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Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.

Han IC, Burnight ER, Ulferts MJ, Worthington KS, Russell SR, Sohn EH, Mullins RF, Stone EM, Tucker BA, Wiley LA.

Hum Gene Ther. 2019 Nov;30(11):1371-1384. doi: 10.1089/hum.2019.159. Epub 2019 Sep 26.


Development of High-Resolution Three-Dimensional-Printed Extracellular Matrix Scaffolds and Their Compatibility with Pluripotent Stem Cells and Early Retinal Cells.

Shrestha A, Allen BN, Wiley LA, Tucker BA, Worthington KS.

J Ocul Pharmacol Ther. 2019 Aug 16. doi: 10.1089/jop.2018.0146. [Epub ahead of print]


Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

Voigt AP, Whitmore SS, Flamme-Wiese MJ, Riker MJ, Wiley LA, Tucker BA, Stone EM, Mullins RF, Scheetz TE.

Exp Eye Res. 2019 Jul;184:234-242. doi: 10.1016/j.exer.2019.05.001. Epub 2019 May 8.


Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.

Thompson JR, Worthington KS, Green BJ, Mullin NK, Jiao C, Kaalberg EE, Wiley LA, Han IC, Russell SR, Sohn EH, Guymon CA, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2019 Aug;94:204-218. doi: 10.1016/j.actbio.2019.04.057. Epub 2019 May 3.


Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.

Scruggs BA, Jiao C, Cranston CM, Kaalberg E, Wang K, Russell SR, Wiley LA, Mullins RF, Stone EM, Tucker BA, Sohn EH.

Stem Cells Transl Med. 2019 Aug;8(8):797-809. doi: 10.1002/sctm.18-0210. Epub 2019 Apr 19.


Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Bohrer LR, Wiley LA, Burnight ER, Cooke JA, Giacalone JC, Anfinson KR, Andorf JL, Mullins RF, Stone EM, Tucker BA.

Genes (Basel). 2019 Apr 5;10(4). pii: E278. doi: 10.3390/genes10040278.


Watch Me Grow: A Well-Child Examination Protocol to Improve Preventive Care in Dominican Children.

Holley MA, Wiley LA, Marass AD.

J Pediatr Health Care. 2019 May - Jun;33(3):263-269. doi: 10.1016/j.pedhc.2018.09.003. Epub 2018 Nov 22.


Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.

Green BJ, Worthington KS, Thompson JR, Bunn SJ, Rethwisch M, Kaalberg EE, Jiao C, Wiley LA, Mullins RF, Stone EM, Sohn EH, Tucker BA, Guymon CA.

Biomacromolecules. 2018 Sep 10;19(9):3682-3692. doi: 10.1021/acs.biomac.8b00784. Epub 2018 Aug 9.


WNT7A/B promote choroidal neovascularization.

Lin JB, Sene A, Wiley LA, Santeford A, Nudleman E, Nakamura R, Lin JB, Moolani HV, Apte RS.

Exp Eye Res. 2018 Sep;174:107-112. doi: 10.1016/j.exer.2018.05.033. Epub 2018 Jun 1.


Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.

Wagoner MD, Bohrer LR, Aldrich BT, Greiner MA, Mullins RF, Worthington KS, Tucker BA, Wiley LA.

Biol Open. 2018 May 8;7(5). pii: bio032102. doi: 10.1242/bio.032102.


CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Burnight ER, Giacalone JC, Cooke JA, Thompson JR, Bohrer LR, Chirco KR, Drack AV, Fingert JH, Worthington KS, Wiley LA, Mullins RF, Stone EM, Tucker BA.

Prog Retin Eye Res. 2018 Jul;65:28-49. doi: 10.1016/j.preteyeres.2018.03.003. Epub 2018 Mar 22. Review.


CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in CLN3 in Induced Pluripotent Stem Cells from Patients with Batten Disease.

Burnight ER, Bohrer LR, Giacalone JC, Klaahsen DL, Daggett HT, East JS, Madumba RA, Worthington KS, Mullins RF, Stone EM, Tucker BA, Wiley LA.

CRISPR J. 2018 Feb;1:75-87. doi: 10.1089/crispr.2017.0015.


Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis.

Abboud JJ, Whittington A, Ahmed M, Himebaugh JT, Wiley LA, Haffar A, Nguyen J.

Ophthalmic Plast Reconstr Surg. 2018 May/Jun;34(3):e76-e77. doi: 10.1097/IOP.0000000000001047.


Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants.

Wiley LA, Burnight ER, Kaalberg EE, Jiao C, Riker MJ, Halder JA, Luse MA, Han IC, Russell SR, Sohn EH, Stone EM, Tucker BA, Mullins RF.

Hum Gene Ther. 2018 Apr;29(4):424-436. doi: 10.1089/hum.2017.179. Epub 2018 Feb 23.


Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.

Wiley LA, Anfinson KR, Cranston CM, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.12.1-4A.12.14. doi: 10.1002/cpsc.30.


Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Burnight ER, Gupta M, Wiley LA, Anfinson KR, Tran A, Triboulet R, Hoffmann JM, Klaahsen DL, Andorf JL, Jiao C, Sohn EH, Adur MK, Ross JW, Mullins RF, Daley GQ, Schlaeger TM, Stone EM, Tucker BA.

Mol Ther. 2017 Sep 6;25(9):1999-2013. doi: 10.1016/j.ymthe.2017.05.015. Epub 2017 Jun 12.


Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.

Sharma TP, Wiley LA, Whitmore SS, Anfinson KR, Cranston CM, Oppedal DJ, Daggett HT, Mullins RF, Tucker BA, Stone EM.

Stem Cell Res. 2017 May;21:58-70. doi: 10.1016/j.scr.2017.03.005. Epub 2017 Mar 18.


Two-photon polymerization for production of human iPSC-derived retinal cell grafts.

Worthington KS, Wiley LA, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2017 Jun;55:385-395. doi: 10.1016/j.actbio.2017.03.039. Epub 2017 Mar 27.


Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.

Worthington KS, Wiley LA, Mullins RF, Tucker BA, Nuxoll E.

J Biomed Mater Res B Appl Biomater. 2016 Nov;104(8):1602-1609. doi: 10.1002/jbm.b.33506. Epub 2015 Aug 28.


cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.

Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA.

Sci Rep. 2016 Jul 29;6:30742. doi: 10.1038/srep30742.


Impaired autophagy in macrophages promotes inflammatory eye disease.

Santeford A, Wiley LA, Park S, Bamba S, Nakamura R, Gdoura A, Ferguson TA, Rao PK, Guan JL, Saitoh T, Akira S, Xavier R, Virgin HW 4th, Apte RS.

Autophagy. 2016 Oct 2;12(10):1876-1885. Epub 2016 Jul 27.


Using Patient-Specific Induced Pluripotent Stem Cells and Wild-Type Mice to Develop a Gene Augmentation-Based Strategy to Treat CLN3-Associated Retinal Degeneration.

Wiley LA, Burnight ER, Drack AV, Banach BB, Ochoa D, Cranston CM, Madumba RA, East JS, Mullins RF, Stone EM, Tucker BA.

Hum Gene Ther. 2016 Oct;27(10):835-846. doi: 10.1089/hum.2016.049. Epub 2016 Jul 11.


A Method for Sectioning and Immunohistochemical Analysis of Stem Cell-Derived 3-D Organoids.

Wiley LA, Beebe DC, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2016 May 12;37:1C.19.1-1C.19.11. doi: 10.1002/cpsc.3.


Neuronal Differentiation of Induced Pluripotent Stem Cells on Surfactant Templated Chitosan Hydrogels.

Worthington KS, Green BJ, Rethwisch M, Wiley LA, Tucker BA, Guymon CA, Salem AK.

Biomacromolecules. 2016 May 9;17(5):1684-95. doi: 10.1021/acs.biomac.6b00098. Epub 2016 Apr 4.


Generating iPSC-Derived Choroidal Endothelial Cells to Study Age-Related Macular Degeneration.

Songstad AE, Wiley LA, Duong K, Kaalberg E, Flamme-Wiese MJ, Cranston CM, Riker MJ, Levasseur D, Stone EM, Mullins RF, Tucker BA.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8258-67. doi: 10.1167/iovs.15-17073.


Differentiation of Induced Pluripotent Stem Cells to Neural Retinal Precursor Cells on Porous Poly-Lactic-co-Glycolic Acid Scaffolds.

Worthington KS, Wiley LA, Guymon CA, Salem AK, Tucker BA.

J Ocul Pharmacol Ther. 2016 Jun;32(5):310-6. doi: 10.1089/jop.2015.0126. Epub 2015 Dec 21.


Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease.

Giacalone JC, Wiley LA, Burnight ER, Songstad AE, Mullins RF, Stone EM, Tucker BA.

Stem Cells Transl Med. 2016 Feb;5(2):132-40. doi: 10.5966/sctm.2015-0206. Epub 2015 Dec 18. Review.


Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.

Zeng S, Whitmore SS, Sohn EH, Riker MJ, Wiley LA, Scheetz TE, Stone EM, Tucker BA, Mullins RF.

J Pathol. 2016 Feb;238(3):446-56. doi: 10.1002/path.4669. Epub 2015 Dec 24.


North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.

Small KW, DeLuca AP, Whitmore SS, Rosenberg T, Silva-Garcia R, Udar N, Puech B, Garcia CA, Rice TA, Fishman GA, Héon E, Folk JC, Streb LM, Haas CM, Wiley LA, Scheetz TE, Fingert JH, Mullins RF, Tucker BA, Stone EM.

Ophthalmology. 2016 Jan;123(1):9-18. doi: 10.1016/j.ophtha.2015.10.006. Epub 2015 Oct 24.


Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.

DeLuca AP, Whitmore SS, Barnes J, Sharma TP, Westfall TA, Scott CA, Weed MC, Wiley JS, Wiley LA, Johnston RM, Schnieders MJ, Lentz SR, Tucker BA, Mullins RF, Scheetz TE, Stone EM, Slusarski DC.

Hum Mol Genet. 2016 Jan 1;25(1):44-56. doi: 10.1093/hmg/ddv446. Epub 2015 Oct 22.


Stem cells as tools for studying the genetics of inherited retinal degenerations.

Wiley LA, Burnight ER, Mullins RF, Stone EM, Tucker BA.

Cold Spring Harb Perspect Med. 2014 Dec 11;5(5):a017160. doi: 10.1101/cshperspect.a017160. Review.


Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.

Wiley LA, Burnight ER, Songstad AE, Drack AV, Mullins RF, Stone EM, Tucker BA.

Prog Retin Eye Res. 2015 Jan;44:15-35. doi: 10.1016/j.preteyeres.2014.10.002. Epub 2014 Nov 4. Review.


Gene therapy using stem cells.

Burnight ER, Wiley LA, Mullins RF, Stone EM, Tucker BA.

Cold Spring Harb Perspect Med. 2014 Nov 13;5(4). pii: a017434. doi: 10.1101/cshperspect.a017434. Review.


Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84. doi: 10.1073/pnas.1324235111. Epub 2014 Aug 19.


Duplication of TBK1 Stimulates Autophagy in iPSC-derived Retinal Cells from a Patient with Normal Tension Glaucoma.

Tucker BA, Solivan-Timpe F, Roos BR, Anfinson KR, Robin AL, Wiley LA, Mullins RF, Fingert JH.

J Stem Cell Res Ther. 2014 Jan 25;3(5):161.


CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.

Burnight ER, Wiley LA, Drack AV, Braun TA, Anfinson KR, Kaalberg EE, Halder JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA.

Gene Ther. 2014 Jul;21(7):662-72. doi: 10.1038/gt.2014.39. Epub 2014 May 8.


Mechanical properties of murine and porcine ocular tissues in compression.

Worthington KS, Wiley LA, Bartlett AM, Stone EM, Mullins RF, Salem AK, Guymon CA, Tucker BA.

Exp Eye Res. 2014 Apr;121:194-9. doi: 10.1016/j.exer.2014.02.020. Epub 2014 Mar 5.


Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.

Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO.

J Clin Invest. 2013 Dec;123(12):5152-64. doi: 10.1172/JCI67653. Epub 2013 Nov 1.


Bacterial biofilm diversity in contact lens-related disease: emerging role of Achromobacter, Stenotrophomonas, and Delftia.

Wiley L, Bridge DR, Wiley LA, Odom JV, Elliott T, Olson JC.

Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3896-905. doi: 10.1167/iovs.11-8762.


The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens.

Wiley LA, Rajagopal R, Dattilo LK, Beebe DC.

Dis Model Mech. 2011 Jul;4(4):484-95. doi: 10.1242/dmm.006593. Epub 2011 Apr 18.


Visualizing lens epithelial cell proliferation in whole lenses.

Wiley LA, Shui YB, Beebe DC.

Mol Vis. 2010 Jul 9;16:1253-9.


The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens.

Wiley LA, Dattilo LK, Kang KB, Giovannini M, Beebe DC.

Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3611-8. doi: 10.1167/iovs.09-4371. Epub 2010 Feb 24.


Microkeratome-assisted anterior lamellar keratoplasty.

Wiley LA, Joseph MA, Pemberton JD.

Arch Ophthalmol. 2008 Mar;126(3):404-8. doi: 10.1001/archopht.126.3.404.


Superior cervical ganglionectomy induces changes in growth factor expression in the rat retina.

Wiley LA, Berkowitz BA, Steinle JJ.

Invest Ophthalmol Vis Sci. 2006 Jan;47(1):439-43.


Sympathetic innervation regulates basement membrane thickening and pericyte number in rat retina.

Wiley LA, Rupp GR, Steinle JJ.

Invest Ophthalmol Vis Sci. 2005 Feb;46(2):744-8.


Exercise training enhances endogenous fibrinolysis in peripheral arterial disease.

Killewich LA, Macko RF, Montgomery PS, Wiley LA, Gardner AW.

J Vasc Surg. 2004 Oct;40(4):741-5.


Long-term administration of topical interferon alfa-2beta in the treatment of conjunctival squamous papilloma.

Morgenstern KE, Givan J, Wiley LA.

Arch Ophthalmol. 2003 Jul;121(7):1052-3. No abstract available.


A single bout of walking exercise enhances endogenous fibrinolysis in stroke patients.

Ivey FM, Womack CJ, Kulaputana O, Dobrovolny CL, Wiley LA, Macko RF.

Med Sci Sports Exerc. 2003 Feb;35(2):193-8.


Obtaining lenticules for lamellar transplantation.

Springs CL, Wiley LA.

J Cataract Refract Surg. 2003 Jan;29(1):5-6; author reply 6. No abstract available.


The effect of external pneumatic compression on regional fibrinolysis in a prospective randomized trial.

Killewich LA, Cahan MA, Hanna DJ, Murakami M, Uchida T, Wiley LA, Hunter GC.

J Vasc Surg. 2002 Nov;36(5):953-8.


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