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Genetic paradox explained by nonsense.

Wilkinson MF.

Nature. 2019 Apr;568(7751):179-180. doi: 10.1038/d41586-019-00823-5. No abstract available.


Human Spermatogonial Stem Cells Scrutinized under the Single-Cell Magnifying Glass.

Tan K, Wilkinson MF.

Cell Stem Cell. 2019 Feb 7;24(2):201-203. doi: 10.1016/j.stem.2019.01.010.


The Neonatal and Adult Human Testis Defined at the Single-Cell Level.

Sohni A, Tan K, Song HW, Burow D, de Rooij DG, Laurent L, Hsieh TC, Rabah R, Hammoud SS, Vicini E, Wilkinson MF.

Cell Rep. 2019 Feb 5;26(6):1501-1517.e4. doi: 10.1016/j.celrep.2019.01.045.


Nonsense shielding: protecting RNA from decay leads to cancer.

Wilkinson MF, Cook-Andersen H.

EMBO J. 2019 Feb 1;38(3). pii: e101417. doi: 10.15252/embj.2018101417. Epub 2019 Jan 24. No abstract available.


A microRNA cluster in the Fragile-X region expressed during spermatogenesis targets FMR1.

Ramaiah M, Tan K, Plank TM, Song HW, Dumdie JN, Jones S, Shum EY, Sheridan SD, Peterson KJ, Gromoll J, Haggarty SJ, Cook-Andersen H, Wilkinson MF.

EMBO Rep. 2019 Feb;20(2). pii: e46566. doi: 10.15252/embr.201846566. Epub 2018 Dec 20.


Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease.

Jaffrey SR, Wilkinson MF.

Nat Rev Neurosci. 2018 Dec;19(12):715-728. doi: 10.1038/s41583-018-0079-z. Review.


Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2.

Dumdie JN, Cho K, Ramaiah M, Skarbrevik D, Mora-Castilla S, Stumpo DJ, Lykke-Andersen J, Laurent LC, Blackshear PJ, Wilkinson MF, Cook-Andersen H.

Dev Cell. 2018 Feb 5;44(3):392-402.e7. doi: 10.1016/j.devcel.2018.01.006. Epub 2018 Feb 5.


RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.

M Plank TD, Wilkinson MF.

Bioessays. 2018 Jan;40(1). doi: 10.1002/bies.201700170. Epub 2017 Dec 13. Review.


A Upf3b-mutant mouse model with behavioral and neurogenesis defects.

Huang L, Shum EY, Jones SH, Lou CH, Dumdie J, Kim H, Roberts AJ, Jolly LA, Espinoza JL, Skarbrevik DM, Phan MH, Cook-Andersen H, Swerdlow NR, Gecz J, Wilkinson MF.

Mol Psychiatry. 2018 Aug;23(8):1773-1786. doi: 10.1038/mp.2017.173. Epub 2017 Sep 26.


The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men.

Borgmann J, Tüttelmann F, Dworniczak B, Röpke A, Song HW, Kliesch S, Wilkinson MF, Laurentino S, Gromoll J.

Hum Mol Genet. 2016 Nov 15;25(22):4898-4910. doi: 10.1093/hmg/ddw313.


The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment.

Song HW, Bettegowda A, Lake BB, Zhao AH, Skarbrevik D, Babajanian E, Sukhwani M, Shum EY, Phan MH, Plank TM, Richardson ME, Ramaiah M, Sridhar V, de Rooij DG, Orwig KE, Zhang K, Wilkinson MF.

Cell Rep. 2016 Sep 27;17(1):149-164. doi: 10.1016/j.celrep.2016.08.090.


The nonsense-mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors.

Lu J, Plank TD, Su F, Shi X, Liu C, Ji Y, Li S, Huynh A, Shi C, Zhu B, Yang G, Wu Y, Wilkinson MF, Lu Y.

J Clin Invest. 2016 Aug 1;126(8):3058-62. doi: 10.1172/JCI86508. Epub 2016 Jun 27.


Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate.

Lou CH, Dumdie J, Goetz A, Shum EY, Brafman D, Liao X, Mora-Castilla S, Ramaiah M, Cook-Andersen H, Laurent L, Wilkinson MF.

Stem Cell Reports. 2016 Jun 14;6(6):844-857. doi: 10.1016/j.stemcr.2016.05.008.


The origin of the abnormal muscle response seen in hemifacial spasm remains controversial.

Kaufmann AM, Wilkinson MF.

Clin Neurophysiol. 2016 Jul;127(7):2704-5. doi: 10.1016/j.clinph.2016.04.020. Epub 2016 May 10. No abstract available.


Analysis of facial motor evoked potentials for assessing a central mechanism in hemifacial spasm.

Wilkinson MF, Chowdhury T, Mutch WA, Kaufmann AM.

J Neurosurg. 2017 Feb;126(2):379-385. doi: 10.3171/2016.2.JNS151384. Epub 2016 May 13.


The Antagonistic Gene Paralogs Upf3a and Upf3b Govern Nonsense-Mediated RNA Decay.

Shum EY, Jones SH, Shao A, Dumdie J, Krause MD, Chan WK, Lou CH, Espinoza JL, Song HW, Phan MH, Ramaiah M, Huang L, McCarrey JR, Peterson KJ, De Rooij DG, Cook-Andersen H, Wilkinson MF.

Cell. 2016 Apr 7;165(2):382-95. doi: 10.1016/j.cell.2016.02.046. Epub 2016 Mar 31.


Molecular biology: Splicing does the two-step.

Cook-Andersen H, Wilkinson MF.

Nature. 2015 May 21;521(7552):300-1. doi: 10.1038/nature14524. Epub 2015 May 13. No abstract available.


Identification of novel post-transcriptional features in olfactory receptor family mRNAs.

Shum EY, Espinoza JL, Ramaiah M, Wilkinson MF.

Nucleic Acids Res. 2015 Oct 30;43(19):9314-26. doi: 10.1093/nar/gkv324. Epub 2015 Apr 23.


RNA degradation drives stem cell differentiation.

Lou CH, Shum EY, Wilkinson MF.

EMBO J. 2015 Jun 12;34(12):1606-8. doi: 10.15252/embj.201591631. Epub 2015 Apr 21. No abstract available.


Evidence that DNA methylation engenders dynamic gene regulation.

Wilkinson MF.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2116. doi: 10.1073/pnas.1502195112. Epub 2015 Apr 6. No abstract available.


The unfolded protein response is shaped by the NMD pathway.

Karam R, Lou CH, Kroeger H, Huang L, Lin JH, Wilkinson MF.

EMBO Rep. 2015 May;16(5):599-609. doi: 10.15252/embr.201439696. Epub 2015 Mar 25.


shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects.

Song HW, Bettegowda A, Oliver D, Yan W, Phan MH, de Rooij DG, Corbett MA, Wilkinson MF.

PLoS One. 2015 Mar 19;10(3):e0118549. doi: 10.1371/journal.pone.0118549. eCollection 2015.


Is hemifacial spasm a phenomenon of the central nervous system? --The role of desflurane on the lateral spread response.

Wilkinson MF, Chowdhury T, Mutch WA, Kaufmann AM.

Clin Neurophysiol. 2015 Jul;126(7):1354-9. doi: 10.1016/j.clinph.2014.09.030. Epub 2014 Oct 12.


Suppressing nonsense--a surprising function for 5-azacytidine.

Shao A, Wilkinson MF.

EMBO Mol Med. 2014 Dec;6(12):1518-20. doi: 10.15252/emmm.201404569.


Hormone-induced and DNA demethylation-induced relief of a tissue-specific and developmentally regulated block in transcriptional elongation.

Rao MK, Matsumoto Y, Richardson ME, Panneerdoss S, Bhardwaj A, Ward JM, Shanker S, Bettegowda A, Wilkinson MF.

J Biol Chem. 2014 Dec 19;289(51):35087-101. doi: 10.1074/jbc.M114.615435. Epub 2014 Oct 20.


The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma.

Liu C, Karam R, Zhou Y, Su F, Ji Y, Li G, Xu G, Lu L, Wang C, Song M, Zhu J, Wang Y, Zhao Y, Foo WC, Zuo M, Valasek MA, Javle M, Wilkinson MF, Lu Y.

Nat Med. 2014 Jun;20(6):596-8. doi: 10.1038/nm.3548. Epub 2014 May 25.


Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach.

De Gendt K, Verhoeven G, Amieux PS, Wilkinson MF.

Mol Endocrinol. 2014 Apr;28(4):575-91. doi: 10.1210/me.2013-1391. Epub 2014 Feb 25.


Transcriptional control of spermatogonial maintenance and differentiation.

Song HW, Wilkinson MF.

Semin Cell Dev Biol. 2014 Jun;30:14-26. doi: 10.1016/j.semcdb.2014.02.005. Epub 2014 Feb 19. Review.


Facial Motor Neuron Excitability in Hemifacial Spasm: A Facial MEP Study.

Wilkinson MF, Kaufmann AM.

Can J Neurol Sci. 2014 Mar;41(2):239-45.


Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway.

Lou CH, Shao A, Shum EY, Espinoza JL, Huang L, Karam R, Wilkinson MF.

Cell Rep. 2014 Feb 27;6(4):748-64. doi: 10.1016/j.celrep.2014.01.028. Epub 2014 Feb 13.


Nonsense-mediated mRNA decay: inter-individual variability and human disease.

Nguyen LS, Wilkinson MF, Gecz J.

Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:175-86. doi: 10.1016/j.neubiorev.2013.10.016. Epub 2013 Nov 14. Review.


Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.

Lasalde C, Rivera AV, León AJ, González-Feliciano JA, Estrella LA, Rodríguez-Cruz EN, Correa ME, Cajigas IJ, Bracho DP, Vega IE, Wilkinson MF, González CI.

Nucleic Acids Res. 2014 Feb;42(3):1916-29. doi: 10.1093/nar/gkt1049. Epub 2013 Nov 5.


The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis.

MacLean JA 2nd, Hu Z, Welborn JP, Song HW, Rao MK, Wayne CM, Wilkinson MF.

J Biol Chem. 2013 Nov 29;288(48):34809-25. doi: 10.1074/jbc.M113.486340. Epub 2013 Oct 11.


Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins.

Maeder ML, Angstman JF, Richardson ME, Linder SJ, Cascio VM, Tsai SQ, Ho QH, Sander JD, Reyon D, Bernstein BE, Costello JF, Wilkinson MF, Joung JK.

Nat Biotechnol. 2013 Dec;31(12):1137-42. doi: 10.1038/nbt.2726. Epub 2013 Oct 9.


Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility.

Richardson ME, Bleiziffer A, Tüttelmann F, Gromoll J, Wilkinson MF.

Hum Mol Genet. 2014 Jan 1;23(1):12-23. doi: 10.1093/hmg/ddt392. Epub 2013 Aug 13.


Regulation of nonsense-mediated mRNA decay: implications for physiology and disease.

Karam R, Wengrod J, Gardner LB, Wilkinson MF.

Biochim Biophys Acta. 2013 Jun-Jul;1829(6-7):624-33. doi: 10.1016/j.bbagrm.2013.03.002. Epub 2013 Mar 13.


The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.

Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast MM, Laurent LC, de Rooij DG, Hsieh TC, Wilkinson MF.

Hum Reprod. 2013 Jun;28(6):1635-46. doi: 10.1093/humrep/det043. Epub 2013 Mar 12.


A transient acute neurological event in a patient undergoing GPI microelectrode mapping: diagnostic dilemma.

Chowdhury T, Wilkinson MF, Krcek JP.

J Neurosurg Anesthesiol. 2013 Apr;25(2):212. doi: 10.1097/ANA.0b013e318287bf2c. No abstract available.


In vitro spermatogenesis: A long journey to get tails.

Song HW, Wilkinson MF.

Spermatogenesis. 2012 Oct 1;2(4):238-244.


Regulation of nonsense-mediated mRNA decay.

Huang L, Wilkinson MF.

Wiley Interdiscip Rev RNA. 2012 Nov-Dec;3(6):807-28. doi: 10.1002/wrna.1137. Epub 2012 Oct 1. Review.


The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis.

MacLean JA 2nd, Hayashi K, Turner TT, Wilkinson MF.

Biol Reprod. 2012 Jun 22;86(6):189. doi: 10.1095/biolreprod.112.099184. Print 2012 Jun.


Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development.

Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF.

Reproduction. 2012 May;143(5):611-24. doi: 10.1530/REP-11-0479. Epub 2012 Mar 5.


How to activate a gene: decap its associated noncoding RNA.

Ramaiah M, Shum EY, Wilkinson MF.

Mol Cell. 2012 Feb 10;45(3):271-3. doi: 10.1016/j.molcel.2012.01.014.


DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.

Bhardwaj A, Song HW, Beildeck M, Kerkhofs S, Castoro R, Shanker S, De Gendt K, Suzuki K, Claessens F, Issa JP, Orgebin-Crist MC, Wilkinson MF.

Mol Endocrinol. 2012 Apr;26(4):538-49. doi: 10.1210/me.2011-1059. Epub 2012 Feb 9.


Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability.

Nguyen LS, Jolly L, Shoubridge C, Chan WK, Huang L, Laumonnier F, Raynaud M, Hackett A, Field M, Rodriguez J, Srivastava AK, Lee Y, Long R, Addington AM, Rapoport JL, Suren S, Hahn CN, Gamble J, Wilkinson MF, Corbett MA, Gecz J.

Mol Psychiatry. 2012 Nov;17(11):1103-15. doi: 10.1038/mp.2011.163. Epub 2011 Dec 20.


RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.

Huang L, Lou CH, Chan W, Shum EY, Shao A, Stone E, Karam R, Song HW, Wilkinson MF.

Mol Cell. 2011 Sep 16;43(6):950-61. doi: 10.1016/j.molcel.2011.06.031.


Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells.

De Gendt K, Denolet E, Willems A, Daniels VW, Clinckemalie L, Denayer S, Wilkinson MF, Claessens F, Swinnen JV, Verhoeven G.

Biol Reprod. 2011 Nov;85(5):934-45. doi: 10.1095/biolreprod.110.090704. Epub 2011 Jul 6.


Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay.

Bruno IG, Karam R, Huang L, Bhardwaj A, Lou CH, Shum EY, Song HW, Corbett MA, Gifford WD, Gecz J, Pfaff SL, Wilkinson MF.

Mol Cell. 2011 May 20;42(4):500-10. doi: 10.1016/j.molcel.2011.04.018.


The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.

Maclean JA, Bettegowda A, Kim BJ, Lou CH, Yang SM, Bhardwaj A, Shanker S, Hu Z, Fan Y, Eckardt S, McLaughlin KJ, Skoultchi AI, Wilkinson MF.

Mol Cell Biol. 2011 Mar;31(6):1275-87. doi: 10.1128/MCB.00734-10. Epub 2011 Jan 18.


Lactate flux during carotid endarterectomy under general anesthesia: correlation with various point-of-care monitors.

Espenell AE, McIntyre IW, Gulati H, Girling LG, Wilkinson MF, Silvaggio JA, Koulack J, West M, Harding GE, Kaufmann AM, Mutch WA.

Can J Anaesth. 2010 Oct;57(10):903-12. doi: 10.1007/s12630-010-9356-7. Epub 2010 Jul 27.


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