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Perspectives on the role of Wnt biology in cancer.

Mirabelli CK, Nusse R, Tuveson DA, Williams BO.

Sci Signal. 2019 Jul 9;12(589). pii: eaay4494. doi: 10.1126/scisignal.aay4494. Review.


Enhanced cortical bone expansion in Lgals3-deficient mice during aging.

Maupin KA, Weaver K, Bergsma A, Christie C, Zhong ZA, Yang T, Williams BO.

Bone Res. 2018 Mar 26;6:7. doi: 10.1038/s41413-017-0003-6. eCollection 2018.


Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82.

Bergsma A, Ganguly SS, Wiegand ME, Dick D, Williams BO, Miranti CK.

Bone Rep. 2019 Jan 30;10:100196. doi: 10.1016/j.bonr.2019.100196. eCollection 2019 Jun.


A quest for clarity in bone erosion: The role of sequestosome 1 in Paget's disease of bone.

Michalski MN, Williams BO.

J Biol Chem. 2018 Jun 15;293(24):9542-9543. doi: 10.1074/jbc.H118.003689.


Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy.

Madan B, McDonald MJ, Foxa GE, Diegel CR, Williams BO, Virshup DM.

Bone Res. 2018 May 25;6:17. doi: 10.1038/s41413-018-0017-8. eCollection 2018.


Global deletion of tetraspanin CD82 attenuates bone growth and enhances bone marrow adipogenesis.

Bergsma A, Ganguly SS, Dick D, Williams BO, Miranti CK.

Bone. 2018 Aug;113:105-113. doi: 10.1016/j.bone.2018.05.020. Epub 2018 May 18.


LRP1 Suppresses Bone Resorption in Mice by Inhibiting the RANKL-Stimulated NF-κB and p38 Pathways During Osteoclastogenesis.

Lu D, Li J, Liu H, Foxa GE, Weaver K, Li J, Williams BO, Yang T.

J Bone Miner Res. 2018 Oct;33(10):1773-1784. doi: 10.1002/jbmr.3469. Epub 2018 Jun 12.


Publisher Correction: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.

Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T.

Nat Commun. 2018 Feb 8;9(1):646. doi: 10.1038/s41467-018-03177-0.


Ginkgolic acid, a sumoylation inhibitor, promotes adipocyte commitment but suppresses adipocyte terminal differentiation of mouse bone marrow stromal cells.

Liu H, Li J, Lu D, Li J, Liu M, He Y, Williams BO, Li J, Yang T.

Sci Rep. 2018 Feb 7;8(1):2545. doi: 10.1038/s41598-018-20244-0.


Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.

Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T.

Nat Commun. 2018 Jan 10;9(1):143. doi: 10.1038/s41467-017-02413-3. Erratum in: Nat Commun. 2018 Feb 8;9(1):646.


Deletion of tumor suppressors adenomatous polyposis coli and Smad4 in murine luminal epithelial cells causes invasive prostate cancer and loss of androgen receptor expression.

Valkenburg KC, De Marzo AM, Williams BO.

Oncotarget. 2017 May 17;8(46):80265-80277. doi: 10.18632/oncotarget.17919. eCollection 2017 Oct 6.


Wnt Signaling in Ewing Sarcoma, Osteosarcoma, and Malignant Peripheral Nerve Sheath Tumors.

Pridgeon MG, Grohar PJ, Steensma MR, Williams BO.

Curr Osteoporos Rep. 2017 Aug;15(4):239-246. doi: 10.1007/s11914-017-0377-9. Review.


Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease.

Yang T, Williams BO.

Physiol Rev. 2017 Jul 1;97(3):1211-1228. doi: 10.1152/physrev.00013.2016. Review.


Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.

DeBruine ZJ, Ke J, Harikumar KG, Gu X, Borowsky P, Williams BO, Xu W, Miller LJ, Xu HE, Melcher K.

Genes Dev. 2017 May 1;31(9):916-926. doi: 10.1101/gad.298331.117. Epub 2017 May 25.


Sclt1 deficiency causes cystic kidney by activating ERK and STAT3 signaling.

Li J, Lu D, Liu H, Williams BO, Overbeek PA, Lee B, Zheng L, Yang T.

Hum Mol Genet. 2017 Aug 1;26(15):2949-2960. doi: 10.1093/hmg/ddx183.


Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC.

Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3.


Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover.

Droscha CJ, Diegel CR, Ethen NJ, Burgers TA, McDonald MJ, Maupin KA, Naidu AS, Wang P, Teh BT, Williams BO.

Bone. 2017 May;98:68-78. doi: 10.1016/j.bone.2016.12.006. Epub 2017 Apr 3.


LRP5: From bedside to bench to bone.

Williams BO.

Bone. 2017 Sep;102:26-30. doi: 10.1016/j.bone.2017.03.044. Epub 2017 Mar 21. Review.


Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.

Walls GV, Stevenson M, Lines KE, Newey PJ, Reed AAC, Bowl MR, Jeyabalan J, Harding B, Bradley KJ, Manek S, Chen J, Wang P, Williams BO, Teh BT, Thakker RV.

Oncogene. 2017 Jul 13;36(28):4025-4036. doi: 10.1038/onc.2017.43. Epub 2017 Mar 13.


CRISPR/CAS9 Technologies.

Williams BO, Warman ML.

J Bone Miner Res. 2017 May;32(5):883-888. doi: 10.1002/jbmr.3086. Epub 2017 Feb 23. Review.


A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells.

Chin AM, Tsai YH, Finkbeiner SR, Nagy MS, Walker EM, Ethen NJ, Williams BO, Battle MA, Spence JR.

Stem Cell Reports. 2016 Nov 8;7(5):826-839. doi: 10.1016/j.stemcr.2016.09.004. Epub 2016 Oct 6.


Mice with a heterozygous Lrp6 deletion have impaired fracture healing.

Burgers TA, Vivanco JF, Zahatnansky J, Moren AJ, Mason JJ, Williams BO.

Bone Res. 2016 Sep 6;4:16025. doi: 10.1038/boneres.2016.25. eCollection 2016.


Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis.

Zhong ZA, Ethen NJ, Williams BO.

Methods Mol Biol. 2016;1481:119-25. doi: 10.1007/978-1-4939-6393-5_13.


Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6.

Schumacher CA, Joiner DM, Less KD, Drewry MO, Williams BO.

Bone Res. 2016 Mar 1;4:15042. doi: 10.1038/boneres.2015.42. eCollection 2016.


Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis.

Williams BO.

Am J Med Genet C Semin Med Genet. 2016 Mar;172C(1):24-6. doi: 10.1002/ajmg.c.31474. Epub 2016 Jan 28. Review.


Wnt signaling in bone and muscle.

Rudnicki MA, Williams BO.

Bone. 2015 Nov;80:60-66. doi: 10.1016/j.bone.2015.02.009. Review.


Response to Wnt Signaling Pathways.

Oursler MJ, Westendorf JJ, Weivoda MM, Ruan M, Hachfeld CM, Howe A, Davey R, Zajac J, Williams BO, Khosla S.

J Bone Miner Res. 2015 Nov;30(11):2135-6. doi: 10.1002/jbmr.2694. Epub 2015 Sep 14. No abstract available.


Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X.

Oncogene. 2016 May 5;35(18):2370-8. doi: 10.1038/onc.2015.297. Epub 2015 Aug 17.


(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice.

Zhong ZA, Peck A, Li S, VanOss J, Snider J, Droscha CJ, Chang TA, Williams BO.

Bone Res. 2015 Jun 9;3:15013. doi: 10.1038/boneres.2015.13. eCollection 2015.


Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.

Zhong ZA, Zahatnansky J, Snider J, Van Wieren E, Diegel CR, Williams BO.

Dev Dyn. 2015 Oct;244(10):1347-55. doi: 10.1002/dvdy.24316. Epub 2015 Aug 21.


Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):65-75. doi: 10.1002/jbmr.2599. Epub 2015 Aug 19.


Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

Valkenburg KC, Hostetter G, Williams BO.

Prostate. 2015 Oct;75(14):1579-85. doi: 10.1002/pros.23032. Epub 2015 Jul 2.


Disruption of tubular Flcn expression as a mouse model for renal tumor induction.

Chen J, Huang D, Rubera I, Futami K, Wang P, Zickert P, Khoo SK, Dykema K, Zhao P, Petillo D, Cao B, Zhang Z, Si S, Schoen SR, Yang XJ, Zhou M, Xiao GQ, Wu G, Nordenskjöld M, Tauc M, Williams BO, Furge KA, Teh BT.

Kidney Int. 2015 Nov;88(5):1057-69. doi: 10.1038/ki.2015.177. Epub 2015 Jun 17.


Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.

Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA.

Circ Res. 2015 Jul 3;117(2):142-56. doi: 10.1161/CIRCRESAHA.117.306712. Epub 2015 Jun 1.


WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis.

Qin L, Yin YT, Zheng FJ, Peng LX, Yang CF, Bao YN, Liang YY, Li XJ, Xiang YQ, Sun R, Li AH, Zou RH, Pei XQ, Huang BJ, Kang TB, Liao DF, Zeng YX, Williams BO, Qian CN.

Oncotarget. 2015 Apr 30;6(12):10239-52.


Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

Peacock JD, Dykema KJ, Toriello HV, Mooney MR, Scholten DJ 2nd, Winn ME, Borgman A, Duesbery NS, Hiemenga JA, Liu C, Campbell S, Nickoloff BP, Williams BO, Steensma M.

Am J Med Genet A. 2015 Jul;167(7):1429-35. doi: 10.1002/ajmg.a.37048. Epub 2015 Mar 21.


Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur.

Collins CJ, Vivanco JF, Sokn SA, Williams BO, Burgers TA, Ploeg HL.

J Biomech. 2015 Jan 21;48(2):310-7. doi: 10.1016/j.jbiomech.2014.11.028. Epub 2014 Nov 28.


Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.

Cui Y, Niziolek PJ, MacDonald BT, Alenina N, Matthes S, Jacobsen CM, Conlon RA, Brommage R, Powell DR, He X, Bader M, Williams BO, Warman ML, Robling AG.

Nat Med. 2014 Nov;20(11):1229-30. doi: 10.1038/nm.3697. No abstract available.


Down regulation of Wnt signaling mitigates hypoxia-induced chemoresistance in human osteosarcoma cells.

Scholten DJ 2nd, Timmer CM, Peacock JD, Pelle DW, Williams BO, Steensma MR.

PLoS One. 2014 Oct 27;9(10):e111431. doi: 10.1371/journal.pone.0111431. eCollection 2014.


WNT signaling in bone development and homeostasis.

Zhong Z, Ethen NJ, Williams BO.

Wiley Interdiscip Rev Dev Biol. 2014 Nov-Dec;3(6):489-500. doi: 10.1002/wdev.159. Epub 2014 Sep 30. Review.


Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.

Valkenburg KC, Yu X, De Marzo AM, Spiering TJ, Matusik RJ, Williams BO.

Prostate. 2014 Nov;74(15):1506-20. doi: 10.1002/pros.22868. Epub 2014 Aug 29.


Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.

Kabiri Z, Greicius G, Madan B, Biechele S, Zhong Z, Zaribafzadeh H, Edison, Aliyev J, Wu Y, Bunte R, Williams BO, Rossant J, Virshup DM.

Development. 2014 Jun;141(11):2206-15.


β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!

Yang J, Mowry LE, Nejak-Bowen KN, Okabe H, Diegel CR, Lang RA, Williams BO, Monga SP.

Hepatology. 2014 Sep;60(3):964-76. doi: 10.1002/hep.27082. Epub 2014 Jul 25.


Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system.

Hoffmann MF, Burgers TA, Mason JJ, Williams BO, Sietsema DL, Jones CB.

Injury. 2014 Jul;45(7):1035-41. doi: 10.1016/j.injury.2014.02.038. Epub 2014 Mar 11.


Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.

Joiner DM, Less KD, Van Wieren EM, Zhang YW, Hess D, Williams BO.

Arthritis Res Ther. 2014 Mar 27;16(2):R81. doi: 10.1186/ar4522.


Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation.

Staal B, Williams BO, Beier F, Vande Woude GF, Zhang YW.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2590-5. doi: 10.1073/pnas.1400744111. Epub 2014 Feb 3.


Wnt signaling regulates homeostasis of the periodontal ligament.

Lim WH, Liu B, Cheng D, Williams BO, Mah SJ, Helms JA.

J Periodontal Res. 2014 Dec;49(6):751-9. doi: 10.1111/jre.12158. Epub 2014 Jan 11.


LRP6 in mesenchymal stem cells is required for bone formation during bone growth and bone remodeling.

Li C, Williams BO, Cao X, Wan M.

Bone Res. 2014 Apr 29;2:14006. doi: 10.1038/boneres.2014.6. eCollection 2014.


Insights into the mechanisms of sclerostin action in regulating bone mass accrual.

Williams BO.

J Bone Miner Res. 2014 Jan;29(1):24-8. doi: 10.1002/jbmr.2154. No abstract available.


Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.

Ke J, Harikumar KG, Erice C, Chen C, Gu X, Wang L, Parker N, Cheng Z, Xu W, Williams BO, Melcher K, Miller LJ, Xu HE.

Genes Dev. 2013 Nov 1;27(21):2305-19. doi: 10.1101/gad.228544.113.

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