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Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism.

Ma G, Wang T, Korhonen PK, Young ND, Nie S, Ang CS, Williamson NA, Reid GE, Gasser RB.

PLoS Pathog. 2019 Jul 23;15(7):e1007960. doi: 10.1371/journal.ppat.1007960. eCollection 2019 Jul.


High throughput LC-MS/MS-based proteomic analysis of excretory-secretory products from short-term in vitro culture of Haemonchus contortus.

Wang T, Ma G, Ang CS, Korhonen PK, Koehler AV, Young ND, Nie S, Williamson NA, Gasser RB.

J Proteomics. 2019 Jul 30;204:103375. doi: 10.1016/j.jprot.2019.05.003. Epub 2019 May 6.


Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.

Pereira-Fantini PM, Pang B, Byars SG, Oakley RB, Perkins EJ, Dargaville PA, Davis PG, Nie S, Williamson NA, Ignjatovic V, Tingay DG.

Am J Respir Cell Mol Biol. 2019 Apr 17. doi: 10.1165/rcmb.2019-0084OC. [Epub ahead of print]


Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death.

Hoque A, Williamson NA, Ameen SS, Ciccotosto GD, Hossain MI, Oakhill JS, Ng DCH, Ang CS, Cheng HC.

Cell Death Dis. 2019 Mar 1;10(3):213. doi: 10.1038/s41419-019-1445-0.


Somatic proteome of Haemonchus contortus.

Wang T, Ma G, Ang CS, Korhonen PK, Xu R, Nie S, Koehler AV, Simpson RJ, Greening DW, Reid GE, Williamson NA, Gasser RB.

Int J Parasitol. 2019 Mar;49(3-4):311-320. doi: 10.1016/j.ijpara.2018.12.003. Epub 2019 Feb 14.


Variability of allergens in commercial fish extracts for skin prick testing.

Ruethers T, Taki AC, Nugraha R, Cao TT, Koeberl M, Kamath SD, Williamson NA, O'Callaghan S, Nie S, Mehr SS, Campbell DE, Lopata AL.

Allergy. 2019 Jul;74(7):1352-1363. doi: 10.1111/all.13748. Epub 2019 Apr 15.


Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture.

Makhoul C, Gosavi P, Duffield R, Delbridge B, Williamson NA, Gleeson PA.

Mol Biol Cell. 2019 Feb 1;30(3):370-386. doi: 10.1091/mbc.E18-05-0313. Epub 2018 Dec 12.


Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

Zhang S, Williamson NA, Bogoyevitch MA.

Sci Data. 2018 Nov 20;5:180262. doi: 10.1038/sdata.2018.262.


The developmental lipidome of Haemonchus contortus.

Wang T, Nie S, Ma G, Korhonen PK, Koehler AV, Ang CS, Reid GE, Williamson NA, Gasser RB.

Int J Parasitol. 2018 Oct;48(12):887-895. doi: 10.1016/j.ijpara.2018.06.002. Epub 2018 Sep 1.


Molecular alterations during larval development of Haemonchus contortus in vitro are under tight post-transcriptional control.

Ma G, Wang T, Korhonen PK, Ang CS, Williamson NA, Young ND, Stroehlein AJ, Hall RS, Koehler AV, Hofmann A, Gasser RB.

Int J Parasitol. 2018 Aug;48(9-10):763-772. doi: 10.1016/j.ijpara.2018.03.008. Epub 2018 May 22.


Operational Experience of an Open-Access, Subscription-Based Mass Spectrometry and Proteomics Facility.

Williamson NA.

J Am Soc Mass Spectrom. 2018 Mar;29(3):439-446. doi: 10.1007/s13361-017-1862-1. Epub 2018 Jan 3.


The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein (FADD).

Scott NE, Giogha C, Pollock GL, Kennedy CL, Webb AI, Williamson NA, Pearson JS, Hartland EL.

J Biol Chem. 2017 Oct 20;292(42):17337-17350. doi: 10.1074/jbc.M117.805036. Epub 2017 Aug 31.


Tear Interferon-Gamma as a Biomarker for Evaporative Dry Eye Disease.

Jackson DC, Zeng W, Wong CY, Mifsud EJ, Williamson NA, Ang CS, Vingrys AJ, Downie LE.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4824-4830. doi: 10.1167/iovs.16-19757.


Changes in the Cytoplasmic Composition of Amino Acids and Proteins Observed in Staphylococcus aureus during Growth under Variable Growth Conditions Representative of the Human Wound Site.

Alreshidi MM, Dunstan RH, Gottfries J, Macdonald MM, Crompton MJ, Ang CS, Williamson NA, Roberts TK.

PLoS One. 2016 Jul 21;11(7):e0159662. doi: 10.1371/journal.pone.0159662. eCollection 2016.


Aurora A phosphorylation of WD40-repeat protein 62 in mitotic spindle regulation.

Lim NR, Yeap YY, Ang CS, Williamson NA, Bogoyevitch MA, Quinn LM, Ng DC.

Cell Cycle. 2016;15(3):413-24. doi: 10.1080/15384101.2015.1127472.


FunRich: An open access standalone functional enrichment and interaction network analysis tool.

Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, Bacic A, Hill AF, Stroud DA, Ryan MT, Agbinya JI, Mariadason JM, Burgess AW, Mathivanan S.

Proteomics. 2015 Aug;15(15):2597-601. doi: 10.1002/pmic.201400515. Epub 2015 Jun 17.


Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.

Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC.

J Cell Sci. 2015 Feb 1;128(3):527-40.


Pancreatic beta cells are highly susceptible to oxidative and ER stresses during the development of diabetes.

Gorasia DG, Dudek NL, Veith PD, Shankar R, Safavi-Hemami H, Williamson NA, Reynolds EC, Hubbard MJ, Purcell AW.

J Proteome Res. 2015 Feb 6;14(2):688-99. doi: 10.1021/pr500643h. Epub 2014 Dec 8.


T-cell activation by transitory neo-antigens derived from distinct microbial pathways.

Corbett AJ, Eckle SB, Birkinshaw RW, Liu L, Patel O, Mahony J, Chen Z, Reantragoon R, Meehan B, Cao H, Williamson NA, Strugnell RA, Van Sinderen D, Mak JY, Fairlie DP, Kjer-Nielsen L, Rossjohn J, McCluskey J.

Nature. 2014 May 15;509(7500):361-5. doi: 10.1038/nature13160. Epub 2014 Apr 2.


A type III effector antagonizes death receptor signalling during bacterial gut infection.

Pearson JS, Giogha C, Ong SY, Kennedy CL, Kelly M, Robinson KS, Lung TW, Mansell A, Riedmaier P, Oates CV, Zaid A, Mühlen S, Crepin VF, Marches O, Ang CS, Williamson NA, O'Reilly LA, Bankovacki A, Nachbur U, Infusini G, Webb AI, Silke J, Strasser A, Frankel G, Hartland EL.

Nature. 2013 Sep 12;501(7466):247-51. doi: 10.1038/nature12524.


Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti).

Hart AJ, Isbister GK, O'Donnell P, Williamson NA, Hodgson WC.

Toxicol Lett. 2013 Jun 7;219(3):262-8. doi: 10.1016/j.toxlet.2013.03.026. Epub 2013 Mar 29.


A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

Hossain MI, Roulston CL, Kamaruddin MA, Chu PW, Ng DC, Dusting GJ, Bjorge JD, Williamson NA, Fujita DJ, Cheung SN, Chan TO, Hill AF, Cheng HC.

J Biol Chem. 2013 Apr 5;288(14):9696-709. doi: 10.1074/jbc.M112.419713. Epub 2013 Feb 11.


MR1 presents microbial vitamin B metabolites to MAIT cells.

Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, Bhati M, Chen Z, Kostenko L, Reantragoon R, Williamson NA, Purcell AW, Dudek NL, McConville MJ, O'Hair RA, Khairallah GN, Godfrey DI, Fairlie DP, Rossjohn J, McCluskey J.

Nature. 2012 Nov 29;491(7426):717-23. doi: 10.1038/nature11605. Epub 2012 Oct 10.


Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails.

Safavi-Hemami H, Gorasia DG, Steiner AM, Williamson NA, Karas JA, Gajewiak J, Olivera BM, Bulaj G, Purcell AW.

J Biol Chem. 2012 Oct 5;287(41):34288-303. doi: 10.1074/jbc.M112.366781. Epub 2012 Aug 13.


Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.

Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J.

Nature. 2012 Jun 28;486(7404):554-8. doi: 10.1038/nature11147.


Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands.

Scull KE, Dudek NL, Corbett AJ, Ramarathinam SH, Gorasia DG, Williamson NA, Purcell AW.

Mol Immunol. 2012 Jun;51(2):136-42. doi: 10.1016/j.molimm.2012.02.117. Epub 2012 Mar 17.


Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway.

Safavi-Hemami H, Siero WA, Gorasia DG, Young ND, Macmillan D, Williamson NA, Purcell AW.

J Proteome Res. 2011 Sep 2;10(9):3904-19. doi: 10.1021/pr1012976. Epub 2011 Aug 11.


Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.

Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC.

Biochemistry. 2011 Aug 9;50(31):6667-77. doi: 10.1021/bi2001938. Epub 2011 Jul 18.


Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring.

Tan CT, Croft NP, Dudek NL, Williamson NA, Purcell AW.

Proteomics. 2011 Jun;11(11):2336-40. doi: 10.1002/pmic.201000531. Epub 2011 May 20.


Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?

Safavi-Hemami H, Siero WA, Kuang Z, Williamson NA, Karas JA, Page LR, MacMillan D, Callaghan B, Kompella SN, Adams DJ, Norton RS, Purcell AW.

J Biol Chem. 2011 Jun 24;286(25):22546-57. doi: 10.1074/jbc.M110.217703. Epub 2011 Apr 19.


Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification.

Reilly CB, Ramarathinam SH, Williamson NA, Purcell AW.

Proteome Sci. 2011 Jan 17;9(1):2. doi: 10.1186/1477-5956-9-2.


A novel strategy for the targeted analysis of protein and peptide metabolites.

Williamson NA, Reilly C, Tan CT, Ramarathinam SH, Jones A, Hunter CL, Rooney FR, Purcell AW.

Proteomics. 2011 Jan;11(2):183-92. doi: 10.1002/pmic.201000474. Epub 2010 Dec 15.


Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb.

Safavi-Hemami H, Young ND, Williamson NA, Purcell AW.

J Proteome Res. 2010 Nov 5;9(11):5610-9. doi: 10.1021/pr100431x. Epub 2010 Sep 29.


Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.


Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins.

Safavi-Hemami H, Bulaj G, Olivera BM, Williamson NA, Purcell AW.

J Biol Chem. 2010 Apr 23;285(17):12735-46. doi: 10.1074/jbc.M109.078691. Epub 2010 Feb 10.


A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus.

Anwari K, Poggio S, Perry A, Gatsos X, Ramarathinam SH, Williamson NA, Noinaj N, Buchanan S, Gabriel K, Purcell AW, Jacobs-Wagner C, Lithgow T.

PLoS One. 2010 Jan 8;5(1):e8619. doi: 10.1371/journal.pone.0008619.


Molecular markers of preterm labor in the choriodecidua.

Shankar R, Johnson MP, Williamson NA, Cullinane F, Purcell AW, Moses EK, Brennecke SP.

Reprod Sci. 2010 Mar;17(3):297-310. doi: 10.1177/1933719109353454. Epub 2009 Dec 15.


The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.

Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC.

Clin Exp Immunol. 2009 May;156(2):226-31. doi: 10.1111/j.1365-2249.2009.03907.x. Epub 2009 Mar 9.


Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.

Petersen J, Wurzbacher SJ, Williamson NA, Ramarathinam SH, Reid HH, Nair AK, Zhao AY, Nastovska R, Rudge G, Rossjohn J, Purcell AW.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2776-81. doi: 10.1073/pnas.0812901106. Epub 2009 Feb 5.


Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.

Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, Kjer-Nielsen L, Mifsud NA, Tait BD, Holdsworth R, Almeida CA, Nolan D, Macdonald WA, Archbold JK, Kellerher AD, Marriott D, Mallal S, Bharadwaj M, Rossjohn J, McCluskey J.

Immunity. 2008 Jun;28(6):822-32. doi: 10.1016/j.immuni.2008.04.020. Erratum in: Immunity. 2008 Jul;29(1):165.


Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity.

Nguyen TH, Mifsud NA, Stewart LA, Rose MJ, Etto TL, Williamson NA, Purcell AW, Kotsimbos T, Schwarer AP.

Protein Expr Purif. 2008 Sep;61(1):22-30. doi: 10.1016/j.pep.2008.05.001. Epub 2008 May 14.


The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK).

Steuten J, Winkel K, Carroll T, Williamson NA, Ignjatovic V, Fung K, Purcell AW, Fry BG.

Toxicon. 2007 Dec 15;50(8):1041-52. Epub 2007 Aug 12.


Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli.

Etto TL, Stewart LA, Nguyen TH, Williamson NA, Purcell AW, Schwarer AP.

Protein Expr Purif. 2007 Jul;54(1):176-82. Epub 2007 Feb 27.


A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.

Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J.

Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28.


Tumors reveal their secrets to cytotoxic T cells.

Williamson NA, Rossjohn J, Purcell AW.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14649-50. Epub 2006 Sep 27. No abstract available.


C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC.

J Biol Chem. 2006 Nov 3;281(44):32988-99. Epub 2006 Sep 7. Erratum in: J Biol Chem. 2015 Jan 2;290(1):240.


A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.

Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS, Williamson NA, Smyth MJ, Besra GS, Reid HH, Bharadwaj M, Godfrey DI, Rossjohn J, McCluskey J.

J Exp Med. 2006 Mar 20;203(3):661-73. Epub 2006 Feb 27.


The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.

Tynan FE, Elhassen D, Purcell AW, Burrows JM, Borg NA, Miles JJ, Williamson NA, Green KJ, Tellam J, Kjer-Nielsen L, McCluskey J, Rossjohn J, Burrows SR.

J Exp Med. 2005 Nov 7;202(9):1249-60.


The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW.

J Exp Med. 2005 Nov 7;202(9):1191-7. Epub 2005 Oct 31.


T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo.

Webb AI, Dunstone MA, Williamson NA, Price JD, de Kauwe A, Chen W, Oakley A, Perlmutter P, McCluskey J, Aguilar MI, Rossjohn J, Purcell AW.

J Immunol. 2005 Sep 15;175(6):3810-8.

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