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Items: 1 to 50 of 149

1.

Celebrating twoness at Science Immunology.

Williams IR.

Sci Immunol. 2018 Jul 6;3(25). pii: eaau2567. doi: 10.1126/sciimmunol.aau2567.

PMID:
29980621
2.

Charting new horizons for Science Immunology.

Williams IR.

Sci Immunol. 2018 Apr 6;3(22). pii: eaat2459. doi: 10.1126/sciimmunol.aat2459.

PMID:
29626171
3.

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling.

Kanaya T, Sakakibara S, Jinnohara T, Hachisuka M, Tachibana N, Hidano S, Kobayashi T, Kimura S, Iwanaga T, Nakagawa T, Katsuno T, Kato N, Akiyama T, Sato T, Williams IR, Ohno H.

J Exp Med. 2018 Feb 5;215(2):501-519. doi: 10.1084/jem.20160659. Epub 2018 Jan 16.

4.

NALT M cells are important for immune induction for the common mucosal immune system.

Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H.

Int Immunol. 2017 Dec 18;29(10):471-478. doi: 10.1093/intimm/dxx064.

PMID:
29186424
5.

CCR6 promotes steady-state mononuclear phagocyte association with the intestinal epithelium, imprinting and immune surveillance.

McDonald KG, Wheeler LW, McDole JR, Joerger S, Gustafsson JK, Kulkarni DH, Knoop KA, Williams IR, Miller MJ, Newberry RD.

Immunology. 2017 Dec;152(4):613-627. doi: 10.1111/imm.12801. Epub 2017 Aug 30.

PMID:
28746740
6.

IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake.

Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H.

J Exp Med. 2017 Jun 5;214(6):1607-1618. doi: 10.1084/jem.20160770. Epub 2017 May 16.

7.

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.

Mylvaganam GH, Rios D, Abdelaal HM, Iyer S, Tharp G, Mavigner M, Hicks S, Chahroudi A, Ahmed R, Bosinger SE, Williams IR, Skinner PJ, Velu V, Amara RR.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1976-1981. doi: 10.1073/pnas.1621418114. Epub 2017 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3366. Mavinger, Maud [corrected to Mavigner, Maud].

8.

Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.

Donaldson DS, Sehgal A, Rios D, Williams IR, Mabbott NA.

PLoS Pathog. 2016 Dec 14;12(12):e1006075. doi: 10.1371/journal.ppat.1006075. eCollection 2016 Dec. Erratum in: PLoS Pathog. 2017 Feb 17;13(2):e1006222.

9.

TNF-α augments RANKL-dependent intestinal M cell differentiation in enteroid cultures.

Wood MB, Rios D, Williams IR.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C498-507. doi: 10.1152/ajpcell.00108.2016. Epub 2016 Jul 13.

10.

M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis.

Cunningham AL, Guentzel MN, Yu JJ, Hung CY, Forsthuber TG, Navara CS, Yagita H, Williams IR, Klose KE, Eaves-Pyles TD, Arulanandam BP.

PLoS One. 2016 Apr 21;11(4):e0153402. doi: 10.1371/journal.pone.0153402. eCollection 2016.

11.

Characterization and application of two RANK-specific antibodies with different biological activities.

Chypre M, Seaman J, Cordeiro OG, Willen L, Knoop KA, Buchanan A, Sainson RC, Williams IR, Yagita H, Schneider P, Mueller CG.

Immunol Lett. 2016 Mar;171:5-14. doi: 10.1016/j.imlet.2016.01.003. Epub 2016 Jan 7.

12.

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria.

Rios D, Wood MB, Li J, Chassaing B, Gewirtz AT, Williams IR.

Mucosal Immunol. 2016 Jul;9(4):907-16. doi: 10.1038/mi.2015.121. Epub 2015 Nov 25.

13.

Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.

Ofotokun I, Titanji K, Vikulina T, Roser-Page S, Yamaguchi M, Zayzafoon M, Williams IR, Weitzmann MN.

Nat Commun. 2015 Sep 22;6:8282. doi: 10.1038/ncomms9282.

14.

An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.

Powell JJ, Thomas-McKay E, Thoree V, Robertson J, Hewitt RE, Skepper JN, Brown A, Hernandez-Garrido JC, Midgley PA, Gomez-Morilla I, Grime GW, Kirkby KJ, Mabbott NA, Donaldson DS, Williams IR, Rios D, Girardin SE, Haas CT, Bruggraber SF, Laman JD, Tanriver Y, Lombardi G, Lechler R, Thompson RP, Pele LC.

Nat Nanotechnol. 2015 Apr;10(4):361-9. doi: 10.1038/nnano.2015.19. Epub 2015 Mar 9.

15.

Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18.

Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT.

Science. 2014 Nov 14;346(6211):861-5. doi: 10.1126/science.1256999.

16.

Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells.

Gonzalez-Hernandez MB, Liu T, Payne HC, Stencel-Baerenwald JE, Ikizler M, Yagita H, Dermody TS, Williams IR, Wobus CE.

J Virol. 2014 Jun;88(12):6934-43. doi: 10.1128/JVI.00204-14. Epub 2014 Apr 2.

17.
18.

Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium.

Mabbott NA, Donaldson DS, Ohno H, Williams IR, Mahajan A.

Mucosal Immunol. 2013 Jul;6(4):666-77. doi: 10.1038/mi.2013.30. Epub 2013 May 22. Review.

19.

The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.

Kobayashi A, Donaldson DS, Erridge C, Kanaya T, Williams IR, Ohno H, Mahajan A, Mabbott NA.

Mucosal Immunol. 2013 Sep;6(5):1027-37. doi: 10.1038/mi.2012.141. Epub 2013 Jan 30.

20.

M cell differentiation: distinct lineage or phenotypic transition? Salmonella provides answers.

Ohno H, Kanaya T, Williams IR.

Cell Host Microbe. 2012 Nov 15;12(5):607-9. doi: 10.1016/j.chom.2012.11.003.

21.

Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations.

Kobayashi A, Donaldson DS, Kanaya T, Fukuda S, Baillie JK, Freeman TC, Ohno H, Williams IR, Mabbott NA.

DNA Res. 2012 Oct;19(5):407-22. doi: 10.1093/dnares/dss022. Epub 2012 Sep 18.

22.

The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.

Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR, Ohno H.

Nat Immunol. 2012 Jun 17;13(8):729-36. doi: 10.1038/ni.2352.

23.

M cell-depletion blocks oral prion disease pathogenesis.

Donaldson DS, Kobayashi A, Ohno H, Yagita H, Williams IR, Mabbott NA.

Mucosal Immunol. 2012 Mar;5(2):216-25. doi: 10.1038/mi.2011.68. Epub 2012 Feb 1.

24.

Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis.

McNamee EN, Masterson JC, Jedlicka P, Collins CB, Williams IR, Rivera-Nieves J.

Gut. 2013 Jan;62(1):53-62. doi: 10.1136/gutjnl-2011-301272. Epub 2012 Jan 20.

25.

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

Medina-Contreras O, Geem D, Laur O, Williams IR, Lira SA, Nusrat A, Parkos CA, Denning TL.

J Clin Invest. 2011 Dec;121(12):4787-95. doi: 10.1172/JCI59150.

26.

Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.

Knoop KA, Butler BR, Kumar N, Newberry RD, Williams IR.

Am J Pathol. 2011 Oct;179(4):1861-71. doi: 10.1016/j.ajpath.2011.06.004. Epub 2011 Aug 18.

27.

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.

Elf S, Blevins D, Jin L, Chung TW, Williams IR, Lee BH, Lin JX, Leonard WJ, Taunton J, Khoury HJ, Kang S.

Blood. 2011 Jun 23;117(25):6885-94. doi: 10.1182/blood-2010-10-315721. Epub 2011 Apr 28.

28.

CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.

Ebisawa M, Hase K, Takahashi D, Kitamura H, Knoop KA, Williams IR, Ohno H.

Int Immunol. 2011 Apr;23(4):261-9. doi: 10.1093/intimm/dxq478. Epub 2011 Mar 21.

29.

Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit.

Duheron V, Hess E, Duval M, Decossas M, Castaneda B, Klöpper JE, Amoasii L, Barbaroux JB, Williams IR, Yagita H, Penninger J, Choi Y, Lézot F, Groves R, Paus R, Mueller CG.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5342-7. doi: 10.1073/pnas.1013054108. Epub 2011 Mar 14.

30.

CCR6 identifies lymphoid tissue inducer cells within cryptopatches.

Lügering A, Ross M, Sieker M, Heidemann J, Williams IR, Domschke W, Kucharzik T.

Clin Exp Immunol. 2010 Jun;160(3):440-9. doi: 10.1111/j.1365-2249.2010.04103.x. Epub 2010 Feb 10.

31.

RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.

Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, Williams IR.

J Immunol. 2009 Nov 1;183(9):5738-47. doi: 10.4049/jimmunol.0901563. Epub 2009 Oct 14.

32.

Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection.

Fournier B, Williams IR, Gewirtz AT, Neish AS.

Infect Immun. 2009 Sep;77(9):4121-9. doi: 10.1128/IAI.00656-09. Epub 2009 Jul 13.

33.

Selective removal of stratum corneum by microdermabrasion to increase skin permeability.

Gill HS, Andrews SN, Sakthivel SK, Fedanov A, Williams IR, Garber DA, Priddy FH, Yellin S, Feinberg MB, Staprans SI, Prausnitz MR.

Eur J Pharm Sci. 2009 Sep 10;38(2):95-103. doi: 10.1016/j.ejps.2009.06.004. Epub 2009 Jun 25.

34.

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.

Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen D, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG.

J Clin Invest. 2009 Apr;119(4):852-64. doi: 10.1172/JCI35901. Epub 2009 Mar 16.

35.

Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation.

Kang S, Elf S, Dong S, Hitosugi T, Lythgoe K, Guo A, Ruan H, Lonial S, Khoury HJ, Williams IR, Lee BH, Roesel JL, Karsenty G, Hanauer A, Taunton J, Boggon TJ, Gu TL, Chen J.

Mol Cell Biol. 2009 Apr;29(8):2105-17. doi: 10.1128/MCB.00998-08. Epub 2009 Feb 17.

36.

TGF-beta upregulation drives tertiary lymphoid organ formation and kidney dysfunction in calcineurin A-alpha heterozygous mice.

Kelly FM, Reddy RN, Roberts BR, Gangappa S, Williams IR, Gooch JL.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F512-20. doi: 10.1152/ajprenal.90629.2008. Epub 2009 Jan 7.

37.

Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.

Chan CB, Abe M, Hashimoto N, Hao C, Williams IR, Liu X, Nakao S, Yamamoto A, Zheng C, Henter JI, Meeths M, Nordenskjold M, Li SY, Hara-Nishimura I, Asano M, Ye K.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):468-73. doi: 10.1073/pnas.0809824105. Epub 2008 Dec 23. Erratum in: Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):6023. Zheng, Chengyun [added]; Henter, Jan-Inge [added]; Meeths, Marie [added]; Nordenskjold, Magnus [added].

38.

Perfusion fixation preserves enhanced yellow fluorescent protein and other cellular markers in lymphoid tissues.

Dauner JG, Chappell CP, Williams IR, Jacob J.

J Immunol Methods. 2009 Jan 30;340(2):116-22. doi: 10.1016/j.jim.2008.10.010. Epub 2008 Nov 11.

39.

Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Holländer GA, Reith W.

Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007.

40.

Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin.

Sanders CJ, Moore DA 3rd, Williams IR, Gewirtz AT.

J Immunol. 2008 Jun 1;180(11):7184-92. Erratum in: J Immunol. 2008 Aug 15;181(4):2933.

41.

Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection: evidence of defective M-cell formation in vivo.

Westphal S, Lügering A, von Wedel J, von Eiff C, Maaser C, Spahn T, Heusipp G, Schmidt MA, Herbst H, Williams IR, Domschke W, Kucharzik T.

Am J Pathol. 2008 Mar;172(3):671-80. doi: 10.2353/ajpath.2008.070393. Epub 2008 Feb 7.

42.

Expression of angiotensin-converting enzyme changes major histocompatibility complex class I peptide presentation by modifying C termini of peptide precursors.

Shen XZ, Lukacher AE, Billet S, Williams IR, Bernstein KE.

J Biol Chem. 2008 Apr 11;283(15):9957-65. doi: 10.1074/jbc.M709574200. Epub 2008 Feb 5.

43.

Differential microenvironment localization of effector and memory CD8 T cells.

Dauner JG, Williams IR, Jacob J.

J Immunol. 2008 Jan 1;180(1):291-9.

44.

Colonic neutrophils in inflammatory bowel disease: double-edged swords of the innate immune system with protective and destructive capacity.

Williams IR, Parkos CA.

Gastroenterology. 2007 Dec;133(6):2049-52. No abstract available.

PMID:
18054577
45.

JAM-A regulates permeability and inflammation in the intestine in vivo.

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, Dermody TS, Nusrat A, Parkos CA.

J Exp Med. 2007 Dec 24;204(13):3067-76. Epub 2007 Nov 26.

46.

Deletion of TLR5 results in spontaneous colitis in mice.

Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT.

J Clin Invest. 2007 Dec;117(12):3909-21.

47.

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses.

Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B.

Nat Immunol. 2007 Oct;8(10):1086-94. Epub 2007 Sep 16.

PMID:
17873879
48.

Molecular cloning and promoter analysis of downregulated in adenoma (DRA).

Alrefai WA, Wen X, Jiang W, Katz JP, Steinbrecher KA, Cohen MB, Williams IR, Dudeja PK, Wu GD.

Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G923-34. Epub 2007 Aug 30.

49.

Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma.

Shen XZ, Li P, Weiss D, Fuchs S, Xiao HD, Adams JA, Williams IR, Capecchi MR, Taylor WR, Bernstein KE.

Am J Pathol. 2007 Jun;170(6):2122-34.

50.

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