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Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).

Zaman M, Huissoon A, Buckland M, Patel S, Alachkar H, Edgar JD, Thomas M, Arumugakani G, Baxendale H, Burns S, Williams AP, Jolles S, Herriot R, Sargur RB, Arkwright PD.

Clin Exp Immunol. 2018 Sep 14. doi: 10.1111/cei.13216. [Epub ahead of print]


UAB30, a novel RXR agonist, decreases tumorigenesis and leptomeningeal disease in group 3 medulloblastoma patient-derived xenografts.

Garner EF, Stafman LL, Williams AP, Aye JM, Goolsby C, Atigadda VR, Moore BP, Nan L, Stewart JE, Hjelmeland AB, Friedman GK, Beierle EA.

J Neurooncol. 2018 Aug 21. doi: 10.1007/s11060-018-2950-1. [Epub ahead of print]


Global patterns of interannual climate-fire relationships.

Abatzoglou JT, Williams AP, Boschetti L, Zubkova M, Kolden CA.

Glob Chang Biol. 2018 Jul 26. doi: 10.1111/gcb.14405. [Epub ahead of print]


A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro.

Williams AP, Waters AM, Stewart JE, Atigadda VR, Mroczek-Musulman E, Muccio DD, Grubbs CJ, Beierle EA.

J Surg Res. 2018 Aug;228:54-62. doi: 10.1016/j.jss.2018.02.057. Epub 2018 Mar 26.


The 2016 southeastern US drought: an extreme departure from centennial wetting and cooling.

Williams AP, Cook BI, Smerdon JE, Bishop DA, Seager R, Mankin JS.

J Geophys Res Atmos. 2017 Oct 27;122(20):10888-10905. doi: 10.1002/2017JD027523. Epub 2017 Oct 4.


Surgical consent practice in the UK following the Montgomery ruling: A national cross-sectional questionnaire study.

McKinnon C, Loughran D, Finn R, Coxwell-Matthewman M, Jeyaretna DS, Williams AP.

Int J Surg. 2018 Jul;55:66-72. doi: 10.1016/j.ijsu.2018.05.016. Epub 2018 May 26.


FTY720 Decreases Tumorigenesis in Group 3 Medulloblastoma Patient-Derived Xenografts.

Garner EF, Williams AP, Stafman LL, Aye JM, Mroczek-Musulman E, Moore BP, Stewart JE, Friedman GK, Beierle EA.

Sci Rep. 2018 May 2;8(1):6913. doi: 10.1038/s41598-018-25263-5.


Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry.

Maccari ME, Abolhassani H, Aghamohammadi A, Aiuti A, Aleinikova O, Bangs C, Baris S, Barzaghi F, Baxendale H, Buckland M, Burns SO, Cancrini C, Cant A, Cathébras P, Cavazzana M, Chandra A, Conti F, Coulter T, Devlin LA, Edgar JDM, Faust S, Fischer A, Garcia-Prat M, Hammarström L, Heeg M, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Kumararatne D, Grimbacher B, Longhurst H, Mahlaoui N, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neven B, Nieters A, Olbrich P, Ozen A, Pachlopnik Schmid J, Picard C, Prader S, Rae W, Reichenbach J, Rusch S, Savic S, Scarselli A, Scheible R, Sediva A, Sharapova SO, Shcherbina A, Slatter M, Soler-Palacin P, Stanislas A, Suarez F, Tucci F, Uhlmann A, van Montfrans J, Warnatz K, Williams AP, Wood P, Kracker S, Condliffe AM, Ehl S.

Front Immunol. 2018 Mar 16;9:543. doi: 10.3389/fimmu.2018.00543. eCollection 2018.


Association of Surgeons in Training conference: Bournemouth 2017.

Williams AP, Harries RL, Mohan HM.

Int J Surg. 2018 Apr;52:361-365. doi: 10.1016/j.ijsu.2017.11.030. Epub 2017 Dec 14.


Anticytokine autoantibodies in a patient with a heterozygous NFKB2 mutation.

Ramakrishnan KA, Rae W, Barcenas-Morales G, Gao Y, Pengelly RJ, Patel SV, Kumararatne DS, Ennis S, Döffinger R, Faust SN, Williams AP.

J Allergy Clin Immunol. 2018 Apr;141(4):1479-1482.e6. doi: 10.1016/j.jaci.2017.11.014. Epub 2017 Dec 7. No abstract available.


Cross-sectional study of the financial cost of training to the surgical trainee in the UK and Ireland.

O'Callaghan J, Mohan HM, Sharrock A, Gokani V, Fitzgerald JE, Williams AP, Harries RL; Council of the Association of Surgeons in Training.

BMJ Open. 2017 Nov 15;7(11):e018086. doi: 10.1136/bmjopen-2017-018086.


Clinical efficacy of a next-generation sequencing gene panel for primary immunodeficiency diagnostics.

Rae W, Ward D, Mattocks C, Pengelly RJ, Eren E, Patel SV, Faust SN, Hunt D, Williams AP.

Clin Genet. 2018 Mar;93(3):647-655. doi: 10.1111/cge.13163. Epub 2018 Feb 2.


Autoimmunity/inflammation in a monogenic primary immunodeficiency cohort.

Rae W, Ward D, Mattocks CJ, Gao Y, Pengelly RJ, Patel SV, Ennis S, Faust SN, Williams AP.

Clin Transl Immunology. 2017 Sep 15;6(9):e155. doi: 10.1038/cti.2017.38. eCollection 2017 Sep.


How do Policy and Institutional Settings Shape Opportunities for Community-Based Primary Health Care? A Comparison of Ontario, Québec and New Zealand.

Tenbensel T, Miller F, Breton M, Couturier Y, Morton-Chang F, Ashton T, Sheridan N, Peckham A, Williams AP, Kenealy T, Wodchis W.

Int J Integr Care. 2017 Jun 27;17(2):13. doi: 10.5334/ijic.2514.


IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection.

Wallington JC, Williams AP, Staples KJ, Wilkinson TMA.

J Allergy Clin Immunol. 2018 Jun;141(6):2182-2195.e6. doi: 10.1016/j.jaci.2017.08.009. Epub 2017 Sep 1.


Factors Associated with Residential Long-Term Care Wait-List Placement in North West Ontario.

Laporte A, Rohit Dass A, Kuluski K, Peckham A, Berta W, Lum J, Williams AP.

Can J Aging. 2017 Sep;36(3):286-305. doi: 10.1017/S071498081700023X. Epub 2017 Jul 6.


A novel germline gain-of-function variant in PIK3CD.

Rae W, Gao Y, Ward D, Mattocks CJ, Eren E, Williams AP.

Clin Immunol. 2017 Aug;181:29-31. doi: 10.1016/j.clim.2017.05.020. Epub 2017 May 31. No abstract available.


Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease.

Rae W, Gao Y, Eren E, Döffinger R, Marshall B, Williams AP.

Case Reports Immunol. 2016;2016:9165641. Epub 2016 Nov 16.


IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus.

Drennan S, D'Avola A, Gao Y, Weigel C, Chrysostomou E, Steele AJ, Zenz T, Plass C, Johnson PW, Williams AP, Packham G, Stevenson FK, Oakes CC, Forconi F.

Leukemia. 2017 Aug;31(8):1686-1694. doi: 10.1038/leu.2016.356. Epub 2016 Nov 28.


Impact of anthropogenic climate change on wildfire across western US forests.

Abatzoglou JT, Williams AP.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11770-11775. Epub 2016 Oct 10.


Precision Molecular Diagnosis Defines Specific Therapy in Combined Immunodeficiency with Megaloblastic Anemia Secondary to MTHFD1 Deficiency.

Ramakrishnan KA, Pengelly RJ, Gao Y, Morgan M, Patel SV, Davies EG, Ennis S, Faust SN, Williams AP.

J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1160-1166.e10. doi: 10.1016/j.jaip.2016.07.014. Epub 2016 Oct 1.


Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort.

Coelho T, Andreoletti G, Ashton JJ, Batra A, Afzal NA, Gao Y, Williams AP, Beattie RM, Ennis S.

Sci Rep. 2016 Oct 5;6:34658. doi: 10.1038/srep34658.


What Gets in the Way of Person-Centred Care for People with Multimorbidity? Lessons from Ontario, Canada.

Kuluski K, Peckham A, Williams AP, Upshur RE.

Healthc Q. 2016;19(2):17-23.


Consultant outcomes publication and surgical training: Consensus recommendations by the association of surgeons in training.

Mohan HM, Gokani VJ, Williams AP, Harries RL; Council of the Association of Surgeons in Training.

Int J Surg. 2016 Nov;36 Suppl 1:S20-S23. doi: 10.1016/j.ijsu.2016.09.077. Epub 2016 Sep 20.


Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.

Gao Y, Arkwright PD, Carter R, Cazaly A, Harrison RJ, Mant A, Cant AJ, Gadola S, Elliott TJ, Khakoo SI, Williams AP.

J Allergy Clin Immunol. 2016 Dec;138(6):1733-1736.e2. doi: 10.1016/j.jaci.2016.06.029. Epub 2016 Jul 27. No abstract available.


Association of surgeons in training 40th anniversary conference: Liverpool #ASiT2016.

Harries RL, Williams AP, McElnay PJ, Gokani VJ; Association of Surgeons in Training Council.

Int J Surg. 2016 Nov;36 Suppl 1:S1-S4. doi: 10.1016/j.ijsu.2016.08.239. Epub 2016 Aug 23.


The future of surgical training in the context of the 'Shape of Training' Review: Consensus recommendations by the Association of Surgeons in Training.

Harries RL, Williams AP, Ferguson HJ, Mohan HM, Beamish AJ, Gokani VJ; Council of the Association of Surgeons in Training.

Int J Surg. 2016 Nov;36 Suppl 1:S5-S9. doi: 10.1016/j.ijsu.2016.08.238. Epub 2016 Aug 22.


Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

Coulter TI, Chandra A, Bacon CM, Babar J, Curtis J, Screaton N, Goodlad JR, Farmer G, Steele CL, Leahy TR, Doffinger R, Baxendale H, Bernatoniene J, Edgar JD, Longhurst HJ, Ehl S, Speckmann C, Grimbacher B, Sediva A, Milota T, Faust SN, Williams AP, Hayman G, Kucuk ZY, Hague R, French P, Brooker R, Forsyth P, Herriot R, Cancrini C, Palma P, Ariganello P, Conlon N, Feighery C, Gavin PJ, Jones A, Imai K, Ibrahim MA, Markelj G, Abinun M, Rieux-Laucat F, Latour S, Pellier I, Fischer A, Touzot F, Casanova JL, Durandy A, Burns SO, Savic S, Kumararatne DS, Moshous D, Kracker S, Vanhaesebroeck B, Okkenhaug K, Picard C, Nejentsev S, Condliffe AM, Cant AJ.

J Allergy Clin Immunol. 2017 Feb;139(2):597-606.e4. doi: 10.1016/j.jaci.2016.06.021. Epub 2016 Jul 16.


Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase δ syndrome.

Rae W, Ramakrishnan KA, Gao Y, Ashton-Key M, Pengelly RJ, Patel SV, Ennis S, Williams AP, Faust SN.

Clin Immunol. 2016 Oct;171:38-40. doi: 10.1016/j.clim.2016.07.017. Epub 2016 Jul 19. No abstract available.


Mucosal-Associated Invariant T (MAIT) Cells Are Impaired in Th17 Associated Primary and Secondary Immunodeficiencies.

Gao Y, Rae W, Ramakrishnan KA, Barcenas-Morales G, Döffinger R, Eren E, Faust SN, Ottensmeier CH, Williams AP.

PLoS One. 2016 May 11;11(5):e0155059. doi: 10.1371/journal.pone.0155059. eCollection 2016.


Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.

Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1208-1218.


Trends toward an earlier peak of the growing season in Northern Hemisphere mid-latitudes.

Xu C, Liu H, Williams AP, Yin Y, Wu X.

Glob Chang Biol. 2016 Aug;22(8):2852-60. doi: 10.1111/gcb.13224. Epub 2016 May 12.


Towards a Community-Based Dementia Care Strategy: How Do We Get There from Here?

Morton-Chang F, Williams AP, Berta W, Laporte A.

Healthc Pap. 2016;16(2):8-32.


Caring for Caregivers: Challenging the Assumptions.

Williams AP, Peckham A, Kuluski K, Lum J, Warrick N, Spalding K, Tam T, Bruce-Barrett C, Grasic M, Im J.

Healthc Pap. 2015;15(1):8-21.


Regulation of synthesis and roles of hyaluronan in peritoneal dialysis.

Bowen T, Meran S, Williams AP, Newbury LJ, Sauter M, Sitter T.

Biomed Res Int. 2015;2015:427038. doi: 10.1155/2015/427038. Epub 2015 Oct 13. Review.


FOREST ECOLOGY. Pervasive drought legacies in forest ecosystems and their implications for carbon cycle models.

Anderegg WR, Schwalm C, Biondi F, Camarero JJ, Koch G, Litvak M, Ogle K, Shaw JD, Shevliakova E, Williams AP, Wolf A, Ziaco E, Pacala S.

Science. 2015 Jul 31;349(6247):528-32. doi: 10.1126/science.aab1833.


Role of Innate T Cells in Anti-Bacterial Immunity.

Gao Y, Williams AP.

Front Immunol. 2015 Jun 11;6:302. doi: 10.3389/fimmu.2015.00302. eCollection 2015. Review.


Current and Future Environmental Balance of Small-Scale Run-of-River Hydropower.

Gallagher J, Styles D, McNabola A, Williams AP.

Environ Sci Technol. 2015 May 19;49(10):6344-51. doi: 10.1021/acs.est.5b00716. Epub 2015 May 6.


Caring for caregivers of high-needs children.

Peckham A, Spalding K, Watkins J, Bruce-Barrett C, Grasic M, Williams AP.

Healthc Q. 2014;17(3):30-5.


Caring for caregivers of high-needs older persons.

Warrick N, Peckham A, Watkins J, Padjen M, Williams AP.

Healthc Q. 2014;17(3):24-9.


The value of lumbar dorsal root ganglion blocks in predicting the response to decompressive surgery in patients with diagnostic doubt.

Williams AP, Germon T.

Spine J. 2015 Mar 2;15(3 Suppl):S44-9. doi: 10.1016/j.spinee.2015.01.004. Epub 2015 Jan 8.


Integrating physiological threshold experiments with climate modeling to project mangrove species' range expansion.

Cavanaugh KC, Parker JD, Cook-Patton SC, Feller IC, Williams AP, Kellner JR.

Glob Chang Biol. 2015 May;21(5):1928-38. doi: 10.1111/gcb.12843. Epub 2015 Feb 6.


Caring for Caregivers: Bridging the Care Gap.

Williams AP, Peckham A, Kuluski K, Lum J, Morton-Chang F.

Healthc Pap. 2015;15(1):62-6.


Global satellite monitoring of climate-induced vegetation disturbances.

McDowell NG, Coops NC, Beck PS, Chambers JQ, Gangodagamage C, Hicke JA, Huang CY, Kennedy R, Krofcheck DJ, Litvak M, Meddens AJ, Muss J, Negrón-Juarez R, Peng C, Schwantes AM, Swenson JJ, Vernon LJ, Williams AP, Xu C, Zhao M, Running SW, Allen CD.

Trends Plant Sci. 2015 Feb;20(2):114-23. doi: 10.1016/j.tplants.2014.10.008. Epub 2014 Dec 11. Review.


Use of transthoracic echocardiography in the evaluation of chest pain: illustrative cases and review of recent guidelines.

Aldwaik M, Williams AP, Le Feuvre S, Cowell R.

BMJ Case Rep. 2014 Dec 8;2014. pii: bcr2014205438. doi: 10.1136/bcr-2014-205438.


Upregulation of FcγRIIb on monocytes is necessary to promote the superagonist activity of TGN1412.

Hussain K, Hargreaves CE, Roghanian A, Oldham RJ, Chan HT, Mockridge CI, Chowdhury F, Frendéus B, Harper KS, Strefford JC, Cragg MS, Glennie MJ, Williams AP, French RR.

Blood. 2015 Jan 1;125(1):102-10. doi: 10.1182/blood-2014-08-593061. Epub 2014 Nov 13.


Immuno-genomic profiling of patients with inflammatory bowel disease: a systematic review of genetic and functional in vivo studies of implicated genes.

Coelho T, Andreoletti G, Ashton JJ, Pengelly RJ, Gao Y, RamaKrishnan A, Batra A, Beattie RM, Williams AP, Ennis S.

Inflamm Bowel Dis. 2014 Oct;20(10):1813-9. doi: 10.1097/MIB.0000000000000174. Review.


Reply: To PMID 24582167.

Gao Y, Gadola S, Grimbacher B, Williams AP.

J Allergy Clin Immunol. 2014 Oct;134(4):990. doi: 10.1016/j.jaci.2014.06.040. Epub 2014 Aug 23. No abstract available.


Multi-centre retrospective analysis of anaphylaxis during general anaesthesia in the United Kingdom: aetiology and diagnostic performance of acute serum tryptase.

Krishna MT, York M, Chin T, Gnanakumaran G, Heslegrave J, Derbridge C, Huissoon A, Diwakar L, Eren E, Crossman RJ, Khan N, Williams AP.

Clin Exp Immunol. 2014 Nov;178(2):399-404. doi: 10.1111/cei.12424.


A quantitative risk assessment for the safety of carcase storage systems for scrapie infected farms.

Adkin A, Jones DL, Eckford RL, Edwards-Jones G, Williams AP.

J Appl Microbiol. 2014 Oct;117(4):940-8. doi: 10.1111/jam.12596. Epub 2014 Jul 21.

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