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Items: 1 to 50 of 57

1.

Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.

Zilber E, Martin GE, Willberg CB, Fox J, Nwokolo N, Fidler S, Frater J; CHERUB Investigators.

AIDS. 2019 Jun 1;33(7):1253-1256. doi: 10.1097/QAD.0000000000002165.

PMID:
31045943
2.

Corrigendum: Application of Blood Flow Restriction to Optimize Exercise Countermeasures for Human Space Flight.

Behringer M, Willberg C.

Front Physiol. 2019 Mar 26;10:276. doi: 10.3389/fphys.2019.00276. eCollection 2019.

3.

Application of Blood Flow Restriction to Optimize Exercise Countermeasures for Human Space Flight.

Behringer M, Willberg C.

Front Physiol. 2019 Jan 25;10:33. doi: 10.3389/fphys.2019.00033. eCollection 2019. Review. Erratum in: Front Physiol. 2019 Mar 26;10:276.

4.

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism.

Bánki Z, Krabbendam L, Klaver D, Leng T, Kruis S, Mehta H, Müllauer B, Orth-Höller D, Stoiber H, Willberg CB, Klenerman P.

Immunol Cell Biol. 2019 Jan 29. doi: 10.1111/imcb.12239. [Epub ahead of print]

PMID:
30695101
5.

Correction: Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2019 Mar;12(2):581. doi: 10.1038/s41385-018-0121-5.

PMID:
30518781
6.

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2018 Sep;11(5):1408-1419. doi: 10.1038/s41385-018-0049-9. Epub 2018 Jun 15. Erratum in: Mucosal Immunol. 2018 Dec 5;:.

7.

CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.

Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N, Lwanga J, Ramjee G, Kaleebu P, Porter K, Willberg CB, Klenerman P, Nwokolo N, Fox J, Fidler S, Frater J.

Front Immunol. 2018 May 4;9:928. doi: 10.3389/fimmu.2018.00928. eCollection 2018.

8.

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.

Kurioka A, Cosgrove C, Simoni Y, van Wilgenburg B, Geremia A, Björkander S, Sverremark-Ekström E, Thurnheer C, Günthard HF, Khanna N; Swiss HIV Cohort Study; Oxford IBD Cohort Investigators, Walker LJ, Arancibia-Cárcamo CV, Newell EW, Willberg CB, Klenerman P.

Front Immunol. 2018 Apr 9;9:486. doi: 10.3389/fimmu.2018.00486. eCollection 2018.

9.

Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis-Specific T-Cell Responses.

Murray LW, Satti I, Meyerowitz J, Jones M, Willberg CB, Ussher JE, Goedhals D, Hurst J, Phillips RE, McShane H, Vuuren CV, Frater J.

J Infect Dis. 2018 May 5;217(11):1782-1792. doi: 10.1093/infdis/jiy052.

10.

Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes.

Kurioka A, Klenerman P, Willberg CB.

Immunology. 2018 Mar 14. doi: 10.1111/imm.12925. [Epub ahead of print] Review.

11.

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation.

Zinser ME, Highton AJ, Kurioka A, Kronsteiner B, Hagel J, Leng T, Marchi E, Phetsouphanh C, Willberg CB, Dunachie SJ, Klenerman P.

Immunol Cell Biol. 2018 Jul;96(6):666-674. doi: 10.1111/imcb.12020. Epub 2018 Mar 9.

12.

MAIT cells and viruses.

Ussher JE, Willberg CB, Klenerman P.

Immunol Cell Biol. 2018 Jul;96(6):630-641. doi: 10.1111/imcb.12008. Epub 2018 Feb 10. Review.

13.

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets.

Kurioka A, Jahun AS, Hannaway RF, Walker LJ, Fergusson JR, Sverremark-Ekström E, Corbett AJ, Ussher JE, Willberg CB, Klenerman P.

Front Immunol. 2017 Aug 30;8:1031. doi: 10.3389/fimmu.2017.01031. eCollection 2017.

14.

HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.

Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR.

J Virol. 2017 Oct 27;91(22). pii: e00544-17. doi: 10.1128/JVI.00544-17. Print 2017 Nov 15.

15.

Expression of lectin-like transcript-1 in human tissues.

Llibre A, Garner L, Partridge A, Freeman GJ, Klenerman P, Willberg CB.

F1000Res. 2016 Dec 29;5:2929. doi: 10.12688/f1000research.10009.1. eCollection 2016.

16.

Erratum: MAIT cells: new guardians of the liver.

Kurioka A, Walker LJ, Klenerman P, Willberg CB.

Clin Transl Immunology. 2017 Feb 24;6(2):e132. doi: 10.1038/cti.2017.5. eCollection 2017 Feb.

17.

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.

Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P.

Sci Transl Med. 2016 Sep 28;8(358):358ra125. doi: 10.1126/scitranslmed.aag1048.

18.

MAIT cells: new guardians of the liver.

Kurioka A, Walker LJ, Klenerman P, Willberg CB.

Clin Transl Immunology. 2016 Aug 19;5(8):e98. doi: 10.1038/cti.2016.51. eCollection 2016 Aug. Review. Erratum in: Clin Transl Immunology. 2017 Feb 24;6(2):e132.

19.

Multi-functional lectin-like transcript-1: A new player in human immune regulation.

Llibre A, Klenerman P, Willberg CB.

Immunol Lett. 2016 Sep;177:62-9. doi: 10.1016/j.imlet.2016.07.007. Epub 2016 Jul 28. Review.

PMID:
27477771
20.

Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes.

Willberg CB, Garrison KE, Jones RB, Meiklejohn DA, Spotts G, Liegler TJ, Ostrowski MA, Karlsson AC, Hecht FM, Nixon DF.

PLoS One. 2016 Jul 25;11(7):e0160293. doi: 10.1371/journal.pone.0160293. eCollection 2016.

21.

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.

Hoffmann M, Pantazis N, Martin GE, Hickling S, Hurst J, Meyerowitz J, Willberg CB, Robinson N, Brown H, Fisher M, Kinloch S, Babiker A, Weber J, Nwokolo N, Fox J, Fidler S, Phillips R, Frater J; SPARTAC and CHERUB Investigators.

PLoS Pathog. 2016 Jul 14;12(7):e1005661. doi: 10.1371/journal.ppat.1005661. eCollection 2016 Jul.

22.

MAIT cells are activated during human viral infections.

van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L; STOP-HCV consortium, Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR, Klenerman P.

Nat Commun. 2016 Jun 23;7:11653. doi: 10.1038/ncomms11653.

23.

Human T cell responses to Japanese encephalitis virus in health and disease.

Turtle L, Bali T, Buxton G, Chib S, Chan S, Soni M, Hussain M, Isenman H, Fadnis P, Venkataswamy MM, Satishkumar V, Lewthwaite P, Kurioka A, Krishna S, Shankar MV, Ahmed R, Begum A, Ravi V, Desai A, Yoksan S, Fernandez S, Willberg CB, Kloverpris HN, Conlon C, Klenerman P, Satchidanandam V, Solomon T.

J Exp Med. 2016 Jun 27;213(7):1331-52. doi: 10.1084/jem.20151517. Epub 2016 May 30.

24.

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells.

Ussher JE, van Wilgenburg B, Hannaway RF, Ruustal K, Phalora P, Kurioka A, Hansen TH, Willberg CB, Phillips RE, Klenerman P.

Eur J Immunol. 2016 Jul;46(7):1600-14. doi: 10.1002/eji.201545969. Epub 2016 May 30.

25.

Subdominant Gag-specific anti-HIV efficacy in an HLA-B*57-positive elite controller.

Leitman EM, Willberg CB, De Burgh-Thomas A, Streeck H, Goulder PJ, Matthews PC.

AIDS. 2016 Mar 27;30(6):972-4. doi: 10.1097/QAD.0000000000001022. No abstract available.

26.

LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.

Llibre A, López-Macías C, Marafioti T, Mehta H, Partridge A, Kanzig C, Rivellese F, Galson JD, Walker LJ, Milne P, Phillips RE, Kelly DF, Freeman GJ, El Shikh ME, Klenerman P, Willberg CB.

J Immunol. 2016 Mar 1;196(5):2085-94. doi: 10.4049/jimmunol.1502462. Epub 2016 Feb 1.

27.

Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.

Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, Meyerowitz J, Willberg C, Koelsch KK, Robinson N, Brown H, Fisher M, Kinloch S, Cooper DA, Schechter M, Tambussi G, Fidler S, Babiker A, Weber J, Kelleher AD, Phillips RE, Frater J.

Nat Commun. 2015 Oct 9;6:8495. doi: 10.1038/ncomms9495.

28.

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

Fergusson JR, Hühn MH, Swadling L, Walker LJ, Kurioka A, Llibre A, Bertoletti A, Holländer G, Newell EW, Davis MM, Sverremark-Ekström E, Powrie F, Capone S, Folgori A, Barnes E, Willberg CB, Ussher JE, Klenerman P.

Mucosal Immunol. 2016 Mar;9(2):401-13. doi: 10.1038/mi.2015.69. Epub 2015 Jul 29.

29.

Molecular Analyses Define Vα7.2-Jα33+ MAIT Cell Depletion in HIV Infection: A Case-Control Study.

Ussher JE, Phalora P, Cosgrove C, Hannaway RF, Rauch A, Günthard HF, Goulder P, Phillips RE, Willberg CB, Klenerman P.

Medicine (Baltimore). 2015 Jul;94(29):e1134. doi: 10.1097/MD.0000000000001134.

30.

Macrophage infection via selective capture of HIV-1-infected CD4+ T cells.

Baxter AE, Russell RA, Duncan CJ, Moore MD, Willberg CB, Pablos JL, Finzi A, Kaufmann DE, Ochsenbauer C, Kappes JC, Groot F, Sattentau QJ.

Cell Host Microbe. 2014 Dec 10;16(6):711-21. doi: 10.1016/j.chom.2014.10.010. Epub 2014 Nov 20.

31.

CD161 defines a transcriptional and functional phenotype across distinct human T cell lineages.

Fergusson JR, Smith KE, Fleming VM, Rajoriya N, Newell EW, Simmons R, Marchi E, Björkander S, Kang YH, Swadling L, Kurioka A, Sahgal N, Lockstone H, Baban D, Freeman GJ, Sverremark-Ekström E, Davis MM, Davenport MP, Venturi V, Ussher JE, Willberg CB, Klenerman P.

Cell Rep. 2014 Nov 6;9(3):1075-88. doi: 10.1016/j.celrep.2014.09.045. Epub 2014 Oct 23.

32.

Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.

Ussher JE, Klenerman P, Willberg CB.

Front Immunol. 2014 Oct 8;5:450. doi: 10.3389/fimmu.2014.00450. eCollection 2014. Review.

33.

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.

Kurioka A, Ussher JE, Cosgrove C, Clough C, Fergusson JR, Smith K, Kang YH, Walker LJ, Hansen TH, Willberg CB, Klenerman P.

Mucosal Immunol. 2015 Mar;8(2):429-40. doi: 10.1038/mi.2014.81. Epub 2014 Oct 1.

34.

A mutation in X-linked inhibitor of apoptosis (G466X) leads to memory inflation of Epstein-Barr virus-specific T cells.

Lopez-Granados E, Stacey M, Kienzler AK, Sierro S, Willberg CB, Fox CP, Rigaud S, Long HM, Hislop AD, Rickinson AB, Patel S, Latour S, Klenerman P, Chapel H.

Clin Exp Immunol. 2014 Dec;178(3):470-82. doi: 10.1111/cei.12427.

35.

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.

Jo J, Tan AT, Ussher JE, Sandalova E, Tang XZ, Tan-Garcia A, To N, Hong M, Chia A, Gill US, Kennedy PT, Tan KC, Lee KH, De Libero G, Gehring AJ, Willberg CB, Klenerman P, Bertoletti A.

PLoS Pathog. 2014 Jun 26;10(6):e1004210. doi: 10.1371/journal.ppat.1004210. eCollection 2014 Jun.

36.

Mutant prolactin receptor and familial hyperprolactinemia.

Newey PJ, Gorvin CM, Cleland SJ, Willberg CB, Bridge M, Azharuddin M, Drummond RS, van der Merwe PA, Klenerman P, Bountra C, Thakker RV.

N Engl J Med. 2013 Nov 21;369(21):2012-2020. doi: 10.1056/NEJMoa1307557. Epub 2013 Nov 6.

37.

CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner.

Ussher JE, Bilton M, Attwod E, Shadwell J, Richardson R, de Lara C, Mettke E, Kurioka A, Hansen TH, Klenerman P, Willberg CB.

Eur J Immunol. 2014 Jan;44(1):195-203. doi: 10.1002/eji.201343509. Epub 2013 Oct 1.

38.

CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ.

Kang YH, Seigel B, Bengsch B, Fleming VM, Billerbeck E, Simmons R, Walker L, Willberg CB, Barnes EJ, Bhagwanani A, Oo YH, Blum HE, Adams DH, Thimme R, Klenerman P.

Front Immunol. 2012 Nov 20;3:346. doi: 10.3389/fimmu.2012.00346. eCollection 2012.

39.

Association of differentiation state of CD4+ T cells and disease progression in HIV-1 perinatally infected children.

Sharp ER, Willberg CB, Kuebler PJ, Abadi J, Fennelly GJ, Dobroszycki J, Wiznia AA, Rosenberg MG, Nixon DF.

PLoS One. 2012;7(1):e29154. doi: 10.1371/journal.pone.0029154. Epub 2012 Jan 11.

40.

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.

Barnes E, Folgori A, Capone S, Swadling L, Aston S, Kurioka A, Meyer J, Huddart R, Smith K, Townsend R, Brown A, Antrobus R, Ammendola V, Naddeo M, O'Hara G, Willberg C, Harrison A, Grazioli F, Esposito ML, Siani L, Traboni C, Oo Y, Adams D, Hill A, Colloca S, Nicosia A, Cortese R, Klenerman P.

Sci Transl Med. 2012 Jan 4;4(115):115ra1. doi: 10.1126/scitranslmed.3003155.

41.

Immunodominance of HIV-1 specific CD8+ T-cell responses is related to disease progression rate in vertically infected adolescents.

Sharp ER, Willberg CB, Kuebler PJ, Abadi J, Fennelly GJ, Dobroszycki J, Wiznia AA, Rosenberg MG, Nixon DF.

PLoS One. 2011;6(7):e21135. doi: 10.1371/journal.pone.0021135. Epub 2011 Jul 19.

42.

MHC-peptide tetramers for the analysis of antigen-specific T cells.

Sims S, Willberg C, Klenerman P.

Expert Rev Vaccines. 2010 Jul;9(7):765-74. doi: 10.1586/erv.10.66. Review.

PMID:
20624049
43.

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.

Willberg CB, Garrison KE, Jones RB, Meiklejohn DA, Spotts G, Liegler TJ, Ostrowski MA, Karlsson AC, Hecht FM, Nixon DF.

PLoS One. 2010 Apr 21;5(4):e10249. doi: 10.1371/journal.pone.0010249. Erratum in: PLoS One. 2016;11(7):e0160293. Meiklejohn, Duncan J [corrected to Meiklejohn, Duncan A].

44.

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties.

Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, Oo YH, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R, Klenerman P.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3006-11. doi: 10.1073/pnas.0914839107. Epub 2010 Jan 28.

45.

Immunity to HIV-1 is influenced by continued natural exposure to exogenous virus.

Willberg CB, McConnell JJ, Eriksson EM, Bragg LA, York VA, Liegler TJ, Hecht FM, Grant RM, Nixon DF.

PLoS Pathog. 2008 Oct;4(10):e1000185. doi: 10.1371/journal.ppat.1000185. Epub 2008 Oct 24.

46.

Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level.

Erickson AL, Willberg CB, McMahan V, Liu A, Buchbinder SP, Grohskopf LA, Grant RM, Nixon DF.

Clin Vaccine Immunol. 2008 Nov;15(11):1745-8. doi: 10.1128/CVI.00247-08. Epub 2008 Sep 24.

47.

Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha.

Willberg CB, Ward SM, Clayton RF, Naoumov NV, McCormick C, Proto S, Harris M, Patel AH, Klenerman P.

PLoS One. 2007 Aug 29;2(8):e791.

48.

Analysis of the relationship between cytokine secretion and proliferative capacity in hepatitis C virus infection.

Semmo N, Krashias G, Willberg C, Klenerman P.

J Viral Hepat. 2007 Jul;14(7):492-502.

PMID:
17576391
49.

Rational peptide selection to detect human immunodeficiency virus type 1-specific T-cell responses under resource-limited conditions.

Willberg CB, Pillai SK, Sharp ER, Rosenberg MG, Agudelo JD, Barbour JD, Nixon DF.

Clin Vaccine Immunol. 2007 Jun;14(6):785-8. Epub 2007 Apr 4.

50.

Treatment interruption in chronic HIV-1 infection: does it deliver?

Willberg CB, Nixon DF.

Curr Opin HIV AIDS. 2007 Jan;2(1):26-30. doi: 10.1097/COH.0b013e3280119307.

PMID:
19372862

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