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Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients.

Ochi T, Vyalova NM, Losenkov IS, Levchuk LA, Osmanova DZ, Mikhalitskaya EV, Loonen AJM, Bosker FJ, Simutkin GG, Bokhan NA, Wilffert B, Ivanova SA.

J Affect Disord. 2019 Dec 1;259:432-439. doi: 10.1016/j.jad.2019.08.058. Epub 2019 Aug 21.


Nationwide analysis of treatment outcomes in children and adolescents routinely treated for tuberculosis in The Netherlands.

Gafar F, Van't Boveneind-Vrubleuskaya N, Akkerman OW, Wilffert B, Alffenaar JC.

Eur Respir J. 2019 Sep 12. pii: 1901402. doi: 10.1183/13993003.01402-2019. [Epub ahead of print]


A gastrointestinal simulation system for dissolution of oral solid dosage forms before and after Roux-en-Y gastric bypass.

Yska JP, Punter RJ, Woerdenbag HJ, Emous M, Frijlink HW, Wilffert B, van Roon EN.

Eur J Hosp Pharm. 2019 May;26(3):152-156. doi: 10.1136/ejhpharm-2017-001360. Epub 2018 Feb 8.


No significant association of type 2 diabetes-related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives.

Martono DP, Heerspink HJL, Hak E, Denig P, Wilffert B.

Diabetes Obes Metab. 2019 Oct;21(10):2267-2273. doi: 10.1111/dom.13803. Epub 2019 Jun 24.


Improving antibacterial prescribing safety in the management of COPD exacerbations: systematic review of observational and clinical studies on potential drug interactions associated with frequently prescribed antibacterials among COPD patients.

Wang Y, Bahar MA, Jansen AME, Kocks JWH, Alffenaar JC, Hak E, Wilffert B, Borgsteede SD.

J Antimicrob Chemother. 2019 Oct 1;74(10):2848-2864. doi: 10.1093/jac/dkz221.


A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia.

Osmanova DZ, Freidin MB, Fedorenko OY, Pozhidaev IV, Boiko AS, Vyalova NM, Tiguntsev VV, Kornetova EG, Loonen AJM, Semke AV, Wilffert B, Bokhan NA, Ivanova SA.

BMC Med Genet. 2019 Apr 9;20(Suppl 1):47. doi: 10.1186/s12881-019-0773-3.


Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors.

Boiko AS, Ivanova SA, Pozhidaev IV, Freidin MB, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM.

World J Biol Psychiatry. 2019 Jan 9:1-6. doi: 10.1080/15622975.2018.1548780. [Epub ahead of print]


No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia.

Levchenko A, Vyalova N, Pozhidaev IV, Boiko AS, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM, Ivanova SA.

Hum Psychopharmacol. 2019 Jan;34(1):e2685. doi: 10.1002/hup.2685. Epub 2019 Jan 8.


Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.

Perwitasari DA, Darmawan E, Mulyani UA, Vlies PV, Alffenaar JC, Atthobar J, Wilffert B.

Int J Mycobacteriol. 2018 Oct-Dec;7(4):380-386. doi: 10.4103/ijmy.ijmy_143_18.


Evaluation of Carbapenems for Treatment of Multi- and Extensively Drug-Resistant Mycobacterium tuberculosis.

van Rijn SP, Zuur MA, Anthony R, Wilffert B, van Altena R, Akkerman OW, de Lange WCM, van der Werf TS, Kosterink JGW, Alffenaar JC.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01489-18. doi: 10.1128/AAC.01489-18. Print 2019 Feb.


A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs.

Daskapan A, Idrus LR, Postma MJ, Wilffert B, Kosterink JGW, Stienstra Y, Touw DJ, Andersen AB, Bekker A, Denti P, Hemanth Kumar AK, Jeremiah K, Kwara A, McIlleron H, Meintjes G, van Oosterhout JJ, Ramachandran G, Rockwood N, Wilkinson RJ, van der Werf TS, Alffenaar JC.

Clin Pharmacokinet. 2019 Jun;58(6):747-766. doi: 10.1007/s40262-018-0716-8. Review.


The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine.

Bahar MA, Kamp J, Borgsteede SD, Hak E, Wilffert B.

Br J Clin Pharmacol. 2018 Dec;84(12):2704-2715. doi: 10.1111/bcp.13741. Epub 2018 Sep 24. Review.


Antituberculosis Drug-induced Liver Injury in Children: Incidence and Risk Factors During the Two-month Intensive Phase of Therapy.

Gafar F, Arifin H, Jurnalis YD, Yani FF, Fitria N, Alffenaar JC, Wilffert B.

Pediatr Infect Dis J. 2019 Jan;38(1):50-53. doi: 10.1097/INF.0000000000002192.


Effects of prophylactic antibiotics on patients with stable COPD: a systematic review and meta-analysis of randomized controlled trials.

Wang Y, Zijp TR, Bahar MA, Kocks JWH, Wilffert B, Hak E.

J Antimicrob Chemother. 2018 Dec 1;73(12):3231-3243. doi: 10.1093/jac/dky326.


Concordance assessment of self-reported medication use in the Netherlands three-generation Lifelines Cohort study with the pharmacy database The PharmLines initiative.

Sediq R, van der Schans J, Dotinga A, Alingh RA, Wilffert B, Bos JH, Schuiling-Veninga CC, Hak E.

Clin Epidemiol. 2018 Aug 16;10:981-989. doi: 10.2147/CLEP.S163037. eCollection 2018.


Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia.

Ivanova SA, Alifirova VM, Pozhidaev IV, Freidin MB, Zhukova IA, Osmanova DZ, Zhukova NG, Mironova YA, Tiguntsev VV, Fedorenko OY, Bokhan NA, Wilffert B, Loonen AJM.

J Pharm Pharm Sci. 2018;21(1):340-346. doi: 10.18433/jpps29903.


The functional variant rs334558 of GSK3B is associated with remission in patients with depressive disorders.

Levchenko A, Losenkov IS, Vyalova NM, Simutkin GG, Bokhan NA, Wilffert B, Loonen AJ, Ivanova SA.

Pharmgenomics Pers Med. 2018 Jul 20;11:121-126. doi: 10.2147/PGPM.S171423. eCollection 2018.


The association between the NAT2 genetic polymorphisms and risk of DILI during anti-TB treatment: a systematic review and meta-analysis.

Zhang M, Wang S, Wilffert B, Tong R, van Soolingen D, van den Hof S, Alffenaar JW.

Br J Clin Pharmacol. 2018 Dec;84(12):2747-2760. doi: 10.1111/bcp.13722. Epub 2018 Oct 3. Review.


Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies.

van Wattum JJ, Leferink TM, Wilffert B, Ter Horst PGJ.

Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):5-17. doi: 10.1111/bcpt.13098. Epub 2018 Sep 7. Review.


UGT1A1 polymorphisms associated with prolactin response in risperidone-treated children and adolescents with autism spectrum disorder.

Hongkaew Y, Medhasi S, Pasomsub E, Ngamsamut N, Puangpetch A, Vanwong N, Chamnanphon M, Limsila P, Suthisisang C, Wilffert B, Sukasem C.

Pharmacogenomics J. 2018 Dec;18(6):740-748. doi: 10.1038/s41397-018-0031-7. Epub 2018 Jun 29.


Long-term incidence and risk factors of cardiovascular events in Asian populations: systematic review and meta-analysis of population-based cohort studies.

Irawati S, Wasir R, Floriaan Schmidt A, Islam A, Feenstra T, Buskens E, Wilffert B, Hak E.

Curr Med Res Opin. 2019 Feb;35(2):291-299. doi: 10.1080/03007995.2018.1491149. Epub 2018 Jul 30.


Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders.

Toshchakova VA, Bakhtiari Y, Kulikov AV, Gusev SI, Trofimova MV, Fedorenko OY, Mikhalitskaya EV, Popova NK, Bokhan NA, Hovens JE, Loonen AJM, Wilffert B, Ivanova SA.

Neuropsychobiology. 2017;75(4):200-210. doi: 10.1159/000487484. Epub 2018 Apr 5.


Discontinuation and dose adjustment of metoprolol after metoprolol-paroxetine/fluoxetine co-prescription in Dutch elderly.

Bahar MA, Wang Y, Bos JHJ, Wilffert B, Hak E.

Pharmacoepidemiol Drug Saf. 2018 Jun;27(6):621-629. doi: 10.1002/pds.4422. Epub 2018 Mar 24.


Pharmacogenetic Information in Clinical Guidelines: The European Perspective.

Swen JJ, Nijenhuis M, van Rhenen M, de Boer-Veger NJ, Buunk AM, Houwink EJF, Mulder H, Rongen GA, van Schaik RHN, van der Weide J, Wilffert B, Deneer VHM, Guchelaar HJ; Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Pharmacists Association (KNMP).

Clin Pharmacol Ther. 2018 May;103(5):795-801. doi: 10.1002/cpt.1049. Epub 2018 Mar 30. Review.


Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study.

Daud ANA, Bergman JEH, Kerstjens-Frederikse WS, van der Vlies P, Hak E, Berger RMF, Groen H, Wilffert B.

Pharmacogenomics. 2017 Jul;18(10):987-1001. doi: 10.2217/pgs-2017-0036. Epub 2017 Jun 22.


Impact of Muscarinic M3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients: A Case-Controlled Study.

Tran YH, Schuiling-Veninga CCM, Bergman JEH, Groen H, Wilffert B.

CNS Drugs. 2017 Jun;31(6):483-493. doi: 10.1007/s40263-017-0436-x.


Pharmacogenetics of drug-drug interaction and drug-drug-gene interaction: a systematic review on CYP2C9, CYP2C19 and CYP2D6.

Bahar MA, Setiawan D, Hak E, Wilffert B.

Pharmacogenomics. 2017 May;18(7):701-739. doi: 10.2217/pgs-2017-0194. Epub 2017 May 8. Review.


Pharmacogenomics and Efficacy of Risperidone Long-Term Treatment in Thai Autistic Children and Adolescents.

Nuntamool N, Ngamsamut N, Vanwong N, Puangpetch A, Chamnanphon M, Hongkaew Y, Limsila P, Suthisisang C, Wilffert B, Sukasem C.

Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):316-324. doi: 10.1111/bcpt.12803. Epub 2017 Jun 19.


Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research.

Daud ANA, Bergsma EL, Bergman JEH, De Walle HEK, Kerstjens-Frederikse WS, Bijker BJ, Hak E, Wilffert B.

BMC Pregnancy Childbirth. 2017 Apr 14;17(1):120. doi: 10.1186/s12884-017-1290-z.


The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly.

Bahar MA, Hak E, Bos JHJ, Borgsteede SD, Wilffert B.

Pharmacoepidemiol Drug Saf. 2017 Jul;26(7):752-765. doi: 10.1002/pds.4200. Epub 2017 Mar 26.


Maternal use of drug substrates of placental transporters and the effect of transporter-mediated drug interactions on the risk of congenital anomalies.

Daud AN, Bergman JE, Oktora MP, Kerstjens-Frederikse WS, Groen H, Bos JH, Hak E, Wilffert B.

PLoS One. 2017 Mar 13;12(3):e0173530. doi: 10.1371/journal.pone.0173530. eCollection 2017.


Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children.

Tran YH, Groen H, Bergman JE, Hak E, Wilffert B.

Pharmacoepidemiol Drug Saf. 2017 Mar;26(3):265-273. doi: 10.1002/pds.4161. Epub 2017 Jan 18.


A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy.

Berm EJ, Gout-Zwart JJ, Luttjeboer J, Wilffert B, Postma MJ.

PLoS One. 2016 Dec 29;11(12):e0169065. doi: 10.1371/journal.pone.0169065. eCollection 2016.


Prolactin gene polymorphism (-1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics.

Ivanova SA, Osmanova DZ, Boiko AS, Pozhidaev IV, Freidin MB, Fedorenko OY, Semke AV, Bokhan NA, Kornetova EG, Rakhmazova LD, Wilffert B, Loonen AJ.

Schizophr Res. 2017 Apr;182:110-114. doi: 10.1016/j.schres.2016.10.029. Epub 2016 Oct 21.


Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia.

Ivanova SA, Osmanova DZ, Freidin MB, Fedorenko OY, Boiko AS, Pozhidaev IV, Semke AV, Bokhan NA, Agarkov AA, Wilffert B, Loonen AJ.

World J Biol Psychiatry. 2017 Apr;18(3):239-246. doi: 10.1080/15622975.2016.1224926. Epub 2016 Sep 22.


4-Aminopyridine as a life-saving treatment in calcium channel antagonist intoxication.

van der Voort PH, Wilffert B, van Roon EN, Uges DR.

Neth J Med. 2016 Jul;74(6):276. No abstract available.


The quality of lactation studies including antipsychotics.

Hummels H, Bertholee D, van der Meer D, Smit JP, Wilffert B, Ter Horst P.

Eur J Clin Pharmacol. 2016 Dec;72(12):1417-1425. Epub 2016 Aug 24. Review.


Predictors of HbA1c levels in patients initiating metformin.

Martono DP, Hak E, Lambers Heerspink H, Wilffert B, Denig P.

Curr Med Res Opin. 2016 Dec;32(12):2021-2028. Epub 2016 Sep 20.


The Risk of Congenital Heart Anomalies Following Prenatal Exposure to Serotonin Reuptake Inhibitors-Is Pharmacogenetics the Key?

Daud AN, Bergman JE, Kerstjens-Frederikse WS, Groen H, Wilffert B.

Int J Mol Sci. 2016 Aug 13;17(8). pii: E1333. doi: 10.3390/ijms17081333. Review.


Pharmacokinetic/pharmacodynamic-based optimization of levofloxacin administration in the treatment of MDR-TB.

Ghimire S, Van't Boveneind-Vrubleuskaya N, Akkerman OW, de Lange WC, van Soolingen D, Kosterink JG, van der Werf TS, Wilffert B, Touw DJ, Alffenaar JW.

J Antimicrob Chemother. 2016 Oct;71(10):2691-703. doi: 10.1093/jac/dkw164. Epub 2016 May 26. Review.


NSAID Use after Bariatric Surgery: a Randomized Controlled Intervention Study.

Yska JP, Gertsen S, Flapper G, Emous M, Wilffert B, van Roon EN.

Obes Surg. 2016 Dec;26(12):2880-2885.


Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations.

Ivanova SA, Loonen AJ, Bakker PR, Freidin MB, Ter Woerds NJ, Al Hadithy AF, Semke AV, Fedorenko OY, Brouwers JR, Bokhan NA, van Os J, van Harten PN, Wilffert B.

SAGE Open Med. 2016 Apr 11;4:2050312116643673. doi: 10.1177/2050312116643673. eCollection 2016.


Relation between CYP2D6 Genotype, Phenotype and Therapeutic Drug Concentrations among Nortriptyline and Venlafaxine Users in Old Age Psychiatry.

Berm E, Kok R, Hak E, Wilffert B.

Pharmacopsychiatry. 2016 Sep;49(5):186-190. Epub 2016 Apr 21.


Current status and opportunities for therapeutic drug monitoring in the treatment of tuberculosis.

Zuur MA, Bolhuis MS, Anthony R, den Hertog A, van der Laan T, Wilffert B, de Lange W, van Soolingen D, Alffenaar JW.

Expert Opin Drug Metab Toxicol. 2016 May;12(5):509-21. doi: 10.1517/17425255.2016.1162785. Epub 2016 Mar 24. Review.


A clinical validation study for application of DBS in therapeutic drug monitoring of antidepressants.

Berm EJ, Odigie B, Bijlsma MJ, Wilffert B, Touw DJ, Maring JG.

Bioanalysis. 2016;8(5):413-24. doi: 10.4155/bio.15.255. Epub 2016 Feb 19.


Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening Tests: A Systematic Review. Second Update of the Literature.

Berm EJ, Looff Md, Wilffert B, Boersma C, Annemans L, Vegter S, Boven JF, Postma MJ.

PLoS One. 2016 Jan 11;11(1):e0146262. doi: 10.1371/journal.pone.0146262. eCollection 2016.


Influence of bariatric surgery on the use of medication.

Yska JP, van der Meer DH, Dreijer AR, Eilander W, Apers JA, Emous M, Totté ER, Wilffert B, van Roon EN.

Eur J Clin Pharmacol. 2016 Feb;72(2):203-9. doi: 10.1007/s00228-015-1971-3. Epub 2015 Nov 3.


Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom.

Yska JP, van Roon EN, de Boer A, Leufkens HG, Wilffert B, de Heide LJ, de Vries F, Lalmohamed A.

JAMA Surg. 2015 Dec;150(12):1126-33. doi: 10.1001/jamasurg.2015.2398.


Pharmacokinetics of clomipramine during pregnancy.

Ter Horst PG, Proost JH, Smit JP, Vries MT, de Jong-van de Berg LT, Wilffert B.

Eur J Clin Pharmacol. 2015 Dec;71(12):1493-500. doi: 10.1007/s00228-015-1944-6. Epub 2015 Sep 29.


National Differences in Requirements for Ethical and Competent Authority Approval for a Multinational Vaccine Trial under the EU Directive 2001/20/EC.

van Doorn E, Hak E, Wilffert B.

Vaccines (Basel). 2015 Apr 14;3(2):263-92. doi: 10.3390/vaccines3020263. Review.

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