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Items: 1 to 50 of 376

1.

Patient derived renal cell carcinoma xenografts exhibit distinct sensitivity patterns in response to antiangiogenic therapy and constitute a suitable tool for biomarker development.

Schueler J, Klingner K, Bug D, Zoeller C, Maier A, Dong M, Willecke K, Peille AL, Steiner E, Landesfeind M, Copland JA, Siegers GM, Haferkamp A, Boehm K, Tsaur I, Schneider M.

Oncotarget. 2018 Jul 24;9(57):30946-30961. doi: 10.18632/oncotarget.25697. eCollection 2018 Jul 24.

2.

Correction to: Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Press E, Alaga KC, Barr K, Shao Q, Bosen F, Willecke K, Laird DW.

Cell Death Dis. 2018 May 24;9(6):630. doi: 10.1038/s41419-018-0639-1.

3.

Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division.

Bickert A, Kern P, van Uelft M, Herresthal S, Ulas T, Gutbrod K, Breiden B, Degen J, Sandhoff K, Schultze JL, Dörmann P, Hartmann D, Bauer R, Willecke K.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):734-749. doi: 10.1016/j.bbalip.2018.04.006. Epub 2018 Apr 10.

PMID:
29653252
4.

Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.

Ströh S, Puller C, Swirski S, Hölzel MB, van der Linde LIS, Segelken J, Schultz K, Block C, Monyer H, Willecke K, Weiler R, Greschner M, Janssen-Bienhold U, Dedek K.

J Neurosci. 2018 Feb 21;38(8):2015-2028. doi: 10.1523/JNEUROSCI.0141-17.2018. Epub 2018 Jan 19.

5.

Connexin43, but not connexin30, contributes to adult neurogenesis in the dentate gyrus.

Zhang J, Griemsmann S, Wu Z, Dobrowolski R, Willecke K, Theis M, Steinhäuser C, Bedner P.

Brain Res Bull. 2018 Jan;136:91-100. doi: 10.1016/j.brainresbull.2017.07.001. Epub 2017 Jul 6.

PMID:
28689039
6.

Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.

Press E, Alaga KC, Barr K, Shao Q, Bosen F, Willecke K, Laird DW.

Cell Death Dis. 2017 Jun 1;8(6):e2845. doi: 10.1038/cddis.2017.234. Erratum in: Cell Death Dis. 2018 May 24;9(6):630.

7.

Physiologic regulation of heart rate and blood pressure involves connexin 36-containing gap junctions.

Lall VK, Bruce G, Voytenko L, Drinkhill M, Wellershaus K, Willecke K, Deuchars J, Deuchars SA.

FASEB J. 2017 Sep;31(9):3966-3977. doi: 10.1096/fj.201600919RR. Epub 2017 May 22.

8.

Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice.

Rieck M, Kremser C, Jobin K, Mettke E, Kurts C, Gräler M, Willecke K, Kolanus W.

Eur J Immunol. 2017 Apr;47(4):677-684. doi: 10.1002/eji.201646623. Epub 2017 Feb 27.

9.

Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies.

Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K.

Stem Cells. 2017 Apr;35(4):859-871. doi: 10.1002/stem.2545. Epub 2016 Dec 20.

10.

Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea.

Brüggen B, Kremser C, Bickert A, Ebel P, Vom Dorp K, Schultz K, Dörmann P, Willecke K, Dedek K.

Eur J Neurosci. 2016 Jul;44(1):1700-13. doi: 10.1111/ejn.13260. Epub 2016 Jun 1.

PMID:
27086873
11.

Fast skeletal myofibers of mdx mouse, model of Duchenne muscular dystrophy, express connexin hemichannels that lead to apoptosis.

Cea LA, Puebla C, Cisterna BA, Escamilla R, Vargas AA, Frank M, Martínez-Montero P, Prior C, Molano J, Esteban-Rodríguez I, Pascual I, Gallano P, Lorenzo G, Pian H, Barrio LC, Willecke K, Sáez JC.

Cell Mol Life Sci. 2016 Jul;73(13):2583-99. doi: 10.1007/s00018-016-2132-2. Epub 2016 Jan 23.

PMID:
26803842
12.

From Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome.

García IE, Bosen F, Mujica P, Pupo A, Flores-Muñoz C, Jara O, González C, Willecke K, Martínez AD.

J Invest Dermatol. 2016 Mar;136(3):574-83. doi: 10.1016/j.jid.2015.11.017. Epub 2016 Jan 8. Review.

13.

Quantified CSF antibody reactivity against myelin in multiple sclerosis.

Sun X, Bakhti M, Fitzner D, Schnaars M, Kruse N, Coskun Ü, Kremser C, Willecke K, Kappos L, Kuhle J, Simons M.

Ann Clin Transl Neurol. 2015 Nov 9;2(12):1116-23. doi: 10.1002/acn3.264. eCollection 2015 Dec.

14.

Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F.

Bosen F, Celli A, Crumrine D, vom Dorp K, Ebel P, Jastrow H, Dörmann P, Winterhager E, Mauro T, Willecke K.

FEBS Lett. 2015 Jul 8;589(15):1904-10. doi: 10.1016/j.febslet.2015.05.047. Epub 2015 Jun 9.

15.

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.

Eberle M, Ebel P, Mayer CA, Barthelmes J, Tafferner N, Ferreiros N, Ulshöfer T, Henke M, Foerch C, de Bazo AM, Grösch S, Geisslinger G, Willecke K, Schiffmann S.

Immunol Cell Biol. 2015 Oct;93(9):825-36. doi: 10.1038/icb.2015.47. Epub 2015 Apr 2.

PMID:
25833068
16.

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice.

Bickert A, Ginkel C, Kol M, vom Dorp K, Jastrow H, Degen J, Jacobs RL, Vance DE, Winterhager E, Jiang XC, Dörmann P, Somerharju P, Holthuis JC, Willecke K.

J Lipid Res. 2015 Apr;56(4):821-35. doi: 10.1194/jlr.M055269. Epub 2015 Feb 9. Erratum in: J Lipid Res. 2017 Apr;58(4):820.

17.

Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice.

Lübkemeier I, Bosen F, Kim JS, Sasse P, Malan D, Fleischmann BK, Willecke K.

Circ Cardiovasc Genet. 2015 Feb;8(1):21-9. doi: 10.1161/CIRCGENETICS.114.000793. Epub 2014 Dec 10.

PMID:
25504652
18.

Renal sulfatides: sphingoid base-dependent localization and region-specific compensation of CerS2-dysfunction.

Marsching C, Rabionet M, Mathow D, Jennemann R, Kremser C, Porubsky S, Bolenz C, Willecke K, Gröne HJ, Hopf C, Sandhoff R.

J Lipid Res. 2014 Nov;55(11):2354-69. doi: 10.1194/jlr.M051839. Epub 2014 Sep 29.

19.

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.

Eberle M, Ebel P, Wegner MS, Männich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, Geisslinger G, Grösch S, Schiffmann S.

Biochem Pharmacol. 2014 Nov 15;92(2):326-35. doi: 10.1016/j.bcp.2014.08.016. Epub 2014 Aug 27.

PMID:
25173988
20.

Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc.

Agullo-Pascual E, Lin X, Leo-Macias A, Zhang M, Liang FX, Li Z, Pfenniger A, Lübkemeier I, Keegan S, Fenyö D, Willecke K, Rothenberg E, Delmar M.

Cardiovasc Res. 2014 Nov 1;104(2):371-81. doi: 10.1093/cvr/cvu195. Epub 2014 Aug 18.

21.

Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells.

Griemsmann S, Höft SP, Bedner P, Zhang J, von Staden E, Beinhauer A, Degen J, Dublin P, Cope DW, Richter N, Crunelli V, Jabs R, Willecke K, Theis M, Seifert G, Kettenmann H, Steinhäuser C.

Cereb Cortex. 2015 Oct;25(10):3420-33. doi: 10.1093/cercor/bhu157. Epub 2014 Jul 17.

22.

Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.

Ebel P, Imgrund S, Vom Dorp K, Hofmann K, Maier H, Drake H, Degen J, Dörmann P, Eckhardt M, Franz T, Willecke K.

Biochem J. 2014 Jul 1;461(1):147-58. doi: 10.1042/BJ20131242.

PMID:
24738593
23.

The Clouston syndrome mutation connexin30 A88V leads to hyperproliferation of sebaceous glands and hearing impairments in mice.

Bosen F, Schütz M, Beinhauer A, Strenzke N, Franz T, Willecke K.

FEBS Lett. 2014 May 2;588(9):1795-801. doi: 10.1016/j.febslet.2014.03.040. Epub 2014 Mar 29.

24.

Cell-specific cre recombinase expression allows selective ablation of glutamate receptors from mouse horizontal cells.

Ströh S, Sonntag S, Janssen-Bienhold U, Schultz K, Cimiotti K, Weiler R, Willecke K, Dedek K.

PLoS One. 2013 Dec 12;8(12):e83076. doi: 10.1371/journal.pone.0083076. eCollection 2013.

25.

The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.

Lübkemeier I, Andrié R, Lickfett L, Bosen F, Stöckigt F, Dobrowolski R, Draffehn AM, Fregeac J, Schultze JL, Bukauskas FF, Schrickel JW, Willecke K.

J Mol Cell Cardiol. 2013 Dec;65:19-32. doi: 10.1016/j.yjmcc.2013.09.008. Epub 2013 Sep 21.

PMID:
24060583
26.

De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy.

Cea LA, Cisterna BA, Puebla C, Frank M, Figueroa XF, Cardozo C, Willecke K, Latorre R, Sáez JC.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16229-34. doi: 10.1073/pnas.1312331110. Epub 2013 Sep 16.

27.

Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities.

Ebel P, Vom Dorp K, Petrasch-Parwez E, Zlomuzica A, Kinugawa K, Mariani J, Minich D, Ginkel C, Welcker J, Degen J, Eckhardt M, Dere E, Dörmann P, Willecke K.

J Biol Chem. 2013 Jul 19;288(29):21433-47. doi: 10.1074/jbc.M113.479907. Epub 2013 Jun 12.

28.

Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes.

May D, Tress O, Seifert G, Willecke K.

J Neurosci. 2013 May 1;33(18):7985-96. doi: 10.1523/JNEUROSCI.5874-12.2013.

29.

Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues.

Kremser C, Klemm AL, van Uelft M, Imgrund S, Ginkel C, Hartmann D, Willecke K.

Histochem Cell Biol. 2013 Nov;140(5):533-47. doi: 10.1007/s00418-013-1091-z. Epub 2013 Apr 17.

PMID:
23591958
30.

The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels.

Riquelme MA, Cea LA, Vega JL, Boric MP, Monyer H, Bennett MV, Frank M, Willecke K, Sáez JC.

Neuropharmacology. 2013 Dec;75:594-603. doi: 10.1016/j.neuropharm.2013.03.022. Epub 2013 Apr 11.

PMID:
23583931
31.

Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels.

Lübkemeier I, Requardt RP, Lin X, Sasse P, Andrié R, Schrickel JW, Chkourko H, Bukauskas FF, Kim JS, Frank M, Malan D, Zhang J, Wirth A, Dobrowolski R, Mohler PJ, Offermanns S, Fleischmann BK, Delmar M, Willecke K.

Basic Res Cardiol. 2013 May;108(3):348. doi: 10.1007/s00395-013-0348-y. Epub 2013 Apr 5.

32.

Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone.

Khodosevich K, Zuccotti A, Kreuzberg MM, Le Magueresse C, Frank M, Willecke K, Monyer H.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20107-12. doi: 10.1073/pnas.1217103109. Epub 2012 Nov 19.

33.

Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension.

Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TA, Kurtz A, Willecke K, de Wit C.

Hypertension. 2012 Dec;60(6):1422-9. doi: 10.1161/HYPERTENSIONAHA.112.201194. Epub 2012 Oct 22.

PMID:
23090768
34.

Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes.

Ginkel C, Hartmann D, vom Dorp K, Zlomuzica A, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Rabionet M, Dere E, Dörmann P, Sandhoff K, Willecke K.

J Biol Chem. 2012 Dec 7;287(50):41888-902. doi: 10.1074/jbc.M112.413500. Epub 2012 Oct 16.

35.

Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart.

Frank M, Wirth A, Andrié RP, Kreuzberg MM, Dobrowolski R, Seifert G, Offermanns S, Nickenig G, Willecke K, Schrickel JW.

Circ Res. 2012 Dec 7;111(12):1528-38. doi: 10.1161/CIRCRESAHA.112.270561. Epub 2012 Sep 14.

PMID:
22982984
36.

Dual reporter approaches for identification of Cre efficacy and astrocyte heterogeneity.

Degen J, Dublin P, Zhang J, Dobrowolski R, Jokwitz M, Karram K, Trotter J, Jabs R, Willecke K, Steinhäuser C, Theis M.

FASEB J. 2012 Nov;26(11):4576-83. doi: 10.1096/fj.12-207183. Epub 2012 Aug 2.

PMID:
22859373
37.

Ablation of retinal horizontal cells from adult mice leads to rod degeneration and remodeling in the outer retina.

Sonntag S, Dedek K, Dorgau B, Schultz K, Schmidt KF, Cimiotti K, Weiler R, Löwel S, Willecke K, Janssen-Bienhold U.

J Neurosci. 2012 Aug 1;32(31):10713-24. doi: 10.1523/JNEUROSCI.0442-12.2012.

38.

Connexin45 is expressed in vascular smooth muscle but its function remains elusive.

Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C.

PLoS One. 2012;7(7):e42287. doi: 10.1371/journal.pone.0042287. Epub 2012 Jul 27.

39.

Changes in object recognition and anxiety-like behaviour in mice expressing a Cx47 mutation that causes Pelizaeus-Merzbacher-like disease.

Zlomuzica A, Tress O, Binder S, Rovira C, Willecke K, Dere E.

Dev Neurosci. 2012;34(2-3):277-87. Epub 2012 Jul 20.

PMID:
22832166
40.

Panglial gap junctional communication is essential for maintenance of myelin in the CNS.

Tress O, Maglione M, May D, Pivneva T, Richter N, Seyfarth J, Binder S, Zlomuzica A, Seifert G, Theis M, Dere E, Kettenmann H, Willecke K.

J Neurosci. 2012 May 30;32(22):7499-518. doi: 10.1523/JNEUROSCI.0392-12.2012.

41.

Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice.

Chapman RJ, Lall VK, Maxeiner S, Willecke K, Deuchars J, King AE.

Brain Struct Funct. 2013 May;218(3):751-65. doi: 10.1007/s00429-012-0426-1. Epub 2012 May 26.

42.

Extracellular Ca²⁺ acts as a mediator of communication from neurons to glia.

Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M.

Sci Signal. 2012 Jan 24;5(208):ra8. doi: 10.1126/scisignal.2002160.

43.

Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium.

Bao M, Kanter EM, Huang RY, Maxeiner S, Frank M, Zhang Y, Schuessler RB, Smith TW, Townsend RR, Rohrs HW, Berthoud VM, Willecke K, Laing JG, Yamada KA.

Channels (Austin). 2011 Nov-Dec;5(6):489-99. doi: 10.4161/chan.5.6.18523. Epub 2011 Nov 1.

44.

Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges.

Lynn BD, Tress O, May D, Willecke K, Nagy JI.

Eur J Neurosci. 2011 Dec;34(11):1783-93. doi: 10.1111/j.1460-9568.2011.07900.x. Epub 2011 Nov 18.

PMID:
22098503
45.

Loss of ceramide synthase 3 causes lethal skin barrier disruption.

Jennemann R, Rabionet M, Gorgas K, Epstein S, Dalpke A, Rothermel U, Bayerle A, van der Hoeven F, Imgrund S, Kirsch J, Nickel W, Willecke K, Riezman H, Gröne HJ, Sandhoff R.

Hum Mol Genet. 2012 Feb 1;21(3):586-608. doi: 10.1093/hmg/ddr494. Epub 2011 Oct 28.

PMID:
22038835
46.

Behavioral alterations and changes in Ca/calmodulin kinase II levels in the striatum of connexin36 deficient mice.

Zlomuzica A, Viggiano D, Degen J, Binder S, Ruocco LA, Sadile AG, Willecke K, Huston JP, Dere E.

Behav Brain Res. 2012 Jan 1;226(1):293-300. doi: 10.1016/j.bbr.2011.08.028. Epub 2011 Aug 25.

PMID:
21889545
47.

Connexin32 can restore hearing in connexin26 deficient mice.

Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, Willecke K.

Eur J Cell Biol. 2011 Oct;90(10):817-24. doi: 10.1016/j.ejcb.2011.05.001. Epub 2011 Aug 2.

PMID:
21813206
48.

Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2).

Dicke N, Pielensticker N, Degen J, Hecker J, Tress O, Bald T, Gellhaus A, Winterhager E, Willecke K.

J Cell Sci. 2011 Aug 15;124(Pt 16):2806-15. doi: 10.1242/jcs.084186.

49.

Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.

Tress O, Maglione M, Zlomuzica A, May D, Dicke N, Degen J, Dere E, Kettenmann H, Hartmann D, Willecke K.

PLoS Genet. 2011 Jul;7(7):e1002146. doi: 10.1371/journal.pgen.1002146. Epub 2011 Jul 7.

50.

The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.

Blankenship AG, Hamby AM, Firl A, Vyas S, Maxeiner S, Willecke K, Feller MB.

J Neurosci. 2011 Jul 6;31(27):9998-10008. doi: 10.1523/JNEUROSCI.5640-10.2011.

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