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Items: 1 to 50 of 221

1.

7-Chloro-4-(Phenylselanyl) Quinoline with Memory Enhancer Action in Aging Rats: Modulation of Neuroplasticity, Acetylcholinesterase Activity, and Cholesterol Levels.

Barth A, Vogt AG, Dos Reis AS, Pinz MP, Krüger R, Domingues WB, Alves D, Campos VF, Pinton S, Paroul N, Wilhelm EA, Luchese C.

Mol Neurobiol. 2019 Feb 25. doi: 10.1007/s12035-019-1530-5. [Epub ahead of print]

PMID:
30805835
2.

Reasons for Premature Conclusion of Late Phase Clinical Trials: An Analysis of ClinicalTrials.gov Registered Phase III Trials.

Guinn D, Wilhelm EE, Shoulson I.

Ther Innov Regul Sci. 2019 Feb 21:2168479019830648. doi: 10.1177/2168479019830648. [Epub ahead of print]

PMID:
30791692
3.

EFFECT OF HIGH-DENSITY ORAL RABIES VACCINE BAITING ON RABIES VIRUS NEUTRALIZING ANTIBODY RESPONSE IN RACCOONS ( PROCYON LOTOR).

Pedersen K, Gilbert AT, Wilhelm ES, Nelson KM, Davis AJ, Kirby JD, VerCauteren KC, Johnson SR, Chipman RB.

J Wildl Dis. 2018 Dec 3. doi: 10.7589/2018-05-138. [Epub ahead of print]

PMID:
30507337
4.

Assessing function of electronic health records for real-world data generation.

Guinn D, Wilhelm EE, Lieberman G, Khozin S.

BMJ Evid Based Med. 2018 Nov 26. pii: bmjebm-2018-111111. doi: 10.1136/bmjebm-2018-111111. [Epub ahead of print] No abstract available.

PMID:
30478146
5.

A novel sensor design for accurate measurement of facial somatosensation in pre-term infants.

Donadio A, Whitehead K, Gonzalez F, Wilhelm E, Formica D, Meek J, Fabrizi L, Burdet E.

PLoS One. 2018 Nov 16;13(11):e0207145. doi: 10.1371/journal.pone.0207145. eCollection 2018.

6.

Na+/K+-ATPase, acetylcholinesterase and glutathione S-transferase activities as new markers of postmortem interval in Swiss mice.

da Fonseca CAR, Paltian J, Dos Reis AS, Bortolatto CF, Wilhelm EA, Luchese C.

Leg Med (Tokyo). 2019 Feb;36:67-72. doi: 10.1016/j.legalmed.2018.11.003. Epub 2018 Nov 3.

PMID:
30415194
7.

Reply to Mynard et al.

Pomella N, Wilhelm EN, Kolyva C, González-Alonso J, Rakobowchuk M, Khir AW.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1496-H1498. doi: 10.1152/ajpheart.00656.2018. No abstract available.

PMID:
30411984
8.

Polysaccharide-based film loaded with vitamin C and propolis: A promising device to accelerate diabetic wound healing.

Voss GT, Gularte MS, Vogt AG, Giongo JL, Vaucher RA, Echenique JVZ, Soares MP, Luchese C, Wilhelm EA, Fajardo AR.

Int J Pharm. 2018 Dec 1;552(1-2):340-351. doi: 10.1016/j.ijpharm.2018.10.009. Epub 2018 Oct 6.

PMID:
30300708
9.

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaat7520. doi: 10.1126/scitranslmed.aat7520.

PMID:
30257953
10.

REPLY to the letter to the editor by MG Vitek.

Wilhelm E, H J S.

Ticks Tick Borne Dis. 2019 Jan;10(1):127. doi: 10.1016/j.ttbdis.2018.09.002. Epub 2018 Sep 7. No abstract available.

PMID:
30253934
11.

The efficacy of microemulsion-based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant- and anxiolytic-like activities in mice.

Wilhelm EA, Vogt AG, Reis AS, Pinz MP, de Souza JF, Haas SE, Pereira AAM, Fajardo AR, Luchese C.

J Pharm Pharmacol. 2018 Dec;70(12):1723-1732. doi: 10.1111/jphp.13018. Epub 2018 Sep 25.

PMID:
30251258
12.

Synthesis and Pharmacological Evaluation of Novel Selenoethers Glycerol Derivatives for the Treatment of Pain and Inflammation: Involvement of Nitrergic and Glutamatergic Systems.

Perin G, Goulart HA, Soares LK, Peglow TJ, Schumacher RF, Pinz MP, Reis AS, Luchese C, Wilhelm EA.

Appl Biochem Biotechnol. 2018 Sep 19. doi: 10.1007/s12010-018-2887-z. [Epub ahead of print]

PMID:
30229431
13.

Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer's disease model.

Pinz MP, Dos Reis AS, Vogt AG, Krüger R, Alves D, Jesse CR, Roman SS, Soares MP, Wilhelm EA, Luchese C.

Biomed Pharmacother. 2018 Sep;105:1006-1014. doi: 10.1016/j.biopha.2018.06.049. Epub 2018 Jun 19.

PMID:
30021335
14.

Alternative assessment of knee joint muscle balance of soccer players through total work-based hamstring: quadriceps ratios.

Minozzo F, Lopez P, Machado CLF, Wilhelm EN, Grazioli R, Pinto RS.

Eur J Sport Sci. 2018 Nov;18(10):1398-1404. doi: 10.1080/17461391.2018.1495271. Epub 2018 Jul 14.

PMID:
30009683
15.

Exercise-Derived Microvesicles: A Review of the Literature.

Wilhelm EN, Mourot L, Rakobowchuk M.

Sports Med. 2018 Sep;48(9):2025-2039. doi: 10.1007/s40279-018-0943-z. Review.

PMID:
29868992
16.

Deficient inhibition in alcohol-dependence: let's consider the role of the motor system!

Quoilin C, Wilhelm E, Maurage P, de Timary P, Duque J.

Neuropsychopharmacology. 2018 Aug;43(9):1851-1858. doi: 10.1038/s41386-018-0074-0. Epub 2018 Apr 26.

PMID:
29728650
17.

Noninvasive assessment of the common carotid artery hemodynamics with increasing exercise work rate using wave intensity analysis.

Pomella N, Wilhelm EN, Kolyva C, González-Alonso J, Rakobowchuk M, Khir AW.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H233-H241. doi: 10.1152/ajpheart.00667.2017. Epub 2018 Mar 23.

18.

Therapeutic and technological potential of 7-chloro-4-phenylselanyl quinoline for the treatment of atopic dermatitis-like skin lesions in mice.

Voss GT, Oliveira RL, de Souza JF, Duarte LFB, Fajardo AR, Alves D, Luchese C, Wilhelm EA.

Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:90-98. doi: 10.1016/j.msec.2017.11.026. Epub 2017 Nov 23.

PMID:
29519447
19.

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B, Andersen RJ, Brumme ZL, Brockman MA.

Antiviral Res. 2018 Apr;152:94-103. doi: 10.1016/j.antiviral.2018.02.017. Epub 2018 Feb 22.

PMID:
29476895
20.

Aging exacerbates cognitive and anxiety alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.

Souza LC, Jesse CR, Del Fabbro L, de Gomes MG, Gomes NS, Filho CB, Goes ATR, Wilhelm EA, Luchese C, Roman SS, Boeira SP.

Mol Cell Neurosci. 2018 Apr;88:93-106. doi: 10.1016/j.mcn.2018.01.005. Epub 2018 Feb 3.

PMID:
29369791
21.

BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.

Delannoy A, Wilhelm E, Eilebrecht S, Alvarado-Cuevas EM, Benecke AG, Bell B.

Cell Death Dis. 2018 Jan 22;9(2):70. doi: 10.1038/s41419-017-0115-3.

22.

Organoselenium group is critical for antioxidant activity of 7-chloro-4-phenylselenyl-quinoline.

Vogt AG, Voss GT, de Oliveira RL, Paltian JJ, Duarte LFB, Alves D, Jesse CR, Roman SS, Roehrs JA, Wilhelm EA, Luchese C.

Chem Biol Interact. 2018 Feb 25;282:7-12. doi: 10.1016/j.cbi.2018.01.003. Epub 2018 Jan 6.

PMID:
29317251
23.

Drug Trials Snapshots and Sexless Drug Labels.

Cook GE, Wilhelm EE.

JAMA Intern Med. 2017 Dec 1;177(12):1868. doi: 10.1001/jamainternmed.2017.5643. No abstract available.

PMID:
29204631
24.

Organoselenium compounds from purines: Synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities and memory improvement effect.

Duarte LFB, Oliveira RL, Rodrigues KC, Voss GT, Godoi B, Schumacher RF, Perin G, Wilhelm EA, Luchese C, Alves D.

Bioorg Med Chem. 2017 Dec 15;25(24):6718-6723. doi: 10.1016/j.bmc.2017.11.019. Epub 2017 Nov 10.

PMID:
29157728
25.

Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress.

Wilhelm EN, González-Alonso J, Chiesa ST, Trangmar SJ, Kalsi KK, Rakobowchuk M.

Physiol Rep. 2017 Nov;5(21). pii: e13496. doi: 10.14814/phy2.13496.

26.

A comprehensive review of the FDA-approved labels of diabetes drugs: Indications, safety, and emerging cardiovascular safety data.

Gourgari E, Wilhelm EE, Hassanzadeh H, Aroda VR, Shoulson I.

J Diabetes Complications. 2017 Dec;31(12):1719-1727. doi: 10.1016/j.jdiacomp.2017.08.005. Epub 2017 Aug 12. Review.

27.

7-Chloro-4-phenylsulfonyl quinoline, a new antinociceptive and anti-inflammatory molecule: Structural improvement of a quinoline derivate with pharmacological activity.

Pinz MP, Reis AS, de Oliveira RL, Voss GT, Vogt AG, Sacramento MD, Roehrs JA, Alves D, Luchese C, Wilhelm EA.

Regul Toxicol Pharmacol. 2017 Nov;90:72-77. doi: 10.1016/j.yrtph.2017.08.014. Epub 2017 Aug 23.

PMID:
28842336
28.

Actuated bed for a closed loop anti-snoring therapy.

Crivelli F, Wilhelm E, van Sluijs R, Riener R.

IEEE Int Conf Rehabil Robot. 2017 Jul;2017:823-827. doi: 10.1109/ICORR.2017.8009350.

PMID:
28813922
29.

Selective A2A receptor antagonist SCH 58261 modulates striatal oxidative stress and alleviates toxicity induced by 3-Nitropropionic acid in male Wistar rats.

Bortolatto CF, Reis AS, Pinz MP, Voss GT, Oliveira RL, Vogt AG, Roman S, Jesse CR, Luchese C, Wilhelm EA.

Metab Brain Dis. 2017 Dec;32(6):1919-1927. doi: 10.1007/s11011-017-0086-1. Epub 2017 Aug 9.

PMID:
28795281
30.

Erratum to: Inaugural Conference on Incorporating Patient-Reported Outcomes and Patient Preference Information into Clinical Research, Clinical Care, and Risk-Benefit Assessments for Neurodegenerative Diseases.

Purks JL, Wilhelm EE, Shoulson I, Creveling J, Dorsey ER, Irony T, LoCastro TM, Pagan F, Ravina B, Simuni T, Sterling M, Tariot P, Anderson KE.

Patient. 2017 Oct;10(5):667-668. doi: 10.1007/s40271-017-0271-7. No abstract available.

PMID:
28766071
31.

I-SPY 2 Breast Cancer Trial as a Model for Innovation in Alzheimer Disease Therapies.

Messmer MF, Wilhelm EE, Shoulson I.

JAMA Neurol. 2017 Sep 1;74(9):1027-1028. doi: 10.1001/jamaneurol.2017.1528. Review. No abstract available.

PMID:
28738114
32.

Organosulfur compound protects against memory decline induced by scopolamine through modulation of oxidative stress and Na+/K+ ATPase activity in mice.

da Silva FD, Pinz MP, de Oliveira RL, Rodrigues KC, Ianiski FR, Bassaco MM, Silveira CC, Jesse CR, Roman SS, Wilhelm EA, Luchese C.

Metab Brain Dis. 2017 Dec;32(6):1819-1828. doi: 10.1007/s11011-017-0067-4. Epub 2017 Jul 14.

PMID:
28710722
33.

Antioxidant compound (E)-2-benzylidene-4-phenyl-1,3-diselenole protects rats against thioacetamide-induced acute hepatotoxicity.

Reis AS, Pinz MP, Bortolatto CF, Jesse CR, Savegnago L, Roman S, Luchese C, Wilhelm EA.

Can J Physiol Pharmacol. 2017 Sep;95(9):1039-1045. doi: 10.1139/cjpp-2016-0118. Epub 2017 Jul 13.

PMID:
28704613
34.

Inaugural Conference on Incorporating Patient-Reported Outcomes and Patient Preference Information into Clinical Research, Clinical Care, and Risk-Benefit Assessments for Neurodegenerative Diseases.

Purks JL, Wilhelm EE, Shoulson I, Creveling J, Dorsey ER, Irony T, LoCastro TM, Pagan F, Ravina B, Simuni T, Sterling M, Tariot P, Anderson KE.

Patient. 2017 Oct;10(5):541-544. doi: 10.1007/s40271-017-0257-5. No abstract available. Erratum in: Patient. 2017 Oct;10 (5):667-668.

35.

Contribution of dopaminergic and noradrenergic systems in the antinociceptive effect of α-(phenylalanyl) acetophenone.

Sousa FSS, Anversa RG, Birmann PT, de Souza MN, Balaguez R, Alves D, Luchese C, Wilhelm EA, Savegnago L.

Pharmacol Rep. 2017 Oct;69(5):871-877. doi: 10.1016/j.pharep.2017.03.016. Epub 2017 Mar 27.

PMID:
28623711
36.

Home Monitoring of Patients with Cystic Fibrosis to Identify and Treat Acute Pulmonary Exacerbations. eICE Study Results.

Lechtzin N, Mayer-Hamblett N, West NE, Allgood S, Wilhelm E, Khan U, Aitken ML, Ramsey BW, Boyle MP, Mogayzel PJ Jr, Gibson RL, Orenstein D, Milla C, Clancy JP, Antony V, Goss CH; eICE Study Team.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1144-1151. doi: 10.1164/rccm.201610-2172OC.

37.

Further analysis of acute antinociceptive and anti-inflammatory actions of 4-phenylselenyl-7-chloroquinoline in mice.

Silva VDG, Reis AS, Pinz MP, da Fonseca CAR, Duarte LFB, Roehrs JA, Alves D, Luchese C, Wilhelm EA.

Fundam Clin Pharmacol. 2017 Oct;31(5):513-525. doi: 10.1111/fcp.12295. Epub 2017 Jun 28.

PMID:
28543930
38.

Antioxidant effect of quinoline derivatives containing or not selenium: Relationship with antinociceptive action quinolines are antioxidant and antinociceptive.

Wilhelm EA, Ferreira AT, Pinz MP, Reis ASD, Vogt AG, Stein AL, Zeni G, Luchese C.

An Acad Bras Cienc. 2017 May;89(1 Suppl 0):457-467. doi: 10.1590/0001-3765201720160668. Epub 2017 May 22.

39.

Common Carotid Artery Diameter, Blood Flow Velocity and Wave Intensity Responses at Rest and during Exercise in Young Healthy Humans: A Reproducibility Study.

Pomella N, Wilhelm EN, Kolyva C, González-Alonso J, Rakobowchuk M, Khir AW.

Ultrasound Med Biol. 2017 May;43(5):943-957. doi: 10.1016/j.ultrasmedbio.2016.12.018. Epub 2017 Feb 23.

40.

Divergent endothelial function but similar platelet microvesicle responses following eccentric and concentric cycling at a similar aerobic power output.

Rakobowchuk M, Ritter O, Wilhelm EN, Isacco L, Bouhaddi M, Degano B, Tordi N, Mourot L.

J Appl Physiol (1985). 2017 Apr 1;122(4):1031-1039. doi: 10.1152/japplphysiol.00602.2016. Epub 2017 Feb 2.

41.

Development, characterization and biocompatibility of chondroitin sulfate/poly(vinyl alcohol)/bovine bone powder porous biocomposite.

da Silva GT, Voss GT, Kaplum V, Nakamura CV, Wilhelm EA, Luchese C, Fajardo AR.

Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:526-535. doi: 10.1016/j.msec.2016.11.069. Epub 2016 Nov 22.

PMID:
28024617
42.

Modulation of the splicing regulatory function of SRSF10 by a novel compound that impairs HIV-1 replication.

Shkreta L, Blanchette M, Toutant J, Wilhelm E, Bell B, Story BA, Balachandran A, Cochrane A, Cheung PK, Harrigan PR, Grierson DS, Chabot B.

Nucleic Acids Res. 2017 Apr 20;45(7):4051-4067. doi: 10.1093/nar/gkw1223.

43.

A method for determining Am-241 activity for large area contamination.

Wilhelm E, Arbor N, Gutierrez S, Ménard S, Nourreddine AM.

Appl Radiat Isot. 2017 Jan;119:86-93. doi: 10.1016/j.apradiso.2016.11.005. Epub 2016 Nov 14. Review.

PMID:
27866124
44.

Exercise intensity modulates the appearance of circulating microvesicles with proangiogenic potential upon endothelial cells.

Wilhelm EN, González-Alonso J, Parris C, Rakobowchuk M.

Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1297-H1310. doi: 10.1152/ajpheart.00516.2016. Epub 2016 Sep 16.

45.

Polymeric nanocapsules as a technological alternative to reduce the toxicity caused by meloxicam in mice.

Villalba BT, Ianiski FR, Vogt AG, Pinz MP, Reis AS, Vaucher RA, Soares MP, Wilhelm EA, Luchese C.

Regul Toxicol Pharmacol. 2016 Nov;81:316-321. doi: 10.1016/j.yrtph.2016.09.023. Epub 2016 Sep 21.

PMID:
27664321
46.

4-phenylselenyl-7-chloroquinoline, a novel multitarget compound with anxiolytic activity: Contribution of the glutamatergic system.

Reis AS, Pinz M, Duarte LFB, Roehrs JA, Alves D, Luchese C, Wilhelm EA.

J Psychiatr Res. 2017 Jan;84:191-199. doi: 10.1016/j.jpsychires.2016.10.007. Epub 2016 Oct 11.

PMID:
27756019
47.

Study of different filtering techniques applied to spectra from airborne gamma spectrometry.

Wilhelm E, Gutierrez S, Arbor N, Ménard S, Nourreddine AM.

J Environ Radioact. 2016 Nov;164:268-279. doi: 10.1016/j.jenvrad.2016.08.003. Epub 2016 Aug 11.

PMID:
27522331
48.

Amyloid-β peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.

Ianiski FR, Rech VC, Nishihira VS, Alves CB, Baldissera MD, Wilhelm EA, Luchese C.

An Acad Bras Cienc. 2016 Jul 11;88(3 Suppl):1829-1840. doi: 10.1590/0001-3765201620150776. Print 2016.

49.

Chitosan/poly(vinyl alcohol)/bovine bone powder biocomposites: A potential biomaterial for the treatment of atopic dermatitis-like skin lesions.

Alves NO, da Silva GT, Weber DM, Luchese C, Wilhelm EA, Fajardo AR.

Carbohydr Polym. 2016 Sep 5;148:115-24. doi: 10.1016/j.carbpol.2016.04.049. Epub 2016 Apr 13.

PMID:
27185122
50.

Echo intensity independently predicts functionality in sedentary older men.

Lopez P, Wilhelm EN, Rech A, Minozzo F, Radaelli R, Pinto RS.

Muscle Nerve. 2017 Jan;55(1):9-15. doi: 10.1002/mus.25168. Epub 2016 Oct 11.

PMID:
27145419

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