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Items: 1 to 50 of 53

1.

A novel form of glycolytic metabolism-dependent cardioprotection revealed by PKCα and β inhibition.

Brennan S, Chen S, Makwana S, Martin CA, Sims MW, Alonazi ASA, Willets JM, Squire IB, Rainbow RD.

J Physiol. 2019 Sep;597(17):4481-4501. doi: 10.1113/JP278332. Epub 2019 Jul 26.

PMID:
31241168
2.

Nociceptin/Orphanin FQ (N/OFQ) conjugated to ATTO594: a novel fluorescent probe for the N/OFQ (NOP) receptor.

Bird MF, Guerrini R, Willets JM, Thompson JP, Caló G, Lambert DG.

Br J Pharmacol. 2018 Dec;175(24):4496-4506. doi: 10.1111/bph.14504. Epub 2018 Nov 6.

3.

Differential regulation of β2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle.

Nash CA, Nelson CP, Mistry R, Moeller-Olsen C, Christofidou E, Challiss RAJ, Willets JM.

Cell Signal. 2018 Nov;51:86-98. doi: 10.1016/j.cellsig.2018.07.013. Epub 2018 Jul 31.

PMID:
30075183
4.

Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions.

Rainbow RD, Brennan S, Jackson R, Beech AJ, Bengreed A, Waldschmidt HV, Tesmer JJG, Challiss RAJ, Willets JM.

Mol Pharmacol. 2018 Sep;94(3):1079-1091. doi: 10.1124/mol.118.112524. Epub 2018 Jul 6.

5.

Reciprocal regulation of β2-adrenoceptor-activated cAMP response-element binding protein signalling by arrestin2 and arrestin3.

Pearce A, Sanders L, Brighton PJ, Rana S, Konje JC, Willets JM.

Cell Signal. 2017 Oct;38:182-191. doi: 10.1016/j.cellsig.2017.07.011. Epub 2017 Jul 18.

PMID:
28733084
6.

Validation of endogenous control reference genes for normalizing gene expression studies in endometrial carcinoma.

Ayakannu T, Taylor AH, Willets JM, Brown L, Lambert DG, McDonald J, Davies Q, Moss EL, Konje JC.

Mol Hum Reprod. 2015 Sep;21(9):723-35. doi: 10.1093/molehr/gav033. Epub 2015 Jun 29.

PMID:
26124453
7.

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.

Willets JM, Nash CA, Rainbow RD, Nelson CP, Challiss RA.

Am J Physiol Cell Physiol. 2015 Aug 1;309(3):C179-89. doi: 10.1152/ajpcell.00079.2015. Epub 2015 May 13.

8.

The evolving role of the endocannabinoid system in gynaecological cancer.

Ayakannu T, Taylor AH, Willets JM, Konje JC.

Hum Reprod Update. 2015 Jul-Aug;21(4):517-35. doi: 10.1093/humupd/dmv022. Epub 2015 May 9. Review.

PMID:
25958409
9.

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.

Brignell JL, Perry MD, Nelson CP, Willets JM, Challiss RA, Davies NW.

PLoS One. 2015 Mar 20;10(3):e0121285. doi: 10.1371/journal.pone.0121285. eCollection 2015.

10.

Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins.

Willets JM, Brighton PJ, Windell LN, Rana S, Nash CA, Konje JC.

Mol Cell Endocrinol. 2015 May 15;407:57-66. doi: 10.1016/j.mce.2015.03.004. Epub 2015 Mar 9.

PMID:
25766502
11.

Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality.

Amoako AA, Marczylo TH, Elson J, Taylor AH, Willets JM, Konje JC.

Fertil Steril. 2014 Nov;102(5):1260-7. doi: 10.1016/j.fertnstert.2014.07.767. Epub 2014 Sep 8.

PMID:
25212838
12.

Human urothelial cell lines as potential models for studying cannabinoid and excitatory receptor interactions in the urinary bladder.

Bakali E, Elliott RA, Taylor AH, Lambert DG, Willets JM, Tincello DG.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jun;387(6):581-9. doi: 10.1007/s00210-014-0973-5. Epub 2014 Mar 21.

PMID:
24652077
13.

The endocannabinoid system and sex steroid hormone-dependent cancers.

Ayakannu T, Taylor AH, Marczylo TH, Willets JM, Konje JC.

Int J Endocrinol. 2013;2013:259676. doi: 10.1155/2013/259676. Epub 2013 Nov 27. Review.

14.

Plasma anandamide and related n-acylethanolamide levels are not elevated in pregnancies complicated by hyperemesis gravidarum.

Gebeh AK, Willets JM, Marczylo TH, Konje JC.

J Matern Fetal Neonatal Med. 2014 Jun;27(9):954-9. doi: 10.3109/14767058.2013.847413. Epub 2013 Oct 22.

PMID:
24117326
15.

Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia.

Amoako AA, Marczylo TH, Marczylo EL, Elson J, Willets JM, Taylor AH, Konje JC.

Hum Reprod. 2013 Aug;28(8):2058-66. doi: 10.1093/humrep/det232. Epub 2013 May 21.

PMID:
23697839
16.

Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity.

Gebeh AK, Willets JM, Bari M, Hirst RA, Marczylo TH, Taylor AH, Maccarrone M, Konje JC.

J Clin Endocrinol Metab. 2013 Mar;98(3):1226-34. doi: 10.1210/jc.2012-3390. Epub 2013 Jan 31.

PMID:
23372171
17.

Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa.

Amoako AA, Gebeh AK, Marczylo EL, Willets JM, Elson J, Marczylo TH, Konje JC.

Andrologia. 2013 Aug;45(4):278-84. doi: 10.1111/and.12006. Epub 2012 Aug 29.

PMID:
22928818
18.

Ectopic pregnancy is associated with high anandamide levels and aberrant expression of FAAH and CB1 in fallopian tubes.

Gebeh AK, Willets JM, Marczylo EL, Taylor AH, Konje JC.

J Clin Endocrinol Metab. 2012 Aug;97(8):2827-35. doi: 10.1210/jc.2012-1780. Epub 2012 Jun 14.

PMID:
22701012
19.

Variation in stability of endogenous reference genes in fallopian tubes and endometrium from healthy and ectopic pregnant women.

Gebeh AK, Marczylo EL, Amoako AA, Willets JM, Konje JC.

Int J Mol Sci. 2012;13(3):2810-26. doi: 10.3390/ijms13032810. Epub 2012 Mar 2.

20.

Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.

Morris GE, Nelson CP, Brighton PJ, Standen NB, Challiss RA, Willets JM.

Am J Physiol Cell Physiol. 2012 Mar 1;302(5):C723-34. doi: 10.1152/ajpcell.00202.2011.. Epub 2011 Dec 7.

21.

The effect of the levonorgestrel-releasing intrauterine system, Mirena® on mast cell numbers in women with endometriosis undergoing symptomatic treatment.

Engemise SL, Willets JM, Emembolu JO, Konje JC.

Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):439-42. doi: 10.1016/j.ejogrb.2011.09.007. Epub 2011 Oct 21.

PMID:
22018831
22.

Approaches to study GPCR regulation in native systems.

Willets JM.

Methods Mol Biol. 2011;746:99-112. doi: 10.1007/978-1-61779-126-0_6.

PMID:
21607854
23.

Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.

Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB, Challiss RA.

Cardiovasc Res. 2011 Sep 1;91(4):694-702. doi: 10.1093/cvr/cvr137. Epub 2011 May 23.

24.

Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium.

Brighton PJ, Marczylo TH, Rana S, Konje JC, Willets JM.

Br J Pharmacol. 2011 Nov;164(5):1479-94. doi: 10.1111/j.1476-5381.2011.01425.x.

25.

Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system.

Engemise SL, Willets JM, Taylor AH, Emembolu JO, Konje JC.

Eur J Obstet Gynecol Reprod Biol. 2011 Jul;157(1):101-6. doi: 10.1016/j.ejogrb.2011.02.013. Epub 2011 Apr 5.

PMID:
21470761
26.

Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells.

Brighton PJ, Rana S, Challiss RJ, Konje JC, Willets JM.

Br J Pharmacol. 2011 Apr;162(7):1603-17. doi: 10.1111/j.1476-5381.2010.01173.x.

27.

Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry.

Amoako AA, Marczylo TH, Lam PM, Willets JM, Derry A, Elson J, Konje JC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 1;878(31):3231-7. doi: 10.1016/j.jchromb.2010.09.024. Epub 2010 Oct 1.

PMID:
21056015
28.

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.

Bambang KN, Karasu T, Gebeh A, Taylor AH, Marczylo TH, Lam P, Willets JM, Konje JC.

Pharmaceuticals (Basel). 2010 Sep 2;3(9):2910-2929. Review.

29.

G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling.

Morris GE, Nelson CP, Everitt D, Brighton PJ, Standen NB, Challiss RA, Willets JM.

Cardiovasc Res. 2011 Jan 1;89(1):193-203. doi: 10.1093/cvr/cvq249. Epub 2010 Aug 12.

30.

Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.

Morris GE, Nelson CP, Standen NB, Challiss RA, Willets JM.

Cardiovasc Res. 2010 Feb 1;85(3):424-33. doi: 10.1093/cvr/cvp310. Epub 2009 Sep 11.

31.

Characterization of anandamide-stimulated cannabinoid receptor signaling in human ULTR myometrial smooth muscle cells.

Brighton PJ, McDonald J, Taylor AH, Challiss RA, Lambert DG, Konje JC, Willets JM.

Mol Endocrinol. 2009 Sep;23(9):1415-27. doi: 10.1210/me.2009-0097. Epub 2009 May 28.

32.

Regulation of oxytocin receptor responsiveness by G protein-coupled receptor kinase 6 in human myometrial smooth muscle.

Willets JM, Brighton PJ, Mistry R, Morris GE, Konje JC, Challiss RA.

Mol Endocrinol. 2009 Aug;23(8):1272-80. doi: 10.1210/me.2009-0047. Epub 2009 May 7.

33.

Visualizing the temporal effects of vasoconstrictors on PKC translocation and Ca2+ signaling in single resistance arterial smooth muscle cells.

Nelson CP, Willets JM, Davies NW, Challiss RA, Standen NB.

Am J Physiol Cell Physiol. 2008 Dec;295(6):C1590-601. doi: 10.1152/ajpcell.00365.2008. Epub 2008 Oct 1.

34.

Selective regulation of H1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells.

Willets JM, Taylor AH, Shaw H, Konje JC, Challiss RA.

Mol Endocrinol. 2008 Aug;22(8):1893-907. doi: 10.1210/me.2007-0463. Epub 2008 May 29.

35.

The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons.

Willets JM, Nelson CP, Nahorski SR, Challiss RA.

J Neurochem. 2007 Dec;103(6):2268-80. Epub 2007 Oct 1.

36.

A single point mutation (N514Y) in the human M3 muscarinic acetylcholine receptor reveals differences in the properties of antagonists: evidence for differential inverse agonism.

Dowling MR, Willets JM, Budd DC, Charlton SJ, Nahorski SR, Challiss RA.

J Pharmacol Exp Ther. 2006 Jun;317(3):1134-42. Epub 2006 Feb 17.

PMID:
16489127
37.

Muscarinic acetylcholine receptor activation enhances hippocampal neuron excitability and potentiates synaptically evoked Ca(2+) signals via phosphatidylinositol 4,5-bisphosphate depletion.

Young KW, Billups D, Nelson CP, Johnston N, Willets JM, Schell MJ, Challiss RA, Nahorski SR.

Mol Cell Neurosci. 2005 Sep;30(1):48-57.

PMID:
15996483
39.

Synaptic activity augments muscarinic acetylcholine receptor-stimulated inositol 1,4,5-trisphosphate production to facilitate Ca2+ release in hippocampal neurons.

Nash MS, Willets JM, Billups B, John Challiss RA, Nahorski SR.

J Biol Chem. 2004 Nov 19;279(47):49036-44. Epub 2004 Sep 1.

41.

Non-visual GRKs: are we seeing the whole picture?

Willets JM, Challiss RA, Nahorski SR.

Trends Pharmacol Sci. 2003 Dec;24(12):626-33. Review.

PMID:
14654303
42.
43.
44.

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

Young KW, Willets JM, Parkinson MJ, Bartlett P, Spiegel S, Nahorski SR, Challiss RA.

Cell Calcium. 2003 Feb;33(2):119-28.

PMID:
12531188
45.
46.
48.

Neurotoxicity of 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) and effects on catecholamine homeostasis in SH-SY5Y cells.

Willets JM, Lambert DG, Lunec J, Griffiths HR, Phillipson O.

Environ Toxicol Pharmacol. 1996 Aug 15;2(1):59-68.

PMID:
21781702
49.

Effects of propofol and thiopentone on potassium- and carbachol-evoked [3H]noradrenaline release and increased [Ca2+]i from SH-SY5Y human neuroblastoma cells.

Lambert DG, Willets JM, Atcheson R, Frost C, Smart D, Rowbotham DJ, Smith G.

Biochem Pharmacol. 1996 Jun 28;51(12):1613-21.

PMID:
8687476
50.

Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.

Willets JM, Lambert DG, Lunec J, Griffiths HR.

Eur J Pharmacol. 1995 Dec 7;293(4):319-26.

PMID:
8748684

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