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Items: 1 to 50 of 168

1.

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and interaction with effectors of the innate immune system.

Smith RE, Salamaga B, Szkuta P, Hajdamowicz N, Prajsnar TK, Bulmer GS, Fontaine T, Kołodziejczyk J, Herry JM, Hounslow AM, Williamson MP, Serror P, Mesnage S.

PLoS Pathog. 2019 May 2;15(5):e1007730. doi: 10.1371/journal.ppat.1007730. eCollection 2019 May.

2.

Structural Investigation into the Threading Intercalation of a Chiral Dinuclear Ruthenium(II) Polypyridyl Complex through a B-DNA Oligonucleotide.

Fairbanks SD, Robertson CC, Keene FR, Thomas JA, Williamson MP.

J Am Chem Soc. 2019 Mar 20;141(11):4644-4652. doi: 10.1021/jacs.8b12280. Epub 2019 Mar 7.

PMID:
30799603
3.

Why the Energy Landscape of Barnase Is Hierarchical.

Pandya MJ, Schiffers S, Hounslow AM, Baxter NJ, Williamson MP.

Front Mol Biosci. 2018 Dec 20;5:115. doi: 10.3389/fmolb.2018.00115. eCollection 2018.

4.

Characterization of low-lying excited states of proteins by high-pressure NMR.

Williamson MP, Kitahara R.

Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):350-358. doi: 10.1016/j.bbapap.2018.10.014. Epub 2018 Oct 24. Review.

PMID:
30366154
5.

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3.

Southam HM, Smith TW, Lyon RL, Liao C, Trevitt CR, Middlemiss LA, Cox FL, Chapman JA, El-Khamisy SF, Hippler M, Williamson MP, Henderson PJF, Poole RK.

Redox Biol. 2018 Sep;18:114-123. doi: 10.1016/j.redox.2018.06.008. Epub 2018 Jun 30.

6.

Structure of a Wbl protein and implications for NO sensing by M. tuberculosis.

Kudhair BK, Hounslow AM, Rolfe MD, Crack JC, Hunt DM, Buxton RS, Smith LJ, Le Brun NE, Williamson MP, Green J.

Nat Commun. 2017 Dec 22;8(1):2280. doi: 10.1038/s41467-017-02418-y.

7.

Pressure-Dependent Chemical Shifts in the R3 Domain of Talin Show that It Is Thermodynamically Poised for Binding to Either Vinculin or RIAM.

Baxter NJ, Zacharchenko T, Barsukov IL, Williamson MP.

Structure. 2017 Dec 5;25(12):1856-1866.e2. doi: 10.1016/j.str.2017.10.008. Epub 2017 Nov 16.

8.

Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins.

Heyam A, Coupland CE, Dégut C, Haley RA, Baxter NJ, Jakob L, Aguiar PM, Meister G, Williamson MP, Lagos D, Plevin MJ.

Nucleic Acids Res. 2017 Dec 1;45(21):12577-12584. doi: 10.1093/nar/gkx928.

9.

MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus.

Blanchet P, Bebin M, Bruet S, Cooper GM, Thompson ML, Duban-Bedu B, Gerard B, Piton A, Suckno S, Deshpande C, Clowes V, Vogt J, Turnpenny P, Williamson MP, Alembik Y; Clinical Sequencing Exploratory Research Study Consortium; Deciphering Developmental Disorders Consortium, Glasgow E, McNeill A.

PLoS Genet. 2017 Aug 31;13(8):e1006957. doi: 10.1371/journal.pgen.1006957. eCollection 2017 Aug.

10.

Multi-site binding of epigallocatechin gallate to human serum albumin measured by NMR and isothermal titration calorimetry.

Eaton JD, Williamson MP.

Biosci Rep. 2017 May 11;37(3). pii: BSR20170209. doi: 10.1042/BSR20170209. Print 2017 Jun 30.

11.

Homeostasis of metabolites in Escherichia coli on transition from anaerobic to aerobic conditions and the transient secretion of pyruvate.

Yasid NA, Rolfe MD, Green J, Williamson MP.

R Soc Open Sci. 2016 Aug 24;3(8):160187. eCollection 2016 Aug.

12.

Molecular Mechanism for the Hofmeister Effect Derived from NMR and DSC Measurements on Barnase.

Bye JW, Baxter NJ, Hounslow AM, Falconer RJ, Williamson MP.

ACS Omega. 2016 Oct 25;1(4):669-679. doi: 10.1021/acsomega.6b00223. eCollection 2016 Oct 31.

13.

Ferrous Iron Binding Key to Mms6 Magnetite Biomineralisation: A Mechanistic Study to Understand Magnetite Formation Using pH Titration and NMR Spectroscopy.

Rawlings AE, Bramble JP, Hounslow AM, Williamson MP, Monnington AE, Cooke DJ, Staniland SS.

Chemistry. 2016 Jun 1;22(23):7885-94. doi: 10.1002/chem.201600322. Epub 2016 Apr 26.

14.

Synthesis of Chlorophyll-Binding Proteins in a Fully Segregated Δycf54 Strain of the Cyanobacterium Synechocystis PCC 6803.

Hollingshead S, Kopečná J, Armstrong DR, Bučinská L, Jackson PJ, Chen GE, Dickman MJ, Williamson MP, Sobotka R, Hunter CN.

Front Plant Sci. 2016 Mar 17;7:292. doi: 10.3389/fpls.2016.00292. eCollection 2016.

15.

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

Xu Y, Streets AJ, Hounslow AM, Tran U, Jean-Alphonse F, Needham AJ, Vilardaga JP, Wessely O, Williamson MP, Ong AC.

J Am Soc Nephrol. 2016 Apr;27(4):1159-73. doi: 10.1681/ASN.2014111074. Epub 2015 Aug 26.

16.

Pressure-Dependent Conformation and Fluctuation in Folded Protein Molecules.

Williamson MP.

Subcell Biochem. 2015;72:109-27. doi: 10.1007/978-94-017-9918-8_6. Review.

PMID:
26174379
17.

Backbone assignment and secondary structure of the PLAT domain of human polycystin-1.

Xu Y, Ong AC, Williamson MP, Hounslow AM.

Biomol NMR Assign. 2015 Oct;9(2):369-73. doi: 10.1007/s12104-015-9612-4. Epub 2015 May 6.

PMID:
25943267
18.

Molecular basis for bacterial peptidoglycan recognition by LysM domains.

Mesnage S, Dellarole M, Baxter NJ, Rouget JB, Dimitrov JD, Wang N, Fujimoto Y, Hounslow AM, Lacroix-Desmazes S, Fukase K, Foster SJ, Williamson MP.

Nat Commun. 2014 Jun 30;5:4269. doi: 10.1038/ncomms5269.

19.

Close identity between alternatively folded state N2 of ubiquitin and the conformation of the protein bound to the ubiquitin-activating enzyme.

Kitazawa S, Kameda T, Kumo A, Yagi-Utsumi M, Baxter NJ, Kato K, Williamson MP, Kitahara R.

Biochemistry. 2014 Jan 28;53(3):447-9. doi: 10.1021/bi401617n. Epub 2014 Jan 10.

PMID:
24401037
20.

Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence.

Wilson T, Costa PJ, Félix V, Williamson MP, Thomas JA.

J Med Chem. 2013 Nov 14;56(21):8674-83. doi: 10.1021/jm401119b. Epub 2013 Oct 23.

21.

Detection of salt bridges to lysines in solution in barnase.

Williamson MP, Hounslow AM, Ford J, Fowler K, Hebditch M, Hansen PE.

Chem Commun (Camb). 2013 Oct 28;49(84):9824-6. doi: 10.1039/c3cc45602a.

PMID:
24030197
22.

Using chemical shift perturbation to characterise ligand binding.

Williamson MP.

Prog Nucl Magn Reson Spectrosc. 2013 Aug;73:1-16. doi: 10.1016/j.pnmrs.2013.02.001. Epub 2013 Mar 21. Review. Erratum in: Prog Nucl Magn Reson Spectrosc. 2014 Jul;80:64.

PMID:
23962882
23.
24.

Pressure-induced chemical shifts as probes for conformational fluctuations in proteins.

Kitahara R, Hata K, Li H, Williamson MP, Akasaka K.

Prog Nucl Magn Reson Spectrosc. 2013 May;71:35-58. doi: 10.1016/j.pnmrs.2012.12.001. Epub 2013 Jan 20. No abstract available.

PMID:
23611314
25.

Solution structure of the Q41N variant of ubiquitin as a model for the alternatively folded N2 state of ubiquitin.

Kitazawa S, Kameda T, Yagi-Utsumi M, Sugase K, Baxter NJ, Kato K, Williamson MP, Kitahara R.

Biochemistry. 2013 Mar 19;52(11):1874-85. doi: 10.1021/bi301420m. Epub 2013 Mar 7.

PMID:
23421577
26.

Intrinsically disordered proteins: administration not executive.

Williamson MP, Potts JR.

Biochem Soc Trans. 2012 Oct;40(5):945-9. Review.

PMID:
22988845
27.

Two different packing arrangements of antiparallel polyalanine.

Asakura T, Okonogi M, Horiguchi K, Aoki A, Saitô H, Knight DP, Williamson MP.

Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1212-5. doi: 10.1002/anie.201105356. Epub 2011 Dec 23. No abstract available.

PMID:
22223629
28.

Amide temperature coefficients in the protein G B1 domain.

Tomlinson JH, Williamson MP.

J Biomol NMR. 2012 Jan;52(1):57-64. doi: 10.1007/s10858-011-9583-4. Epub 2011 Nov 11.

PMID:
22076570
29.

Reprogramming of Escherichia coli K-12 metabolism during the initial phase of transition from an anaerobic to a micro-aerobic environment.

Trotter EW, Rolfe MD, Hounslow AM, Craven CJ, Williamson MP, Sanguinetti G, Poole RK, Green J.

PLoS One. 2011;6(9):e25501. doi: 10.1371/journal.pone.0025501. Epub 2011 Sep 27.

30.

Ab initio calculations of deuterium isotope effects on chemical shifts of salt-bridged lysines.

Ullah S, Ishimoto T, Williamson MP, Hansen PE.

J Phys Chem B. 2011 Mar 31;115(12):3208-15. doi: 10.1021/jp1111789. Epub 2011 Mar 9.

PMID:
21388110
31.

Experimental evidence that the membrane-spanning helix of PufX adopts a bent conformation that facilitates dimerisation of the Rhodobacter sphaeroides RC-LH1 complex through N-terminal interactions.

Ratcliffe EC, Tunnicliffe RB, Ng IW, Adams PG, Qian P, Holden-Dye K, Jones MR, Williamson MP, Hunter CN.

Biochim Biophys Acta. 2011 Jan;1807(1):95-107. doi: 10.1016/j.bbabio.2010.10.003. Epub 2010 Oct 16.

32.

Structural origins of pH-dependent chemical shifts in the B1 domain of protein G.

Tomlinson JH, Green VL, Baker PJ, Williamson MP.

Proteins. 2010 Nov 1;78(14):3000-16. doi: 10.1002/prot.22825.

PMID:
20715051
33.

Protein-protein interactions.

Williamson MP, Sutcliffe MJ.

Biochem Soc Trans. 2010 Aug;38(4):875-8. doi: 10.1042/BST0380875. Review.

PMID:
20658969
34.

Signature active site architectures illuminate the molecular basis for ligand specificity in family 35 carbohydrate binding module.

Correia MA, Abbott DW, Gloster TM, Fernandes VO, Prates JA, Montanier C, Dumon C, Williamson MP, Tunnicliffe RB, Liu Z, Flint JE, Davies GJ, Henrissat B, Coutinho PM, Fontes CM, Gilbert HJ.

Biochemistry. 2010 Jul 27;49(29):6193-205. doi: 10.1021/bi1006139.

PMID:
20496884
35.

Differentiating quadruplexes: binding preferences of a luminescent dinuclear ruthenium(II) complex with four-stranded DNA structures.

Wilson T, Williamson MP, Thomas JA.

Org Biomol Chem. 2010 Jun 7;8(11):2617-21. doi: 10.1039/b924263e. Epub 2010 Mar 29.

PMID:
20485796
36.

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P.

EMBO J. 2010 Apr 7;29(7):1176-91. doi: 10.1038/emboj.2010.18. Epub 2010 Feb 18.

37.

Dimerization of protein G B1 domain at low pH: a conformational switch caused by loss of a single hydrogen bond.

Tomlinson JH, Craven CJ, Williamson MP, Pandya MJ.

Proteins. 2010 May 15;78(7):1652-61. doi: 10.1002/prot.22683.

PMID:
20112422
38.

Structure of the complex of [Ru(tpm)(dppz)py](2+) with a B-DNA oligonucleotide - a single-substituent binding switch for a metallo-intercalator.

Waywell P, Gonzalez V, Gill MR, Adams H, Meijer AJ, Williamson MP, Thomas JA.

Chemistry. 2010 Feb 22;16(8):2407-17. doi: 10.1002/chem.200901758.

PMID:
20108276
39.

Structural analysis of the binding of the diquaternary pyridophenazine derivative dqdppn to B-DNA oligonucleotides.

Waywell P, Thomas JA, Williamson MP.

Org Biomol Chem. 2010 Feb 7;8(3):648-54. doi: 10.1039/b918252g. Epub 2009 Dec 7.

PMID:
20090983
40.

Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling.

Long J, Garner TP, Pandya MJ, Craven CJ, Chen P, Shaw B, Williamson MP, Layfield R, Searle MS.

J Mol Biol. 2010 Feb 12;396(1):178-94. doi: 10.1016/j.jmb.2009.11.032. Epub 2009 Nov 17.

PMID:
19931284
41.

Pressure-dependent structure changes in barnase on ligand binding reveal intermediate rate fluctuations.

Wilton DJ, Kitahara R, Akasaka K, Pandya MJ, Williamson MP.

Biophys J. 2009 Sep 2;97(5):1482-90. doi: 10.1016/j.bpj.2009.06.022.

42.

Intra- and intermolecular effects on 1H chemical shifts in a silk model Peptide determined by high-field solid state 1H NMR and empirical calculations.

Suzuki Y, Takahashi R, Shimizu T, Tansho M, Yamauchi K, Williamson MP, Asakura T.

J Phys Chem B. 2009 Jul 23;113(29):9756-61. doi: 10.1021/jp903020p.

PMID:
19569641
43.

Pressure-dependent 13C chemical shifts in proteins: origins and applications.

Wilton DJ, Kitahara R, Akasaka K, Williamson MP.

J Biomol NMR. 2009 May;44(1):25-33. doi: 10.1007/s10858-009-9312-4. Epub 2009 Mar 24.

44.

Characterization of salt bridges to lysines in the protein G B1 domain.

Tomlinson JH, Ullah S, Hansen PE, Williamson MP.

J Am Chem Soc. 2009 Apr 8;131(13):4674-84. doi: 10.1021/ja808223p.

PMID:
19281232
45.

The interaction of amyloid Abeta(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR.

Nakazawa Y, Suzuki Y, Williamson MP, Saitô H, Asakura T.

Chem Phys Lipids. 2009 Mar;158(1):54-60. doi: 10.1016/j.chemphyslip.2008.12.001. Epub 2008 Dec 24.

46.

Automated protein structure calculation from NMR data.

Williamson MP, Craven CJ.

J Biomol NMR. 2009 Mar;43(3):131-43. doi: 10.1007/s10858-008-9295-6. Epub 2009 Jan 10.

47.

Use of quantitative (1)H NMR chemical shift changes for ligand docking into barnase.

Cioffi M, Hunter CA, Packer MJ, Pandya MJ, Williamson MP.

J Biomol NMR. 2009 Jan;43(1):11-9. doi: 10.1007/s10858-008-9286-7. Epub 2008 Nov 1.

PMID:
18979065
48.

Structural change in a B-DNA helix with hydrostatic pressure.

Wilton DJ, Ghosh M, Chary KV, Akasaka K, Williamson MP.

Nucleic Acids Res. 2008 Jul;36(12):4032-7. doi: 10.1093/nar/gkn350. Epub 2008 May 31.

49.

Binding of topotecan to a nicked DNA oligomer in solution.

Bocian W, Kawecki R, Bednarek E, Sitkowski J, Williamson MP, Hansen PE, Kozerski L.

Chemistry. 2008;14(9):2788-94. doi: 10.1002/chem.200700732.

PMID:
18214879
50.

Pressure-induced changes in the solution structure of the GB1 domain of protein G.

Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP.

Proteins. 2008 May 15;71(3):1432-40.

PMID:
18076052

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