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Items: 31


Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.

De Koker S, Van Hoecke L, De Beuckelaer A, Roose K, Deswarte K, Willart MA, Bogaert P, Naessens T, De Geest BG, Saelens X, Lambrecht BN, Grooten J.

Sci Rep. 2017 Jul 20;7(1):5986. doi: 10.1038/s41598-017-06236-6.


Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells.

Schuijs MJ, Willart MA, Vergote K, Gras D, Deswarte K, Ege MJ, Madeira FB, Beyaert R, van Loo G, Bracher F, von Mutius E, Chanez P, Lambrecht BN, Hammad H.

Science. 2015 Sep 4;349(6252):1106-10. doi: 10.1126/science.aac6623.


PAMPs and DAMPs in allergy exacerbation models.

Willart MA, Poulliot P, Lambrecht BN, Kool M.

Methods Mol Biol. 2013;1032:185-204. doi: 10.1007/978-1-62703-496-8_15.


Cytokine targets in airway inflammation.

Schuijs MJ, Willart MA, Hammad H, Lambrecht BN.

Curr Opin Pharmacol. 2013 Jun;13(3):351-61. doi: 10.1016/j.coph.2013.03.013. Epub 2013 May 2. Review.


The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β.

Gloudemans AK, Plantinga M, Guilliams M, Willart MA, Ozir-Fazalalikhan A, van der Ham A, Boon L, Harris NL, Hammad H, Hoogsteden HC, Yazdanbakhsh M, Hendriks RW, Lambrecht BN, Smits HH.

PLoS One. 2013;8(3):e59822. doi: 10.1371/journal.pone.0059822. Epub 2013 Mar 20.


Ursodeoxycholic acid suppresses eosinophilic airway inflammation by inhibiting the function of dendritic cells through the nuclear farnesoid X receptor.

Willart MA, van Nimwegen M, Grefhorst A, Hammad H, Moons L, Hoogsteden HC, Lambrecht BN, Kleinjan A.

Allergy. 2012 Dec;67(12):1501-10. doi: 10.1111/all.12019. Epub 2012 Sep 25.


Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.

Willart MA, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht BN, Hammad H.

J Exp Med. 2012 Jul 30;209(8):1505-17. doi: 10.1084/jem.20112691. Epub 2012 Jul 16.


Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.

De Geest BG, Willart MA, Lambrecht BN, Pollard C, Vervaet C, Remon JP, Grooten J, De Koker S.

Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3862-6. doi: 10.1002/anie.201200048. Epub 2012 Mar 12.


Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection.

De Geest BG, Willart MA, Hammad H, Lambrecht BN, Pollard C, Bogaert P, De Filette M, Saelens X, Vervaet C, Remon JP, Grooten J, De Koker S.

ACS Nano. 2012 Mar 27;6(3):2136-49. doi: 10.1021/nn205099c. Epub 2012 Feb 13.


An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma.

Kool M, Willart MA, van Nimwegen M, Bergen I, Pouliot P, Virchow JC, Rogers N, Osorio F, Reis e Sousa C, Hammad H, Lambrecht BN.

Immunity. 2011 Apr 22;34(4):527-40. doi: 10.1016/j.immuni.2011.03.015. Epub 2011 Apr 7. Erratum in: Immunity. 2011 Apr 22;34(4):627. Reis E Sousa, Caetano [corrected to Reis e Sousa, Caetano]..


Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis.

Festjens N, Bogaert P, Batni A, Houthuys E, Plets E, Vanderschaeghe D, Laukens B, Asselbergh B, Parthoens E, De Rycke R, Willart MA, Jacques P, Elewaut D, Brouckaert P, Lambrecht BN, Huygen K, Callewaert N.

EMBO Mol Med. 2011 Apr;3(4):222-34. doi: 10.1002/emmm.201000125. Epub 2011 Feb 16.


Designing polymeric particles for antigen delivery.

De Koker S, Lambrecht BN, Willart MA, van Kooyk Y, Grooten J, Vervaet C, Remon JP, De Geest BG.

Chem Soc Rev. 2011 Jan;40(1):320-39. doi: 10.1039/b914943k. Epub 2010 Nov 9. Review.


Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen.

Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M, Muskens F, Lambrecht BN.

J Exp Med. 2010 Sep 27;207(10):2097-111. doi: 10.1084/jem.20101563. Epub 2010 Sep 6.


Lentiviral gene therapy of murine hematopoietic stem cells ameliorates the Pompe disease phenotype.

van Til NP, Stok M, Aerts Kaya FS, de Waard MC, Farahbakhshian E, Visser TP, Kroos MA, Jacobs EH, Willart MA, van der Wegen P, Scholte BJ, Lambrecht BN, Duncker DJ, van der Ploeg AT, Reuser AJ, Verstegen MM, Wagemaker G.

Blood. 2010 Jul 1;115(26):5329-37. doi: 10.1182/blood-2009-11-252874. Epub 2010 Apr 12.


Alarming dendritic cells for allergic sensitization.

Willart MA, Hammad H.

Allergol Int. 2010 Jun;59(2):95-103. doi: 10.2332/allergolint.09-RAI-0162. Epub 2010 Feb 25. Review.


Diesel exhaust particles stimulate adaptive immunity by acting on pulmonary dendritic cells.

Provoost S, Maes T, Willart MA, Joos GF, Lambrecht BN, Tournoy KG.

J Immunol. 2010 Jan 1;184(1):426-32. doi: 10.4049/jimmunol.0902564. Epub 2009 Nov 30.


Studying the function of dendritic cells in mouse models of asthma.

Pouliot P, Willart MA, Hammad H, Lambrecht BN.

Methods Mol Biol. 2010;595:331-49. doi: 10.1007/978-1-60761-421-0_22.


The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen.

Willart MA, Jan de Heer H, Hammad H, Soullié T, Deswarte K, Clausen BE, Boon L, Hoogsteden HC, Lambrecht BN.

J Exp Med. 2009 Nov 23;206(12):2823-35. doi: 10.1084/jem.20082401. Epub 2009 Oct 26.


Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice.

GeurtsvanKessel CH, Willart MA, Bergen IM, van Rijt LS, Muskens F, Elewaut D, Osterhaus AD, Hendriks R, Rimmelzwaan GF, Lambrecht BN.

J Exp Med. 2009 Oct 26;206(11):2339-49. doi: 10.1084/jem.20090410. Epub 2009 Sep 28.


An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.

Kool M, van Nimwegen M, Willart MA, Muskens F, Boon L, Smit JJ, Coyle A, Clausen BE, Hoogsteden HC, Lambrecht BN, Hammad H.

J Immunol. 2009 Jul 15;183(2):1074-82. doi: 10.4049/jimmunol.0900471. Epub 2009 Jun 24.


Cholera toxin B suppresses allergic inflammation through induction of secretory IgA.

Smits HH, Gloudemans AK, van Nimwegen M, Willart MA, Soullié T, Muskens F, de Jong EC, Boon L, Pilette C, Johansen FE, Hoogsteden HC, Hammad H, Lambrecht BN.

Mucosal Immunol. 2009 Jul;2(4):331-9. doi: 10.1038/mi.2009.16. Epub 2009 Apr 29.


House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells.

Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN.

Nat Med. 2009 Apr;15(4):410-6. doi: 10.1038/nm.1946. Epub 2009 Mar 29.


Mechanism of action of clinically approved adjuvants.

Lambrecht BN, Kool M, Willart MA, Hammad H.

Curr Opin Immunol. 2009 Feb;21(1):23-9. doi: 10.1016/j.coi.2009.01.004. Epub 2009 Feb 24. Review.


Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis.

KleinJan A, Willart MA, Kuipers H, Coyle AJ, Hoogsteden HC, Lambrecht BN.

Transplantation. 2008 Nov 27;86(10):1436-44. doi: 10.1097/TP.0b013e3181886baa.


The danger within: endogenous danger signals, atopy and asthma.

Willart MA, Lambrecht BN.

Clin Exp Allergy. 2009 Jan;39(1):12-9. doi: 10.1111/j.1365-2222.2008.03118.x. Epub 2008 Oct 30. Review.


Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells.

GeurtsvanKessel CH, Willart MA, van Rijt LS, Muskens F, Kool M, Baas C, Thielemans K, Bennett C, Clausen BE, Hoogsteden HC, Osterhaus AD, Rimmelzwaan GF, Lambrecht BN.

J Exp Med. 2008 Jul 7;205(7):1621-34. doi: 10.1084/jem.20071365.


Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells.

Kool M, Soullié T, van Nimwegen M, Willart MA, Muskens F, Jung S, Hoogsteden HC, Hammad H, Lambrecht BN.

J Exp Med. 2008 Apr 14;205(4):869-82. doi: 10.1084/jem.20071087. Epub 2008 Mar 24.


Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection.

Smits HH, Hammad H, van Nimwegen M, Soullie T, Willart MA, Lievers E, Kadouch J, Kool M, Kos-van Oosterhoud J, Deelder AM, Lambrecht BN, Yazdanbakhsh M.

J Allergy Clin Immunol. 2007 Oct;120(4):932-40. Epub 2007 Aug 8.


Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.

Idzko M, Hammad H, van Nimwegen M, Kool M, Willart MA, Muskens F, Hoogsteden HC, Luttmann W, Ferrari D, Di Virgilio F, Virchow JC Jr, Lambrecht BN.

Nat Med. 2007 Aug;13(8):913-9. Epub 2007 Jul 15.


Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.

Idzko M, Hammad H, van Nimwegen M, Kool M, Müller T, Soullié T, Willart MA, Hijdra D, Hoogsteden HC, Lambrecht BN.

J Clin Invest. 2006 Nov;116(11):2935-44.


Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen.

de Heer HJ, Hammad H, Soullié T, Hijdra D, Vos N, Willart MA, Hoogsteden HC, Lambrecht BN.

J Exp Med. 2004 Jul 5;200(1):89-98.

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