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Items: 1 to 50 of 252

1.

Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association.

Kukuk L, Dingley AJ, Granzin J, Nagel-Steger L, Thiagarajan-Rosenkranz P, Ciupka D, Hänel K, Batra-Safferling R, Pacheco V, Stoldt M, Pfeffer K, Beer-Hammer S, Willbold D, Koenig BW.

Sci Rep. 2019 Jan 10;9(1):54. doi: 10.1038/s41598-018-37185-3.

2.

Structural Studies of Autophagy-Related Proteins.

Schwarten M, Weiergräber OH, Petrović D, Strodel B, Willbold D.

Methods Mol Biol. 2019;1880:17-56. doi: 10.1007/978-1-4939-8873-0_2.

PMID:
30610688
3.

Integrated NMR, Fluorescence and MD Benchmark Study of Protein Mechanics and Hydrodynamics.

Möckel C, Kubiak J, Schillinger O, Kuehnemuth R, Della Corte D, Schröder GF, Willbold D, Strodel B, Seidel CAM, Neudecker P.

J Phys Chem B. 2018 Dec 10. doi: 10.1021/acs.jpcb.8b08903. [Epub ahead of print]

PMID:
30525615
4.

A near atomic-scale view at the composition of amyloid-beta fibrils by atom probe tomography.

Rusitzka KAK, Stephenson LT, Szczepaniak A, Gremer L, Raabe D, Willbold D, Gault B.

Sci Rep. 2018 Dec 4;8(1):17615. doi: 10.1038/s41598-018-36110-y.

5.

Zika virus NS2B/NS3 proteinase: A new target for an old drug - Suramin a lead compound for NS2B/NS3 proteinase inhibition.

Coronado MA, Eberle RJ, Bleffert N, Feuerstein S, Olivier DS, de Moraes FR, Willbold D, Arni RK.

Antiviral Res. 2018 Dec;160:118-125. doi: 10.1016/j.antiviral.2018.10.019. Epub 2018 Oct 28.

PMID:
30393012
6.

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2.

Schemmert S, Schartmann E, Honold D, Zafiu C, Ziehm T, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neurobiol Dis. 2018 Nov 2;124:36-45. doi: 10.1016/j.nbd.2018.10.021. [Epub ahead of print]

7.

Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation.

Viennet T, Wördehoff MM, Uluca B, Poojari C, Shaykhalishahi H, Willbold D, Strodel B, Heise H, Buell AK, Hoyer W, Etzkorn M.

Commun Biol. 2018 May 3;1:44. doi: 10.1038/s42003-018-0049-z. eCollection 2018.

8.

A d-enantiomeric peptide interferes with heteroassociation of amyloid-β oligomers and prion protein.

Rösener NS, Gremer L, Reinartz E, König A, Brener O, Heise H, Hoyer W, Neudecker P, Willbold D.

J Biol Chem. 2018 Oct 12;293(41):15748-15764. doi: 10.1074/jbc.RA118.003116. Epub 2018 Aug 21.

PMID:
30131337
9.

Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis.

Schulte M, Petrović D, Neudecker P, Hartmann R, Pietruszka J, Willbold S, Willbold D, Panwalkar V.

ACS Catal. 2018 May 4;8(5):3971-3984. doi: 10.1021/acscatal.7b04408. Epub 2018 Mar 27.

10.

Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.

11.

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer's Mice with Full-blown Pathology.

Schemmert S, Schartmann E, Zafiu C, Kass B, Hartwig S, Lehr S, Bannach O, Langen KJ, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Mol Neurobiol. 2018 Jul 12. doi: 10.1007/s12035-018-1209-3. [Epub ahead of print]

PMID:
30003517
12.

Mechanistic Basis of the Fast Dark Recovery of the Short LOV Protein DsLOV from Dinoroseobacter shibae.

Fettweiss T, Röllen K, Granzin J, Reiners O, Endres S, Drepper T, Willbold D, Jaeger KE, Batra-Safferling R, Krauss U.

Biochemistry. 2018 Aug 14;57(32):4833-4847. doi: 10.1021/acs.biochem.8b00645. Epub 2018 Jul 24.

PMID:
29989797
13.

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer's Disease.

Schartmann E, Schemmert S, Niemietz N, Honold D, Ziehm T, Tusche M, Elfgen A, Gering I, Brener O, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;64(3):859-873. doi: 10.3233/JAD-180165.

14.

Relevance of N-terminal residues for amyloid-β binding to platelet integrin αIIbβ3, integrin outside-in signaling and amyloid-β fibril formation.

Donner L, Gremer L, Ziehm T, Gertzen CGW, Gohlke H, Willbold D, Elvers M.

Cell Signal. 2018 Oct;50:121-130. doi: 10.1016/j.cellsig.2018.06.015. Epub 2018 Jun 30.

PMID:
29964150
15.

Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating d-Peptides in the Interaction with Amyloid-Beta Monomers.

Ziehm T, Buell AK, Willbold D.

ACS Chem Neurosci. 2018 Nov 21;9(11):2679-2688. doi: 10.1021/acschemneuro.8b00132. Epub 2018 Jun 21.

PMID:
29893543
16.

Proline Restricts Loop I Conformation of the High Affinity WW Domain from Human Nedd4-1 to a Ligand Binding-Competent Type I β-Turn.

Schulte M, Panwalkar V, Freischem S, Willbold D, Dingley AJ.

J Phys Chem B. 2018 Apr 19;122(15):4219-4230. doi: 10.1021/acs.jpcb.7b11637. Epub 2018 Apr 10.

PMID:
29595969
17.

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice.

Dunkelmann T, Schemmert S, Honold D, Teichmann K, Butzküven E, Demuth HU, Shah NJ, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

J Alzheimers Dis. 2018;63(1):115-130. doi: 10.3233/JAD-170775.

18.

Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.

Cavini IA, Munte CE, Erlach MB, van Groen T, Kadish I, Zhang T, Ziehm T, Nagel-Steger L, Kutzsche J, Kremer W, Willbold D, Kalbitzer HR.

Chem Commun (Camb). 2018 Mar 27;54(26):3294-3297. doi: 10.1039/c8cc01458b.

PMID:
29537428
19.

Advancements of the sFIDA method for oligomer-based diagnostics of neurodegenerative diseases.

Kulawik A, Heise H, Zafiu C, Willbold D, Bannach O.

FEBS Lett. 2018 Feb;592(4):516-534. doi: 10.1002/1873-3468.12983. Epub 2018 Feb 8. Review.

PMID:
29360176
20.

Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein.

Yerabham ASK, Müller-Schiffmann A, Ziehm T, Stadler A, Köber S, Indurkhya X, Marreiros R, Trossbach SV, Bradshaw NJ, Prikulis I, Willbold D, Weiergräber OH, Korth C.

PLoS One. 2018 Jan 11;13(1):e0191162. doi: 10.1371/journal.pone.0191162. eCollection 2018.

21.

Aβ oligomer eliminating compounds interfere successfully with pEAβ(3-42) induced motor neurodegenerative phenotype in transgenic mice.

Dunkelmann T, Teichmann K, Ziehm T, Schemmert S, Frenzel D, Tusche M, Dammers C, Jürgens D, Langen KJ, Demuth HU, Shah NJ, Kutzsche J, Willuweit A, Willbold D.

Neuropeptides. 2018 Feb;67:27-35. doi: 10.1016/j.npep.2017.11.011. Epub 2017 Nov 27.

PMID:
29273382
22.

Development and validation of an UHPLC-ESI-QTOF-MS method for quantification of the highly hydrophilic amyloid-β oligomer eliminating all-D-enantiomeric peptide RD2 in mouse plasma.

Hupert M, Elfgen A, Schartmann E, Schemmert S, Buscher B, Kutzsche J, Willbold D, Santiago-Schübel B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:123-129. doi: 10.1016/j.jchromb.2017.12.009. Epub 2017 Dec 8.

PMID:
29248770
23.

Comparison of blood-brain barrier penetration efficiencies between linear and cyclic all-d-enantiomeric peptides developed for the treatment of Alzheimer's disease.

Schartmann E, Schemmert S, Ziehm T, Leithold LHE, Jiang N, Tusche M, Joni Shah N, Langen KJ, Kutzsche J, Willbold D, Willuweit A.

Eur J Pharm Sci. 2018 Mar 1;114:93-102. doi: 10.1016/j.ejps.2017.12.005. Epub 2017 Dec 7.

PMID:
29225107
24.

Structure and interaction of Corynebacterium pseudotuberculosis cold shock protein A with Y-box single-stranded DNA fragment.

Caruso IP, Panwalkar V, Coronado MA, Dingley AJ, Cornélio ML, Willbold D, Arni RK, Eberle RJ.

FEBS J. 2018 Jan;285(2):372-390. doi: 10.1111/febs.14350. Epub 2017 Dec 29.

25.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

26.

Structural insights into ion conduction by channelrhodopsin 2.

Volkov O, Kovalev K, Polovinkin V, Borshchevskiy V, Bamann C, Astashkin R, Marin E, Popov A, Balandin T, Willbold D, Büldt G, Bamberg E, Gordeliy V.

Science. 2017 Nov 24;358(6366). pii: eaan8862. doi: 10.1126/science.aan8862.

PMID:
29170206
27.

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease.

Kutzsche J, Schemmert S, Tusche M, Neddens J, Rabl R, Jürgens D, Brener O, Willuweit A, Hutter-Paier B, Willbold D.

Molecules. 2017 Oct 10;22(10). pii: E1693. doi: 10.3390/molecules22101693.

28.

Pyroglutamate-modified Aβ(3-42) affects aggregation kinetics of Aβ(1-42) by accelerating primary and secondary pathways.

Dammers C, Schwarten M, Buell AK, Willbold D.

Chem Sci. 2017 Jul 1;8(7):4996-5004. doi: 10.1039/c6sc04797a. Epub 2017 May 5.

29.

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth.

Wördehoff MM, Shaykhalishahi H, Groß L, Gremer L, Stoldt M, Buell AK, Willbold D, Hoyer W.

J Mol Biol. 2017 Oct 13;429(20):3018-3030. doi: 10.1016/j.jmb.2017.09.005. Epub 2017 Sep 13.

30.

The Atg8 Family of Proteins-Modulating Shape and Functionality of Autophagic Membranes.

Abdollahzadeh I, Schwarten M, Gensch T, Willbold D, Weiergräber OH.

Front Genet. 2017 Aug 28;8:109. doi: 10.3389/fgene.2017.00109. eCollection 2017. Review.

31.

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

Gremer L, Schölzel D, Schenk C, Reinartz E, Labahn J, Ravelli RBG, Tusche M, Lopez-Iglesias C, Hoyer W, Heise H, Willbold D, Schröder GF.

Science. 2017 Oct 6;358(6359):116-119. doi: 10.1126/science.aao2825. Epub 2017 Sep 7.

32.

Direct binding to GABARAP family members is essential for HIV-1 Nef plasma membrane localization.

Boeske A, Schwarten M, Ma P, Tusche M, Mötter J, Möller C, Neudecker P, Hoffmann S, Willbold D.

Sci Rep. 2017 Jul 20;7(1):5979. doi: 10.1038/s41598-017-06319-4.

33.

Surprisingly high stability of the Aβ oligomer eliminating all-d-enantiomeric peptide D3 in media simulating the route of orally administered drugs.

Elfgen A, Santiago-Schübel B, Gremer L, Kutzsche J, Willbold D.

Eur J Pharm Sci. 2017 Sep 30;107:203-207. doi: 10.1016/j.ejps.2017.07.015. Epub 2017 Jul 12.

PMID:
28711713
34.

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.

PMID:
28581708
35.

1H, 13C, and 15N backbone and sidechain resonance assignments of a monomeric variant of E. coli deoxyribose-5-phosphate aldolase.

Schulte M, Stoldt M, Neudecker P, Pietruszka J, Willbold D, Panwalkar V.

Biomol NMR Assign. 2017 Oct;11(2):197-201. doi: 10.1007/s12104-017-9747-6. Epub 2017 May 30.

PMID:
28560616
36.

Aβ42 pentamers/hexamers are the smallest detectable oligomers in solution.

Wolff M, Zhang-Haagen B, Decker C, Barz B, Schneider M, Biehl R, Radulescu A, Strodel B, Willbold D, Nagel-Steger L.

Sci Rep. 2017 May 30;7(1):2493. doi: 10.1038/s41598-017-02370-3.

37.

Fluorescence correlation spectroscopy reveals a cooperative unfolding of monomeric amyloid-β 42 with a low Gibbs free energy.

Schneider M, Walta S, Cadek C, Richtering W, Willbold D.

Sci Rep. 2017 May 19;7(1):2154. doi: 10.1038/s41598-017-02410-y.

38.

Mechanism of transmembrane signaling by sensor histidine kinases.

Gushchin I, Melnikov I, Polovinkin V, Ishchenko A, Yuzhakova A, Buslaev P, Bourenkov G, Grudinin S, Round E, Balandin T, Borshchevskiy V, Willbold D, Leonard G, Büldt G, Popov A, Gordeliy V.

Science. 2017 Jun 9;356(6342). pii: eaah6345. doi: 10.1126/science.aah6345. Epub 2017 May 18.

PMID:
28522691
39.

Multiple WW domains of Nedd4-1 undergo conformational exchange that is quenched upon peptide binding.

Panwalkar V, Neudecker P, Willbold D, Dingley AJ.

FEBS Lett. 2017 Jun;591(11):1573-1583. doi: 10.1002/1873-3468.12664. Epub 2017 May 22.

40.

Pyroglutamate-Modified Amyloid-β(3-42) Shows α-Helical Intermediates before Amyloid Formation.

Dammers C, Reiss K, Gremer L, Lecher J, Ziehm T, Stoldt M, Schwarten M, Willbold D.

Biophys J. 2017 Apr 25;112(8):1621-1633. doi: 10.1016/j.bpj.2017.03.007.

41.

Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1.

Jaguva Vasudevan AA, Hofmann H, Willbold D, Häussinger D, Koenig BW, Münk C.

J Mol Biol. 2017 Apr 21;429(8):1171-1191. doi: 10.1016/j.jmb.2017.03.015. Epub 2017 Mar 16.

PMID:
28315663
42.

Investigating Structure and Dynamics of Atg8 Family Proteins.

Weiergräber OH, Schwarten M, Strodel B, Willbold D.

Methods Enzymol. 2017;587:115-142. doi: 10.1016/bs.mie.2016.09.056. Epub 2016 Dec 1. Review.

PMID:
28253952
43.

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.

Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C.

J Biol Chem. 2017 Apr 21;292(16):6468-6477. doi: 10.1074/jbc.M116.773903. Epub 2017 Mar 1.

44.

Erratum to: High-Resolution Structure of a Membrane Protein Transferred from Amphipol to a Lipidic Mesophase.

Polovinkin V, Gushchin I, Sintsov M, Round E, Balandin T, Chervakov P, Shevchenko V, Utrobin P, Popov A, Borshchevskiy V, Mishin A, Kuklin A, Willbold D, Chupin V, Popot JL, Gordeliy V.

J Membr Biol. 2017 Apr;250(2):237. doi: 10.1007/s00232-017-9949-y. No abstract available.

PMID:
28229180
45.

Structure of a LOV protein in apo-state and implications for construction of LOV-based optical tools.

Arinkin V, Granzin J, Röllen K, Krauss U, Jaeger KE, Willbold D, Batra-Safferling R.

Sci Rep. 2017 Feb 17;7:42971. doi: 10.1038/srep42971.

46.

Nanoparticle standards for immuno-based quantitation of α-synuclein oligomers in diagnostics of Parkinson's disease and other synucleinopathies.

Herrmann Y, Bujnicki T, Zafiu C, Kulawik A, Kühbach K, Peters L, Fabig J, Willbold J, Bannach O, Willbold D.

Clin Chim Acta. 2017 Mar;466:152-159. doi: 10.1016/j.cca.2017.01.010. Epub 2017 Jan 11.

PMID:
28088342
47.

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease.

Dammers C, Yolcu D, Kukuk L, Willbold D, Pickhardt M, Mandelkow E, Horn AH, Sticht H, Malhis MN, Will N, Schuster J, Funke SA.

PLoS One. 2016 Dec 22;11(12):e0167432. doi: 10.1371/journal.pone.0167432. eCollection 2016.

48.

High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs.

Thomaier M, Gremer L, Dammers C, Fabig J, Neudecker P, Willbold D.

Biochemistry. 2016 Dec 6;55(48):6662-6672. Epub 2016 Nov 18.

PMID:
27933798
49.

sFIDA automation yields sub-femtomolar limit of detection for Aβ aggregates in body fluids.

Herrmann Y, Kulawik A, Kühbach K, Hülsemann M, Peters L, Bujnicki T, Kravchenko K, Linnartz C, Willbold J, Zafiu C, Bannach O, Willbold D.

Clin Biochem. 2017 Mar;50(4-5):244-247. doi: 10.1016/j.clinbiochem.2016.11.001. Epub 2016 Nov 5.

PMID:
27823959
50.

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.

J Biol Chem. 2016 Dec 16;291(51):26364-26376. Epub 2016 Nov 4.

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