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The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program.

Hoare SRJ, Fleck BA, Williams JP, Grigoriadis DE.

Drug Discov Today. 2019 Sep 23. pii: S1359-6446(19)30355-1. doi: 10.1016/j.drudis.2019.09.011. [Epub ahead of print]


Assessment of erythrocyte damage and in-line pressure changes associated with simulated transfusion of canine blood through microaggregate filters.

Cooley-Lock KM, Williams JP, Williams ML, Elder SH, Wills RW, Olivier AK, Archer TM, Mackin AJ, Thomason JM.

Am J Vet Res. 2019 Sep;80(9):852-861. doi: 10.2460/ajvr.80.9.852.


Space-like 56Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice.

Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA.

Sci Rep. 2019 Aug 20;9(1):12118. doi: 10.1038/s41598-019-48615-1.


Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients.

Thomas PW, Blackwell JEM, Herrod PJJ, Peacock O, Singh R, Williams JP, Hurst NG, Speake WJ, Bhalla A, Lund JN.

Tech Coloproctol. 2019 Aug;23(8):761-767. doi: 10.1007/s10151-019-02056-0. Epub 2019 Aug 7.


Ozone Inhibits APP/Aβ Production and Improves Cognition in an APP/PS1 Transgenic Mouse Model.

Lin SY, Ma J, An JX, Qian XY, Wang Y, Cope DK, Williams JP.

Neuroscience. 2019 Jul 23;418:110-121. doi: 10.1016/j.neuroscience.2019.07.027. [Epub ahead of print]


Acute and late effects of combined internal and external radiation exposures on the hematopoietic system.

Calvi LM, Frisch BJ, Kingsley PD, Koniski AD, Love TM, Williams JP, Palis J.

Int J Radiat Biol. 2019 Jul 30:1-15. doi: 10.1080/09553002.2019.1644932. [Epub ahead of print]


A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry: Application to the characterisation of metabolites in rat urine.

Nye LC, Williams JP, Munjoma NC, Letertre MPM, Coen M, Bouwmeester R, Martens L, Swann JR, Nicholson JK, Plumb RS, McCullagh M, Gethings LA, Lai S, Langridge JI, Vissers JPC, Wilson ID.

J Chromatogr A. 2019 Sep 27;1602:386-396. doi: 10.1016/j.chroma.2019.06.056. Epub 2019 Jun 27.


Methane emissions from abandoned coal and oil and gas developments in New Brunswick and Nova Scotia.

Williams JP, Risk D, Marshall A, Nickerson N, Martell A, Creelman C, Grace M, Wach G.

Environ Monit Assess. 2019 Jul 2;191(8):479. doi: 10.1007/s10661-019-7602-1.


Why most published meta-analysis findings are false.

Doleman B, Williams JP, Lund J.

Tech Coloproctol. 2019 Sep;23(9):925-928. doi: 10.1007/s10151-019-02020-y. Epub 2019 Jun 25. No abstract available.


Aquaporin-4 and MOG autoantibody discovery in idiopathic transverse myelitis epidemiology.

Sechi E, Shosha E, Williams JP, Pittock SJ, Weinshenker BG, Keegan BM, Zalewski NL, Lopez-Chiriboga AS, Jitprapaikulsan J, Flanagan EP.

Neurology. 2019 Jul 23;93(4):e414-e420. doi: 10.1212/WNL.0000000000007828. Epub 2019 Jun 24.


Short-term pre-operative high-intensity interval training does not improve fitness of colorectal cancer patients.

Boereboom CL, Blackwell JEM, Williams JP, Phillips BE, Lund JN.

Scand J Med Sci Sports. 2019 Sep;29(9):1383-1391. doi: 10.1111/sms.13460. Epub 2019 May 29.


Association between surgeon special interest and mortality after emergency laparotomy.

Boyd-Carson H, Doleman B, Herrod PJJ, Anderson ID, Williams JP, Lund JN, Tierney GM; NELA Collaboration.

Br J Surg. 2019 Jun;106(7):940-948. doi: 10.1002/bjs.11146. Epub 2019 Apr 25. Erratum in: Br J Surg. 2019 Sep;106(10):1403.


The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Gallagher IJ, Kadi F, Szewczyk NJ, Atherton PJ, Etheridge T.

Aging (Albany NY). 2019 Apr 15;11(7):2111-2126. doi: 10.18632/aging.101904.


Retraction mechanics of Finochietto-style self-retaining thoracic retractors.

Chanoit G, Pell CA, Bolotin G, Buckner GD, Williams JP, Crenshaw HC.

Biomed Eng Online. 2019 Apr 16;18(1):45. doi: 10.1186/s12938-019-0664-z.


Saving normal tissues - a goal for the ages.

Groves AM, Williams JP.

Int J Radiat Biol. 2019 Jul;95(7):920-935. doi: 10.1080/09553002.2019.1589654. Epub 2019 Mar 29.


Reliability of frailty assessment in the critically ill: a multicentre prospective observational study.

Pugh RJ, Battle CE, Thorpe C, Lynch C, Williams JP, Campbell A, Subbe CP, Whitaker R, Szakmany T, Clegg AP, Lone NI.

Anaesthesia. 2019 Jun;74(6):758-764. doi: 10.1111/anae.14596. Epub 2019 Feb 21.


Quick and simple; psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection.

Herrod PJJ, Boyd-Carson H, Doleman B, Trotter J, Schlichtemeier S, Sathanapally G, Somerville J, Williams JP, Lund JN.

Tech Coloproctol. 2019 Feb;23(2):129-134. doi: 10.1007/s10151-019-1928-0. Epub 2019 Feb 21.


Introducing a new sedation policy in a large district general hospital: before and after cohort analysis.

Frawley A, Hickey J, Weaver C, Williams JP, Szakmany T.

Anaesthesiol Intensive Ther. 2019;51(1):4-10. doi: 10.5603/AIT.a2019.0004. Epub 2019 Feb 12.


Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy.

Ghita M, Dunne V, Hanna GG, Prise KM, Williams JP, Butterworth KT.

Br J Radiol. 2019 Mar;92(1095):20180473. doi: 10.1259/bjr.20180473. Epub 2019 Feb 13. Review.


The efficacy of 'static' training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Herrod PJJ, Blackwell JEM, Moss BF, Gates A, Atherton PJ, Lund JN, Williams JP, Phillips BE.

Eur J Appl Physiol. 2019 Mar;119(3):645-652. doi: 10.1007/s00421-018-4054-1. Epub 2018 Dec 27.


Pre-emptive and preventive opioids for postoperative pain in adults undergoing all types of surgery.

Doleman B, Leonardi-Bee J, Heinink TP, Bhattacharjee D, Lund JN, Williams JP.

Cochrane Database Syst Rev. 2018 Dec 3;12:CD012624. doi: 10.1002/14651858.CD012624.pub2.


Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation.

Beach TA, Groves AM, Williams JP, Finkelstein JN.

Int J Radiat Biol. 2018 Oct 25:1-16. doi: 10.1080/09553002.2018.1532619. [Epub ahead of print]


The effect of ultrasound-guided percutaneous ozone injection around cervical dorsal root ganglion in zoster-associated pain: a retrospective study.

Lin SY, Zhang SZ, An JX, Qian XY, Gao XY, Wang Y, Zhao WX, Eastwood D, Cope DK, Williams JP.

J Pain Res. 2018 Oct 4;11:2179-2188. doi: 10.2147/JPR.S163340. eCollection 2018.


Recurrent DNA damage is associated with persistent injury in progressive radiation-induced pulmonary fibrosis.

Beach TA, Groves AM, Johnston CJ, Williams JP, Finkelstein JN.

Int J Radiat Biol. 2018 Dec;94(12):1104-1115. doi: 10.1080/09553002.2018.1516907. Epub 2018 Sep 21.


Use of propofol for prevention of post-delivery nausea during cesarean section: a double-blind, randomized, placebo-controlled trial.

Niu K, Liu H, Chen RW, Fang QW, Wen H, Guo SM, Williams JP, An JX.

J Anesth. 2018 Oct;32(5):748-755. doi: 10.1007/s00540-018-2549-x. Epub 2018 Sep 12.


Direct evidence of surface exposed water ice in the lunar polar regions.

Li S, Lucey PG, Milliken RE, Hayne PO, Fisher E, Williams JP, Hurley DM, Elphic RC.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8907-8912. doi: 10.1073/pnas.1802345115. Epub 2018 Aug 20.


A Potential Biomarker for Predicting the Risk of Radiation-Induced Fibrosis in the Lung.

Groves AM, Williams JP, Hernady E, Reed C, Fenton B, Love T, Finkelstein JN, Johnston CJ.

Radiat Res. 2018 Nov;190(5):513-525. doi: 10.1667/RR15122.1. Epub 2018 Aug 17.


What Is Your Diagnosis?

Williams JP, Brinkman EL.

J Am Vet Med Assoc. 2018 Aug 1;253(3):265-268. doi: 10.2460/javma.253.3.265. No abstract available.


Antibodies in Autoimmune Human Neurological Disease: Pathogenesis and Immunopathology.

Williams JP, Carlson NG, Greenlee JE.

Semin Neurol. 2018 Jun;38(3):267-277. doi: 10.1055/s-0038-1660501. Epub 2018 Jul 16. Review.


The Effect of Different Closed Suction Catheter Designs and pMDI Adapters on Aerosol Delivery in Simulated Adult Mechanical Ventilation With and Without Exhaled Humidity.

Williams JP, Ari A, Shanmugam R, Fink JB.

Respir Care. 2018 Sep;63(9):1154-1161. doi: 10.4187/respcare.06085. Epub 2018 May 29.


Extreme Ultraviolet Radiation: A Means of Ion Activation for Tandem Mass Spectrometry.

Giuliani A, Williams JP, Green MR.

Anal Chem. 2018 Jun 19;90(12):7176-7180. doi: 10.1021/acs.analchem.8b01789. Epub 2018 Jun 6.


Short-Term (<8 wk) High-Intensity Interval Training in Diseased Cohorts.

Blackwell JEM, Doleman B, Herrod PJJ, Ricketts S, Phillips BE, Lund JN, Williams JP.

Med Sci Sports Exerc. 2018 Sep;50(9):1740-1749. doi: 10.1249/MSS.0000000000001634.


VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine).

Harriott ND, Williams JP, Smith EB, Bozigian HP, Grigoriadis DE.

Prog Med Chem. 2018;57(1):87-111. doi: 10.1016/bs.pmch.2017.12.002. Epub 2018 Mar 7. Review.


Normal tissue damage: its importance, history and challenges for the future.

Williams JP, Newhauser W.

Br J Radiol. 2018 Apr 9:20180048. doi: 10.1259/bjr.20180048. [Epub ahead of print]


Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis.

Herrod PJJ, Doleman B, Blackwell JEM, O'Boyle F, Williams JP, Lund JN, Phillips BE.

J Am Soc Hypertens. 2018 Apr;12(4):248-267. doi: 10.1016/j.jash.2018.01.008. Epub 2018 Feb 2. Review.


Postoperative inflammation and insulin resistance in relation to body composition, adiposity and carbohydrate treatment: A randomised controlled study.

Tewari N, Awad S, Duška F, Williams JP, Bennett A, Macdonald IA, Lobo DN.

Clin Nutr. 2019 Feb;38(1):204-212. doi: 10.1016/j.clnu.2018.01.032. Epub 2018 Feb 15.


Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia.

An JX, Liu H, Chen RW, Wang Y, Zhao WX, Eastwood D, Williams JP.

J Pain Res. 2018 Jan 31;11:255-263. doi: 10.2147/JPR.S140369. eCollection 2018.


Clinically significant reductions in morphine consumption need to take account of baseline risk: presentation of a novel meta-analysis methodology.

Doleman B, Lund JN, Williams JP.

Br J Anaesth. 2018 Feb;120(2):414-415. doi: 10.1016/j.bja.2017.12.012. Epub 2018 Jan 8. No abstract available.


Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis.

Groves AM, Johnston CJ, Williams JP, Finkelstein JN.

Radiat Res. 2018 Mar;189(3):300-311. doi: 10.1667/RR14874.1. Epub 2018 Jan 13.


Development and implementation of a theatre booking form and morning briefing meeting to improve emergency theatre efficiency.

Williams JP, Spernaes I, Duff E, Argent M, Frankish J, Dinham H.

J Perioper Pract. 2017 Oct;27(10):217-223.


Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion.

Begolly S, Olschowka JA, Love T, Williams JP, O'Banion MK.

Glia. 2018 Apr;66(4):846-861. doi: 10.1002/glia.23288. Epub 2017 Dec 30.


Size, growth, and density data for shallow-water sea urchins from Mexico to the Aleutian Islands, Alaska, 1956-2016.

Ebert TA, Barr LM, Bodkin JL, Burcham D, Bureau D, Carson HS, L Caruso N, Caselle JE, Claisse JT, Clemente S, Davis K, Detwiler PM, Dixon JD, Duggins DO, Engle JM, Estes JA, Groth SD, Grupe BM, Halmay P, Hebert KP, Hernández JC, Jurgens LJ, Kalvass PE, Kenner MC, Konar B, Kushner DJ, Lee LC, Leighton DL, Montaño-Moctezuma G, Eric Munk J, Olguin I, Palleiro JS, Parker DO, Pearse JS, Pondella DJ, Rogers-Bennett L, Schroeter SC, Shelton AO, Sonnenholzner J, Taniguchi IK, VanBlaricom GR, Watson JC, Weitzman BP, Williams JP, Yakimishyn J, Zhang Z.

Ecology. 2018 Mar;99(3):761. doi: 10.1002/ecy.2123. Epub 2018 Jan 23.


Improving Patient-reported Pain During Radiotherapy Through Nurse Involvement and Patient Education.

Holtzman AL, Williams JP, Hutchinson DF, Morris CG, Yeung AR.

Am J Clin Oncol. 2018 Oct;41(10):1028-1030. doi: 10.1097/COC.0000000000000415.


Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism.

Wilkinson DJ, Hossain T, Limb MC, Phillips BE, Lund J, Williams JP, Brook MS, Cegielski J, Philp A, Ashcroft S, Rathmacher JA, Szewczyk NJ, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2068-2075. doi: 10.1016/j.clnu.2017.09.024. Epub 2017 Oct 6.


Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Wilkinson DJ, Bukhari SSI, Phillips BE, Limb MC, Cegielski J, Brook MS, Rankin D, Mitchell WK, Kobayashi H, Williams JP, Lund J, Greenhaff PL, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2011-2021. doi: 10.1016/j.clnu.2017.09.008. Epub 2017 Sep 23.


Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Mitchell WK, Phillips BE, Hill I, Greenhaff P, Lund JN, Williams JP, Rankin D, Wilkinson DJ, Smith K, Atherton PJ.

Clin Sci (Lond). 2017 Oct 27;131(21):2643-2653. doi: 10.1042/CS20171230. Print 2017 Nov 1.


Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males.

Quinlan JI, Maganaris CN, Franchi MV, Smith K, Atherton PJ, Szewczyk NJ, Greenhaff PL, Phillips BE, Blackwell JI, Boereboom C, Williams JP, Lund J, Narici MV.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):539-545. doi: 10.1093/gerona/glx149.


The efficacy of unsupervised home-based exercise regimens in comparison to supervised laboratory-based exercise training upon cardio-respiratory health facets.

Blackwell J, Atherton PJ, Smith K, Doleman B, Williams JP, Lund JN, Phillips BE.

Physiol Rep. 2017 Sep;5(17). pii: e13390. doi: 10.14814/phy2.13390.

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