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Secukinumab for patients failing previous TNFα-inhibitor therapy: results of a randomised open-label study (Signature).

Warren RB, Barker J, Finlay AY, Burden AD, Kirby B, Armendariz Y, Williams R, Hatchard C, Khare S, Griffiths CEM.

Br J Dermatol. 2019 Oct 18. doi: 10.1111/bjd.18623. [Epub ahead of print]


Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy.

Williams RH, Tsunematsu T, Thomas AM, Bogyo K, Yamanaka A, Kilduff TS.

J Neurosci. 2019 Oct 18. pii: 0311-19. doi: 10.1523/JNEUROSCI.0311-19.2019. [Epub ahead of print]


Strongyloides stercoralis Hyperinfection and Concomitant Cytomegalovirus Gastroenteritis in an Immunocompromised Host.

Crowe BR, Duenas SM, Serrano A, Kingsbery J, Williams R.

ACG Case Rep J. 2019 Jul 15;6(7):e00135. doi: 10.14309/crj.0000000000000135. eCollection 2019 Jul.


A genome-wide assessment of the ancestral neural crest gene regulatory network.

Hockman D, Chong-Morrison V, Green SA, Gavriouchkina D, Candido-Ferreira I, Ling ITC, Williams RM, Amemiya CT, Smith JJ, Bronner ME, Sauka-Spengler T.

Nat Commun. 2019 Oct 16;10(1):4689. doi: 10.1038/s41467-019-12687-4.


An Obstructing Fecal Bezoar in a Patient with Scleroderma with Successful Colonoscopic Disimpaction.

Sarnoff R, Girmay B, Bhakta D, Mocharla R, Williams R.

ACG Case Rep J. 2019 Apr 11;6(4):e00059. doi: 10.14309/crj.0000000000000059. eCollection 2019 Apr.


Clostridium perfringens type D epsilon toxin produces a rapid and dose-dependent cytotoxic effect on cerebral microvascular endothelial cells in vitro.

Mander KA, Uzal FA, Williams R, Finnie JW.

J Vet Diagn Invest. 2019 Oct 14:1040638719882745. doi: 10.1177/1040638719882745. [Epub ahead of print]


Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Anandapadamanaban M, Masson GR, Perisic O, Berndt A, Kaufman J, Johnson CM, Santhanam B, Rogala KB, Sabatini DM, Williams RL.

Science. 2019 Oct 11;366(6462):203-210. doi: 10.1126/science.aax3939.


Impact of family practice continuity of care on unplanned hospital use for people with serious mental illness.

Ride J, Kasteridis P, Gutacker N, Doran T, Rice N, Gravelle H, Kendrick T, Mason A, Goddard M, Siddiqi N, Gilbody S, Williams R, Aylott L, Dare C, Jacobs R.

Health Serv Res. 2019 Oct 9. doi: 10.1111/1475-6773.13211. [Epub ahead of print]


A Diverse Array of Fluvial Depositional Systems in Arabia Terra: Evidence for mid-Noachian to Early Hesperian Rivers on Mars.

Davis JM, Gupta S, Balme M, Grindrod PM, Fawdon P, Dickeson ZI, Williams RME.

J Geophys Res Planets. 2019 Jul;124(7):1913-1934. doi: 10.1029/2019JE005976. Epub 2019 Jul 22.


TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells.

Tseng WY, Huang YS, Clanchy F, McNamee K, Perocheau D, Ogbechi J, Luo SF, Feldmann M, McCann FE, Williams RO.

Proc Natl Acad Sci U S A. 2019 Oct 9. pii: 201909687. doi: 10.1073/pnas.1909687116. [Epub ahead of print]


Recognising and understanding cryopyrin-associated periodic syndrome in adults.

Williams R, Hawkins P, Lane T.

Br J Nurs. 2019 Oct 10;28(18):1180-1186. doi: 10.12968/bjon.2019.28.18.1180.


Mortality risk in atrial fibrillation: the role of aspirin, vitamin K and non-vitamin K antagonists.

Gieling E, de Vries F, Williams R, van Onzenoort HAW, de Boer A, Ten Cate V, Kramers C, Burden A.

Int J Clin Pharm. 2019 Oct 8. doi: 10.1007/s11096-019-00916-1. [Epub ahead of print]


Generation of TD50 values for carcinogenicity study data.

Thresher A, Gosling JP, Williams R.

Toxicol Res (Camb). 2019 Jul 25;8(5):696-703. doi: 10.1039/c9tx00118b. eCollection 2019 Sep 1.


Epidemiology of Secondary School Boys' and Girls' Basketball Injuries: National Athletic Treatment, Injury and Outcomes Network.

Allen AN, Wasserman EB, Williams RM, Simon JE, Dompier TP, Kerr ZY, Valier ARS.

J Athl Train. 2019 Oct 3. doi: 10.4085/1062-6050-330-18. [Epub ahead of print]


Formulation Composition and Process Affect Counterion for CSP7 Peptide.

Sahakijpijarn S, Moon C, Koleng JJ, Williams RO 3rd.

Pharmaceutics. 2019 Sep 29;11(10). pii: E498. doi: 10.3390/pharmaceutics11100498.


A systematic analysis of the optimization of computerized physician order entry and clinical decision support systems: A qualitative study in English hospitals.

Wiegel V, King A, Mozaffar H, Cresswell K, Williams R, Sheik A.

Health Informatics J. 2019 Sep 30:1460458219868650. doi: 10.1177/1460458219868650. [Epub ahead of print]


Fitness-related benefits: land-based versus aqua-base.

Williams RE, Barreira TV, Tseh W.

J Sports Med Phys Fitness. 2019 Sep 23. doi: 10.23736/S0022-4707.19.09675-0. [Epub ahead of print]


Resolving a clinical tuberculosis outbreak using palaeogenomic genome reconstruction methodologies.

Jones R, Velasco MS, Harris LG, Morgan S, Temple M, Ruddy MC, Williams R, Perry MD, Hitchings M, Wilkinson TS, Humphrey T, Gilbert MTP, Davies AP.

Tuberculosis (Edinb). 2019 Sep 23;119:101865. doi: 10.1016/ [Epub ahead of print]


Sulfate Deficiency as a Risk Factor for Autism.

Williams RJ.

J Autism Dev Disord. 2019 Sep 27. doi: 10.1007/s10803-019-04240-5. [Epub ahead of print]


Exploring the perceived medical ethics and law training needs of UK foundation doctors.

Machin LL, Latcham N, Lavelle C, Williams RA, Corfield L.

Med Teach. 2019 Sep 26:1-9. doi: 10.1080/0142159X.2019.1665636. [Epub ahead of print]


Predictors of Stroke after Minimally Invasive Mitral Valve Surgery Without the Cross-Clamp.

Williams RD, Foley NM, Vyas R, Huang S, Kertai MD, Balsara KR, Petracek MR, Shah AS, Absi TS.

Semin Thorac Cardiovasc Surg. 2019 Sep 23. pii: S1043-0679(19)30270-9. doi: 10.1053/j.semtcvs.2019.09.001. [Epub ahead of print]


Comparative genomic analysis of the pheromone receptor Class 1 family (V1R) reveals extreme complexity in mouse lemurs (genus, Microcebus) and a chromosomal hotspot across mammals.

Hunnicutt KE, Tiley GP, Williams RC, Larsen PA, Blanco MB, Rasoloarison RM, Campbell CR, Zhu K, Weisrock DW, Matsunami H, Yoder AD.

Genome Biol Evol. 2019 Sep 26. pii: evz200. doi: 10.1093/gbe/evz200. [Epub ahead of print]


Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.

Takeda AJ, Maher TJ, Zhang Y, Lanahan SM, Bucklin ML, Compton SR, Tyler PM, Comrie WA, Matsuda M, Olivier KN, Pittaluga S, McElwee JJ, Long Priel DA, Kuhns DB, Williams RL, Mustillo PJ, Wymann MP, Koneti Rao V, Lucas CL.

Nat Commun. 2019 Sep 25;10(1):4364. doi: 10.1038/s41467-019-12311-5.


Effect of Light Flashes vs Sham Therapy During Sleep With Adjunct Cognitive Behavioral Therapy on Sleep Quality Among Adolescents: A Randomized Clinical Trial.

Kaplan KA, Mashash M, Williams R, Batchelder H, Starr-Glass L, Zeitzer JM.

JAMA Netw Open. 2019 Sep 4;2(9):e1911944. doi: 10.1001/jamanetworkopen.2019.11944.


Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase.

Dan Q, Newmister SA, Klas KR, Fraley AE, McAfoos TJ, Somoza AD, Sunderhaus JD, Ye Y, Shende VV, Yu F, Sanders JN, Brown WC, Zhao L, Paton RS, Houk KN, Smith JL, Sherman DH, Williams RM.

Nat Chem. 2019 Sep 23. doi: 10.1038/s41557-019-0326-6. [Epub ahead of print]


Metabolomics and microbial composition increase insight into the impact of dietary differences in cirrhosis.

Cox IJ, Idilman R, Fagan A, Turan D, Ajayi L, Le Guennec AD, Taylor-Robinson SD, Karakaya F, Gavis E, Andrew Atkinson R, Williams R, Sikaroodi M, Nizam S, Gillevet PM, Bajaj JS.

Liver Int. 2019 Sep 23. doi: 10.1111/liv.14256. [Epub ahead of print]


Examination of the relationship of diet quality with cardiometabolic risk factors in apparently healthy college students.

Williams RA, Rose AM, Bruno RS, Hanks AS, Kennel JA, McDonald JD, Labyk AN, Gunther C.

J Educ Health Promot. 2019 Aug 30;8:148. doi: 10.4103/jehp.jehp_12_19. eCollection 2019.


Health professional and at-risk BRCA young adult perspectives about information needs: What does Gen Y need to know?

Young AL, Butow PN, Tucker KM, Williams R, Healey E, Wakefield CE.

J Genet Couns. 2019 Sep 19. doi: 10.1002/jgc4.1167. [Epub ahead of print]


Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers.

Page EC, Bancroft EK, Brook MN, Assel M, Hassan Al Battat M, Thomas S, Taylor N, Chamberlain A, Pope J, Raghallaigh HN, Evans DG, Rothwell J, Maehle L, Grindedal EM, James P, Mascarenhas L, McKinley J, Side L, Thomas T, van Asperen C, Vasen H, Kiemeney LA, Ringelberg J, Jensen TD, Osther PJS, Helfand BT, Genova E, Oldenburg RA, Cybulski C, Wokolorczyk D, Ong KR, Huber C, Lam J, Taylor L, Salinas M, Feliubadaló L, Oosterwijk JC, van Zelst-Stams W, Cook J, Rosario DJ, Domchek S, Powers J, Buys S, O'Toole K, Ausems MGEM, Schmutzler RK, Rhiem K, Izatt L, Tripathi V, Teixeira MR, Cardoso M, Foulkes WD, Aprikian A, van Randeraad H, Davidson R, Longmuir M, Ruijs MWG, Helderman van den Enden ATJM, Adank M, Williams R, Andrews L, Murphy DG, Halliday D, Walker L, Liljegren A, Carlsson S, Azzabi A, Jobson I, Morton C, Shackleton K, Snape K, Hanson H, Harris M, Tischkowitz M, Taylor A, Kirk J, Susman R, Chen-Shtoyerman R, Spigelman A, Pachter N, Ahmed M, Ramon Y Cajal T, Zgajnar J, Brewer C, Gadea N, Brady AF, van Os T, Gallagher D, Johannsson O, Donaldson A, Barwell J, Nicolai N, Friedman E, Obeid E, Greenhalgh L, Murthy V, Copakova L, Saya S, McGrath J, Cooke P, Rønlund K, Richardson K, Henderson A, Teo SH, Arun B, Kast K, Dias A, Aaronson NK, Ardern-Jones A, Bangma CH, Castro E, Dearnaley D, Eccles DM, Tricker K, Eyfjord J, Falconer A, Foster C, Gronberg H, Hamdy FC, Stefansdottir V, Khoo V, Lindeman GJ, Lubinski J, Axcrona K, Mikropoulos C, Mitra A, Moynihan C, Rennert G, Suri M, Wilson P, Dudderidge T; IMPACT Study Collaborators, Offman J, Kote-Jarai Z, Vickers A, Lilja H, Eeles RA.

Eur Urol. 2019 Sep 16. pii: S0302-2838(19)30668-2. doi: 10.1016/j.eururo.2019.08.019. [Epub ahead of print]


Erratum to: Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients.

Den Heijer CDJ, Hoebe CJPA, Driessen JHM, Wolffs P, Van Den Broek IVF, Hoenderboom BM, Williams R, De Vries F, Dukers-Muijrers NHTM.

Clin Infect Dis. 2019 Sep 19. pii: ciz897. doi: 10.1093/cid/ciz897. [Epub ahead of print] No abstract available.


Psychological screening of adults and young people following the Manchester Arena incident.

French P, Barrett A, Allsopp K, Williams R, Brewin CR, Hind D, Sutton R, Stancombe J, Chitsabesan P.

BJPsych Open. 2019 Sep 19;5(5):e85. doi: 10.1192/bjo.2019.61.


Antimicrobial Nitric Oxide Releasing Contact Lens Gels for the Treatment of Microbial Keratitis.

Aveyard J, Deller RC, Lace R, Williams RL, Kaye SB, Kolegraff KN, Curran JM, D'Sa RA.

ACS Appl Mater Interfaces. 2019 Oct 16;11(41):37491-37501. doi: 10.1021/acsami.9b13958. Epub 2019 Oct 2.


WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition.

Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, Colagiuri S, Guariguata L, Motala AA, Ogurtsova K, Shaw JE, Bright D, Williams R.

Diabetes Res Clin Pract. 2019 Sep 10:107843. doi: 10.1016/j.diabres.2019.107843. [Epub ahead of print] No abstract available.


Aflatoxin levels in maize and peanut and blood in women and children: The case of Timor-Leste.

de Almeida L, Williams R, Soares DM, Nesbitt H, Wright G, Erskine W.

Sci Rep. 2019 Sep 11;9(1):13158. doi: 10.1038/s41598-019-49584-1.


Kids and Teens in Court (KTIC): A Model for Preparing Child Witnesses for Court.

Peterson L, Rolls Reutz JA, Hazen AL, Habib A, Williams R.

Am J Community Psychol. 2019 Sep 11. doi: 10.1002/ajcp.12390. [Epub ahead of print]


Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Cacciottolo TM, Perikari A, van der Klaauw A, Henning E, Stadler LKJ, Keogh J, Farooqi IS, Tenin G, Keavney B, Ryan E, Budd R, Bewley M, Coelho P, Rumsey W, Sanchez Y, McCafferty J, Dockrell D, Walmsley S, Whyte M, Liu Y, Choy MK, Tenin G, Abraham S, Black G, Keavney B, Ford T, Stanley B, Good R, Rocchiccioli P, McEntegart M, Watkins S, Eteiba H, Shaukat A, Lindsay M, Robertson K, Hood S, McGeoch R, McDade R, Sidik N, McCartney P, Corcoran D, Collison D, Rush C, McConnachie A, Touyz R, Oldroyd K, Berry C, Gazdagh G, Diver L, Marshall J, McGowan R, Ahmed F; DDD Study, Tobias E, Curtis E, Parsons C, Maslin K, D'Angelo S, Moon R, Crozier S, Gossiel F, Bishop N, Kennedy S, Papageorghiou A, Fraser R, Gandhi S, Prentice A, Inskip H, Godfrey K, Schoenmakers I, Javaid MK, Eastell R, Cooper C, Harvey N, Watt ER, Howden A, Mirchandani A, Coelho P, Hukelmann JL, Sadiku P, Plant TM, Cantrell DA, Whyte MKB, Walmsley SR, Mordi I, Forteath C, Wong A, Mohan M, Palmer C, Doney A, Rena G, Lang C, Gray EH, Azarian S, Riva A, Edwards H, McPhail MJW, Williams R, Chokshi S, Patel VC, Edwards LA, Page D, Miossec M, Williams S, Monaghan R, Fotiou E; CHANGE Study Collaborators, CheartED Study Collaborators, Santibanez-Koref M, Keavney B, Badat M, Mettananda S, Hua P, Schwessinger R, Hughes J, Higgs D, Davies J.

QJM. 2019 Sep 1;112(9):724-729. doi: 10.1093/qjmed/hcz175. No abstract available.


Chlamydia trachomatis and the Risk of Pelvic Inflammatory Disease, Ectopic Pregnancy, and Female Infertility: A Retrospective Cohort Study Among Primary Care Patients.

den Heijer CDJ, Hoebe CJPA, Driessen JHM, Wolffs P, van den Broek IVF, Hoenderboom BM, Williams R, de Vries F, Dukers-Muijrers NHTM.

Clin Infect Dis. 2019 Oct 15;69(9):1517-1525. doi: 10.1093/cid/ciz429.


Outcomes of complex abdominal wall reconstruction at the time of CRS and HIPEC.

Baglien B, Ngaage LM, Rosen C, Williams R, Bafford AC, Rada EM, Hanna NN, Rasko YM.

Surg Oncol. 2019 Sep;30:27-32. doi: 10.1016/j.suronc.2019.05.010. Epub 2019 May 23.


Communication and coping intervention for mothers of adolescents with type 1 diabetes: Rationale and trial design.

Jaser SS, Hamburger ER, Pagoto S, Williams R, Meyn A, Jones AC, Simmons JH.

Contemp Clin Trials. 2019 Sep 6;85:105844. doi: 10.1016/j.cct.2019.105844. [Epub ahead of print]


Retrospective analysis of an intraoperative aberrometry database: a study investigating absolute prediction in eyes implanted with low cylinder power toric intraocular lenses.

Cionni RJ, Breen M, Hamilton C, Williams R.

Clin Ophthalmol. 2019 Aug 6;13:1485-1492. doi: 10.2147/OPTH.S191887. eCollection 2019.


Educational Impact of a Pulsatile Human Cadaver Circulation Model for Endovascular Training.

Nesbitt CI, Tingle SJ, Williams R, McCaslin JE, Searle R, Mafeld S, Stansby GP.

Eur J Vasc Endovasc Surg. 2019 Oct;58(4):602-608. doi: 10.1016/j.ejvs.2019.03.026. Epub 2019 Sep 5.


Poly-ε-lysine based hydrogels as synthetic substrates for the expansion of corneal endothelial cells for transplantation.

Kennedy S, Lace R, Carserides C, Gallagher AG, Wellings DA, Williams RL, Levis HJ.

J Mater Sci Mater Med. 2019 Sep 4;30(9):102. doi: 10.1007/s10856-019-6303-1.


Unaccompanied homeless youth have extremely poor diet quality and nutritional status.

Hatsu I, Gunther C, Hade E, Vandergriff S, Slesnick N, Williams R, Bruno RS, Kennel J.

Int J Adolesc Youth. 2019;24(3):319-332. doi: 10.1080/02673843.2018.1538885. Epub 2018 Oct 27.


An application of the Science Impact Framework to the Cancer Prevention and Control Research Network from 2014-2018.

Ko LK, Jang SH, Friedman DB, Glanz K, Leeman J, Hannon PA, Shannon J, Cole A, Williams R, Vu T.

Prev Med. 2019 Aug 31:105821. doi: 10.1016/j.ypmed.2019.105821. [Epub ahead of print]


Immunomodulatory effects of dietary IMUNO-2865 in mice, pre-and post-vaccine challenge with parainfluenza virus 5.

Mayer J, Williams R, Kleine S, He B, Meichner T, Gogal RM Jr.

Int Immunopharmacol. 2019 Aug 27;76:105846. doi: 10.1016/j.intimp.2019.105846. [Epub ahead of print]


Modelling the interactive behaviour of users with a medication safety dashboard in a primary care setting.

Yera A, Muguerza J, Arbelaitz O, Perona I, Keers RN, Ashcroft DM, Williams R, Peek N, Jay C, Vigo M.

Int J Med Inform. 2019 Sep;129:395-403. doi: 10.1016/j.ijmedinf.2019.07.014. Epub 2019 Jul 23.


The FLASHE Study: Racial and Sex Disparities in Adolescent and Parent Modifiable Cancer Risk Behavior.

Xu L, Odum M, Williams RD, Housman JM.

Am J Health Behav. 2019 Sep 1;43(5):912-923. doi: 10.5993/AJHB.43.5.4.


Process Mining in Primary Care: Avoiding Adverse Events Due to Hazardous Prescribing.

Williams R, Ashcroft DM, Brown B, Rojas E, Peek N, Johnson O.

Stud Health Technol Inform. 2019 Aug 21;264:447-451. doi: 10.3233/SHTI190261.


Conservation genomic analysis reveals ancient introgression and declining levels of genetic diversity in Madagascar's hibernating dwarf lemurs.

Williams RC, Blanco MB, Poelstra JW, Hunnicutt KE, Comeault AA, Yoder AD.

Heredity (Edinb). 2019 Aug 21. doi: 10.1038/s41437-019-0260-9. [Epub ahead of print]


Author Correction: Dynamical nonlinear memory capacitance in biomimetic membranes.

Najem JS, Hasan MS, Williams RS, Weiss RJ, Rose GS, Taylor GJ, Sarles SA, Collier CP.

Nat Commun. 2019 Aug 21;10(1):3852. doi: 10.1038/s41467-019-11779-5.

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