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Items: 1 to 50 of 92

1.

Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation.

Lu J, Willars GB.

Biochem J. 2019 Feb 8;476(3):513-533. doi: 10.1042/BCJ20180853.

PMID:
30626614
2.

Ligand-Specific Signaling Profiles and Resensitization Mechanisms of the Neuromedin U2 Receptor.

Alhosaini K, Bahattab O, Qassam H, Challiss RAJ, Willars GB.

Mol Pharmacol. 2018 Jul;94(1):674-688. doi: 10.1124/mol.117.111070. Epub 2018 May 3.

PMID:
29724789
3.

Small lipidated anti-obesity compounds derived from neuromedin U.

Micewicz ED, Bahattab OS, Willars GB, Waring AJ, Navab M, Whitelegge JP, McBride WH, Ruchala P.

Eur J Med Chem. 2015 Aug 28;101:616-26. doi: 10.1016/j.ejmech.2015.07.020. Epub 2015 Jul 14.

4.

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA, Dowell SJ, Willars GB, Ladds G.

J Biol Chem. 2015 Sep 18;290(38):23009-22. doi: 10.1074/jbc.M114.624601. Epub 2015 Jul 21.

5.

British Pharmacological Society, 5th Focused Meeting on Cell Signalling: Matters arising ….

Willars GB, Tobin AB, Challiss RA.

Br J Pharmacol. 2015 Jul;172(13):3194-5. doi: 10.1111/bph.13171. No abstract available.

6.

The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels.

Martin KJ, Muessel MJ, Pullar CE, Willars GB, Wardlaw AJ.

PLoS One. 2015 Feb 6;10(2):e0116250. doi: 10.1371/journal.pone.0116250. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134924.

7.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

8.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

9.

Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at the GLP-1 receptor.

Li N, Lu J, Willars GB.

PLoS One. 2012;7(10):e47936. doi: 10.1371/journal.pone.0047936. Epub 2012 Oct 19.

10.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Bampton ET, Huang Y, Willars GB.

Methods Mol Biol. 2013;937:51-93.

PMID:
23007579
11.

Evidence that Ca2+ within the microdomain of the L-type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1.

Selway J, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP.

PLoS One. 2012;7(3):e33004. doi: 10.1371/journal.pone.0033004. Epub 2012 Mar 7.

12.

Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.

Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, Willars GB.

Mol Endocrinol. 2011 Oct;25(10):1804-18. doi: 10.1210/me.2011-1160. Epub 2011 Aug 25.

13.

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP.

Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6.

14.

Generation of epitope-tagged GPCRs.

Huang Y, Willars GB.

Methods Mol Biol. 2011;746:53-84. doi: 10.1007/978-1-61779-126-0_4.

PMID:
21607852
15.

PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells.

Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP.

Mol Endocrinol. 2011 Feb;25(2):315-26. doi: 10.1210/me.2010-0309. Epub 2010 Dec 30.

16.

Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor.

Coopman K, Huang Y, Johnston N, Bradley SJ, Wilkinson GF, Willars GB.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):795-808. doi: 10.1124/jpet.110.166009. Epub 2010 May 27.

17.

Characterization of the migration of lung and blood T cells in response CXCL12 in a three-dimensional matrix.

Day CE, Guillen C, Willars GB, Wardlaw AJ.

Immunology. 2010 Aug;130(4):564-71. doi: 10.1111/j.1365-2567.2010.03257.x. Epub 2010 Mar 17.

18.

Proinsulin C-peptide antagonizes the profibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways.

Hills CE, Willars GB, Brunskill NJ.

Mol Endocrinol. 2010 Apr;24(4):822-31. doi: 10.1210/me.2009-0391. Epub 2010 Mar 2.

19.

Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor.

Huang Y, Wilkinson GF, Willars GB.

Br J Pharmacol. 2010 Jan;159(1):237-51. doi: 10.1111/j.1476-5381.2009.00517.x. Epub 2009 Nov 27.

20.

Full and partial agonists of muscarinic M3 receptors reveal single and oscillatory Ca2+ responses by beta 2-adrenoceptors.

Kurian N, Hall CJ, Wilkinson GF, Sullivan M, Tobin AB, Willars GB.

J Pharmacol Exp Ther. 2009 Aug;330(2):502-12. doi: 10.1124/jpet.109.153619. Epub 2009 May 6.

21.

C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy.

Hills CE, Al-Rasheed N, Al-Rasheed N, Willars GB, Brunskill NJ.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F614-21. doi: 10.1152/ajprenal.90500.2008. Epub 2008 Dec 17.

22.

Elk-1, CREB, and MKP-1 regulate Egr-1 expression in gonadotropin-releasing hormone stimulated gonadotrophs.

Mayer SI, Willars GB, Nishida E, Thiel G.

J Cell Biochem. 2008 Dec 1;105(5):1267-78. doi: 10.1002/jcb.21927.

PMID:
18814180
23.

Insulin-like growth factor-I inhibits rat arterial K(ATP) channels through pI 3-kinase.

Hayabuchi Y, Willars GB, Standen NB, Davies NW.

Biochem Biophys Res Commun. 2008 Oct 3;374(4):742-6. doi: 10.1016/j.bbrc.2008.07.100. Epub 2008 Jul 29.

PMID:
18671941
24.

Lack of receptor-selective effects of either RGS2, RGS3 or RGS4 on muscarinic M3- and gonadotropin-releasing hormone receptor-mediated signalling through G alpha q/11.

Karakoula A, Tovey SC, Brighton PJ, Willars GB.

Eur J Pharmacol. 2008 Jun 10;587(1-3):16-24. doi: 10.1016/j.ejphar.2008.03.047. Epub 2008 Apr 4.

PMID:
18457830
25.

Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue.

Brighton PJ, Wise A, Dass NB, Willars GB.

J Pharmacol Exp Ther. 2008 Apr;325(1):154-64. doi: 10.1124/jpet.107.132803. Epub 2008 Jan 7.

PMID:
18180374
26.

Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits.

Cockerill SL, Tobin AB, Torrecilla I, Willars GB, Standen NB, Mitcheson JS.

J Physiol. 2007 Jun 1;581(Pt 2):479-93. Epub 2007 Mar 15.

27.

Mammalian RGS proteins: multifunctional regulators of cellular signalling.

Willars GB.

Semin Cell Dev Biol. 2006 Jun;17(3):363-76. Epub 2006 Apr 3. Review.

PMID:
16687250
28.

C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cells.

Al-Rasheed NM, Willars GB, Brunskill NJ.

J Am Soc Nephrol. 2006 Apr;17(4):986-95. Epub 2006 Mar 1.

29.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Willars GB.

Methods Mol Biol. 2006;312:57-85. No abstract available.

PMID:
16422191
30.

Confocal microscopy: theory and applications for cellular signaling.

Tovey SC, Brighton PJ, Willars GB.

Methods Mol Biol. 2005;312:57-85. doi: 10.1385/1-59259-949-4:057. Review.

PMID:
21341092
32.
33.
34.

Neuromedin U and its receptors: structure, function, and physiological roles.

Brighton PJ, Szekeres PG, Willars GB.

Pharmacol Rev. 2004 Jun;56(2):231-48. Review.

PMID:
15169928
35.

Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells.

Al-Rasheed NM, Meakin F, Royal EL, Lewington AJ, Brown J, Willars GB, Brunskill NJ.

Diabetologia. 2004 Jun;47(6):987-97. Epub 2004 May 26.

PMID:
15164168
37.

Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+.

Werry TD, Wilkinson GF, Willars GB.

Biochem J. 2003 Sep 1;374(Pt 2):281-96. Review.

38.

G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction.

Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ.

J Biol Chem. 2003 Jun 6;278(23):21307-13. Epub 2003 Apr 1.

39.

Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells.

Koizumi S, Rosa P, Willars GB, Challiss RA, Taverna E, Francolini M, Bootman MD, Lipp P, Inoue K, Roder J, Jeromin A.

J Biol Chem. 2002 Aug 16;277(33):30315-24. Epub 2002 May 28.

40.

Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells.

Werry TD, Christie MI, Dainty IA, Wilkinson GF, Willars GB.

Br J Pharmacol. 2002 Mar;135(5):1199-208.

41.
42.

Single-cell imaging of graded Ins(1,4,5)P3 production following G-protein-coupled-receptor activation.

Nash MS, Young KW, Willars GB, Challiss RA, Nahorski SR.

Biochem J. 2001 May 15;356(Pt 1):137-42.

43.

Desensitization and internalization of human and xenopus gonadotropin-releasing hormone receptors expressed in alphaT4 pituitary cells using recombinant adenovirus.

Hislop JN, Madziva MT, Everest HM, Harding T, Uney JB, Willars GB, Millar RP, Troskie BE, Davidson JS, McArdle CA.

Endocrinology. 2000 Dec;141(12):4564-75.

PMID:
11108269
44.
45.

Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropes.

Willars GB, Royall JE, Nahorski SR, El-Gehani F, Everest H, McArdle CA.

J Biol Chem. 2001 Feb 2;276(5):3123-9. Epub 2000 Nov 7.

46.

Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells.

Witherow DS, Wang Q, Levay K, Cabrera JL, Chen J, Willars GB, Slepak VZ.

J Biol Chem. 2000 Aug 11;275(32):24872-80.

47.

Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization.

Blomenröhr M, Heding A, Sellar R, Leurs R, Bogerd J, Eidne KA, Willars GB.

Mol Pharmacol. 1999 Dec;56(6):1229-37. Erratum in: Mol Pharmacol 2000 Jan;57(1):211.

PMID:
10570050
48.

Receptor phosphorylation does not mediate cross talk between muscarinic M(3) and bradykinin B(2) receptors.

Willars GB, Müller-Esterl W, Nahorski SR.

Am J Physiol. 1999 Nov;277(5):C859-69. doi: 10.1152/ajpcell.1999.277.5.C859.

PMID:
10564078
49.

Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization.

Willars GB, Heding A, Vrecl M, Sellar R, Blomenröhr M, Nahorski SR, Eidne KA.

J Biol Chem. 1999 Oct 15;274(42):30146-53.

50.

The tail of the gonadotrophin-releasing hormone receptor: desensitization at, and distal to, G protein-coupled receptors.

McArdle CA, Davidson JS, Willars GB.

Mol Cell Endocrinol. 1999 May 25;151(1-2):129-36. Review.

PMID:
10411327

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