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Items: 9


Using Machine Learning to Aid the Interpretation of Urine Steroid Profiles.

Wilkes EH, Rumsby G, Woodward GM.

Clin Chem. 2018 Nov;64(11):1586-1595. doi: 10.1373/clinchem.2018.292201. Epub 2018 Aug 10.


Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells.

Casado P, Wilkes EH, Miraki-Moud F, Hadi MM, Rio-Machin A, Rajeeve V, Pike R, Iqbal S, Marfa S, Lea N, Best S, Gribben J, Fitzgibbon J, Cutillas PR.

Leukemia. 2018 Aug;32(8):1818-1822. doi: 10.1038/s41375-018-0032-1. Epub 2018 Apr 7. No abstract available.


PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.

Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker AM, Kapitonova E, Bakhouche BA, Tanner Y, Wang J, Gadaleta E, Chelala C, Moore KM, Marshall JF, Chupin J, Schmid P, Jones JL, Lockley M, Cutillas PR, Grose RP.

Cell Rep. 2018 Feb 27;22(9):2469-2481. doi: 10.1016/j.celrep.2018.02.028.


Kinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability.

Wilkes EH, Casado P, Rajeeve V, Cutillas PR.

Mol Cell Proteomics. 2017 Sep;16(9):1694-1704. doi: 10.1074/mcp.O116.064360. Epub 2017 Jul 3.


Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition.

Dermit M, Casado P, Rajeeve V, Wilkes EH, Foxler DE, Campbell H, Critchlow S, Sharp TV, Gribben JG, Unwin R, Cutillas PR.

Oncogene. 2017 May 11;36(19):2762-2774. doi: 10.1038/onc.2016.435. Epub 2016 Dec 19.


A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases.

Montfort A, Pearce O, Maniati E, Vincent BG, Bixby L, Böhm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M, Balkwill FR.

Clin Cancer Res. 2017 Jan 1;23(1):250-262. doi: 10.1158/1078-0432.CCR-16-0081. Epub 2016 Jun 27.


Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data.

Terfve CD, Wilkes EH, Casado P, Cutillas PR, Saez-Rodriguez J.

Nat Commun. 2015 Sep 10;6:8033. doi: 10.1038/ncomms9033.


Empirical inference of circuitry and plasticity in a kinase signaling network.

Wilkes EH, Terfve C, Gribben JG, Saez-Rodriguez J, Cutillas PR.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7719-24. doi: 10.1073/pnas.1423344112. Epub 2015 Jun 9.


Approaches for measuring signalling plasticity in the context of resistance to targeted cancer therapies.

Wilkes EH, Casado P, Cutillas PR.

Biochem Soc Trans. 2014 Aug;42(4):791-7. doi: 10.1042/BST20140029. Review.


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