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TOMM40 '523 Associations with Baseline and Longitudinal Cognition in APOE ɛ3 Homozygotes.

Watts A, Wilkins HM, Michaelis E, Swerdlow RH.

J Alzheimers Dis. 2019 Jul 15. doi: 10.3233/JAD-190293. [Epub ahead of print]


A 360° Rotational Positioning Protocol of Organ Donors May Increase Lungs Available for Transplantation.

Mendez MA, Fesmire AJ, Johnson SS, Neel DR, Markham LE, Olson JC, Ott M, Sangha H, Vasquez DG, Whitt SP, Wilkins HE 3rd, Moncure M.

Crit Care Med. 2019 Aug;47(8):1058-1064. doi: 10.1097/CCM.0000000000003805.


Phase 1 Open-Label, Multicenter Study of First-in-Class RORγ Agonist LYC-55716 (Cintirorgon): Safety, Tolerability, and Preliminary Evidence of Antitumor Activity.

Mahalingam D, Wang JS, Hamilton EP, Sarantopoulos J, Nemunaitis J, Weems G, Carter L, Hu X, Schreeder M, Wilkins HJ.

Clin Cancer Res. 2019 Jun 15;25(12):3508-3516. doi: 10.1158/1078-0432.CCR-18-3185. Epub 2019 Feb 28.


Proceedings of the 3rd BEAT-PCD Conference and 4th PCD Training School.

Farley H, Rubbo B, Bukowy-Bieryllo Z, Fassad M, Goutaki M, Harman K, Hogg C, Kuehni CE, Lopes S, Nielsen KG, Norris DP, Reula A, Rumman N, Shoemark A, Wilkins H, Wisse A, Lucas JS, Marthin JK.

BMC Proc. 2018 Dec 18;12(Suppl 16):64. doi: 10.1186/s12919-018-0161-6. eCollection 2018.


Effects of Microglial Cytokines on Alzheimer's Disease-Related Phenomena.

Ji Y, Wang X, Kalicki C, Menta BW, Baumgardner M, Koppel SJ, Weidling IW, Perez-Ortiz J, Wilkins HM, Swerdlow RH.

J Alzheimers Dis. 2019;67(3):1021-1034. doi: 10.3233/JAD-180820.


Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription.

Kumar RP, Ray S, Home P, Saha B, Bhattacharya B, Wilkins HM, Chavan H, Ganguly A, Milano-Foster J, Paul A, Krishnamurthy P, Swerdlow RH, Paul S.

Development. 2018 Oct 1;145(19). pii: dev162644. doi: 10.1242/dev.162644.


Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial.

Statland JM, Moore D, Wang Y, Walsh M, Mozaffar T, Elman L, Nations SP, Mitsumoto H, Fernandes JA, Saperstein D, Hayat G, Herbelin L, Karam C, Katz J, Wilkins HM, Agbas A, Swerdlow RH, Santella RM, Dimachkie MM, Barohn RJ; Rasagiline Investigators of the Muscle Study Group and Western ALS Consortium.

Muscle Nerve. 2019 Feb;59(2):201-207. doi: 10.1002/mus.26335. Epub 2018 Nov 26.


Corrigendum to: Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.

Brinkley TE, Berger M, Callahan KE, Fieo RA, Jennings LA, Morris JK, Wilkins HM, Kritchevsky SB.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):432. doi: 10.1093/gerona/gly156. No abstract available.


Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions.

Brinkley TE, Berger M, Callahan KE, Fieo RA, Jennings LA, Morris JK, Wilkins HM, Kritchevsky SB.

J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1229-1237. doi: 10.1093/gerona/gly041.


The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord.

Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins HM, Linseman DA.

Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.


Human-specific phages infecting Enterococcus host strain MW47: are they reliable microbial source tracking markers?

Purnell SE, Ebdon JE, Wilkins H, Taylor HD.

J Appl Microbiol. 2018 May;124(5):1274-1282. doi: 10.1111/jam.13700. Epub 2018 Feb 18.


Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis.

Ma E, Chen P, Wilkins HM, Wang T, Swerdlow RH, Chen Q.

Free Radic Biol Med. 2017 Dec;113:36-47. doi: 10.1016/j.freeradbiomed.2017.09.008. Epub 2017 Sep 12.


A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione.

Winter AN, Ross EK, Daliparthi V, Sumner WA, Kirchhof DM, Manning E, Wilkins HM, Linseman DA.

Oxid Med Cell Longev. 2017;2017:3103272. doi: 10.1155/2017/3103272. Epub 2017 Aug 15.


Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death.

Wang X, Zhang Q, Bao R, Zhang N, Wang Y, Polo-Parada L, Tarim A, Alemifar A, Han X, Wilkins HM, Swerdlow RH, Wang X, Ding S.

Cell Rep. 2017 Aug 29;20(9):2184-2200. doi: 10.1016/j.celrep.2017.08.022.


Using Atomic Force Microscopy to Characterize the Conformational Properties of Proteins and Protein-DNA Complexes That Carry Out DNA Repair.

LeBlanc S, Wilkins H, Li Z, Kaur P, Wang H, Erie DA.

Methods Enzymol. 2017;592:187-212. doi: 10.1016/bs.mie.2017.04.004. Epub 2017 Jun 16.


A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial.

Wilkins HM, Mahnken JD, Welch P, Bothwell R, Koppel S, Jackson RL, Burns JM, Swerdlow RH.

J Alzheimers Dis. 2017;59(1):291-300. doi: 10.3233/JAD-170077.


Effect of APOE ε4 Genotype on Metabolic Biomarkers in Aging and Alzheimer's Disease.

Morris JK, Uy RAZ, Vidoni ED, Wilkins HM, Archer AE, Thyfault JP, Miles JM, Burns JM.

J Alzheimers Dis. 2017;58(4):1129-1135. doi: 10.3233/JAD-170148.


A bioenergetics systems evaluation of ketogenic diet liver effects.

Hutfles LJ, Wilkins HM, Koppel SJ, Weidling IW, Selfridge JE, Tan E, Thyfault JP, Slawson C, Fenton AW, Zhu H, Swerdlow RH.

Appl Physiol Nutr Metab. 2017 Sep;42(9):955-962. doi: 10.1139/apnm-2017-0068. Epub 2017 May 17.


Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration.

Wilkins HM, Weidling IW, Ji Y, Swerdlow RH.

Front Immunol. 2017 Apr 26;8:508. doi: 10.3389/fimmu.2017.00508. eCollection 2017. Review.


Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients.

Wilkins HM, Koppel SJ, Bothwell R, Mahnken J, Burns JM, Swerdlow RH.

Redox Biol. 2017 Aug;12:828-832. doi: 10.1016/j.redox.2017.04.010. Epub 2017 Apr 13.


An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis.

Winter AN, Ross EK, Wilkins HM, Stankiewicz TR, Wallace T, Miller K, Linseman DA.

Nutr Neurosci. 2018 Jul;21(6):414-426. doi: 10.1080/1028415X.2017.1297023. Epub 2017 Mar 9.


Mitochondria, Cybrids, Aging, and Alzheimer's Disease.

Swerdlow RH, Koppel S, Weidling I, Hayley C, Ji Y, Wilkins HM.

Prog Mol Biol Transl Sci. 2017;146:259-302. doi: 10.1016/bs.pmbts.2016.12.017. Epub 2017 Feb 1. Review.


Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial.

Morris JK, Vidoni ED, Johnson DK, Van Sciver A, Mahnken JD, Honea RA, Wilkins HM, Brooks WM, Billinger SA, Swerdlow RH, Burns JM.

PLoS One. 2017 Feb 10;12(2):e0170547. doi: 10.1371/journal.pone.0170547. eCollection 2017.


New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.

Wilkins HM, Morris JK.

Curr Pharm Des. 2017;23(5):731-752. doi: 10.2174/1381612822666161230144517. Review.


Extracellular Mitochondria and Mitochondrial Components Act as Damage-Associated Molecular Pattern Molecules in the Mouse Brain.

Wilkins HM, Koppel SJ, Weidling IW, Roy N, Ryan LN, Stanford JA, Swerdlow RH.

J Neuroimmune Pharmacol. 2016 Dec;11(4):622-628. Epub 2016 Aug 25.


Amyloid precursor protein processing and bioenergetics.

Wilkins HM, Swerdlow RH.

Brain Res Bull. 2017 Jul;133:71-79. doi: 10.1016/j.brainresbull.2016.08.009. Epub 2016 Aug 18. Review.


Impaired fasting glucose is associated with increased regional cerebral amyloid.

Morris JK, Vidoni ED, Wilkins HM, Archer AE, Burns NC, Karcher RT, Graves RS, Swerdlow RH, Thyfault JP, Burns JM.

Neurobiol Aging. 2016 Aug;44:138-142. doi: 10.1016/j.neurobiolaging.2016.04.017. Epub 2016 May 7.


Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure.

Wilkins HM, Koppel S, Carl SM, Ramanujan S, Weidling I, Michaelis ML, Michaelis EK, Swerdlow RH.

J Neurochem. 2016 Apr;137(1):76-87. doi: 10.1111/jnc.13545. Epub 2016 Mar 11.


Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease.

Wilkins HM, Swerdlow RH.

Curr Top Med Chem. 2016;16(8):849-57. Review.


MutL traps MutS at a DNA mismatch.

Qiu R, Sakato M, Sacho EJ, Wilkins H, Zhang X, Modrich P, Hingorani MM, Erie DA, Weninger KR.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):10914-9. doi: 10.1073/pnas.1505655112. Epub 2015 Aug 17.


A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement.

Macchi Z, Wang Y, Moore D, Katz J, Saperstein D, Walk D, Simpson E, Genge A, Bertorini T, Fernandes JA, Swenson A, Elman L, Dimachkie M, Herbelin L, Miller J, Lu J, Wilkins H, Swerdlow RH, Statland J, Barohn R; Western ALS (WALS) Rasagiline Study Group.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):345-52. doi: 10.3109/21678421.2015.1026826. Epub 2015 Apr 2.


TNFα in cerebral ischemia: another stroke against you?

Wilkins HM, Swerdlow RH.

J Neurochem. 2015 Feb;132(4):369-72. doi: 10.1111/jnc.13028. Epub 2015 Feb 5. No abstract available.


Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells.

Wilkins HM, Carl SM, Weber SG, Ramanujan SA, Festoff BW, Linseman DA, Swerdlow RH.

J Alzheimers Dis. 2015;45(1):305-18. doi: 10.3233/JAD-142334.


Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies.

Wilkins HM, Carl SM, Swerdlow RH.

Redox Biol. 2014;2:619-31. doi: 10.1016/j.redox.2014.03.006. Epub 2014 Apr 1. Review.


Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection.

Wilkins HM, Carl SM, Greenlief AC, Festoff BW, Swerdlow RH.

Front Aging Neurosci. 2014 Nov 10;6:311. doi: 10.3389/fnagi.2014.00311. eCollection 2014. Review.


Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure.

Selfridge JE, Wilkins HM, E L, Carl SM, Koppel S, Funk E, Fields T, Lu J, Tang EP, Slawson C, Wang W, Zhu H, Swerdlow RH.

J Bioenerg Biomembr. 2015 Apr;47(1-2):1-11. doi: 10.1007/s10863-014-9570-z. Epub 2014 Aug 8.


Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.

Wilkins HM, Harris JL, Carl SM, E L, Lu J, Eva Selfridge J, Roy N, Hutfles L, Koppel S, Morris J, Burns JM, Michaelis ML, Michaelis EK, Brooks WM, Swerdlow RH.

Hum Mol Genet. 2014 Dec 15;23(24):6528-41. doi: 10.1093/hmg/ddu371. Epub 2014 Jul 15.


Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport.

Wilkins HM, Brock S, Gray JJ, Linseman DA.

J Neurochem. 2014 Jul;130(1):75-86. doi: 10.1111/jnc.12709. Epub 2014 Apr 2.


A Cystine-Rich Whey Supplement (Immunocal(®)) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.

Ross EK, Winter AN, Wilkins HM, Sumner WA, Duval N, Patterson D, Linseman DA.

Antioxidants (Basel). 2014 Dec 12;3(4):843-65. doi: 10.3390/antiox3040843.


Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress.

Wilkins HM, Kirchhof D, Manning E, Joseph JW, Linseman DA.

J Biol Chem. 2013 Feb 15;288(7):5091-101. doi: 10.1074/jbc.M112.405738. Epub 2013 Jan 2.


Does social anxiety predict rumination and co-rumination among adolescents?

Jose PE, Wilkins H, Spendelow JS.

J Clin Child Adolesc Psychol. 2012;41(1):86-91. doi: 10.1080/15374416.2012.632346.


Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial.

Newhouse P, Kellar K, Aisen P, White H, Wesnes K, Coderre E, Pfaff A, Wilkins H, Howard D, Levin ED.

Neurology. 2012 Jan 10;78(2):91-101. doi: 10.1212/WNL.0b013e31823efcbb.


Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial.

Spergel JM, Rothenberg ME, Collins MH, Furuta GT, Markowitz JE, Fuchs G 3rd, O'Gorman MA, Abonia JP, Young J, Henkel T, Wilkins HJ, Liacouras CA.

J Allergy Clin Immunol. 2012 Feb;129(2):456-63, 463.e1-3. doi: 10.1016/j.jaci.2011.11.044. Epub 2011 Dec 28.


Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA.

J Alzheimers Dis. 2012;28(4):855-68. doi: 10.3233/JAD-2011-111172.


Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione.

Wilkins HM, Marquardt K, Lash LH, Linseman DA.

Free Radic Biol Med. 2012 Jan 15;52(2):410-9. doi: 10.1016/j.freeradbiomed.2011.10.495. Epub 2011 Nov 9.


Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study.

Castro M, Mathur S, Hargreave F, Boulet LP, Xie F, Young J, Wilkins HJ, Henkel T, Nair P; Res-5-0010 Study Group.

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1125-32. doi: 10.1164/rccm.201103-0396OC. Epub 2011 Aug 18.


Nutraceutical antioxidants as novel neuroprotective agents.

Kelsey NA, Wilkins HM, Linseman DA.

Molecules. 2010 Nov 3;15(11):7792-814. doi: 10.3390/molecules15117792. Review.


Estrogen treatment impairs cognitive performance after psychosocial stress and monoamine depletion in postmenopausal women.

Newhouse PA, Dumas J, Wilkins H, Coderre E, Sites CK, Naylor M, Benkelfat C, Young SN.

Menopause. 2010 Jul;17(4):860-73. doi: 10.1097/gme.0b013e3181e15df4.


Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.

Harbison RA, Ryan KR, Wilkins HM, Schroeder EK, Loucks FA, Bouchard RJ, Linseman DA.

Neurotox Res. 2011 Apr;19(3):374-88. doi: 10.1007/s12640-010-9172-4. Epub 2010 Mar 24.


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