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UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts.

Williams AP, Garner EF, Stafman LL, Aye JM, Quinn CH, Marayati R, Stewart JE, Atigadda VR, Mroczek-Musulman E, Moore BP, Beierle EA, Friedman GK.

Transl Oncol. 2019 Jul 26;12(10):1364-1374. doi: 10.1016/j.tranon.2019.07.003. [Epub ahead of print]


Oceanic and radiative forcing of medieval megadroughts in the American Southwest.

Steiger NJ, Smerdon JE, Cook BI, Seager R, Williams AP, Cook ER.

Sci Adv. 2019 Jul 24;5(7):eaax0087. doi: 10.1126/sciadv.aax0087. eCollection 2019 Jul.


Development and Evaluation of a Theory-Based Approach to Reducing Carbon Monoxide (CO) Morbidity and Mortality: The CO Blitz Model.

Dawson RM, Williams AP, Richardson J.

J Community Health Nurs. 2019 Jul-Sep;36(3):115-123. doi: 10.1080/07370016.2019.1630967.


Pentalogy of Cantrell.

Williams AP, Marayati R, Beierle EA.

Semin Pediatr Surg. 2019 Apr;28(2):106-110. doi: 10.1053/j.sempedsurg.2019.04.006. Epub 2019 Apr 9. Review.


Twentieth-century hydroclimate changes consistent with human influence.

Marvel K, Cook BI, Bonfils CJW, Durack PJ, Smerdon JE, Williams AP.

Nature. 2019 May;569(7754):59-65. doi: 10.1038/s41586-019-1149-8. Epub 2019 May 1.


Economic and environmental efficiency of UK and Ireland water companies: Influence of exogenous factors and rurality.

Walker NL, Norton A, Harris I, Williams AP, Styles D.

J Environ Manage. 2019 Jul 1;241:363-373. doi: 10.1016/j.jenvman.2019.03.093. Epub 2019 Apr 23.


PP2A activation alone and in combination with cisplatin decreases cell growth and tumor formation in human HuH6 hepatoblastoma cells.

Stafman LL, Williams AP, Marayati R, Aye JM, Stewart JE, Mroczek-Musulman E, Beierle EA.

PLoS One. 2019 Apr 10;14(4):e0214469. doi: 10.1371/journal.pone.0214469. eCollection 2019.


The presence of PIM3 increases hepatoblastoma tumorigenesis and tumor initiating cell phenotype and is associated with decreased patient survival.

Stafman LL, Waldrop MG, Williams AP, Aye JM, Stewart JE, Mroczek-Musulman E, Yoon KJ, Whelan K, Beierle EA.

J Pediatr Surg. 2019 Jun;54(6):1206-1213. doi: 10.1016/j.jpedsurg.2019.02.029. Epub 2019 Feb 28.


Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort.

Wilkinson TMA, Aris E, Bourne SC, Clarke SC, Peeters M, Pascal TG, Taddei L, Tuck AC, Kim VL, Ostridge KK, Staples KJ, Williams NP, Williams AP, Wootton SA, Devaster JM.

ERJ Open Res. 2019 Feb 25;5(1). pii: 00248-2018. doi: 10.1183/23120541.00248-2018. eCollection 2019 Feb. Erratum in: ERJ Open Res. 2019 Jul 29;5(3):.


Tree-ring isotopes capture interannual vegetation productivity dynamics at the biome scale.

Levesque M, Andreu-Hayles L, Smith WK, Williams AP, Hobi ML, Allred BW, Pederson N.

Nat Commun. 2019 Feb 14;10(1):742. doi: 10.1038/s41467-019-08634-y.


Exacerbation of the 2013-2016 Pan-Caribbean Drought by Anthropogenic Warming.

Herrera DA, Ault TR, Fasullo JT, Coats SJ, Carrillo CM, Cook BI, Williams AP.

Geophys Res Lett. 2018 Oct 16;45(19):10619-10626. doi: 10.1029/2018GL079408. Epub 2018 Oct 7.


Strengthened scientific support for the Endangerment Finding for atmospheric greenhouse gases.

Duffy PB, Field CB, Diffenbaugh NS, Doney SC, Dutton Z, Goodman S, Heinzerling L, Hsiang S, Lobell DB, Mickley LJ, Myers S, Natali SM, Parmesan C, Tierney S, Williams AP.

Science. 2019 Feb 8;363(6427). pii: eaat5982. doi: 10.1126/science.aat5982. Epub 2018 Dec 13. Review.


Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma.

Stafman LL, Williams AP, Garner EF, Aye JM, Stewart JE, Yoon KJ, Whelan K, Beierle EA.

Transl Oncol. 2019 Feb;12(2):200-208. doi: 10.1016/j.tranon.2018.10.008. Epub 2018 Nov 6.


Corruption of neuroblastoma patient derived xenografts with human T cell lymphoma.

Williams AP, Stewart JE, Stafman LL, Aye JM, Mroczek-Musulman E, Ren C, Yoon K, Whelan K, Beierle EA.

J Pediatr Surg. 2018 Oct 22. pii: S0022-3468(18)30681-X. doi: 10.1016/j.jpedsurg.2018.10.051. [Epub ahead of print]


Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth.

Williams AP, Garner EF, Waters AM, Stafman LL, Aye JM, Markert H, Stewart JE, Beierle EA.

Transl Oncol. 2019 Jan;12(1):84-95. doi: 10.1016/j.tranon.2018.09.011. Epub 2018 Oct 1.


Rebalancing health systems toward community-based care: The role of subsectoral politics.

Peckham A, Morton-Chang F, Williams AP, Miller FA.

Health Policy. 2018 Nov;122(11):1260-1265. doi: 10.1016/j.healthpol.2018.09.014. Epub 2018 Sep 28.


Clinical and laboratory features of seventy-eight UK patients with Good's syndrome (thymoma and hypogammaglobulinaemia).

Zaman M, Huissoon A, Buckland M, Patel S, Alachkar H, Edgar JD, Thomas M, Arumugakani G, Baxendale H, Burns S, Williams AP, Jolles S, Herriot R, Sargur RB, Arkwright PD.

Clin Exp Immunol. 2019 Jan;195(1):132-138. doi: 10.1111/cei.13216. Epub 2018 Oct 21.


UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts.

Garner EF, Stafman LL, Williams AP, Aye JM, Goolsby C, Atigadda VR, Moore BP, Nan L, Stewart JE, Hjelmeland AB, Friedman GK, Beierle EA.

J Neurooncol. 2018 Nov;140(2):209-224. doi: 10.1007/s11060-018-2950-1. Epub 2018 Aug 21.


Global patterns of interannual climate-fire relationships.

Abatzoglou JT, Williams AP, Boschetti L, Zubkova M, Kolden CA.

Glob Chang Biol. 2018 Nov;24(11):5164-5175. doi: 10.1111/gcb.14405. Epub 2018 Aug 24.


A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.

Williams AP, Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA.

J Surg Res. 2018 Aug;228:54-62. doi: 10.1016/j.jss.2018.02.057. Epub 2018 Mar 26.


The 2016 southeastern US drought: an extreme departure from centennial wetting and cooling.

Williams AP, Cook BI, Smerdon JE, Bishop DA, Seager R, Mankin JS.

J Geophys Res Atmos. 2017 Oct 27;122(20):10888-10905. doi: 10.1002/2017JD027523. Epub 2017 Oct 4.


Surgical consent practice in the UK following the Montgomery ruling: A national cross-sectional questionnaire study.

McKinnon C, Loughran D, Finn R, Coxwell-Matthewman M, Jeyaretna DS, Williams AP.

Int J Surg. 2018 Jul;55:66-72. doi: 10.1016/j.ijsu.2018.05.016. Epub 2018 May 26.


FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts.

Garner EF, Williams AP, Stafman LL, Aye JM, Mroczek-Musulman E, Moore BP, Stewart JE, Friedman GK, Beierle EA.

Sci Rep. 2018 May 2;8(1):6913. doi: 10.1038/s41598-018-25263-5.


Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Maccari ME, Abolhassani H, Aghamohammadi A, Aiuti A, Aleinikova O, Bangs C, Baris S, Barzaghi F, Baxendale H, Buckland M, Burns SO, Cancrini C, Cant A, Cathébras P, Cavazzana M, Chandra A, Conti F, Coulter T, Devlin LA, Edgar JDM, Faust S, Fischer A, Garcia-Prat M, Hammarström L, Heeg M, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Kumararatne D, Grimbacher B, Longhurst H, Mahlaoui N, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neven B, Nieters A, Olbrich P, Ozen A, Pachlopnik Schmid J, Picard C, Prader S, Rae W, Reichenbach J, Rusch S, Savic S, Scarselli A, Scheible R, Sediva A, Sharapova SO, Shcherbina A, Slatter M, Soler-Palacin P, Stanislas A, Suarez F, Tucci F, Uhlmann A, van Montfrans J, Warnatz K, Williams AP, Wood P, Kracker S, Condliffe AM, Ehl S.

Front Immunol. 2018 Mar 16;9:543. doi: 10.3389/fimmu.2018.00543. eCollection 2018.


Association of Surgeons in Training conference: Bournemouth 2017.

Williams AP, Harries RL, Mohan HM.

Int J Surg. 2018 Apr;52:361-365. doi: 10.1016/j.ijsu.2017.11.030. Epub 2017 Dec 14.


Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation.

Ramakrishnan KA, Rae W, Barcenas-Morales G, Gao Y, Pengelly RJ, Patel SV, Kumararatne DS, Ennis S, Döffinger R, Faust SN, Williams AP.

J Allergy Clin Immunol. 2018 Apr;141(4):1479-1482.e6. doi: 10.1016/j.jaci.2017.11.014. Epub 2017 Dec 7. No abstract available.


Cross-sectional study of the financial cost of training to the surgical trainee in the UK and Ireland.

O'Callaghan J, Mohan HM, Sharrock A, Gokani V, Fitzgerald JE, Williams AP, Harries RL; Council of the Association of Surgeons in Training.

BMJ Open. 2017 Nov 15;7(11):e018086. doi: 10.1136/bmjopen-2017-018086.


Clinical efficacy of a next-generation sequencing gene panel for primary immunodeficiency diagnostics.

Rae W, Ward D, Mattocks C, Pengelly RJ, Eren E, Patel SV, Faust SN, Hunt D, Williams AP.

Clin Genet. 2018 Mar;93(3):647-655. doi: 10.1111/cge.13163. Epub 2018 Feb 2.


Autoimmunity/inflammation in a monogenic primary immunodeficiency cohort.

Rae W, Ward D, Mattocks CJ, Gao Y, Pengelly RJ, Patel SV, Ennis S, Faust SN, Williams AP.

Clin Transl Immunology. 2017 Sep 15;6(9):e155. doi: 10.1038/cti.2017.38. eCollection 2017 Sep.


How do Policy and Institutional Settings Shape Opportunities for Community-Based Primary Health Care? A Comparison of Ontario, Québec and New Zealand.

Tenbensel T, Miller F, Breton M, Couturier Y, Morton-Chang F, Ashton T, Sheridan N, Peckham A, Williams AP, Kenealy T, Wodchis W.

Int J Integr Care. 2017 Jun 27;17(2):13. doi: 10.5334/ijic.2514.


IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection.

Wallington JC, Williams AP, Staples KJ, Wilkinson TMA.

J Allergy Clin Immunol. 2018 Jun;141(6):2182-2195.e6. doi: 10.1016/j.jaci.2017.08.009. Epub 2017 Sep 1.


Precipitation, temperature, and teleconnection signals across the combined North American, Monsoon Asia, and Old World Drought Atlases.

Baek SH, Smerdon JE, Coats S, Williams AP, Cook BI, Cook ER, Seager R.

J Clim. 2017 Sep;30(18):7141-7155. doi: 10.1175/JCLI-D-16-0766.1. Epub 2017 Aug 8.


Factors Associated with Residential Long-Term Care Wait-List Placement in North West Ontario.

Laporte A, Rohit Dass A, Kuluski K, Peckham A, Berta W, Lum J, Williams AP.

Can J Aging. 2017 Sep;36(3):286-305. doi: 10.1017/S071498081700023X. Epub 2017 Jul 6.


A novel germline gain-of-function variant in PIK3CD.

Rae W, Gao Y, Ward D, Mattocks CJ, Eren E, Williams AP.

Clin Immunol. 2017 Aug;181:29-31. doi: 10.1016/j.clim.2017.05.020. Epub 2017 May 31. No abstract available.


Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease.

Rae W, Gao Y, Eren E, Döffinger R, Marshall B, Williams AP.

Case Reports Immunol. 2016;2016:9165641. Epub 2016 Nov 16.


IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.

Drennan S, D'Avola A, Gao Y, Weigel C, Chrysostomou E, Steele AJ, Zenz T, Plass C, Johnson PW, Williams AP, Packham G, Stevenson FK, Oakes CC, Forconi F.

Leukemia. 2017 Aug;31(8):1686-1694. doi: 10.1038/leu.2016.356. Epub 2016 Nov 28.


Impact of anthropogenic climate change on wildfire across western US forests.

Abatzoglou JT, Williams AP.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11770-11775. Epub 2016 Oct 10.


Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.

Ramakrishnan KA, Pengelly RJ, Gao Y, Morgan M, Patel SV, Davies EG, Ennis S, Faust SN, Williams AP.

J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1160-1166.e10. doi: 10.1016/j.jaip.2016.07.014. Epub 2016 Oct 1.


Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort.

Coelho T, Andreoletti G, Ashton JJ, Batra A, Afzal NA, Gao Y, Williams AP, Beattie RM, Ennis S.

Sci Rep. 2016 Oct 5;6:34658. doi: 10.1038/srep34658.


What Gets in the Way of Person-Centred Care for People with Multimorbidity? Lessons from Ontario, Canada.

Kuluski K, Peckham A, Williams AP, Upshur RE.

Healthc Q. 2016;19(2):17-23.


Consultant outcomes publication and surgical training: Consensus recommendations by the association of surgeons in training.

Mohan HM, Gokani VJ, Williams AP, Harries RL; Council of the Association of Surgeons in Training.

Int J Surg. 2016 Nov;36 Suppl 1:S20-S23. doi: 10.1016/j.ijsu.2016.09.077. Epub 2016 Sep 20.


Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.

Gao Y, Arkwright PD, Carter R, Cazaly A, Harrison RJ, Mant A, Cant AJ, Gadola S, Elliott TJ, Khakoo SI, Williams AP.

J Allergy Clin Immunol. 2016 Dec;138(6):1733-1736.e2. doi: 10.1016/j.jaci.2016.06.029. Epub 2016 Jul 27. No abstract available.


Association of surgeons in training 40th anniversary conference: Liverpool #ASiT2016.

Harries RL, Williams AP, McElnay PJ, Gokani VJ; Association of Surgeons in Training Council.

Int J Surg. 2016 Nov;36 Suppl 1:S1-S4. doi: 10.1016/j.ijsu.2016.08.239. Epub 2016 Aug 23.


The future of surgical training in the context of the 'Shape of Training' Review: Consensus recommendations by the Association of Surgeons in Training.

Harries RL, Williams AP, Ferguson HJ, Mohan HM, Beamish AJ, Gokani VJ; Council of the Association of Surgeons in Training.

Int J Surg. 2016 Nov;36 Suppl 1:S5-S9. doi: 10.1016/j.ijsu.2016.08.238. Epub 2016 Aug 22.


Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

Coulter TI, Chandra A, Bacon CM, Babar J, Curtis J, Screaton N, Goodlad JR, Farmer G, Steele CL, Leahy TR, Doffinger R, Baxendale H, Bernatoniene J, Edgar JD, Longhurst HJ, Ehl S, Speckmann C, Grimbacher B, Sediva A, Milota T, Faust SN, Williams AP, Hayman G, Kucuk ZY, Hague R, French P, Brooker R, Forsyth P, Herriot R, Cancrini C, Palma P, Ariganello P, Conlon N, Feighery C, Gavin PJ, Jones A, Imai K, Ibrahim MA, Markelj G, Abinun M, Rieux-Laucat F, Latour S, Pellier I, Fischer A, Touzot F, Casanova JL, Durandy A, Burns SO, Savic S, Kumararatne DS, Moshous D, Kracker S, Vanhaesebroeck B, Okkenhaug K, Picard C, Nejentsev S, Condliffe AM, Cant AJ.

J Allergy Clin Immunol. 2017 Feb;139(2):597-606.e4. doi: 10.1016/j.jaci.2016.06.021. Epub 2016 Jul 16.


Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase δ syndrome.

Rae W, Ramakrishnan KA, Gao Y, Ashton-Key M, Pengelly RJ, Patel SV, Ennis S, Williams AP, Faust SN.

Clin Immunol. 2016 Oct;171:38-40. doi: 10.1016/j.clim.2016.07.017. Epub 2016 Jul 19. No abstract available.


Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies.

Gao Y, Rae W, Ramakrishnan KA, Barcenas-Morales G, Döffinger R, Eren E, Faust SN, Ottensmeier CH, Williams AP.

PLoS One. 2016 May 11;11(5):e0155059. doi: 10.1371/journal.pone.0155059. eCollection 2016.


Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.

Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1208-1218.


Trends toward an earlier peak of the growing season in Northern Hemisphere mid-latitudes.

Xu C, Liu H, Williams AP, Yin Y, Wu X.

Glob Chang Biol. 2016 Aug;22(8):2852-60. doi: 10.1111/gcb.13224. Epub 2016 May 12.


Towards a Community-Based Dementia Care Strategy: How Do We Get There from Here?

Morton-Chang F, Williams AP, Berta W, Laporte A.

Healthc Pap. 2016;16(2):8-32.


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