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Items: 1 to 50 of 263

1.

Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.

Krichel C, Möckel C, Schillinger O, Huesgen PF, Sticht H, Strodel B, Weiergräber OH, Willbold D, Neudecker P.

Sci Rep. 2019 Oct 2;9(1):14167. doi: 10.1038/s41598-019-48155-8.

2.

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents.

Perov S, Lidor O, Salinas N, Golan N, Tayeb-Fligelman E, Deshmukh M, Willbold D, Landau M.

PLoS Pathog. 2019 Aug 30;15(8):e1007978. doi: 10.1371/journal.ppat.1007978. eCollection 2019 Aug.

3.

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy.

Röder C, Vettore N, Mangels LN, Gremer L, Ravelli RBG, Willbold D, Hoyer W, Buell AK, Schröder GF.

Nat Commun. 2019 Aug 21;10(1):3754. doi: 10.1038/s41467-019-11320-8.

4.

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils.

Agerschou ED, Flagmeier P, Saridaki T, Galvagnion C, Komnig D, Heid L, Prasad V, Shaykhalishahi H, Willbold D, Dobson CM, Voigt A, Falkenburger B, Hoyer W, Buell AK.

Elife. 2019 Aug 21;8. pii: e46112. doi: 10.7554/eLife.46112.

5.

Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies.

Zhang T, Nagel-Steger L, Willbold D.

ChemistryOpen. 2019 Jul 22;8(7):989-994. doi: 10.1002/open.201900167. eCollection 2019 Jul.

6.

Do We Need Anti-Prion Compounds to Treat Alzheimer's Disease?

Willbold D, Kutzsche J.

Molecules. 2019 Jun 15;24(12). pii: E2237. doi: 10.3390/molecules24122237. Review.

7.

Interference with Amyloid-β Nucleation by Transient Ligand Interaction.

Zhang T, Loschwitz J, Strodel B, Nagel-Steger L, Willbold D.

Molecules. 2019 Jun 5;24(11). pii: E2129. doi: 10.3390/molecules24112129.

8.

Autophagy-Related Proteins GABARAP and LC3B Label Structures of Similar Size but Different Shape in Super-Resolution Imaging.

Abdollahzadeh I, Hendriks J, Sanwald JL, Simons IM, Hoffmann S, Weiergräber OH, Willbold D, Gensch T.

Molecules. 2019 May 13;24(9). pii: E1833. doi: 10.3390/molecules24091833.

9.

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers.

Elfgen A, Hupert M, Bochinsky K, Tusche M, González de San Román Martin E, Gering I, Sacchi S, Pollegioni L, Huesgen PF, Hartmann R, Santiago-Schübel B, Kutzsche J, Willbold D.

Sci Rep. 2019 Apr 5;9(1):5715. doi: 10.1038/s41598-019-41993-6.

10.

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.

Klinker S, Stindt S, Gremer L, Bode JG, Gertzen CGW, Gohlke H, Weiergräber OH, Hoffmann S, Willbold D.

J Biol Chem. 2019 May 3;294(18):7388-7402. doi: 10.1074/jbc.RA119.007656. Epub 2019 Mar 12.

PMID:
30862675
11.

The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels.

Simons IM, Mohrlüder J, Feederle R, Kremmer E, Zobel T, Dobner J, Bleffert N, Hoffmann S, Willbold D.

Sci Rep. 2019 Jan 24;9(1):526. doi: 10.1038/s41598-018-36717-1.

12.

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.

Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-Rosenkranz P, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, Pfeffer K, Beer-Hammer S, Willbold D, Koenig BW.

Sci Rep. 2019 Jan 10;9(1):54. doi: 10.1038/s41598-018-37185-3.

13.

Structural Studies of Autophagy-Related Proteins.

Schwarten M, Weiergräber OH, Petrović D, Strodel B, Willbold D.

Methods Mol Biol. 2019;1880:17-56. doi: 10.1007/978-1-4939-8873-0_2.

PMID:
30610688
14.

Integrated NMR, Fluorescence, and Molecular Dynamics Benchmark Study of Protein Mechanics and Hydrodynamics.

Möckel C, Kubiak J, Schillinger O, Kühnemuth R, Della Corte D, Schröder GF, Willbold D, Strodel B, Seidel CAM, Neudecker P.

J Phys Chem B. 2019 Feb 21;123(7):1453-1480. doi: 10.1021/acs.jpcb.8b08903. Epub 2019 Jan 8.

15.

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography.

Rusitzka KAK, Stephenson LT, Szczepaniak A, Gremer L, Raabe D, Willbold D, Gault B.

Sci Rep. 2018 Dec 4;8(1):17615. doi: 10.1038/s41598-018-36110-y.

16.

Zika virus NS2B/NS3 proteinase: A new target for an old drug - Suramin a lead compound for NS2B/NS3 proteinase inhibition.

Coronado MA, Eberle RJ, Bleffert N, Feuerstein S, Olivier DS, de Moraes FR, Willbold D, Arni RK.

Antiviral Res. 2018 Dec;160:118-125. doi: 10.1016/j.antiviral.2018.10.019. Epub 2018 Oct 28.

PMID:
30393012
17.

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2.

Schemmert S, Schartmann E, Honold D, Zafiu C, Ziehm T, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neurobiol Dis. 2019 Apr;124:36-45. doi: 10.1016/j.nbd.2018.10.021. Epub 2018 Nov 2.

18.

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation.

Viennet T, Wördehoff MM, Uluca B, Poojari C, Shaykhalishahi H, Willbold D, Strodel B, Heise H, Buell AK, Hoyer W, Etzkorn M.

Commun Biol. 2018 May 3;1:44. doi: 10.1038/s42003-018-0049-z. eCollection 2018.

19.

A d-enantiomeric peptide interferes with heteroassociation of amyloid-β oligomers and prion protein.

Rösener NS, Gremer L, Reinartz E, König A, Brener O, Heise H, Hoyer W, Neudecker P, Willbold D.

J Biol Chem. 2018 Oct 12;293(41):15748-15764. doi: 10.1074/jbc.RA118.003116. Epub 2018 Aug 21.

PMID:
30131337
20.

Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis.

Schulte M, Petrović D, Neudecker P, Hartmann R, Pietruszka J, Willbold S, Willbold D, Panwalkar V.

ACS Catal. 2018 May 4;8(5):3971-3984. doi: 10.1021/acscatal.7b04408. Epub 2018 Mar 27.

21.

Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.

22.

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.

Schemmert S, Schartmann E, Zafiu C, Kass B, Hartwig S, Lehr S, Bannach O, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Mol Neurobiol. 2019 Mar;56(3):2211-2223. doi: 10.1007/s12035-018-1209-3. Epub 2018 Jul 12.

23.

Mechanistic Basis of the Fast Dark Recovery of the Short LOV Protein DsLOV from Dinoroseobacter shibae.

Fettweiss T, Röllen K, Granzin J, Reiners O, Endres S, Drepper T, Willbold D, Jaeger KE, Batra-Safferling R, Krauss U.

Biochemistry. 2018 Aug 14;57(32):4833-4847. doi: 10.1021/acs.biochem.8b00645. Epub 2018 Jul 24.

PMID:
29989797
24.

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease.

Schartmann E, Schemmert S, Niemietz N, Honold D, Ziehm T, Tusche M, Elfgen A, Gering I, Brener O, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;64(3):859-873. doi: 10.3233/JAD-180165.

25.

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.

Donner L, Gremer L, Ziehm T, Gertzen CGW, Gohlke H, Willbold D, Elvers M.

Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30.

PMID:
29964150
26.

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers.

Ziehm T, Buell AK, Willbold D.

ACS Chem Neurosci. 2018 Nov 21;9(11):2679-2688. doi: 10.1021/acschemneuro.8b00132. Epub 2018 Jun 21.

PMID:
29893543
27.

Proline Restricts Loop I Conformation of the High Affinity WW Domain from Human Nedd4-1 to a Ligand Binding-Competent Type I β-Turn.

Schulte M, Panwalkar V, Freischem S, Willbold D, Dingley AJ.

J Phys Chem B. 2018 Apr 19;122(15):4219-4230. doi: 10.1021/acs.jpcb.7b11637. Epub 2018 Apr 10.

PMID:
29595969
28.

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice.

Dunkelmann T, Schemmert S, Honold D, Teichmann K, Butzküven E, Demuth HU, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;63(1):115-130. doi: 10.3233/JAD-170775.

29.

Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.

Cavini IA, Munte CE, Erlach MB, van Groen T, Kadish I, Zhang T, Ziehm T, Nagel-Steger L, Kutzsche J, Kremer W, Willbold D, Kalbitzer HR.

Chem Commun (Camb). 2018 Mar 27;54(26):3294-3297. doi: 10.1039/c8cc01458b.

PMID:
29537428
30.

Advancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases.

Kulawik A, Heise H, Zafiu C, Willbold D, Bannach O.

FEBS Lett. 2018 Feb;592(4):516-534. doi: 10.1002/1873-3468.12983. Epub 2018 Feb 8. Review.

31.

Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein.

Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C.

PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018.

32.

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27.

PMID:
29273382
33.

Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-β oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma.

Hupert M, Elfgen A, Schartmann E, Schemmert S, Buscher B, Kutzsche J, Willbold D, Santiago-Schübel B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:123-129. doi: 10.1016/j.jchromb.2017.12.009. Epub 2017 Dec 8.

PMID:
29248770
34.

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.

Schartmann E, Schemmert S, Ziehm T, Leithold LHE, Jiang N, Tusche M, Joni Shah N, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

Eur J Pharm Sci. 2018 Mar 1;114:93-102. doi: 10.1016/j.ejps.2017.12.005. Epub 2017 Dec 7.

PMID:
29225107
35.

Structure and interaction of Corynebacterium pseudotuberculosis cold shock protein A with Y-box single-stranded DNA fragment.

Caruso IP, Panwalkar V, Coronado MA, Dingley AJ, Cornélio ML, Willbold D, Arni RK, Eberle RJ.

FEBS J. 2018 Jan;285(2):372-390. doi: 10.1111/febs.14350. Epub 2017 Dec 29.

36.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

37.

Structural insights into ion conduction by channelrhodopsin 2.

Volkov O, Kovalev K, Polovinkin V, Borshchevskiy V, Bamann C, Astashkin R, Marin E, Popov A, Balandin T, Willbold D, Büldt G, Bamberg E, Gordeliy V.

Science. 2017 Nov 24;358(6366). pii: eaan8862. doi: 10.1126/science.aan8862.

PMID:
29170206
38.

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease.

Kutzsche J, Schemmert S, Tusche M, Neddens J, Rabl R, Jürgens D, Brener O, Willuweit A, Hutter-Paier B, Willbold D.

Molecules. 2017 Oct 10;22(10). pii: E1693. doi: 10.3390/molecules22101693.

39.

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways.

Dammers C, Schwarten M, Buell AK, Willbold D.

Chem Sci. 2017 Jul 1;8(7):4996-5004. doi: 10.1039/c6sc04797a. Epub 2017 May 5.

40.

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.

Wördehoff MM, Shaykhalishahi H, Groß L, Gremer L, Stoldt M, Buell AK, Willbold D, Hoyer W.

J Mol Biol. 2017 Oct 13;429(20):3018-3030. doi: 10.1016/j.jmb.2017.09.005. Epub 2017 Sep 13.

41.

The Atg8 Family of Proteins-Modulating Shape and Functionality of Autophagic Membranes.

Abdollahzadeh I, Schwarten M, Gensch T, Willbold D, Weiergräber OH.

Front Genet. 2017 Aug 28;8:109. doi: 10.3389/fgene.2017.00109. eCollection 2017. Review.

42.

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF.

Science. 2017 Oct 6;358(6359):116-119. doi: 10.1126/science.aao2825. Epub 2017 Sep 7.

43.

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.

Boeske A, Schwarten M, Ma P, Tusche M, Mötter J, Möller C, Neudecker P, Hoffmann S, Willbold D.

Sci Rep. 2017 Jul 20;7(1):5979. doi: 10.1038/s41598-017-06319-4.

44.

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs.

Elfgen A, Santiago-Schübel B, Gremer L, Kutzsche J, Willbold D.

Eur J Pharm Sci. 2017 Sep 30;107:203-207. doi: 10.1016/j.ejps.2017.07.015. Epub 2017 Jul 12.

PMID:
28711713
45.

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.

PMID:
28581708
46.

1H, 13C, and 15N backbone and sidechain resonance assignments of a monomeric variant of E. coli deoxyribose-5-phosphate aldolase.

Schulte M, Stoldt M, Neudecker P, Pietruszka J, Willbold D, Panwalkar V.

Biomol NMR Assign. 2017 Oct;11(2):197-201. doi: 10.1007/s12104-017-9747-6. Epub 2017 May 30.

PMID:
28560616
47.

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution.

Wolff M, Zhang-Haagen B, Decker C, Barz B, Schneider M, Biehl R, Radulescu A, Strodel B, Willbold D, Nagel-Steger L.

Sci Rep. 2017 May 30;7(1):2493. doi: 10.1038/s41598-017-02370-3.

48.

Fluorescence correlation spectroscopy reveals a cooperative unfolding of monomeric amyloid-β 42 with a low Gibbs free energy.

Schneider M, Walta S, Cadek C, Richtering W, Willbold D.

Sci Rep. 2017 May 19;7(1):2154. doi: 10.1038/s41598-017-02410-y.

49.

Mechanism of transmembrane signaling by sensor histidine kinases.

Gushchin I, Melnikov I, Polovinkin V, Ishchenko A, Yuzhakova A, Buslaev P, Bourenkov G, Grudinin S, Round E, Balandin T, Borshchevskiy V, Willbold D, Leonard G, Büldt G, Popov A, Gordeliy V.

Science. 2017 Jun 9;356(6342). pii: eaah6345. doi: 10.1126/science.aah6345. Epub 2017 May 18.

PMID:
28522691
50.

Multiple WW domains of Nedd4-1 undergo conformational exchange that is quenched upon peptide binding.

Panwalkar V, Neudecker P, Willbold D, Dingley AJ.

FEBS Lett. 2017 Jun;591(11):1573-1583. doi: 10.1002/1873-3468.12664. Epub 2017 May 22.

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