry funding was associated with increased use of core outcome sets.

Kirkham JJ, Bracken M, Hind L, Pennington K, Clarke M, Williamson PR.

J Clin Epidemiol. 2019 Nov;115:90-97. doi: 10.1016/j.jclinepi.2019.07.007. Epub 2019 Jul 18.


Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.

Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, Garcia-Finana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M.

Southampton (UK): NIHR Journals Library; 2019 Jul.


Timing Of Primary Surgery for cleft palate (TOPS): protocol for a randomised trial of palate surgery at 6 months versus 12 months of age.

Shaw W, Semb G, Lohmander A, Persson C, Willadsen E, Clayton-Smith J, Trindade IK, Munro KJ, Gamble C, Harman N, Conroy EJ, Weichart D, Williamson P.

BMJ Open. 2019 Jul 11;9(7):e029780. doi: 10.1136/bmjopen-2019-029780.


Scottish consensus statement on the role of FeNO in adult asthma.

Kuo CR, Spears M, Haughney J, Smith A, Miller J, Bradshaw T, Murray L, Williamson P, Lipworth B.

Respir Med. 2019 Aug;155:54-57. doi: 10.1016/j.rmed.2019.07.010. Epub 2019 Jul 6. Review.


Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis.

Blessing WA, Okajima SM, Cubria MB, Villa-Camacho JC, Perez-Viloria M, Williamson PM, Sabogal AN, Suarez S, Ang LH, White S, Flynn E, Rodriguez EK, Grinstaff MW, Nazarian A.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12183-12192. doi: 10.1073/pnas.1900355116. Epub 2019 Jun 3.


Audiologic and Otologic Complications of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Patients.

King KA, Ansari G, Panackal AA, Zalewski C, Anjum S, Bennett JE, Beri A, Kim HJ, Hammoud D, Brewer CC, Williamson PR.

Otol Neurotol. 2019 Jul;40(6):e657-e664. doi: 10.1097/MAO.0000000000002242.


Efficacy of Oral Encochleated Amphotericin B in a Mouse Model of Cryptococcal Meningoencephalitis.

Lu R, Hollingsworth C, Qiu J, Wang A, Hughes E, Xin X, Konrath KM, Elsegeiny W, Park YD, Atakulu L, Craft JC, Tramont EC, Mannino R, Williamson PR.

mBio. 2019 May 28;10(3). pii: e00724-19. doi: 10.1128/mBio.00724-19.


Issues in the determination of 'responders' and 'non-responders' in physiological research.

Atkinson G, Williamson P, Batterham AM.

Exp Physiol. 2019 Aug;104(8):1215-1225. doi: 10.1113/EP087712. Epub 2019 Jun 9. Review.


Pirfenidone in Heart Failure with Preserved Ejection Fraction-Rationale and Design of the PIROUETTE Trial.

Lewis GA, Schelbert EB, Naish JH, Bedson E, Dodd S, Eccleson H, Clayton D, Jimenez BD, McDonagh T, Williams SG, Cooper A, Cunnington C, Ahmed FZ, Viswesvaraiah R, Russell S, Neubauer S, Williamson PR, Miller CA.

Cardiovasc Drugs Ther. 2019 Aug;33(4):461-470. doi: 10.1007/s10557-019-06876-y.


Protocol for the development of a core outcome set for cauda equina syndrome: systematic literature review, qualitative interviews, Delphi survey and consensus meeting.

Srikandarajah N, Noble AJ, Wilby M, Clark S, Williamson PR, Marson AG.

BMJ Open. 2019 May 1;9(4):e024002. doi: 10.1136/bmjopen-2018-024002.


Identifying Possible Outcome Domains from Existing Outcome Measures to Inform an OMERACT Core Domain Set for Safety in Rheumatology Trials.

Klokker L, Berthelsen DB, Woodworth T, Andersen KM, Furst DE, Devoe D, Williamson PR, Suarez-Almazor ME, Strand V, Leong AL, Goel N, Boers M, Brooks PM, March L, Sloan VS, Tugwell P, Simon LS, Christensen R.

J Rheumatol. 2019 Sep;46(9):1173-1178. doi: 10.3899/jrheum.190196. Epub 2019 May 1.


Diagnostic Modalities for Acute Compartment Syndrome of the Extremities: A Systematic Review.

Mortensen SJ, Vora MM, Mohamadi A, Wright CL, Hanna P, Lechtig A, Egan J, Williamson PM, Wixted JJ, Rutkove SB, Nazarian A.

JAMA Surg. 2019 Jul 1;154(7):655-665. doi: 10.1001/jamasurg.2019.1050.


Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT.

Ramanan AV, Dick AD, Jones AP, Hughes DA, McKay A, Rosala-Hallas A, Williamson PR, Hardwick B, Hickey H, Rainford N, Hickey G, Kolamunnage-Dona R, Culeddu G, Plumpton C, Wood E, Compeyrot-Lacassagne S, Woo P, Edelsten C, Beresford MW.

Health Technol Assess. 2019 Apr;23(15):1-140. doi: 10.3310/hta23150.


Development of a hybrid CFD-PBPK model to predict the transport of xenon gas around a human respiratory system to systemic regions.

Haghnegahdar A, Zhao J, Kozak M, Williamson P, Feng Y.

Heliyon. 2019 Apr 10;5(4):e01461. doi: 10.1016/j.heliyon.2019.e01461. eCollection 2019 Apr.


Improvement was needed in the standards of development for cancer core outcome sets.

Gargon E, Williamson PR, Blazeby JM, Kirkham JJ.

J Clin Epidemiol. 2019 Aug;112:36-44. doi: 10.1016/j.jclinepi.2019.04.006. Epub 2019 Apr 19.


What is important to people living with dementia?: the 'long-list' of outcome items in the development of a core outcome set for use in the evaluation of non-pharmacological community-based health and social care interventions.

Harding AJE, Morbey H, Ahmed F, Opdebeeck C, Lasrado R, Williamson PR, Swarbrick C, Leroi I, Challis D, Hellstrom I, Burns A, Keady J, Reilly ST.

BMC Geriatr. 2019 Mar 27;19(1):94. doi: 10.1186/s12877-019-1103-5.


Incorporating patients' perspectives into the initial stages of core outcome set development: a rapid review of qualitative studies of type 2 diabetes.

Gorst SL, Young B, Williamson PR, Wilding JPH, Harman NL.

BMJ Open Diabetes Res Care. 2019 Feb 28;7(1):e000615. doi: 10.1136/bmjdrc-2018-000615. eCollection 2019. Review.


The Pat1-Lsm complex prevents 3' to 5' degradation of a specific subset of ATG mRNAs during nitrogen starvation-induced autophagy.

Gatica D, Hu G, Zhang N, Williamson PR, Klionsky DJ.

Autophagy. 2019 Apr;15(4):750-751. doi: 10.1080/15548627.2019.1587262. Epub 2019 Mar 18.


A Multicenter, Longitudinal Cohort Study of Cryptococcosis in Human Immunodeficiency Virus-negative People in the United States.

Marr KA, Sun Y, Spec A, Lu N, Panackal A, Bennett J, Pappas P, Ostrander D, Datta K, Zhang SX, Williamson PR; Cryptococcus Infection Network Cohort Study Working Group .

Clin Infect Dis. 2020 Jan 2;70(2):252-261. doi: 10.1093/cid/ciz193.


Improving outcome reporting in clinical trial reports and protocols: study protocol for the Instrument for reporting Planned Endpoints in Clinical Trials (InsPECT).

Butcher NJ, Monsour A, Mew EJ, Szatmari P, Pierro A, Kelly LE, Farid-Kapadia M, Chee-A-Tow A, Saeed L, Monga S, Ungar W, Terwee CB, Vohra S, Fergusson D, Askie LM, Williamson PR, Chan AW, Moher D, Offringa M.

Trials. 2019 Mar 6;20(1):161. doi: 10.1186/s13063-019-3248-0.


Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017.

Smith TO, Mansfield M, Hawker GA, Hunter DJ, March LM, Boers M, Shea BJ, Christensen R, Guillemin F, Terwee CB, Williamson PR, Roos EM, Loeser RF, Schnitzer TJ, Kloppenburg M, Neogi T, Ladel CH, Kalsi G, Kaiser U, Buttel TW, Ashford AE, Mobasheri A, Arden NK, Tennant A, Hochberg MC, de Wit M, Tugwell P, Conaghan PG.

J Rheumatol. 2019 Aug;46(8):976-980. doi: 10.3899/jrheum.181066. Epub 2019 Mar 1.


Quantitative analysis of 14N quadrupolar coupling using 1H detected 14N solid-state NMR.

Jarvis JA, Concistre M, Haies IM, Bounds RW, Kuprov I, Carravetta M, Williamson PTF.

Phys Chem Chem Phys. 2019 Mar 13;21(11):5941-5949. doi: 10.1039/c8cp06276e.


Copy number variation and variant discovery in Bullmastiff dogs.

Mortlock SA, Williamson P, Khatkar MS.

Anim Genet. 2019 Apr;50(2):177-181. doi: 10.1111/age.12754. Epub 2019 Feb 21.


Core Outcome Set-STAndardised Protocol Items: the COS-STAP Statement.

Kirkham JJ, Gorst S, Altman DG, Blazeby JM, Clarke M, Tunis S, Williamson PR; COS-STAP Group.

Trials. 2019 Feb 11;20(1):116. doi: 10.1186/s13063-019-3230-x.


SAM Composition and Electrode Roughness Affect Performance of a DNA Biosensor for Antibiotic Resistance.

Butterworth A, Blues E, Williamson P, Cardona M, Gray L, Corrigan DK.

Biosensors (Basel). 2019 Feb 7;9(1). pii: E22. doi: 10.3390/bios9010022.


Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches.

Moshref M, Tangey B, Gilor C, Papas KK, Williamson P, Loomba-Albrecht L, Sheehy P, Kol A.

Stem Cells Transl Med. 2019 May;8(5):450-455. doi: 10.1002/sctm.18-0163. Epub 2019 Feb 5. Review.

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