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Items: 1 to 50 of 331

1.

Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions.

Gala UH, Miller DA, Williams RO 3rd.

Biochim Biophys Acta Rev Cancer. 2019 Oct 31;1873(1):188319. doi: 10.1016/j.bbcan.2019.188319. [Epub ahead of print] Review.

2.

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells.

Tseng WY, Huang YS, Clanchy F, McNamee K, Perocheau D, Ogbechi J, Luo SF, Feldmann M, McCann FE, Williams RO.

Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21666-21672. doi: 10.1073/pnas.1909687116. Epub 2019 Oct 9.

PMID:
31597740
3.

Formulation Composition and Process Affect Counterion for CSP7 Peptide.

Sahakijpijarn S, Moon C, Koleng JJ, Williams RO 3rd.

Pharmaceutics. 2019 Sep 29;11(10). pii: E498. doi: 10.3390/pharmaceutics11100498.

4.

How broadly can poly(urethane)-based implants be applied to drugs of varied properties?

Lowinger MB, Ormes JD, Su Y, Small JH, Williams RO 3rd, Zhang F.

Int J Pharm. 2019 Sep 10;568:118550. doi: 10.1016/j.ijpharm.2019.118550. Epub 2019 Jul 20.

PMID:
31336152
5.

In Memoriam: Dr. Paul B. Myrdal.

Kuehl PJ, Smyth HD, Stein SW, Williams RO 3rd.

AAPS PharmSciTech. 2019 Jun 3;20(5):211. doi: 10.1208/s12249-019-1430-z. No abstract available.

PMID:
31161303
6.

cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs.

Kawalkowska JZ, Ogbechi J, Venables PJ, Williams RO.

Sci Adv. 2019 May 1;5(5):eaaw5422. doi: 10.1126/sciadv.aaw5422. eCollection 2019 May.

7.

Enhanced Aerosolization of High Potency Nanoaggregates of Voriconazole by Dry Powder Inhalation.

Moon C, Watts AB, Lu X, Su Y, Williams RO 3rd.

Mol Pharm. 2019 May 6;16(5):1799-1812. doi: 10.1021/acs.molpharmaceut.8b00907. Epub 2019 Apr 10.

PMID:
30925839
8.

Influence of mechanical and thermal energy on nifedipine amorphous solid dispersions prepared by hot melt extrusion: Preparation and physical stability.

Ma X, Huang S, Lowinger MB, Liu X, Lu X, Su Y, Williams RO 3rd.

Int J Pharm. 2019 Apr 20;561:324-334. doi: 10.1016/j.ijpharm.2019.03.014. Epub 2019 Mar 8.

PMID:
30858115
9.

Delivery Technologies for Orally Inhaled Products: an Update.

Moon C, Smyth HDC, Watts AB, Williams RO 3rd.

AAPS PharmSciTech. 2019 Feb 19;20(3):117. doi: 10.1208/s12249-019-1314-2. Review.

PMID:
30783904
10.

Homogeneity of amorphous solid dispersions - an example with KinetiSol®.

Jermain SV, Miller D, Spangenberg A, Lu X, Moon C, Su Y, Williams RO.

Drug Dev Ind Pharm. 2019 May;45(5):724-735. doi: 10.1080/03639045.2019.1569037. Epub 2019 Jan 25.

PMID:
30653376
11.

Can drug release rate from implants be tailored using poly(urethane) mixtures?

Lowinger MB, Su Y, Lu X, Williams RO 3rd, Zhang F.

Int J Pharm. 2019 Feb 25;557:390-401. doi: 10.1016/j.ijpharm.2018.11.067. Epub 2018 Dec 6.

PMID:
30529658
12.

Solid-state NMR analysis of crystalline and amorphous Indomethacin: An experimental protocol for full resonance assignments.

Lu X, Xu W, Hanada M, Jermain SV, Williams RO 3rd, Su Y.

J Pharm Biomed Anal. 2019 Feb 20;165:47-55. doi: 10.1016/j.jpba.2018.11.001. Epub 2018 Nov 6.

PMID:
30503894
13.

Ibudilast Inhibits Chemokine Expression in Rheumatoid Arthritis Synovial Fibroblasts and Exhibits Immunomodulatory Activity in Experimental Arthritis.

Clanchy FIL, Williams RO.

Arthritis Rheumatol. 2019 May;71(5):703-711. doi: 10.1002/art.40787. Epub 2019 Apr 12.

PMID:
30474934
14.

Intranasal immunization with aluminum salt-adjuvanted dry powder vaccine.

Thakkar SG, Warnken ZN, Alzhrani RF, Valdes SA, Aldayel AM, Xu H, Williams RO 3rd, Cui Z.

J Control Release. 2018 Dec 28;292:111-118. doi: 10.1016/j.jconrel.2018.10.020. Epub 2018 Oct 16.

PMID:
30339906
15.

Functional and phenotypic heterogeneity of Th17 cells in health and disease.

Bystrom J, Clanchy FIL, Taher TE, Al-Bogami M, Ong VH, Abraham DJ, Williams RO, Mageed RA.

Eur J Clin Invest. 2019 Jan;49(1):e13032. doi: 10.1111/eci.13032. Epub 2018 Nov 1. Review.

PMID:
30289986
16.

Nebulization of Single-Chain Tissue-Type and Single-Chain Urokinase Plasminogen Activator for Treatment of Inhalational Smoke-Induced Acute Lung Injury.

Surasarang SH, Sahakijpijarn S, Florova G, Komissarov AA, Nelson CL, Perenlei E, Fukuda S, Wolfson MR, Shaffer TH, Idell S, Williams RO 3rd.

J Drug Deliv Sci Technol. 2018 Aug;48:19-27. doi: 10.1016/j.jddst.2018.04.013. Epub 2018 Apr 30.

17.

Predicting physical stability of ternary amorphous solid dispersions using specific mechanical energy in a hot melt extrusion process.

Hanada M, Jermain SV, Lu X, Su Y, Williams RO 3rd.

Int J Pharm. 2018 Sep 5;548(1):571-585. doi: 10.1016/j.ijpharm.2018.07.029. Epub 2018 Jul 10.

PMID:
30006310
18.

Process engineering and pharmaceutical manufacturing technologies.

Maniruzzaman M, Nokhodchi A, Williams RO 3rd.

Drug Deliv Transl Res. 2018 Dec;8(6):1593-1594. doi: 10.1007/s13346-018-0559-8. No abstract available.

PMID:
29978333
19.

A modified USP induction port to characterize nasal spray plume geometry and predict turbinate deposition under flow.

Moraga-Espinoza D, Warnken Z, Moore A, Williams RO 3rd, Smyth HDC.

Int J Pharm. 2018 Sep 5;548(1):305-313. doi: 10.1016/j.ijpharm.2018.06.058. Epub 2018 Jun 27.

PMID:
29960037
20.

Paul B. Myrdal, Ph.D. (June 25, 1967-May 19, 2018).

Williams ROB 3rd.

AAPS PharmSciTech. 2018 Aug;19(6):2449. doi: 10.1208/s12249-018-1106-0. No abstract available.

PMID:
29931610
21.

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator.

Fukuda S, Enkhbaatar P, Nelson C, Cox RA, Wolfson MR, Shaffer TH, Williams RO 3rd, Surasarang SH, Sawittree S, Florova G, Komissarov AA, Koenig K, Sarva K, Ndetan HT, Singh KP, Idell S.

Clin Transl Med. 2018 Jun 18;7(1):17. doi: 10.1186/s40169-018-0196-3.

22.

Generation of a Weakly Acidic Amorphous Solid Dispersion of the Weak Base Ritonavir with Equivalent In Vitro and In Vivo Performance to Norvir Tablet.

Ellenberger DJ, Miller DA, Kucera SU, Williams RO 3rd.

AAPS PharmSciTech. 2018 Jul;19(5):1985-1997. doi: 10.1208/s12249-018-1060-x. Epub 2018 Jun 4.

PMID:
29869311
23.

Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®: a Review.

Ellenberger DJ, Miller DA, Williams RO 3rd.

AAPS PharmSciTech. 2018 Jul;19(5):1933-1956. doi: 10.1208/s12249-018-1007-2. Epub 2018 May 30. Review.

PMID:
29846889
24.

Solving the Delivery Problems of Triclabendazole Using Cyclodextrins.

Real D, Leonardi D, Williams RO 3rd, Repka MA, Salomon CJ.

AAPS PharmSciTech. 2018 Jul;19(5):2311-2321. doi: 10.1208/s12249-018-1057-5. Epub 2018 May 29.

PMID:
29845501
25.

Sustained Release Drug Delivery Applications of Polyurethanes.

Lowinger MB, Barrett SE, Zhang F, Williams RO 3rd.

Pharmaceutics. 2018 May 9;10(2). pii: E55. doi: 10.3390/pharmaceutics10020055. Review.

26.

Therapy: Arming the regulators - new strategies to treat autoimmunity.

Williams RO, Tseng WY.

Nat Rev Rheumatol. 2018 Mar 21;14(4):188-189. doi: 10.1038/nrrheum.2018.50. No abstract available.

PMID:
29559717
27.

Improved Vemurafenib Dissolution and Pharmacokinetics as an Amorphous Solid Dispersion Produced by KinetiSol® Processing.

Ellenberger DJ, Miller DA, Kucera SU, Williams RO 3rd.

AAPS PharmSciTech. 2018 Jul;19(5):1957-1970. doi: 10.1208/s12249-018-0988-1. Epub 2018 Mar 14.

PMID:
29541940
28.

Sustained-release amorphous solid dispersions.

Maincent J, Williams RO 3rd.

Drug Deliv Transl Res. 2018 Dec;8(6):1714-1725. doi: 10.1007/s13346-018-0494-8. Review.

PMID:
29498004
29.

Personalized Medicine in Nasal Delivery: The Use of Patient-Specific Administration Parameters To Improve Nasal Drug Targeting Using 3D-Printed Nasal Replica Casts.

Warnken ZN, Smyth HDC, Davis DA, Weitman S, Kuhn JG, Williams RO 3rd.

Mol Pharm. 2018 Apr 2;15(4):1392-1402. doi: 10.1021/acs.molpharmaceut.7b00702. Epub 2018 Mar 6.

PMID:
29485888
30.

ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.

Hecht I, Toporik A, Podojil JR, Vaknin I, Cojocaru G, Oren A, Aizman E, Liang SC, Leung L, Dicken Y, Novik A, Marbach-Bar N, Elmesmari A, Tange C, Gilmour A, McIntyre D, Kurowska-Stolarska M, McNamee K, Leitner J, Greenwald S, Dassa L, Levine Z, Steinberger P, Williams RO, Miller SD, McInnes IB, Neria E, Rotman G.

J Immunol. 2018 Mar 15;200(6):2025-2037. doi: 10.4049/jimmunol.1700325. Epub 2018 Feb 5.

31.

An update on coating/manufacturing techniques of microneedles.

Tarbox TN, Watts AB, Cui Z, Williams RO 3rd.

Drug Deliv Transl Res. 2018 Dec;8(6):1828-1843. doi: 10.1007/s13346-017-0466-4. Review.

PMID:
29288358
32.

Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - An update.

Jermain SV, Brough C, Williams RO 3rd.

Int J Pharm. 2018 Jan 15;535(1-2):379-392. doi: 10.1016/j.ijpharm.2017.10.051. Epub 2017 Nov 8. Review.

PMID:
29128423
33.

T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis.

Arshad M, Bhatti A, John P, Jalil F, Borghese F, Kawalkowska JZ, Williams RO, Clanchy FIL.

Cytokine. 2018 Apr;104:130-135. doi: 10.1016/j.cyto.2017.10.002. Epub 2017 Oct 7.

PMID:
29017772
34.

Enhanced Dissolution of a Porous Carrier-Containing Ternary Amorphous Solid Dispersion System Prepared by a Hot Melt Method.

Hanada M, Jermain SV, Williams RO 3rd.

J Pharm Sci. 2018 Jan;107(1):362-371. doi: 10.1016/j.xphs.2017.09.025. Epub 2017 Oct 6.

PMID:
28989021
35.

Effects of the Preparation Process on the Properties of Amorphous Solid Dispersions.

Huang S, Williams RO 3rd.

AAPS PharmSciTech. 2018 Jul;19(5):1971-1984. doi: 10.1208/s12249-017-0861-7. Epub 2017 Sep 18. Review.

PMID:
28924730
36.

Formulation for a novel inhaled peptide therapeutic for idiopathic pulmonary fibrosis.

Hengsawas Surasarang S, Florova G, Komissarov AA, Shetty S, Idell S, Williams RO 3rd.

Drug Dev Ind Pharm. 2018 Feb;44(2):184-198. doi: 10.1080/03639045.2017.1371736. Epub 2017 Nov 10.

37.

Processing thermally labile drugs by hot-melt extrusion: The lesson with gliclazide.

Huang S, O'Donnell KP, Delpon de Vaux SM, O'Brien J, Stutzman J, Williams RO 3rd.

Eur J Pharm Biopharm. 2017 Oct;119:56-67. doi: 10.1016/j.ejpb.2017.05.014. Epub 2017 Jun 3.

PMID:
28583588
38.

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF+ T Lymphocytes.

Bystrom J, Clanchy FI, Taher TE, Al-Bogami MM, Muhammad HA, Alzabin S, Mangat P, Jawad AS, Williams RO, Mageed RA.

Clin Rev Allergy Immunol. 2017 Oct;53(2):265-276. doi: 10.1007/s12016-017-8610-y.

39.

Effect of anti-malarial interventions on trends of malaria cases, hospital admissions and deaths, 2005-2015, Ghana.

Aregawi M, Malm KL, Wahjib M, Kofi O, Allotey NK, Yaw PN, Abba-Baffoe W, Segbaya S, Owusu-Antwi F, Kharchi AT, Williams RO, Saalfeld M, Workneh N, Shargie EB, Noor AM, Bart-Plange C.

Malar J. 2017 Apr 26;16(1):177. doi: 10.1186/s12936-017-1828-6.

40.

Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs.

LaFountaine JS, Prasad LK, Miller DA, McGinity JW, Williams RO 3rd.

Eur J Pharm Biopharm. 2017 Apr;113:157-167. doi: 10.1016/j.ejpb.2016.12.031. Epub 2017 Jan 11.

PMID:
28088635
41.

The immunogenicity of thin-film freeze-dried, aluminum salt-adjuvanted vaccine when exposed to different temperatures.

Thakkar SG, Ruwona TB, Williams RO 3rd, Cui Z.

Hum Vaccin Immunother. 2017 Apr 3;13(4):936-946. doi: 10.1080/21645515.2016.1259042. Epub 2017 Jan 4.

42.

Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis.

Hull DN, Cooksley H, Chokshi S, Williams RO, Abraham S, Taylor PC.

Arthritis Res Ther. 2016 Dec 23;18(1):303. doi: 10.1186/s13075-016-1197-5.

43.

Influence of process parameters on the preparation of pharmaceutical films by electrostatic powder deposition.

Prasad LK, LaFountaine JS, Keen JM, Williams RO 3rd, McGinity JW.

Int J Pharm. 2016 Dec 30;515(1-2):94-103. doi: 10.1016/j.ijpharm.2016.10.014. Epub 2016 Oct 8.

PMID:
27725271
44.

Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole.

Hengsawas Surasarang S, Keen JM, Huang S, Zhang F, McGinity JW, Williams RO 3rd.

Drug Dev Ind Pharm. 2017 May;43(5):797-811. doi: 10.1080/03639045.2016.1220577. Epub 2016 Oct 20.

PMID:
27616147
45.

Solubility Advantage (and Disadvantage) of Pharmaceutical Amorphous Solid Dispersions.

Huang S, Mao C, Williams RO 3rd, Yang CY.

J Pharm Sci. 2016 Dec;105(12):3549-3561. doi: 10.1016/j.xphs.2016.08.017. Epub 2016 Sep 28.

PMID:
27692620
46.

Impact of the Mass Drug Administration for malaria in response to the Ebola outbreak in Sierra Leone.

Aregawi M, Smith SJ, Sillah-Kanu M, Seppeh J, Kamara AR, Williams RO, Aponte JJ, Bosman A, Alonso P.

Malar J. 2016 Sep 20;15:480. doi: 10.1186/s12936-016-1493-1.

47.

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.

Maincent JP, Najvar LK, Kirkpatrick WR, Huang S, Patterson TF, Wiederhold NP, Peters JI, Williams RO 3rd.

Drug Dev Ind Pharm. 2017 Feb;43(2):264-274. doi: 10.1080/03639045.2016.1236811. Epub 2016 Oct 5.

48.

TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases.

Bystrom J, Clanchy FI, Taher TE, Mangat P, Jawad AS, Williams RO, Mageed RA.

Cytokine. 2018 Jan;101:4-13. doi: 10.1016/j.cyto.2016.09.001. Epub 2016 Sep 14. Review.

PMID:
27639923
49.

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ.

Sci Rep. 2016 May 23;6:26430. doi: 10.1038/srep26430.

50.

Electrostatic powder coating: Principles and pharmaceutical applications.

Prasad LK, McGinity JW, Williams RO 3rd.

Int J Pharm. 2016 May 30;505(1-2):289-302. doi: 10.1016/j.ijpharm.2016.04.016. Epub 2016 Apr 13. Review.

PMID:
27085644

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