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Items: 1 to 50 of 784

1.

A class of highly selective inhibitors bind to an active state of PI3Kγ.

Gangadhara G, Dahl G, Bohnacker T, Rae R, Gunnarsson J, Blaho S, Öster L, Lindmark H, Karabelas K, Pemberton N, Tyrchan C, Mogemark M, Wymann MP, Williams RL, Perry MWD, Papavoine T, Petersen J.

Nat Chem Biol. 2019 Feb 4. doi: 10.1038/s41589-018-0215-0. [Epub ahead of print]

PMID:
30718815
2.

Sleeping Beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors.

Beckmann PJ, Larson JD, Larsson AT, Ostergaard JP, Wagner S, Rahrmann EP, Shamsan GA, Otto GM, Williams RL, Wang J, Lee C, Tschida BR, Das P, Dubuc AM, Moriarity BS, Picard D, Wu X, Rodriguez FJ, Rosemarie Q, Krebs RD, Molan AM, Demer AM, Frees MM, Rizzardi AE, Schmechel SC, Eberhart CG, Jenkins RB, Wechsler-Reya RJ, Odde DJ, Huang A, Taylor MD, Sarver AL, Largaespada DA.

Cancer Res. 2019 Jan 23. pii: canres.1261.2018. doi: 10.1158/0008-5472.CAN-18-1261. [Epub ahead of print]

PMID:
30674530
3.

Organotypic Culture of Bone-Like Structures Using Composite Ceramic-Fibrin Scaffolds.

Iordachescu A, Williams RL, Hulley PA, Grover LM.

Curr Protoc Stem Cell Biol. 2019 Feb;48(1):e79. doi: 10.1002/cpsc.79. Epub 2019 Jan 14.

PMID:
30644181
4.

Sustained release of decorin to the surface of the eye enables scarless corneal regeneration.

Hill LJ, Moakes RJA, Vareechon C, Butt G, Ng A, Brock K, Chouhan G, Vincent RC, Abbondante S, Williams RL, Barnes NM, Pearlman E, Wallace GR, Rauz S, Logan A, Grover LM.

NPJ Regen Med. 2018 Dec 21;3:23. doi: 10.1038/s41536-018-0061-4. eCollection 2018.

5.

Formulation of a covalently bonded hydroxyapatite and poly(ether ether ketone) composite.

Hughes EA, Parkes A, Williams RL, Jenkins MJ, Grover LM.

J Tissue Eng. 2018 Dec 17;9:2041731418815570. doi: 10.1177/2041731418815570. eCollection 2018 Jan-Dec.

6.

Total knee arthroplasty in patients with prior adjacent multi-organism osteomyelitis.

Williams RL, Khan W, Roberts-Huntleigh N, Morgan-Jones R.

Acta Orthop Belg. 2018 Jun;84(2):184-191.

PMID:
30462602
7.

Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12176-12181. doi: 10.1073/pnas.1803446115. Epub 2018 Nov 15.

8.

VPS34 complexes from a structural perspective.

Ohashi Y, Tremel S, Williams RL.

J Lipid Res. 2019 Feb;60(2):229-241. doi: 10.1194/jlr.R089490. Epub 2018 Nov 5.

9.

Expanding adolescent access to hormonal contraception: an update on over-the-counter, pharmacist prescribing, and web-based telehealth approaches.

Williams RL, Meredith AH, Ott MA.

Curr Opin Obstet Gynecol. 2018 Dec;30(6):458-464. doi: 10.1097/GCO.0000000000000497.

PMID:
30299318
10.

The effects of morpholine pre-treated and carboxymethylated cellulose nanofibrils on the properties of alginate-based hydrogels.

Onyianta AJ, Castellano M, Dorris M, Williams RL, Vicini S.

Carbohydr Polym. 2018 Oct 15;198:320-327. doi: 10.1016/j.carbpol.2018.06.084. Epub 2018 Jun 22.

PMID:
30093005
11.

Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.

Kassa J, Timperley CM, Bird M, Williams RL, Green AC, Tattersall JEH.

Toxicology. 2018 Sep 1;408:95-100. doi: 10.1016/j.tox.2018.07.008. Epub 2018 Jul 10.

PMID:
30005893
12.

Racial/Gender Biases in Student Clinical Decision-Making: a Mixed-Method Study of Medical School Attributes Associated with Lower Incidence of Biases.

Williams RL, Vasquez CE, Getrich CM, Kano M, Boursaw B, Krabbenhoft C, Sussman AL.

J Gen Intern Med. 2018 Dec;33(12):2056-2064. doi: 10.1007/s11606-018-4543-2. Epub 2018 Jul 11.

PMID:
29998436
13.

Successful Utilization of Mechanical Thrombectomy in a Presentation of Pediatric Acute Ischemic Stroke.

Kim ES, Mason EK, Koons A, Quinn SM, Williams RL.

Case Rep Pediatr. 2018 Apr 15;2018:5378247. doi: 10.1155/2018/5378247. eCollection 2018.

14.

Characteristics Associated with Confidential Consultation for Adolescents in Primary Care.

Lewis Gilbert A, McCord AL, Ouyang F, Etter DJ, Williams RL, Hall JA, Tu W, Downs SM, Aalsma MC.

J Pediatr. 2018 Aug;199:79-84.e1. doi: 10.1016/j.jpeds.2018.02.044. Epub 2018 Apr 6.

PMID:
29631769
15.

Bright Single InAsP Quantum Dots at Telecom Wavelengths in Position-Controlled InP Nanowires: The Role of the Photonic Waveguide.

Haffouz S, Zeuner KD, Dalacu D, Poole PJ, Lapointe J, Poitras D, Mnaymneh K, Wu X, Couillard M, Korkusinski M, Schöll E, Jöns KD, Zwiller V, Williams RL.

Nano Lett. 2018 May 9;18(5):3047-3052. doi: 10.1021/acs.nanolett.8b00550. Epub 2018 Apr 5.

PMID:
29616557
16.

Modulated release from implantable ocular silicone oil tamponade drug reservoirs.

Cauldbeck H, Le Hellaye M, McDonald TO, Long M, Williams RL, Rannard SP, Kearns VR.

J Polym Sci A Polym Chem. 2018 Apr 15;56(8):938-946. doi: 10.1002/pola.28973. Epub 2018 Feb 9.

17.

Moving Away from the Tip of the Pyramid: Screening and Brief Intervention for Risky Alcohol and Opioid Use in Underserved Patients.

Venner KL, Sánchez V, Garcia J, Williams RL, Sussman AL.

J Am Board Fam Med. 2018 Mar-Apr;31(2):243-251. doi: 10.3122/jabfm.2018.02.170134.

18.

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.

Bunney TD, Inglis AJ, Sanfelice D, Farrell B, Kerr CJ, Thompson GS, Masson GR, Thiyagarajan N, Svergun DI, Williams RL, Breeze AL, Katan M.

Structure. 2018 Mar 6;26(3):446-458.e8. doi: 10.1016/j.str.2018.01.016. Epub 2018 Feb 22.

19.

Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications.

Cooke ME, Jones SW, Ter Horst B, Moiemen N, Snow M, Chouhan G, Hill LJ, Esmaeli M, Moakes RJA, Holton J, Nandra R, Williams RL, Smith AM, Grover LM.

Adv Mater. 2018 Apr;30(14):e1705013. doi: 10.1002/adma.201705013. Epub 2018 Feb 12. Review.

PMID:
29430770
20.

Interfacial Mineral Fusion and Tubule Entanglement as a Means to Harden a Bone Augmentation Material.

Hughes EAB, Cox SC, Cooke ME, Davies OG, Williams RL, Hall TJ, Grover LM.

Adv Healthc Mater. 2018 Apr;7(7):e1701166. doi: 10.1002/adhm.201701166. Epub 2018 Jan 11.

PMID:
29325202
21.

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling.

Buckles TC, Ziemba BP, Masson GR, Williams RL, Falke JJ.

Biophys J. 2017 Dec 5;113(11):2396-2405. doi: 10.1016/j.bpj.2017.09.018.

22.

Recipient T Cell Exhaustion and Successful Adoptive Transfer of Haploidentical Natural Killer Cells.

Williams RL, Cooley S, Bachanova V, Blazar BR, Weisdorf DJ, Miller JS, Verneris MR.

Biol Blood Marrow Transplant. 2018 Mar;24(3):618-622. doi: 10.1016/j.bbmt.2017.11.022. Epub 2017 Nov 29.

PMID:
29197679
23.

Suicide Screening in Primary Care: Use of an Electronic Screener to Assess Suicidality and Improve Provider Follow-Up for Adolescents.

Etter DJ, McCord A, Ouyang F, Gilbert AL, Williams RL, Hall JA, Tu W, Downs SM, Aalsma MC.

J Adolesc Health. 2018 Feb;62(2):191-197. doi: 10.1016/j.jadohealth.2017.08.026. Epub 2017 Nov 28.

24.

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing.

Williams RL, Anandapadamanaban M.

Biochemistry. 2017 Dec 12;56(49):6411-6412. doi: 10.1021/acs.biochem.7b01120. Epub 2017 Nov 29. No abstract available.

PMID:
29185712
25.

Physician Intervention to Positive Depression Screens Among Adolescents in Primary Care.

Aalsma MC, Zerr AM, Etter DJ, Ouyang F, Gilbert AL, Williams RL, Hall JA, Downs SM.

J Adolesc Health. 2018 Feb;62(2):212-218. doi: 10.1016/j.jadohealth.2017.08.023. Epub 2017 Nov 23. Erratum in: J Adolesc Health. 2018 Jun;62(6):754.

26.

Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.

Kassa J, Timperley CM, Bird M, Williams RL, Green AC, Tattersall JEH.

Basic Clin Pharmacol Toxicol. 2018 Apr;122(4):429-435. doi: 10.1111/bcpt.12935. Epub 2017 Dec 5.

PMID:
29117635
27.

Annexin-enriched osteoblast-derived vesicles act as an extracellular site of mineral nucleation within developing stem cell cultures.

Davies OG, Cox SC, Williams RL, Tsaroucha D, Dorrepaal RM, Lewis MP, Grover LM.

Sci Rep. 2017 Oct 3;7(1):12639. doi: 10.1038/s41598-017-13027-6.

28.

Development of a Poly-ε-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis.

Gallagher AG, McLean K, Stewart RMK, Wellings DA, Allison HE, Williams RL.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4499-4505. doi: 10.1167/iovs.17-22301.

PMID:
28873175
29.

The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation.

Dickinson SC, Sutton CA, Brady K, Salerno A, Katopodi T, Williams RL, West CC, Evseenko D, Wu L, Pang S, Ferro de Godoy R, Goodship AE, Péault B, Blom AW, Kafienah W, Hollander AP.

Stem Cells. 2017 Nov;35(11):2280-2291. doi: 10.1002/stem.2691. Epub 2017 Aug 30.

30.

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.

Beaufils F, Cmiljanovic N, Cmiljanovic V, Bohnacker T, Melone A, Marone R, Jackson E, Zhang X, Sele A, Borsari C, Mestan J, Hebeisen P, Hillmann P, Giese B, Zvelebil M, Fabbro D, Williams RL, Rageot D, Wymann MP.

J Med Chem. 2017 Sep 14;60(17):7524-7538. doi: 10.1021/acs.jmedchem.7b00930. Epub 2017 Sep 1.

31.

Diet Quality Scores of Australian Adults Who Have Completed the Healthy Eating Quiz.

Williams RL, Rollo ME, Schumacher T, Collins CE.

Nutrients. 2017 Aug 15;9(8). pii: E880. doi: 10.3390/nu9080880.

32.

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry.

Kearns VR, Tasker J, Zhuola, Akhtar R, Bachhuka A, Vasilev K, Sheridan CM, Williams RL.

J Mater Sci Mater Med. 2017 Aug;28(8):124. doi: 10.1007/s10856-017-5926-3. Epub 2017 Jul 13.

33.

Effects of freezing, fixation and dehydration on surface roughness properties of porcine left anterior descending coronary arteries.

Burton HE, Williams RL, Espino DM.

Micron. 2017 Oct;101:78-86. doi: 10.1016/j.micron.2017.06.009. Epub 2017 Jun 22.

PMID:
28662414
34.

Structures of closed and open conformations of dimeric human ATM.

Baretić D, Pollard HK, Fisher DI, Johnson CM, Santhanam B, Truman CM, Kouba T, Fersht AR, Phillips C, Williams RL.

Sci Adv. 2017 May 10;3(5):e1700933. doi: 10.1126/sciadv.1700933. eCollection 2017 May.

35.

Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry.

Masson GR, Maslen SL, Williams RL.

Biochem J. 2017 May 16;474(11):1867-1877. doi: 10.1042/BCJ20170127.

36.

The innominate tubercle of the femur: Application to anterior surgical approaches to the hip.

Kielbasinski Podlaszewska O, Bekvalac J, Williams RL, Adds PJ.

Clin Anat. 2017 Jul;30(5):578-584. doi: 10.1002/ca.22870. Epub 2017 Apr 3.

PMID:
28281291
37.

Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.

Bohnacker T, Prota AE, Beaufils F, Burke JE, Melone A, Inglis AJ, Rageot D, Sele AM, Cmiljanovic V, Cmiljanovic N, Bargsten K, Aher A, Akhmanova A, Díaz JF, Fabbro D, Zvelebil M, Williams RL, Steinmetz MO, Wymann MP.

Nat Commun. 2017 Mar 9;8:14683. doi: 10.1038/ncomms14683.

38.
39.

Biologically Analogous Calcium Phosphate Tubes from a Chemical Garden.

Hughes EA, Williams RL, Cox SC, Grover LM.

Langmuir. 2017 Feb 28;33(8):2059-2067. doi: 10.1021/acs.langmuir.6b04574. Epub 2017 Feb 10.

40.

Development of decellularized conjunctiva as a substrate for the ex vivo expansion of conjunctival epithelium.

Kasbekar S, Kaye SB, Williams RL, Stewart RMK, Leow-Dyke S, Rooney P.

J Tissue Eng Regen Med. 2018 Feb;12(2):e973-e982. doi: 10.1002/term.2419. Epub 2017 Jun 12.

PMID:
28112872
41.

Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces.

Townsend L, Williams RL, Anuforom O, Berwick MR, Halstead F, Hughes E, Stamboulis A, Oppenheim B, Gough J, Grover L, Scott RA, Webber M, Peacock AF, Belli A, Logan A, de Cogan F.

J R Soc Interface. 2017 Jan;14(126). pii: 20160657. doi: 10.1098/rsif.2016.0657.

42.

Prosthetic joints: shining lights on challenging blind spots.

Saeed K, Dryden M, Bassetti M, Bonnet E, Bouza E, Chan M, Cortes N, Davis JS, Esposito S, Giordano G, Gould I, Hartwright D, Lye D, Marin M, Morgan-Jones R, Lajara-Marco F, Righi E, Romano CL, Segreti J, Unal S, Williams RL, Yalcin AN; International Society of Chemotherapy.

Int J Antimicrob Agents. 2017 Feb;49(2):153-161. doi: 10.1016/j.ijantimicag.2016.10.015. Epub 2016 Nov 28. Review. No abstract available.

PMID:
27939092
43.

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ.

Biochemistry. 2016 Nov 22;55(46):6395-6405. Epub 2016 Nov 10.

44.

eHealth technologies to support nutrition and physical activity behaviors in diabetes self-management.

Rollo ME, Aguiar EJ, Williams RL, Wynne K, Kriss M, Callister R, Collins CE.

Diabetes Metab Syndr Obes. 2016 Nov 4;9:381-390. eCollection 2016. Review.

45.

Controlling drug release from non-aqueous environments: Moderating delivery from ocular silicone oil drug reservoirs to combat proliferative vitreoretinopathy.

Cauldbeck H, Le Hellaye M, Long M, Kennedy SM, Williams RL, Kearns VR, Rannard SP.

J Control Release. 2016 Dec 28;244(Pt A):41-51. doi: 10.1016/j.jconrel.2016.11.010. Epub 2016 Nov 12.

46.

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.

Ohashi Y, Soler N, García Ortegón M, Zhang L, Kirsten ML, Perisic O, Masson GR, Burke JE, Jakobi AJ, Apostolakis AA, Johnson CM, Ohashi M, Ktistakis NT, Sachse C, Williams RL.

Autophagy. 2016 Nov;12(11):2129-2144. Epub 2016 Sep 14.

47.

Acetic Acid as Part of a Debridement Protocol During Revision Total Knee Arthroplasty.

Williams RL, Ayre WN, Khan WS, Mehta A, Morgan-Jones R.

J Arthroplasty. 2017 Mar;32(3):953-957. doi: 10.1016/j.arth.2016.09.010. Epub 2016 Sep 28.

PMID:
27776909
48.

Towards better characterization and quantification of emulsification of silicone oil in vitro.

Chan YK, Czanner G, Shum HC, Williams RL, Cheung N, Wong D.

Acta Ophthalmol. 2017 Aug;95(5):e385-e392. doi: 10.1111/aos.13258. Epub 2016 Oct 24.

49.

Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.

Harrod A, Fulton J, Nguyen VTM, Periyasamy M, Ramos-Garcia L, Lai CF, Metodieva G, de Giorgio A, Williams RL, Santos DB, Gomez PJ, Lin ML, Metodiev MV, Stebbing J, Castellano L, Magnani L, Coombes RC, Buluwela L, Ali S.

Oncogene. 2017 Apr 20;36(16):2286-2296. doi: 10.1038/onc.2016.382. Epub 2016 Oct 17.

50.

The Diet Quality of Competitive Adolescent Male Rugby Union Players with Energy Balance Estimated Using Different Physical Activity Coefficients.

Burrows T, Harries SK, Williams RL, Lum C, Callister R.

Nutrients. 2016 Sep 7;8(9). pii: E548. doi: 10.3390/nu8090548.

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