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Items: 1 to 50 of 53

1.

Lack of β-amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo.

Vnencak M, Schölvinck ML, Schwarzacher SW, Deller T, Willem M, Jedlicka P.

Brain Struct Funct. 2019 Jan 30. doi: 10.1007/s00429-019-01836-6. [Epub ahead of print]

PMID:
30701309
2.

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C.

Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7.

PMID:
30617257
3.

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation.

Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A.

Theranostics. 2018 Sep 9;8(18):4957-4968. doi: 10.7150/thno.27868. eCollection 2018.

4.

Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis.

Krämer LM, Brettschneider J, Lennerz JK, Walcher D, Fang L, Rosenbohm A, Balakrishnan K, Benckendorff J, Möller P, Just S, Willem M, Ludolph AC, Thal DR.

Sci Rep. 2018 Nov 9;8(1):16594. doi: 10.1038/s41598-018-34808-7.

5.

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM.

Acta Neuropathol. 2018 Jul;136(1):19-40. doi: 10.1007/s00401-018-1846-7. Epub 2018 Apr 23.

PMID:
29687257
6.

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein.

Pousinha PA, Mouska X, Raymond EF, Gwizdek C, Dhib G, Poupon G, Zaragosi LE, Giudici C, Bethus I, Pacary E, Willem M, Marie H.

Elife. 2017 Jul 6;6. pii: e25659. doi: 10.7554/eLife.25659.

7.

Young microglia restore amyloid plaque clearance of aged microglia.

Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S.

EMBO J. 2017 Mar 1;36(5):583-603. doi: 10.15252/embj.201694591. Epub 2016 Dec 21.

8.

Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.

Seipold L, Damme M, Prox J, Rabe B, Kasparek P, Sedlacek R, Altmeppen H, Willem M, Boland B, Glatzel M, Saftig P.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230. doi: 10.1016/j.bbamcr.2016.11.003. Epub 2016 Nov 3.

9.

Proteolytic processing of Neuregulin-1.

Willem M.

Brain Res Bull. 2016 Sep;126(Pt 2):178-182. doi: 10.1016/j.brainresbull.2016.07.003. Epub 2016 Jul 5. Review.

PMID:
27393467
10.

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein.

Ben Halima S, Mishra S, Raja KMP, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L.

Cell Rep. 2016 Mar 8;14(9):2127-2141. doi: 10.1016/j.celrep.2016.01.076. Epub 2016 Feb 25.

11.

[Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets].

Busche MA, Staufenbiel M, Willem M, Haass C, Förstl H.

Nervenarzt. 2016 Nov;87(11):1163-1174. Review. German.

PMID:
26781314
12.

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.

J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.

13.

η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.

PMID:
26322584
14.

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C.

Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093.

15.

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P.

J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013.

16.

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.

Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C.

EMBO J. 2013 Jul 17;32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21.

17.

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C.

J Neurosci. 2013 May 1;33(18):7856-69. doi: 10.1523/JNEUROSCI.3372-12.2013.

18.

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes.

van Bebber F, Hruscha A, Willem M, Schmid B, Haass C.

J Neurochem. 2013 Nov;127(4):471-81. doi: 10.1111/jnc.12198. Epub 2013 Mar 11.

19.

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF.

EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.

20.

BACE1 dependent neuregulin processing: review.

Fleck D, Garratt AN, Haass C, Willem M.

Curr Alzheimer Res. 2012 Feb;9(2):178-83. Review.

PMID:
22455478
21.

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.

Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Müller WE.

Antioxid Redox Signal. 2012 Jun 15;16(12):1421-33. doi: 10.1089/ars.2011.4173. Epub 2012 Feb 28.

22.

Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.

Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C.

J Biol Chem. 2011 Dec 30;286(52):45063-72. doi: 10.1074/jbc.M111.296921. Epub 2011 Nov 7.

23.

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination.

Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M, Haass C, Möbius W, Nave KA, Schwab MH.

Glia. 2012 Feb;60(2):203-17. doi: 10.1002/glia.21255. Epub 2011 Nov 2.

24.

BACE1 Dependent Neuregulin Proteolysis.

Fleck D, Garratt AN, Haass C, Willem M.

Curr Alzheimer Res. 2011 May 23. [Epub ahead of print]

PMID:
21605034
25.

PLAYgrounds: effect of a PE playground program in primary schools on PA levels during recess in 6 to 12 year old children. Design of a prospective controlled trial.

Janssen M, Toussaint HM, Van Willem M, Verhagen EA.

BMC Public Health. 2011 May 8;11:282. doi: 10.1186/1471-2458-11-282.

26.

PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism.

Katsouri L, Parr C, Bogdanovic N, Willem M, Sastre M.

J Alzheimers Dis. 2011;25(1):151-62. doi: 10.3233/JAD-2011-101356.

PMID:
21358044
27.

Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C.

J Neurosci. 2011 Feb 2;31(5):1885-94. doi: 10.1523/JNEUROSCI.5757-10.2011.

28.

Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.

Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.

Neurodegener Dis. 2009;6(5-6):230-9. doi: 10.1159/000236902. Epub 2009 Sep 9.

PMID:
19738368
29.

Function, regulation and therapeutic properties of beta-secretase (BACE1).

Willem M, Lammich S, Haass C.

Semin Cell Dev Biol. 2009 Apr;20(2):175-82. doi: 10.1016/j.semcdb.2009.01.003. Epub 2009 Jan 20. Review.

PMID:
19429494
30.

Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.

Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9775-80. doi: 10.1073/pnas.0800507105. Epub 2008 Jul 14.

31.

Macrocyclic statine-based inhibitors of BACE-1.

Barazza A, Götz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L.

Chembiochem. 2007 Nov 23;8(17):2078-91.

PMID:
17963207
32.

Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.

Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhövd C, Reichert AS, Kretzschmar HA, Haass C, Herms J.

J Neurochem. 2007 Aug;102(4):1264-75.

PMID:
17763532
33.

Control of peripheral nerve myelination by the beta-secretase BACE1.

Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C.

Science. 2006 Oct 27;314(5799):664-6. Epub 2006 Sep 21.

34.
35.

Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.

Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L, Mayer U.

Hum Mol Genet. 2006 Mar 15;15(6):989-98. Epub 2006 Feb 13.

PMID:
16476707
36.

Basement membrane-dependent survival of retinal ganglion cells.

Halfter W, Willem M, Mayer U.

Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1000-9.

PMID:
15728558
37.
38.

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.

Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C.

J Biol Chem. 2004 Dec 17;279(51):53205-12. Epub 2004 Oct 12.

39.

Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice.

Porter JD, Merriam AP, Khanna S, Andrade FH, Richmonds CR, Leahy P, Cheng G, Karathanasis P, Zhou X, Kusner LL, Adams ME, Willem M, Mayer U, Kaminski HJ.

FASEB J. 2003 May;17(8):893-5. Epub 2003 Mar 28.

PMID:
12670877
40.

Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice.

Nawrotzki R, Willem M, Miosge N, Brinkmeier H, Mayer U.

Hum Mol Genet. 2003 Mar 1;12(5):483-95.

PMID:
12588796
41.

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.

Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C.

J Biol Chem. 2003 Feb 21;278(8):5531-8. Epub 2002 Dec 5.

42.

A critical function of the pial basement membrane in cortical histogenesis.

Halfter W, Dong S, Yip YP, Willem M, Mayer U.

J Neurosci. 2002 Jul 15;22(14):6029-40.

43.

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C.

EMBO Rep. 2002 Jul;3(7):688-94.

44.

A non-amyloidogenic function of BACE-2 in the secretory pathway.

Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J.

J Neurochem. 2002 Jun;81(5):1011-20.

45.

Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.

Willem M, Miosge N, Halfter W, Smyth N, Jannetti I, Burghart E, Timpl R, Mayer U.

Development. 2002 Jun;129(11):2711-22.

46.

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

Edbauer D, Willem M, Lammich S, Steiner H, Haass C.

J Biol Chem. 2002 Apr 19;277(16):13389-93. Epub 2002 Jan 23.

47.

Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis.

Flügel A, Berkowicz T, Ritter T, Labeur M, Jenne DE, Li Z, Ellwart JW, Willem M, Lassmann H, Wekerle H.

Immunity. 2001 May;14(5):547-60.

48.

Phosphorylation regulates intracellular trafficking of beta-secretase.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2001 May 4;276(18):14634-41. Epub 2001 Jan 29.

49.

Neuronal FasL induces cell death of encephalitogenic T lymphocytes.

Flügel A, Schwaiger FW, Neumann H, Medana I, Willem M, Wekerle H, Kreutzberg GW, Graeber MB.

Brain Pathol. 2000 Jul;10(3):353-64.

PMID:
10885654
50.

Maturation and pro-peptide cleavage of beta-secretase.

Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2000 Oct 6;275(40):30849-54.

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