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Items: 24

1.

Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

Małecki J, Willemen HLDM, Pinto R, Ho AYY, Moen A, Eijkelkamp N, Falnes PØ.

J Biol Chem. 2019 Jun 18. pii: jbc.RA119.009045. doi: 10.1074/jbc.RA119.009045. [Epub ahead of print]

2.

Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

Małecki JM, Willemen HLDM, Pinto R, Ho AYY, Moen A, Kjønstad IF, Burgering BMT, Zwartkruis F, Eijkelkamp N, Falnes PØ.

J Biol Chem. 2019 Jan 25;294(4):1128-1141. doi: 10.1074/jbc.RA118.005473. Epub 2018 Dec 10.

PMID:
30530489
3.

Identification of FAM173B as a protein methyltransferase promoting chronic pain.

Willemen HLDM, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen LJJ, Tromp J, Gonzalez Cano R, Zhou W, Jakobsson ME, Małecki J, Posthuma G, Habib AM, Heijnen CJ, Falnes PØ, Eijkelkamp N.

PLoS Biol. 2018 Feb 14;16(2):e2003452. doi: 10.1371/journal.pbio.2003452. eCollection 2018 Feb.

4.

Divergent roles of immune cells and their mediators in pain.

Raoof R, Willemen HLDM, Eijkelkamp N.

Rheumatology (Oxford). 2018 Mar 1;57(3):429-440. doi: 10.1093/rheumatology/kex308. Review.

5.

IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain.

Eijkelkamp N, Steen-Louws C, Hartgring SA, Willemen HL, Prado J, Lafeber FP, Heijnen CJ, Hack CE, van Roon JA, Kavelaars A.

J Neurosci. 2016 Jul 13;36(28):7353-63. doi: 10.1523/JNEUROSCI.0092-16.2016.

6.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

7.

Monocytes/Macrophages control resolution of transient inflammatory pain.

Willemen HL, Eijkelkamp N, Garza Carbajal A, Wang H, Mack M, Zijlstra J, Heijnen CJ, Kavelaars A.

J Pain. 2014 May;15(5):496-506. doi: 10.1016/j.jpain.2014.01.491.

8.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.

9.

Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.

Wang H, Heijnen CJ, van Velthoven CT, Willemen HL, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, Kavelaars A.

J Clin Invest. 2013 Dec;123(12):5023-34. doi: 10.1172/JCI66241. Epub 2013 Nov 15.

10.

Therapeutic potential of genetically modified mesenchymal stem cells after neonatal hypoxic-ischemic brain damage.

van Velthoven CT, Braccioli L, Willemen HL, Kavelaars A, Heijnen CJ.

Mol Ther. 2014 Mar;22(3):645-654. doi: 10.1038/mt.2013.260. Epub 2013 Oct 31.

11.

Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke.

van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM.

Stroke. 2013 May;44(5):1426-32. doi: 10.1161/STROKEAHA.111.000326. Epub 2013 Mar 28.

12.

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage.

Nijboer CH, Heijnen CJ, Degos V, Willemen HL, Gressens P, Kavelaars A.

Neurobiol Dis. 2013 Jun;54:206-15. doi: 10.1016/j.nbd.2012.12.013. Epub 2013 Jan 8.

13.

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.

Peters MJ, Broer L, Willemen HL, Eiriksdottir G, Hocking LJ, Holliday KL, Horan MA, Meulenbelt I, Neogi T, Popham M, Schmidt CO, Soni A, Valdes AM, Amin N, Dennison EM, Eijkelkamp N, Harris TB, Hart DJ, Hofman A, Huygen FJ, Jameson KA, Jones GT, Launer LJ, Kerkhof HJ, de Kruijf M, McBeth J, Kloppenburg M, Ollier WE, Oostra B, Payton A, Rivadeneira F, Smith BH, Smith AV, Stolk L, Teumer A, Thomson W, Uitterlinden AG, Wang K, van Wingerden SH, Arden NK, Cooper C, Felson D, Gudnason V, Macfarlane GJ, Pendleton N, Slagboom PE, Spector TD, Völzke H, Kavelaars A, van Duijn CM, Williams FM, van Meurs JB.

Ann Rheum Dis. 2013 Mar;72(3):427-36. doi: 10.1136/annrheumdis-2012-201742. Epub 2012 Sep 6.

14.

MicroRNA-124 as a novel treatment for persistent hyperalgesia.

Willemen HL, Huo XJ, Mao-Ying QL, Zijlstra J, Heijnen CJ, Kavelaars A.

J Neuroinflammation. 2012 Jun 25;9:143. doi: 10.1186/1742-2094-9-143.

15.

G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling.

Eijkelkamp N, Heijnen CJ, Carbajal AG, Willemen HL, Wang H, Minett MS, Wood JN, Schedlowski M, Dantzer R, Kelley KW, Kavelaars A.

Mol Med. 2012 May 9;18:556-64. doi: 10.2119/molmed.2011.00398.

16.

Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study.

van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Amarouchi K, Kavelaars A, Heijnen CJ.

Biol Psychiatry. 2012 Feb 15;71(4):309-16. doi: 10.1016/j.biopsych.2011.10.026. Epub 2011 Dec 2.

PMID:
22137507
17.

Microglial GRK2: a novel regulator of transition from acute to chronic pain.

Kavelaars A, Eijkelkamp N, Willemen HL, Wang H, Carbajal AG, Heijnen CJ.

Brain Behav Immun. 2011 Aug;25(6):1055-60. doi: 10.1016/j.bbi.2011.03.019. Epub 2011 Apr 5.

PMID:
21473908
18.

Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment.

van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Heijnen CJ, Kavelaars A.

Am J Psychiatry. 2011 Jan;168(1):89-96. doi: 10.1176/appi.ajp.2010.10050706. Epub 2010 Nov 15.

PMID:
21078706
19.

Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.

Eijkelkamp N, Wang H, Garza-Carbajal A, Willemen HL, Zwartkruis FJ, Wood JN, Dantzer R, Kelley KW, Heijnen CJ, Kavelaars A.

J Neurosci. 2010 Sep 22;30(38):12806-15. doi: 10.1523/JNEUROSCI.3142-10.2010.

20.

Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling.

Willemen HL, Eijkelkamp N, Wang H, Dantzer R, Dorn GW 2nd, Kelley KW, Heijnen CJ, Kavelaars A.

Pain. 2010 Sep;150(3):550-60. doi: 10.1016/j.pain.2010.06.015. Epub 2010 Jul 6.

21.

GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain.

Eijkelkamp N, Heijnen CJ, Willemen HL, Deumens R, Joosten EA, Kleibeuker W, den Hartog IJ, van Velthoven CT, Nijboer C, Nassar MA, Dorn GW 2nd, Wood JN, Kavelaars A.

J Neurosci. 2010 Feb 10;30(6):2138-49. doi: 10.1523/JNEUROSCI.5752-09.2010.

22.

Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice.

Nijboer CH, Heijnen CJ, Willemen HL, Groenendaal F, Dorn GW 2nd, van Bel F, Kavelaars A.

Brain Behav Immun. 2010 Mar;24(3):420-6. doi: 10.1016/j.bbi.2009.11.009. Epub 2009 Nov 22.

23.

Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus.

Brouns SJ, Turnbull AP, Willemen HL, Akerboom J, van der Oost J.

J Mol Biol. 2007 Aug 31;371(5):1249-60. Epub 2007 Jun 8.

PMID:
17610898
24.

Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.

Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J.

J Biol Chem. 2006 Sep 15;281(37):27378-88. Epub 2006 Jul 17.

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