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Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer.

Nair S, Trummell HQ, Rajbhandari R, Thudi NK, Nozell SE, Warram JM, Willey CD, Yang ES, Placzek WJ, Bonner JA, Bredel M.

PLoS One. 2020 Feb 18;15(2):e0229077. doi: 10.1371/journal.pone.0229077. eCollection 2020.


Focal Management of Large Brain Metastases and Risk of Leptomeningeal Disease.

Marcrom SR, Foreman PM, Colvin TB, McDonald AM, Kirkland RS, Popple RA, Riley KO, Markert JM, Willey CD, Bredel M, Fiveash JB.

Adv Radiat Oncol. 2019 Aug 5;5(1):34-42. doi: 10.1016/j.adro.2019.07.016. eCollection 2020 Jan-Feb.


Intratumoral spatial heterogeneity of BTK kinomic activity dictates distinct therapeutic response within a single glioblastoma tumor.

Ibrahim AN, Yamashita D, Anderson JC, Abdelrashid M, Alwakeal A, Estevez-Ordonez D, Komarova S, Markert JM, Goidts V, Willey CD, Nakano I.

J Neurosurg. 2019 Oct 18:1-12. doi: 10.3171/2019.7.JNS191376. [Epub ahead of print]


The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.

Aye JM, Stafman LL, Williams AP, Garner EF, Stewart JE, Anderson JC, Mruthyunjayappa S, Waldrop MG, Goolsby CD, Markert HR, Quinn C, Marayati R, Mroczek-Musulman E, Willey CD, Yoon KJ, Whelan KF, Beierle EA.

Oncotarget. 2019 Sep 17;10(53):5534-5548. doi: 10.18632/oncotarget.27165. eCollection 2019 Sep 17.


HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data.

Tran AN, Dussaq AM, Kennell T Jr, Willey CD, Hjelmeland AB.

BMC Bioinformatics. 2019 Sep 9;20(1):463. doi: 10.1186/s12859-019-3059-z.


A Novel Assay for Profiling GBM Cancer Model Heterogeneity and Drug Screening.

Stackhouse CT, Rowland JR, Shevin RS, Singh R, Gillespie GY, Willey CD.

Cells. 2019 Jul 11;8(7). pii: E702. doi: 10.3390/cells8070702.


Differential escape mechanisms in cetuximab-resistant head and neck cancer cells.

Willey CD, Anderson JC, Trummell HQ, Naji F, de Wijn R, Yang ES, Bredel M, Thudi NK, Bonner JA.

Biochem Biophys Res Commun. 2019 Sep 10;517(1):36-42. doi: 10.1016/j.bbrc.2019.06.159. Epub 2019 Jul 13.


Electromagnetic Transponder Based Tracking and Gating in the Radiotherapeutic Treatment of Thoracic Malignancies.

Boggs DH, Popple R, McDonald A, Minnich D, Willey CD, Spencer S, Shen S, Dobelbower MC.

Pract Radiat Oncol. 2019 Nov;9(6):456-464. doi: 10.1016/j.prro.2019.06.021. Epub 2019 Jul 5.


BEERE: a web server for biomedical entity expansion, ranking and explorations.

Yue Z, Willey CD, Hjelmeland AB, Chen JY.

Nucleic Acids Res. 2019 Jul 2;47(W1):W578-W586. doi: 10.1093/nar/gkz428.


Optical surface guidance for submillimeter monitoring of patient position during frameless stereotactic radiotherapy.

Covington EL, Fiveash JB, Wu X, Brezovich I, Willey CD, Riley K, Popple RA.

J Appl Clin Med Phys. 2019 Jun;20(6):91-98. doi: 10.1002/acm2.12611. Epub 2019 May 16.


Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.

Eustace NJ, Anderson JC, Langford CP, Trummell HQ, Hicks PH, Jarboe JS, Mobley JA, Hjelmeland AB, Hackney JR, Pedersen RT, Cosby K, Gillespie GY, Bonner JA, Willey CD.

Int J Oncol. 2019 Jun;54(6):2039-2053. doi: 10.3892/ijo.2019.4766. Epub 2019 Mar 29.


Cancer Explant Models.

Stackhouse CT, Gillespie GY, Willey CD.

Curr Top Microbiol Immunol. 2019 Mar 20. doi: 10.1007/82_2019_157. [Epub ahead of print]


Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer.

Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK.

Cancer Res. 2019 Apr 15;79(8):1831-1843. doi: 10.1158/0008-5472.CAN-18-2636. Epub 2019 Feb 7.


Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection.

Barrett OC, Hackney JR, McDonald AM, Willey CD, Bredel M, Fiveash JB.

Int J Radiat Oncol Biol Phys. 2019 Feb 1;103(2):453-459. doi: 10.1016/j.ijrobp.2018.09.019. Epub 2018 Sep 22.


Kinomics toolbox-A web platform for analysis and viewing of kinomic peptide array data.

Dussaq AM, Kennell T Jr, Eustace NJ, Anderson JC, Almeida JS, Willey CD.

PLoS One. 2018 Aug 21;13(8):e0202139. doi: 10.1371/journal.pone.0202139. eCollection 2018.


Adjuvant anti-angiogenic therapy enhances chemotherapeutic uptake in a murine model of head and neck cancer.

Prince AC, Patel NG, Moore LS, McGee AS, Ahn JC, Willey CD, Carroll WR, Rosenthal EL, Warram JM.

J Drug Target. 2019 Feb;27(2):193-200. doi: 10.1080/1061186X.2018.1497040. Epub 2018 Aug 20.


Kinomic profiling of glioblastoma cells reveals PLCG1 as a target in restricted glucose.

Walker K, Boyd NH, Anderson JC, Willey CD, Hjelmeland AB.

Biomark Res. 2018 Jun 14;6:22. doi: 10.1186/s40364-018-0136-9. eCollection 2018.


Combinatorial Drug Testing in 3D Microtumors Derived from GBM Patient-Derived Xenografts Reveals Cytotoxic Synergy in Pharmacokinomics-informed Pathway Interactions.

Gilbert AN, Anderson JC, Duarte CW, Shevin RS, Langford CP, Singh R, Gillespie GY, Willey CD.

Sci Rep. 2018 May 30;8(1):8412. doi: 10.1038/s41598-018-26840-4.


Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death.

Britain CM, Holdbrooks AT, Anderson JC, Willey CD, Bellis SL.

J Ovarian Res. 2018 Feb 5;11(1):12. doi: 10.1186/s13048-018-0385-0.


Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.

Yamada K, Huang ZQ, Raska M, Reily C, Anderson JC, Suzuki H, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Tomino Y, Gharavi AG, Weinmann A, Julian BA, Willey CD, Novak J.

Kidney Int Rep. 2017 Jul 19;2(6):1194-1207. doi: 10.1016/j.ekir.2017.07.002. eCollection 2017 Nov.


Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease.

Foreman PM, Jackson BE, Singh KP, Romeo AK, Guthrie BL, Fisher WS, Riley KO, Markert JM, Willey CD, Bredel M, Fiveash JB.

J Clin Neurosci. 2018 Mar;49:48-55. doi: 10.1016/j.jocn.2017.12.009. Epub 2017 Dec 14.


Fractionated stereotactic radiation therapy for intact brain metastases.

Marcrom SR, McDonald AM, Thompson JW, Popple RA, Riley KO, Markert JM, Willey CD, Bredel M, Fiveash JB.

Adv Radiat Oncol. 2017 Jul 19;2(4):564-571. doi: 10.1016/j.adro.2017.07.006. eCollection 2017 Oct-Dec.


MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines.

Rohrbach TD, Jones RB, Hicks PH, Weaver AN, Cooper TS, Eustace NJ, Yang ES, Jarboe JS, Anderson JC, Willey CD.

Oncol Lett. 2017 Mar;13(3):1216-1222. doi: 10.3892/ol.2016.5550. Epub 2016 Dec 29.


Kinase analysis of penile squamous cell carcinoma on multiple platforms to identify potential therapeutic targets.

Yang ES, Willey CD, Mehta A, Crowley MR, Crossman DK, Chen D, Anderson JC, Naik G, Della Manna DL, Cooper TS, Sonpavde G.

Oncotarget. 2017 Mar 28;8(13):21710-21718. doi: 10.18632/oncotarget.15558.


Kinomic profiling identifies focal adhesion kinase 1 as a therapeutic target in advanced clear cell renal cell carcinoma.

Ghosh AP, Willey CD, Anderson JC, Welaya K, Chen D, Mehta A, Ghatalia P, Madan A, Naik G, Sudarshan S, Sonpavde G.

Oncotarget. 2017 Apr 25;8(17):29220-29232. doi: 10.18632/oncotarget.16352.


Primary Sellar Rhabdomyosarcoma Arising in Association With a Pituitary Adenoma.

Duncan VE, Nabors LB, Warren PP, Conry RM, Willey CD, Perry A, Riley KO, Hackney JR.

Int J Surg Pathol. 2016 Dec;24(8):753-756. Epub 2016 Jul 14.


Mechanistic Parameterization of the Kinomic Signal in Peptide Arrays.

Dussaq A, Anderson JC, Willey CD, Almeida JS.

J Proteomics Bioinform. 2016 May;9(5):151-157. Epub 2016 May 24.


Correction: Kinomic Profiling of Electromagnetic Navigational Bronchoscopy Specimens: A New Approach for Personalized Medicine.

Anderson JC, Minnich DJ, Dobelbower MC, Denton AJ, Dussaq AM, Gilbert AN, Rohrbach TD, Arafat W, Welaya K, Bonner JA, Willey CD.

PLoS One. 2016 Aug 24;11(8):e0161986. doi: 10.1371/journal.pone.0161986. eCollection 2016.


Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing.

Gilbert AN, Shevin RS, Anderson JC, Langford CP, Eustace N, Gillespie GY, Singh R, Willey CD.

J Vis Exp. 2016 Jun 9;(112). doi: 10.3791/54026.



Anderson JC, Taylor RB, Fiveash JB, de Wijn R, Gillespie GY, Willey CD.

Med Res Arch. 2015 Jul;2015(3). doi: 10.18103/mra.v0i3.104.


Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome.

Straka C, Ying J, Kong FM, Willey CD, Kaminski J, Kim DW.

Springerplus. 2016 Feb 29;5:229. doi: 10.1186/s40064-016-1900-7. eCollection 2016. Review.


The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization.

Rohrbach TD, Shah N, Jackson WP, Feeney EV, Scanlon S, Gish R, Khodadadi R, Hyde SO, Hicks PH, Anderson JC, Jarboe JS, Willey CD.

PLoS One. 2015 Oct 15;10(10):e0140870. doi: 10.1371/journal.pone.0140870. eCollection 2015.


Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition.

Bonner JA, Trummell HQ, Bonner AB, Willey CD, Bredel M, Yang ES.

BMC Cancer. 2015 Oct 12;15:673. doi: 10.1186/s12885-015-1679-x.


High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes.

Anderson JC, Willey CD, Mehta A, Welaya K, Chen D, Duarte CW, Ghatalia P, Arafat W, Madan A, Sudarshan S, Naik G, Grizzle WE, Choueiri TK, Sonpavde G.

PLoS One. 2015 Sep 25;10(9):e0139267. doi: 10.1371/journal.pone.0139267. eCollection 2015.


Patient-Derived Xenografts as a Model System for Radiation Research.

Willey CD, Gilbert AN, Anderson JC, Gillespie GY.

Semin Radiat Oncol. 2015 Oct;25(4):273-80. doi: 10.1016/j.semradonc.2015.05.008. Epub 2015 May 14. Review.


Hypofractionated stereotactic radiosurgery with concurrent bevacizumab for recurrent malignant gliomas: the University of Alabama at Birmingham experience.

Clark GM, McDonald AM, Nabors LB, Fathalla-Shaykh H, Han X, Willey CD, Markert JM, Guthrie BL, Bredel M, Fiveash JB.

Neurooncol Pract. 2014 Dec;1(4):172-177.


A Kinase-Independent Function of c-Src Mediates p130Cas Phosphorylation at the Serine-639 Site in Pressure Overloaded Myocardium.

Palanisamy AP, Suryakumar G, Panneerselvam K, Willey CD, Kuppuswamy D.

J Cell Biochem. 2015 Dec;116(12):2793-803. doi: 10.1002/jcb.25224.


Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.

Seu L, Sabbaj S, Duverger A, Wagner F, Anderson JC, Davies E, Wolschendorf F, Willey CD, Saag MS, Goepfert P, Kutsch O.

J Virol. 2015 Jul;89(13):6656-72. doi: 10.1128/JVI.00571-15. Epub 2015 Apr 15.


Kinomic profiling of electromagnetic navigational bronchoscopy specimens: a new approach for personalized medicine.

Anderson JC, Minnich DJ, Dobelbower MC, Denton AJ, Dussaq AM, Gilbert AN, Rohrbach TD, Arafat W, Welaya K, Bonner JA, Willey CD.

PLoS One. 2014 Dec 30;9(12):e116388. doi: 10.1371/journal.pone.0116388. eCollection 2014. Erratum in: PLoS One. 2016;11(8):e0161986.


Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity.

Rohrbach TD, Jarboe JS, Anderson JC, Trummell HQ, Hicks PH, Weaver AN, Yang ES, Oster RA, Deshane JS, Steele C, Siegal GP, Bonner JA, Willey CD.

Int J Oncol. 2015 Mar;46(3):1079-88. doi: 10.3892/ijo.2014.2799. Epub 2014 Dec 17.


The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways.

Isayeva T, Xu J, Ragin C, Dai Q, Cooper T, Carroll W, Dayan D, Vered M, Wenig B, Rosenthal E, Grizzle W, Anderson J, Willey CD, Yang ES, Brandwein-Gensler M.

Mod Pathol. 2015 May;28(5):631-53. doi: 10.1038/modpathol.2014.149. Epub 2014 Dec 19.


Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease.

Reily C, Ueda H, Huang ZQ, Mestecky J, Julian BA, Willey CD, Novak J.

J Immunol Res. 2014;2014:197548. doi: 10.1155/2014/197548. Epub 2014 Jul 23. Review.


Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines.

Anderson JC, Duarte CW, Welaya K, Rohrbach TD, Bredel M, Yang ES, Choradia NV, Thottassery JV, Yancey Gillespie G, Bonner JA, Willey CD.

Radiother Oncol. 2014 Jun;111(3):468-74. doi: 10.1016/j.radonc.2014.04.010. Epub 2014 May 8.


Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma.

Sonpavde G, Willey CD, Sudarshan S.

Expert Opin Investig Drugs. 2014 Mar;23(3):305-15. doi: 10.1517/13543784.2014.871259. Epub 2014 Jan 3. Review.


Mini-review: bmx kinase inhibitors for cancer therapy.

Jarboe JS, Dutta S, Velu SE, Willey CD.

Recent Pat Anticancer Drug Discov. 2013 Sep;8(3):228-38. Review.


MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma.

Jarboe JS, Anderson JC, Duarte CW, Mehta T, Nowsheen S, Hicks PH, Whitley AC, Rohrbach TD, McCubrey RO, Chiu S, Burleson TM, Bonner JA, Gillespie GY, Yang ES, Willey CD.

Clin Cancer Res. 2012 Jun 1;18(11):3030-41. doi: 10.1158/1078-0432.CCR-11-3091. Epub 2012 May 22.


Kinomic profiling approach identifies Trk as a novel radiation modulator.

Jarboe JS, Jaboin JJ, Anderson JC, Nowsheen S, Stanley JA, Naji F, Ruijtenbeek R, Tu T, Hallahan DE, Yang ES, Bonner JA, Willey CD.

Radiother Oncol. 2012 Jun;103(3):380-7. doi: 10.1016/j.radonc.2012.03.014. Epub 2012 May 5.


Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner.

Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, Mehta T, McCubrey RO, Khodarev NN, Weichselbaum RR, Gillespie GY.

PLoS One. 2012;7(1):e29653. doi: 10.1371/journal.pone.0029653. Epub 2012 Jan 5.


Treatment of small cell lung cancer with TRA-8 in combination with cisplatin and radiation.

Bonner JA, Willey CD, Yang ES, Dobelbower MC, Sanford LL, Bright SJ, Buchsbaum DJ, Raisch KP.

Radiother Oncol. 2011 Oct;101(1):183-9. doi: 10.1016/j.radonc.2011.05.083. Epub 2011 Jun 30.


Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma.

Bonner JA, Yang ES, Trummell HQ, Nowsheen S, Willey CD, Raisch KP.

Radiother Oncol. 2011 Jun;99(3):339-43. doi: 10.1016/j.radonc.2011.05.070. Epub 2011 Jun 23.


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