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Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells.

Gwynne L, Sedgwick AC, Gardiner JE, Williams GT, Kim G, Lowe JP, Maillard JY, Jenkins ATA, Bull SD, Sessler JL, Yoon J, James TD.

Front Chem. 2019 Apr 30;7:255. doi: 10.3389/fchem.2019.00255. eCollection 2019.


Feasibility and economic assessment of chromocolonoscopy for detection of proximal serrated neoplasia within a population-based colorectal cancer screening programme (CONSCOP): an open-label, randomised controlled non-inferiority trial.

Hurt C, Ramaraj R, Farr A, Morgan M, Williams N, Philips CJ, Williams GT, Gardner G, Porter C, Sampson J, Hillier S, Heard H, Dolwani S; CONSCOP Clinical Research Consortium.

Lancet Gastroenterol Hepatol. 2019 May;4(5):364-375. doi: 10.1016/S2468-1253(19)30035-4. Epub 2019 Mar 16.


Lect2 deficiency is characterised by altered cytokine levels and promotion of intestinal tumourigenesis.

Greenow KR, Zverev M, May S, Kendrick H, Williams GT, Phesse T, Parry L.

Oncotarget. 2018 Nov 23;9(92):36430-36443. doi: 10.18632/oncotarget.26335. eCollection 2018 Nov 23.


An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates.

Sedgwick AC, Dou WT, Jiao JB, Wu L, Williams GT, Jenkins ATA, Bull SD, Sessler JL, He XP, James TD.

J Am Chem Soc. 2018 Oct 31;140(43):14267-14271. doi: 10.1021/jacs.8b08457. Epub 2018 Oct 16.


Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

May S, Owen H, Phesse TJ, Greenow KR, Jones GR, Blackwood A, Cook PC, Towers C, Gallimore AM, Williams GT, Stürzl M, Britzen-Laurent N, Sansom OJ, MacDonald AS, Bird AP, Clarke AR, Parry L.

J Pathol. 2018 Jul;245(3):270-282. doi: 10.1002/path.5074. Epub 2018 May 16.


Dye Displacement Assay for Saccharides using Benzoxaborole Hydrogels.

Lampard EV, Sedgwick AC, Sombuttan T, Williams GT, Wannalerse B, Jenkins ATA, Bull SD, James TD.

ChemistryOpen. 2018 Jan 30;7(3):266-268. doi: 10.1002/open.201700193. eCollection 2018 Mar.


Burden and Profile of Somatic Mutation in Duodenal Adenomas from Patients with Familial Adenomatous- and MUTYH-associated Polyposis.

Thomas LE, Hurley JJ, Meuser E, Jose S, Ashelford KE, Mort M, Idziaszczyk S, Maynard J, Brito HL, Harry M, Walters A, Raja M, Walton SJ, Dolwani S, Williams GT, Morgan M, Moorghen M, Clark SK, Sampson JR.

Clin Cancer Res. 2017 Nov 1;23(21):6721-6732. doi: 10.1158/1078-0432.CCR-17-1269. Epub 2017 Aug 8.


Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.

Kizilors A, Pickard MR, Schulte CE, Yacqub-Usman K, McCarthy NJ, Gan SU, Darling D, Gäken J, Williams GT, Farzaneh F.

Biosci Rep. 2017 Jul 27. pii: BSR20170843. doi: 10.1042/BSR20170843. [Epub ahead of print]


Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Daly CS, Shaw P, Ordonez LD, Williams GT, Quist J, Grigoriadis A, Van Es JH, Clevers H, Clarke AR, Reed KR.

Oncogene. 2017 Mar 30;36(13):1793-1803. doi: 10.1038/onc.2016.342. Epub 2016 Oct 3.


Challenging diagnostic issues in adenomatous polyps with epithelial misplacement in bowel cancer screening: 5 years' experience of the Bowel Cancer Screening Programme Expert Board.

Griggs RK, Novelli MR, Sanders DS, Warren BF, Williams GT, Quirke P, Shepherd NA.

Histopathology. 2017 Feb;70(3):466-472. doi: 10.1111/his.13092. Epub 2016 Nov 15.


Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer.

Jezkova J, Williams JS, Pinto F, Sammut SJ, Williams GT, Gollins S, McFarlane RJ, Reis RM, Wakeman JA.

Oncotarget. 2016 Mar 8;7(10):11478-86. doi: 10.18632/oncotarget.7202.


The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells.

Pickard MR, Williams GT.

Oncotarget. 2016 Mar 1;7(9):10104-16. doi: 10.18632/oncotarget.7173.


Directed evolution of human scFvs in DT40 cells.

Lim AW, Williams GT, Rada C, Sale JE.

Protein Eng Des Sel. 2016 Feb;29(2):39-48. doi: 10.1093/protein/gzv058. Epub 2015 Oct 30.


Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes.

Rashid M, Fischer A, Wilson CH, Tiffen J, Rust AG, Stevens P, Idziaszczyk S, Maynard J, Williams GT, Mustonen V, Sampson JR, Adams DJ.

J Pathol. 2016 Jan;238(1):98-108. doi: 10.1002/path.4643. Epub 2015 Nov 2.


Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer.

Raja M, Zverev M, Seipel K, Williams GT, Clarke AR, Shaw PH.

Mol Cancer Ther. 2015 Oct;14(10):2175-86. doi: 10.1158/1535-7163.MCT-15-0223. Epub 2015 Jul 23.


Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA.

Pickard MR, Williams GT.

Genes (Basel). 2015 Jul 7;6(3):484-99. doi: 10.3390/genes6030484. Review.


High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression.

Bento DC, Jones E, Junaid S, Tull J, Williams GT, Godkin A, Ager A, Gallimore A.

Oncoimmunology. 2015 Apr 2;4(3):e974374. eCollection 2015 Mar.


Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells.

Yacqub-Usman K, Pickard MR, Williams GT.

Prostate. 2015 May;75(7):693-705. doi: 10.1002/pros.22952. Epub 2015 Feb 3.


Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.

Hudson WH, Pickard MR, de Vera IM, Kuiper EG, Mourtada-Maarabouni M, Conn GL, Kojetin DJ, Williams GT, Ortlund EA.

Nat Commun. 2014 Nov 7;5:5395. doi: 10.1038/ncomms6395.


Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine.

Holik AZ, Young M, Krzystyniak J, Williams GT, Metzger D, Shorning BY, Clarke AR.

PLoS Genet. 2014 Jul 10;10(7):e1004453. doi: 10.1371/journal.pgen.1004453. eCollection 2014 Jul.


Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy.

Pickard MR, Williams GT.

Breast Cancer Res Treat. 2014 Jun;145(2):359-70. doi: 10.1007/s10549-014-2974-y. Epub 2014 May 1.


A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine?

Maughan TS, Meade AM, Adams RA, Richman SD, Butler R, Fisher D, Wilson RH, Jasani B, Taylor GR, Williams GT, Sampson JR, Seymour MT, Nichols LL, Kenny SL, Nelson A, Sampson CM, Hodgkinson E, Bridgewater JA, Furniss DL, Roy R, Pope MJ, Pope JK, Parmar M, Quirke P, Kaplan R.

Br J Cancer. 2014 Apr 29;110(9):2178-86. doi: 10.1038/bjc.2014.182. Epub 2014 Apr 17.


Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells.

Mourtada-Maarabouni M, Williams GT.

Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):468-73. doi: 10.1016/j.clml.2014.02.011. Epub 2014 Mar 3.


Interleukin-6 signaling drives fibrosis in unresolved inflammation.

Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA.

Immunity. 2014 Jan 16;40(1):40-50. doi: 10.1016/j.immuni.2013.10.022. Epub 2014 Jan 9.


Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.

Mourtada-Maarabouni M, Williams GT.

Biomed Res Int. 2013;2013:358015. doi: 10.1155/2013/358015. Epub 2013 Nov 11.


PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.

Davies EJ, Marsh Durban V, Meniel V, Williams GT, Clarke AR.

J Pathol. 2014 May;233(1):27-38. doi: 10.1002/path.4312. Epub 2014 Jan 23.


Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency.

Greenow KR, Clarke AR, Williams GT, Jones R.

Oncogene. 2014 Jul 31;33(31):4089-96. doi: 10.1038/onc.2013.371. Epub 2013 Sep 16.


Cited1 deficiency suppresses intestinal tumorigenesis.

Méniel V, Song F, Phesse T, Young M, Poetz O, Parry L, Jenkins JR, Williams GT, Dunwoodie SL, Watson A, Clarke AR.

PLoS Genet. 2013;9(8):e1003638. doi: 10.1371/journal.pgen.1003638. Epub 2013 Aug 1.


Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability.

Roger L, Jones RE, Heppel NH, Williams GT, Sampson JR, Baird DM.

J Natl Cancer Inst. 2013 Aug 21;105(16):1202-11. doi: 10.1093/jnci/djt191. Epub 2013 Aug 5.


Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines.

Pickard MR, Mourtada-Maarabouni M, Williams GT.

Biochim Biophys Acta. 2013 Oct;1832(10):1613-23. doi: 10.1016/j.bbadis.2013.05.005. Epub 2013 May 12.


Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales.

Turner JK, Williams GT, Morgan M, Wright M, Dolwani S.

Histopathology. 2013 May;62(6):916-24. doi: 10.1111/his.12110.


PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.

Marsh V, Davies EJ, Williams GT, Clarke AR.

J Pathol. 2013 Jun;230(2):165-73. doi: 10.1002/path.4189.


A prospective study of the accuracy and concordance between in-situ and postfixation measurements of colorectal polyp size and their potential impact upon surveillance.

Turner JK, Wright M, Morgan M, Williams GT, Dolwani S.

Eur J Gastroenterol Hepatol. 2013 May;25(5):562-7. doi: 10.1097/MEG.0b013e32835d1f2d.


The influence of dietary β-glucan, PAMP exposure and Aeromonas salmonicida on apoptosis modulation in common carp (Cyprinus carpio).

Miest JJ, Falco A, Pionnier NP, Frost P, Irnazarow I, Williams GT, Hoole D.

Fish Shellfish Immunol. 2012 Oct;33(4):846-56.


Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer and the predictive role of endoluminal ultrasonography.

Reid TD, Chan DS, Roberts SA, Crosby TD, Williams GT, Lewis WG.

Br J Cancer. 2012 Dec 4;107(12):1925-31. doi: 10.1038/bjc.2012.511. Epub 2012 Nov 20.


Conditional disruption of Axin1 leads to development of liver tumors in mice.

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jardé T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC.

Gastroenterology. 2012 Dec;143(6):1650-9. doi: 10.1053/j.gastro.2012.08.047. Epub 2012 Sep 6.


Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types.

Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT.

Curr Cancer Drug Targets. 2013 Jan;13(1):80-91.


Relative Prognostic Value of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Operable Oesophagogastric Cancer.

Chan DS, Campbell F, Edwards P, Jasani B, Williams GT, Lewis WG.

ISRN Surg. 2012;2012:804891. doi: 10.5402/2012/804891. Epub 2012 Jul 26.


Professor Bryan F Warren: an appreciation (15 April 1958-28 March 2012).

Shepherd NA, Novelli MR, Williams GT.

J Clin Pathol. 2012 Sep;65(9):863-4. doi: 10.1136/jclinpath-2012-200925. Epub 2012 Jul 6. No abstract available.


Professor Bryan F Warren--obituary.

Shepherd NA, Novelli MR, Williams GT.

Histopathology. 2012 Jul;61(1):138-9. doi: 10.1111/j.1365-2559.2012.04325.x. No abstract available.


Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1.

Siew EL, Chan KM, Williams GT, Ross D, Inayat-Hussain SH.

Free Radic Biol Med. 2012 Oct 15;53(8):1616-24. doi: 10.1016/j.freeradbiomed.2012.05.046. Epub 2012 Jun 9.


Professor Bryan F Warren (15 April 1958-28 March 2012): an appreciation.

Shepherd NA, Novelli MR, Williams GT.

J Pathol. 2012 Jul;227(3):e3-4. doi: 10.1002/path.4048. No abstract available.


Are snoRNAs and snoRNA host genes new players in cancer?

Williams GT, Farzaneh F.

Nat Rev Cancer. 2012 Jan 19;12(2):84-8. doi: 10.1038/nrc3195. Review.


Results of accelerated postoperative rehabilitation using novel "suture frame" repair of Achilles tendon rupture.

Talbot JC, Williams GT, Bismil Q, Shaw DL, Schilders E.

J Foot Ankle Surg. 2012 Mar-Apr;51(2):147-51. doi: 10.1053/j.jfas.2011.10.045. Epub 2011 Dec 6.


Relative prognostic value of TNM7 vs TNM6 in staging oesophageal cancer.

Reid TD, Sanyaolu LN, Chan D, Williams GT, Lewis WG.

Br J Cancer. 2011 Sep 6;105(6):842-6. doi: 10.1038/bjc.2011.320. Epub 2011 Aug 16.


Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci.

Pruzina S, Williams GT, Kaneva G, Davies SL, Martín-López A, Brüggemann M, Vieira SM, Jeffs SA, Sattentau QJ, Neuberger MS.

Protein Eng Des Sel. 2011 Oct;24(10):791-9. doi: 10.1093/protein/gzr038. Epub 2011 Aug 2.


Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.

Pickard MR, Mourtada-Maarabouni M, Williams GT.

Biochim Biophys Acta. 2011 Sep;1812(9):1146-53. doi: 10.1016/j.bbadis.2011.04.009. Epub 2011 Apr 29.


A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes.

Williams GT, Mourtada-Maarabouni M, Farzaneh F.

Biochem Soc Trans. 2011 Apr;39(2):482-6. doi: 10.1042/BST0390482. Review.


An improved Abbott ARCHITECT assay for the detection of hepatitis B virus surface antigen (HBsAg).

Lou SC, Pearce SK, Lukaszewska TX, Taylor RE, Williams GT, Leary TP.

J Clin Virol. 2011 May;51(1):59-63. doi: 10.1016/j.jcv.2011.01.019. Epub 2011 Mar 1.


Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer.

Pickard MR, Edwards SE, Cooper CS, Williams GT.

Prostate. 2010 Oct 1;70(14):1513-23. doi: 10.1002/pros.21186.


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