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Contagious Disease and Self-Defence.

Wilkinson TM.

Res Publica. 2007;13(4):339-359. doi: 10.1007/s11158-007-9024-0. Epub 2007 Mar 13.


Non-typeable Haemophilus influenzae protein vaccine in adults with COPD: A phase 2 clinical trial.

Wilkinson TMA, Schembri S, Brightling C, Bakerly ND, Lewis K, MacNee W, Rombo L, Hedner J, Allen M, Walker PP, De Ryck I, Tasciotti A, Casula D, Moris P, Testa M, Arora AK.

Vaccine. 2019 Sep 24;37(41):6102-6111. doi: 10.1016/j.vaccine.2019.07.100. Epub 2019 Aug 22.


A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.


Acquired immune responses to the seasonal trivalent influenza vaccination in COPD.

Staples KJ, Williams NP, Bonduelle O, Hutton AJ, Cellura D, Marriott AC, Combadière B, Wilkinson TMA.

Clin Exp Immunol. 2019 Oct;198(1):71-82. doi: 10.1111/cei.13336. Epub 2019 Jun 17.


Using Novel Computed Tomography Analysis to Describe the Contribution and Distribution of Emphysema and Small Airways Disease in Chronic Obstructive Pulmonary Disease.

Ostridge K, Gove K, Paas KHW, Burke H, Freeman A, Harden S, Kirby M, Peterson S, Sieren J, McCrae C, Vaarala O, Staples KJ, Wilkinson TMA.

Ann Am Thorac Soc. 2019 Aug;16(8):990-997. doi: 10.1513/AnnalsATS.201810-669OC.


Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort.

Wilkinson TMA, Aris E, Bourne SC, Clarke SC, Peeters M, Pascal TG, Taddei L, Tuck AC, Kim VL, Ostridge KK, Staples KJ, Williams NP, Williams AP, Wootton SA, Devaster JM.

ERJ Open Res. 2019 Feb 25;5(1). pii: 00248-2018. doi: 10.1183/23120541.00248-2018. eCollection 2019 Feb. Erratum in: ERJ Open Res. 2019 Jul 29;5(3):.


Obesity, equity and choice.

Wilkinson TM.

J Med Ethics. 2019 May;45(5):323-328. doi: 10.1136/medethics-2018-104848. Epub 2018 Oct 30.


Development of flow cytometric opsonophagocytosis and antibody-mediated complement deposition assays for non-typeable Haemophilus influenzae.

Thomas SR, Leung S, Knox K, Wilkinson TMA, Staples KJ, Lestrate P, Wauters D, Gorringe A, Taylor SC.

BMC Microbiol. 2018 Oct 29;18(1):167. doi: 10.1186/s12866-018-1314-5.


Patients with Chronic Obstructive Pulmonary Disease harbour a variation of Haemophilus species.

Osman KL, Jefferies JMC, Woelk CH, Devos N, Pascal TG, Mortier MC, Devaster JM, Wilkinson TMA, Cleary DW, Clarke SC; AERIS Study Group.

Sci Rep. 2018 Oct 3;8(1):14734. doi: 10.1038/s41598-018-32973-3.


Plasma levels of soluble VEGF receptor isoforms, circulating pterins and VEGF system SNPs as prognostic biomarkers in patients with acute coronary syndromes.

Marks ECA, Wilkinson TM, Frampton CM, Skelton L, Pilbrow AP, Yandle TG, Pemberton CJ, Doughty RN, Whalley GA, Ellis CJ, Troughton RW, Owen MC, Pattinson NR, Cameron VA, Richards AM, Gieseg SP, Palmer BR.

BMC Cardiovasc Disord. 2018 Aug 15;18(1):169. doi: 10.1186/s12872-018-0894-1.


Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus.

Cooper GE, Ostridge K, Khakoo SI, Wilkinson TMA, Staples KJ.

Front Immunol. 2018 Jul 20;9:1671. doi: 10.3389/fimmu.2018.01671. eCollection 2018.


Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD.

Williams NP, Ostridge K, Devaster JM, Kim V, Coombs NA, Bourne S, Clarke SC, Harden S, Abbas A, Aris E, Lambert C, Tuck A, Williams A, Wootton S, Staples KJ, Wilkinson TMA; AERIS Study Group.

Respir Res. 2018 Jul 28;19(1):143. doi: 10.1186/s12931-018-0842-8.


Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD.

Ostridge K, Williams NP, Kim V, Harden S, Bourne S, Clarke SC, Aris E, Mesia-Vela S, Devaster JM, Tuck A, Williams A, Wootton S, Staples KJ, Wilkinson TMA; AERIS Study Group.

Respir Res. 2018 Feb 20;19(1):31. doi: 10.1186/s12931-018-0734-y.


COPD exacerbations: transforming outcomes through research.

Hurst JR, Bafadhel M, Bolton CE, Quint JK, Sapey E, Wilkinson TMA.

Lancet Respir Med. 2018 Mar;6(3):172-174. doi: 10.1016/S2213-2600(18)30049-3. Epub 2018 Feb 9. No abstract available.


Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations.

Mayhew D, Devos N, Lambert C, Brown JR, Clarke SC, Kim VL, Magid-Slav M, Miller BE, Ostridge KK, Patel R, Sathe G, Simola DF, Staples KJ, Sung R, Tal-Singer R, Tuck AC, Van Horn S, Weynants V, Williams NP, Devaster JM, Wilkinson TMA; AERIS Study Group.

Thorax. 2018 May;73(5):422-430. doi: 10.1136/thoraxjnl-2017-210408. Epub 2018 Jan 31.


Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort.

Kim VL, Coombs NA, Staples KJ, Ostridge KK, Williams NP, Wootton SA, Devaster JM, Aris E, Clarke SC, Tuck AC, Bourne SC, Wilkinson TMA; AERIS Study Group.

Eur Respir J. 2017 Oct 12;50(4). pii: 1700853. doi: 10.1183/13993003.00853-2017. Print 2017 Oct.


Are inhaled corticosteroids increasing the "load" for some patients with COPD?

Wilkinson TMA.

Eur Respir J. 2017 Oct 5;50(4). pii: 1701848. doi: 10.1183/13993003.01848-2017. Print 2017 Oct. No abstract available.


IL-12 and IL-7 synergize to control mucosal-associated invariant T-cell cytotoxic responses to bacterial infection.

Wallington JC, Williams AP, Staples KJ, Wilkinson TMA.

J Allergy Clin Immunol. 2018 Jun;141(6):2182-2195.e6. doi: 10.1016/j.jaci.2017.08.009. Epub 2017 Sep 1.


Immune checkpoints in chronic obstructive pulmonary disease.

Wilkinson TMA.

Eur Respir Rev. 2017 Jun 28;26(144). pii: 170045. doi: 10.1183/16000617.0045-2017. Print 2017 Jun 30. Review.


Rising medical student debt: should we be alarmed?

Wilkinson TM.

N Z Med J. 2017 Jun 16;130(1457):23-25. No abstract available.


Long term health outcomes among Returned Peace Corps Volunteers after malaria prophylaxis, 1995-2014.

Tan KR, Henderson SJ, Williamson J, Ferguson RW, Wilkinson TM, Jung P, Arguin PM.

Travel Med Infect Dis. 2017 May - Jun;17:50-55. doi: 10.1016/j.tmaid.2017.05.003. Epub 2017 May 6.


IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter.

Spalluto CM, Singhania A, Cellura D, Woelk CH, Sanchez-Elsner T, Staples KJ, Wilkinson TMA.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):428-438. doi: 10.1165/rcmb.2016-0392OC.


Correction: Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

Staples KJ, Taylor S, Thomas S, Leung S, Cox K, Pascal TG, Ostridge K, Welch L, Tuck AC, Clarke SC, Gorringe A, Wilkinson TMA.

PLoS One. 2017 Apr 25;12(4):e0176749. doi: 10.1371/journal.pone.0176749. eCollection 2017.


A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD.

Wilkinson TMA, Aris E, Bourne S, Clarke SC, Peeters M, Pascal TG, Schoonbroodt S, Tuck AC, Kim V, Ostridge K, Staples KJ, Williams N, Williams A, Wootton S, Devaster JM; AERIS Study Group.

Thorax. 2017 Oct;72(10):919-927. doi: 10.1136/thoraxjnl-2016-209023. Epub 2017 Apr 21.


Seasonality, risk factors and burden of community-acquired pneumonia in COPD patients: a population database study using linked health care records.

Williams NP, Coombs NA, Johnson MJ, Josephs LK, Rigge LA, Staples KJ, Thomas M, Wilkinson TM.

Int J Chron Obstruct Pulmon Dis. 2017 Jan 17;12:313-322. doi: 10.2147/COPD.S121389. eCollection 2017.


Managing complex respiratory patients in the community: an evaluation of a pilot integrated respiratory care service.

Gillett K, Lippiett K, Astles C, Longstaff J, Orlando R, Lin SX, Powell A, Roberts C, Chauhan AJ, Thomas M, Wilkinson TM.

BMJ Open Respir Res. 2016 Dec 5;3(1):e000145. doi: 10.1136/bmjresp-2016-000145. eCollection 2016.


Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD.

Staples KJ, Taylor S, Thomas S, Leung S, Cox K, Pascal TG, Ostridge K, Welch L, Tuck AC, Clarke SC, Gorringe A, Wilkinson TM.

PLoS One. 2016 Nov 29;11(11):e0167250. doi: 10.1371/journal.pone.0167250. eCollection 2016. Erratum in: PLoS One. 2017 Apr 25;12 (4):e0176749.


Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells.

Hutton AJ, Polak ME, Spalluto CM, Wallington JC, Pickard C, Staples KJ, Warner JA, Wilkinson TM.

J Immunol. 2017 Jan 1;198(1):110-118. Epub 2016 Nov 28.


Selection into medical school: from tools to domains.

Wilkinson TM, Wilkinson TJ.

BMC Med Educ. 2016 Oct 3;16(1):258.


Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36.

Cooper GE, Pounce ZC, Wallington JC, Bastidas-Legarda LY, Nicholas B, Chidomere C, Robinson EC, Martin K, Tocheva AS, Christodoulides M, Djukanovic R, Wilkinson TM, Staples KJ.

PLoS One. 2016 Oct 4;11(10):e0163889. doi: 10.1371/journal.pone.0163889. eCollection 2016.


Reply: The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease.

Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Sep 1;194(5):644-5. doi: 10.1164/rccm.201604-0863LE. No abstract available.


Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases.

Ostridge K, Williams N, Kim V, Harden S, Bourne S, Coombs NA, Elkington PT, Estepar RS, Washko G, Staples KJ, Wilkinson TM.

Respir Res. 2016 Jul 26;17(1):92. doi: 10.1186/s12931-016-0402-z.


Should Children Be Given Priority in Kidney Allocation?

Wilkinson TM, Dittmer ID.

J Bioeth Inq. 2016 Dec;13(4):535-545. doi: 10.1007/s11673-016-9737-x. Epub 2016 Jul 8.


Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection.

Marriott AC, Dennis M, Kane JA, Gooch KE, Hatch G, Sharpe S, Prevosto C, Leeming G, Zekeng EG, Staples KJ, Hall G, Ryan KA, Bate S, Moyo N, Whittaker CJ, Hallis B, Silman NJ, Lalvani A, Wilkinson TM, Hiscox JA, Stewart JP, Carroll MW.

PLoS One. 2016 Jun 16;11(6):e0157887. doi: 10.1371/journal.pone.0157887. eCollection 2016.


Present and future utility of computed tomography scanning in the assessment and management of COPD.

Ostridge K, Wilkinson TM.

Eur Respir J. 2016 Jul;48(1):216-28. doi: 10.1183/13993003.00041-2016. Epub 2016 May 26. Review.


Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.

Hinks TS, Wallington JC, Williams AP, Djukanović R, Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Nov 15;194(10):1208-1218.


Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD.

Ostridge K, Williams N, Kim V, Bennett M, Harden S, Welch L, Bourne S, Coombs NA, Elkington PT, Staples KJ, Wilkinson TM.

Thorax. 2016 Feb;71(2):126-32. doi: 10.1136/thoraxjnl-2015-207428. Epub 2015 Dec 8.


Dysregulation of Antiviral Function of CD8(+) T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1-PD-L1 Axis.

McKendry RT, Spalluto CM, Burke H, Nicholas B, Cellura D, Al-Shamkhani A, Staples KJ, Wilkinson TM.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):642-51. doi: 10.1164/rccm.201504-0782OC.


A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

Nicholas B, Staples KJ, Moese S, Meldrum E, Ward J, Dennison P, Havelock T, Hinks TS, Amer K, Woo E, Chamberlain M, Singh N, North M, Pink S, Wilkinson TM, Djukanović R.

J Immunol. 2015 Jun 15;194(12):6144-54. doi: 10.4049/jimmunol.1402283. Epub 2015 May 1.


Viral infection of human lung macrophages increases PDL1 expression via IFNβ.

Staples KJ, Nicholas B, McKendry RT, Spalluto CM, Wallington JC, Bragg CW, Robinson EC, Martin K, Djukanović R, Wilkinson TM.

PLoS One. 2015 Mar 16;10(3):e0121527. doi: 10.1371/journal.pone.0121527. eCollection 2015.


Recurrence of high-grade cervical abnormalities following conservative management of cervical intraepithelial neoplasia grade 2.

Wilkinson TM, Sykes PH, Simcock B, Petrich S.

Am J Obstet Gynecol. 2015 Jun;212(6):769.e1-7. doi: 10.1016/j.ajog.2015.01.010. Epub 2015 Jan 9.


Getting consent into perspective.

Wilkinson TM.

Clin Anat. 2014 Sep;27(6):844-6. doi: 10.1002/ca.22412. Epub 2014 May 2.


Taylor on presumed consent.

Wilkinson TM.

J Med Ethics. 2014 Sep;40(9):638-9. doi: 10.1136/medethics-2013-101756. Epub 2013 Dec 18. No abstract available.


A Two-Pathway Mathematical Model of the LH Response to GnRH that Predicts Self-Priming.

Evans JJ, Wilkinson TM, Wall DJ.

Int J Endocrinol. 2013;2013:410348. doi: 10.1155/2013/410348. Epub 2013 Nov 11.


Thinking harder about nudges.

Wilkinson TM.

J Med Ethics. 2013 Aug;39(8):486. doi: 10.1136/medethics-2013-101687. No abstract available.


Respect for the dead and the ethics of anatomy.

Wilkinson TM.

Clin Anat. 2014 Apr;27(3):286-90. doi: 10.1002/ca.22263. Epub 2013 May 29.


Preparation courses for a medical admissions test: effectiveness contrasts with opinion.

Wilkinson TM, Wilkinson TJ.

Med Educ. 2013 Apr;47(4):417-24. doi: 10.1111/medu.12124.


Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.

Kliwinski C, Cooper PR, Perkinson R, Mabus JR, Tam SH, Wilkinson TM, Giles-Komar J, Scallon B, Powers GD, Hornby PJ.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G262-70. doi: 10.1152/ajpgi.00340.2012. Epub 2012 Dec 6.


Consent and the use of the bodies of the dead.

Wilkinson TM.

J Med Philos. 2012 Oct;37(5):445-63. doi: 10.1093/jmp/jhs041. Epub 2012 Oct 24.


Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans.

Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, Staples KJ, Dong T, Douek DC, McMichael AJ, Xu XN.

Nat Med. 2012 Jan 29;18(2):274-80. doi: 10.1038/nm.2612.


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