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Items: 49

1.

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function.

Thomas S, Mohammed F, Reijmers RM, Woolston A, Stauss T, Kennedy A, Stirling D, Holler A, Green L, Jones D, Matthews KK, Price DA, Chain BM, Heemskerk MHM, Morris EC, Willcox BE, Stauss HJ.

Nat Commun. 2019 Oct 1;10(1):4451. doi: 10.1038/s41467-019-12441-w.

2.

Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer.

Brooks JM, Menezes AN, Ibrahim M, Archer L, Lal N, Bagnall CJ, von Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul B, Ryan GB, Bao R, Khattri A, Lee SP, Ogbureke KUE, Middleton G, Tennant DA, Beggs AD, Deeks J, West CML, Cazier JB, Willcox BE, Seiwert TY, Mehanna H.

Clin Cancer Res. 2019 Sep 1;25(17):5315-5328. doi: 10.1158/1078-0432.CCR-18-3314. Epub 2019 Jun 10.

PMID:
31182433
3.

Human Vδ1+ T Cells in the Immune Response to Plasmodium falciparum Infection.

Hviid L, Smith-Togobo C, Willcox BE.

Front Immunol. 2019 Feb 14;10:259. doi: 10.3389/fimmu.2019.00259. eCollection 2019. Review.

4.

Publisher Correction: γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

Willcox BE, Willcox CR.

Nat Immunol. 2019 Apr;20(4):516. doi: 10.1038/s41590-019-0358-5.

PMID:
30816307
5.

γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

Willcox BE, Willcox CR.

Nat Immunol. 2019 Feb;20(2):121-128. doi: 10.1038/s41590-018-0304-y. Epub 2019 Jan 21. Review. Erratum in: Nat Immunol. 2019 Apr;20(4):516.

PMID:
30664765
6.

Application of the immunoregulatory receptor LILRB1 as a crystallisation chaperone for human class I MHC complexes.

Mohammed F, Stones DH, Willcox BE.

J Immunol Methods. 2019 Jan;464:47-56. doi: 10.1016/j.jim.2018.10.011. Epub 2018 Oct 24.

PMID:
30365927
7.

Vδ2+ T Cells-Two Subsets for the Price of One.

Davey MS, Willcox CR, Hunter S, Oo YH, Willcox BE.

Front Immunol. 2018 Sep 25;9:2106. doi: 10.3389/fimmu.2018.02106. eCollection 2018. Review. No abstract available.

8.

Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire.

Willcox CR, Davey MS, Willcox BE.

Front Immunol. 2018 Jul 2;9:1501. doi: 10.3389/fimmu.2018.01501. eCollection 2018. Review.

9.

Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations.

Hunter S, Willcox CR, Davey MS, Kasatskaya SA, Jeffery HC, Chudakov DM, Oo YH, Willcox BE.

J Hepatol. 2018 Sep;69(3):654-665. doi: 10.1016/j.jhep.2018.05.007. Epub 2018 May 18.

10.

The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets.

Davey MS, Willcox CR, Hunter S, Kasatskaya SA, Remmerswaal EBM, Salim M, Mohammed F, Bemelman FJ, Chudakov DM, Oo YH, Willcox BE.

Nat Commun. 2018 May 2;9(1):1760. doi: 10.1038/s41467-018-04076-0.

11.

Recasting Human Vδ1 Lymphocytes in an Adaptive Role.

Davey MS, Willcox CR, Baker AT, Hunter S, Willcox BE.

Trends Immunol. 2018 Jun;39(6):446-459. doi: 10.1016/j.it.2018.03.003. Epub 2018 Apr 18. Review.

12.

Synthesis and Biological Evaluation of ( E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses.

Davey MS, Malde R, Mykura RC, Baker AT, Taher TE, Le Duff CS, Willcox BE, Mehellou Y.

J Med Chem. 2018 Mar 8;61(5):2111-2117. doi: 10.1021/acs.jmedchem.7b01824. Epub 2018 Feb 23.

13.

ULBPs: regulators of human lymphocyte stress recognition.

Zuo J, Willcox BE, Moss P.

Oncotarget. 2017 Nov 13;8(63):106157-106158. doi: 10.18632/oncotarget.22417. eCollection 2017 Dec 5. No abstract available.

14.

KRAS Mutation and Consensus Molecular Subtypes 2 and 3 Are Independently Associated with Reduced Immune Infiltration and Reactivity in Colorectal Cancer.

Lal N, White BS, Goussous G, Pickles O, Mason MJ, Beggs AD, Taniere P, Willcox BE, Guinney J, Middleton GW.

Clin Cancer Res. 2018 Jan 1;24(1):224-233. doi: 10.1158/1078-0432.CCR-17-1090. Epub 2017 Oct 23.

15.

The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.

Mohammed F, Stones DH, Zarling AL, Willcox CR, Shabanowitz J, Cummings KL, Hunt DF, Cobbold M, Engelhard VH, Willcox BE.

Oncotarget. 2017 Apr 8;8(33):54160-54172. doi: 10.18632/oncotarget.16952. eCollection 2017 Aug 15.

16.

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.

Salim M, Knowles TJ, Baker AT, Davey MS, Jeeves M, Sridhar P, Wilkie J, Willcox CR, Kadri H, Taher TE, Vantourout P, Hayday A, Mehellou Y, Mohammed F, Willcox BE.

ACS Chem Biol. 2017 Oct 20;12(10):2631-2643. doi: 10.1021/acschembio.7b00694. Epub 2017 Sep 14.

17.

Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q.

Lal N, Willcox CR, Beggs A, Taniere P, Shikotra A, Bradding P, Adams R, Fisher D, Middleton G, Tselepis C, Willcox BE.

J Pathol Clin Res. 2017 Jul 14;3(3):155-170. doi: 10.1002/cjp2.70. eCollection 2017 Jul.

18.

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.

Khan KA, Naylor AJ, Khan A, Noy PJ, Mambretti M, Lodhia P, Athwal J, Korzystka A, Buckley CD, Willcox BE, Mohammed F, Bicknell R.

Oncogene. 2017 Nov 2;36(44):6097-6108. doi: 10.1038/onc.2017.214. Epub 2017 Jul 3.

19.

A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.

Zuo J, Willcox CR, Mohammed F, Davey M, Hunter S, Khan K, Antoun A, Katakia P, Croudace J, Inman C, Parry H, Briggs D, Malladi R, Willcox BE, Moss P.

Sci Signal. 2017 May 30;10(481). pii: eaai8904. doi: 10.1126/scisignal.aai8904.

PMID:
28559451
20.

Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2.

Marlin R, Pappalardo A, Kaminski H, Willcox CR, Pitard V, Netzer S, Khairallah C, Lomenech AM, Harly C, Bonneville M, Moreau JF, Scotet E, Willcox BE, Faustin B, Déchanet-Merville J.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3163-3168. doi: 10.1073/pnas.1621052114. Epub 2017 Mar 7.

21.

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.

Davey MS, Willcox CR, Joyce SP, Ladell K, Kasatskaya SA, McLaren JE, Hunter S, Salim M, Mohammed F, Price DA, Chudakov DM, Willcox BE.

Nat Commun. 2017 Mar 1;8:14760. doi: 10.1038/ncomms14760.

22.

Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression.

Salim M, Willcox CR, Mohammed F, Hayday AC, Overduin M, Willcox BE, Knowles TJ.

Biomol NMR Assign. 2016 Oct;10(2):357-60. doi: 10.1007/s12104-016-9700-0. Epub 2016 Aug 4.

23.

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.

Salim M, Knowles TJ, Hart R, Mohammed F, Woodward MJ, Willcox CR, Overduin M, Hayday AC, Willcox BE.

J Biol Chem. 2016 Apr 22;291(17):9310-21. doi: 10.1074/jbc.M116.722066. Epub 2016 Feb 25.

24.

An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy.

Lal N, Beggs AD, Willcox BE, Middleton GW.

Oncoimmunology. 2015 Apr 2;4(3):e976052. eCollection 2015 Mar.

25.

Resolving the mystery of pyrophosphate antigen presentation.

Willcox CR, Mohammed F, Willcox BE.

Nat Immunol. 2013 Sep;14(9):886-7. doi: 10.1038/ni.2689. No abstract available.

PMID:
23959177
26.

Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor.

Willcox CR, Pitard V, Netzer S, Couzi L, Salim M, Silberzahn T, Moreau JF, Hayday AC, Willcox BE, Déchanet-Merville J.

Nat Immunol. 2012 Sep;13(9):872-9. doi: 10.1038/ni.2394. Epub 2012 Aug 12.

PMID:
22885985
27.

Structural and energetic evidence for highly peptide-specific tumor antigen targeting via allo-MHC restriction.

Simpson AA, Mohammed F, Salim M, Tranter A, Rickinson AB, Stauss HJ, Moss PA, Steven NM, Willcox BE.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21176-81. doi: 10.1073/pnas.1108422109. Epub 2011 Dec 12.

28.

A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.

Montamat-Sicotte DJ, Millington KA, Willcox CR, Hingley-Wilson S, Hackforth S, Innes J, Kon OM, Lammas DA, Minnikin DE, Besra GS, Willcox BE, Lalvani A.

J Clin Invest. 2011 Jun;121(6):2493-503. doi: 10.1172/JCI46216. Epub 2011 May 16.

29.

Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance.

Cheng H, Mohammed F, Nam G, Chen Y, Qi J, Garner LI, Allen RL, Yan J, Willcox BE, Gao GF.

J Biol Chem. 2011 May 20;286(20):18013-25. doi: 10.1074/jbc.M111.221028. Epub 2011 Mar 30.

30.

Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition.

Nicholls S, Piper KP, Mohammed F, Dafforn TR, Tenzer S, Salim M, Mahendra P, Craddock C, van Endert P, Schild H, Cobbold M, Engelhard VH, Moss PA, Willcox BE.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3889-94. doi: 10.1073/pnas.0900411106. Epub 2009 Feb 20.

31.

Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self.

Mohammed F, Cobbold M, Zarling AL, Salim M, Barrett-Wilt GA, Shabanowitz J, Hunt DF, Engelhard VH, Willcox BE.

Nat Immunol. 2008 Nov;9(11):1236-43. doi: 10.1038/ni.1660. Epub 2008 Oct 5.

32.

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.

Dover LG, Bhatt A, Bhowruth V, Willcox BE, Besra GS.

Expert Rev Vaccines. 2008 May;7(4):481-97. doi: 10.1586/14760584.7.4.481. Review.

PMID:
18444894
33.

Structures and functions of microbial lipid antigens presented by CD1.

Willcox BE, Willcox CR, Dover LG, Besra G.

Curr Top Microbiol Immunol. 2007;314:73-110. Review.

PMID:
17593658
34.
35.

Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecules.

Antrobus RD, Khan N, Hislop AD, Montamat-Sicotte D, Garner LI, Rickinson AB, Moss PA, Willcox BE.

J Infect Dis. 2005 Jun 1;191(11):1842-53. Epub 2005 Apr 26.

PMID:
15871117
36.

Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor.

Willcox BE, Thomas LM, Bjorkman PJ.

Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3.

PMID:
12897781
37.
38.

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.

O'Callaghan CA, Cerwenka A, Willcox BE, Lanier LL, Bjorkman PJ.

Immunity. 2001 Aug;15(2):201-11.

39.

Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53.

Dorrell L, Willcox BE, Jones EY, Gillespie G, Njai H, Sabally S, Jaye A, DeGleria K, Rostron T, Lepin E, McMichael A, Whittle H, Rowland-Jones S.

Eur J Immunol. 2001 Jun;31(6):1747-56.

40.

Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.

Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK.

Nat Immunol. 2001 May;2(5):443-51.

PMID:
11323699
41.

Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalpha.

Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI, Jones EY, Van Der Merwe PA, Bell JI, Jakobsen BK.

J Biol Chem. 2000 May 19;275(20):15232-8.

42.

Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.

Willcox BE, Gao GF, Wyer JR, O'Callaghan CA, Boulter JM, Jones EY, van der Merwe PA, Bell JI, Jakobsen BK.

Protein Sci. 1999 Nov;8(11):2418-23.

43.

TCR binding to peptide-MHC stabilizes a flexible recognition interface.

Willcox BE, Gao GF, Wyer JR, Ladbury JE, Bell JI, Jakobsen BK, van der Merwe PA.

Immunity. 1999 Mar;10(3):357-65.

44.

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.

Wyer JR, Willcox BE, Gao GF, Gerth UC, Davis SJ, Bell JI, van der Merwe PA, Jakobsen BK.

Immunity. 1999 Feb;10(2):219-25.

45.

BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation.

O'callaghan CA, Byford MF, Wyer JR, Willcox BE, Jakobsen BK, McMichael AJ, Bell JI.

Anal Biochem. 1999 Jan 1;266(1):9-15.

PMID:
9887208
46.

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.

O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY.

Mol Cell. 1998 Mar;1(4):531-41.

47.

Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E.

O'Callaghan CA, Tormo J, Willcox BE, Blundell CD, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY.

Protein Sci. 1998 May;7(5):1264-6.

48.

Assembly and crystallization of the complex between the human T cell coreceptor CD8alpha homodimer and HLA-A2.

Gao GF, Gerth UC, Wyer JR, Willcox BE, O'Callaghan CA, Zhang Z, Jones EY, Bell JI, Jakobsen BK.

Protein Sci. 1998 May;7(5):1245-9.

49.

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.

Hopkins AL, Ren J, Esnouf RM, Willcox BE, Jones EY, Ross C, Miyasaka T, Walker RT, Tanaka H, Stammers DK, Stuart DI.

J Med Chem. 1996 Apr 12;39(8):1589-600.

PMID:
8648598

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