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Items: 1 to 50 of 247


The Diagnosis and Management of Macular Telangiectasia.

Christakis PG, Fine HF, Wiley HE.

Ophthalmic Surg Lasers Imaging Retina. 2019 Mar 1;50(3):139-144. doi: 10.3928/23258160-20190301-02. No abstract available.


Motivations and Decision-Making Processes of Men with X-linked Retinoschisis Considering Participation in an Ocular Gene Therapy Trial.

Turriff A, Blain D, Similuk M, Biesecker B, Wiley H, Cukras C, Sieving PA.

Am J Ophthalmol. 2019 Mar 15. pii: S0002-9394(19)30107-2. doi: 10.1016/j.ajo.2019.03.009. [Epub ahead of print]


Carrier-assisted single-tube processing approach for targeted proteomics analysis of low numbers of mammalian cells.

Zhang P, Gaffrey MJ, Zhu Y, Chrisler WB, Fillmore TL, Yi L, Nicora CD, Zhang T, Wu H, Jacobs JM, Tang K, Kagan J, Srivastava S, Rodland KD, Qian WJ, Smith RD, Liu T, Wiley HS, Shi T.

Anal Chem. 2018 Dec 17. doi: 10.1021/acs.analchem.8b04258. [Epub ahead of print]


Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial.

Chew EY, Clemons TE, Jaffe GJ, Johnson CA, Farsiu S, Lad EM, Guymer R, Rosenfeld P, Hubschman JP, Constable I, Wiley H, Singerman LJ, Gillies M, Comer G, Blodi B, Eliott D, Yan J, Bird A, Friedlander M; Macular Telangiectasia Type 2-Phase 2 CNTF Research Group.

Ophthalmology. 2018 Oct 4. pii: S0161-6420(18)31427-1. doi: 10.1016/j.ophtha.2018.09.041. [Epub ahead of print]


Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration.

Chen KG, Alvarez JA, Yazdanie M, Papudesu C, Wong WT, Wiley HE, Keenan TD, Chew EY, Ferris FL 3rd, Cukras CA.

Ophthalmology. 2018 Sep 29. pii: S0161-6420(18)31121-7. doi: 10.1016/j.ophtha.2018.09.039. [Epub ahead of print]


Facile carrier-assisted targeted mass spectrometric approach for proteomic analysis of low numbers of mammalian cells.

Shi T, Gaffrey MJ, Fillmore TL, Nicora CD, Yi L, Zhang P, Shukla AK, Wiley HS, Rodland KD, Liu T, Smith RD, Qian WJ.

Commun Biol. 2018 Aug 6;1:103. doi: 10.1038/s42003-018-0107-6. eCollection 2018.


Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.

Cukras C, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Park TK, Hiriyanna S, Wright JF, Colosi P, Wu Z, Bush RA, Wei LL, Sieving PA.

Mol Ther. 2018 Sep 5;26(9):2282-2294. doi: 10.1016/j.ymthe.2018.05.025. Epub 2018 Jul 7.


A systems perspective of heterocellular signaling.

Wells A, Wiley HS.

Essays Biochem. 2018 Oct 26;62(4):607-617. doi: 10.1042/EBC20180015. Print 2018 Oct 26. Review.


Blazing Signature Filter: a library for fast pairwise similarity comparisons.

Lee JY, Fujimoto GM, Wilson R, Wiley HS, Payne SH.

BMC Bioinformatics. 2018 Jun 11;19(1):221. doi: 10.1186/s12859-018-2210-6.


Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway.

Yi L, Shi T, Gritsenko MA, X'avia Chan CY, Fillmore TL, Hess BM, Swensen AC, Liu T, Smith RD, Wiley HS, Qian WJ.

Anal Chem. 2018 Apr 17;90(8):5256-5263. doi: 10.1021/acs.analchem.8b00071. Epub 2018 Apr 3.


Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina.

Wang H, Shepard MJ, Zhang C, Dong L, Walker D, Guedez L, Park S, Wang Y, Chen S, Pang Y, Zhang Q, Gao C, Wong WT, Wiley H, Pacak K, Chew EY, Zhuang Z, Chan CC.

Cancer Res. 2018 Mar 1;78(5):1266-1274. doi: 10.1158/0008-5472.CAN-17-1718. Epub 2018 Jan 4.


How low can you go?

Wiley HS.

Elife. 2018 Jan 4;7. pii: e33604. doi: 10.7554/eLife.33604.


Decoding Signal Processing at the Single-Cell Level.

Wiley HS.

Cell Syst. 2017 Dec 27;5(6):542-543. doi: 10.1016/j.cels.2017.12.003.


Systemic Sunitinib Malate Treatment for Advanced Juxtapapillary Retinal Hemangioblastomas Associated with von Hippel-Lindau Disease.

Knickelbein JE, Jacobs-El N, Wong WT, Wiley HE, Cukras CA, Meyerle CB, Chew EY.

Ophthalmol Retina. 2017 May-Jun;1(3):181-187. doi: 10.1016/j.oret.2016.10.007.


Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated 'Omics Approach.

Lindemann SR, Mobberley JM, Cole JK, Markillie LM, Taylor RC, Huang E, Chrisler WB, Wiley HS, Lipton MS, Nelson WC, Fredrickson JK, Romine MF.

Front Microbiol. 2017 Jun 13;8:1020. doi: 10.3389/fmicb.2017.01020. eCollection 2017.


Evolution of Geographic Atrophy in Participants Treated with Ranibizumab for Neovascular Age-related Macular Degeneration.

Thavikulwat AT, Jacobs-El N, Kim JS, Agrón E, Hasan J, Meyerle CB, Valent D, Cukras CA, Wiley HE, Wong WT, Chew EY.

Ophthalmol Retina. 2017 Jan-Feb;1(1):34-41. doi: 10.1016/j.oret.2016.09.005.


Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation.

Yazdanie M, Alvarez J, Agrón E, Wong WT, Wiley HE, Ferris FL 3rd, Chew EY, Cukras C.

Ophthalmology. 2017 Sep;124(9):1332-1339. doi: 10.1016/j.ophtha.2017.05.005. Epub 2017 Jun 8.


Platform-Independent Cirrus and Spectralis Thickness Measurements in Eyes with Diabetic Macular Edema Using Fully Automated Software.

Willoughby AS, Chiu SJ, Silverman RK, Farsiu S, Bailey C, Wiley HE, Ferris FL 3rd, Jaffe GJ.

Transl Vis Sci Technol. 2017 Feb 7;6(1):9. doi: 10.1167/tvst.6.1.9. eCollection 2017 Feb.


Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway.

Shi T, Niepel M, McDermott JE, Gao Y, Nicora CD, Chrisler WB, Markillie LM, Petyuk VA, Smith RD, Rodland KD, Sorger PK, Qian WJ, Wiley HS.

Sci Signal. 2016 Jul 12;9(436):rs6. doi: 10.1126/scisignal.aaf0891.


Science Signaling Podcast for 12 July 2016: Adaptor proteins limit signaling.

Wiley HS, VanHook AM.

Sci Signal. 2016 Jul 12;9(436):c16. doi: 10.1126/scisignal.aah4492.


A Crossover Design for Comparative Efficacy: A 36-Week Randomized Trial of Bevacizumab and Ranibizumab for Diabetic Macular Edema.

Wiley HE, Thompson DJ, Bailey C, Chew EY, Cukras CA, Jaffe GJ, Lee RW, Loken EK, Meyerle CB, Wong W, Ferris FL 3rd.

Ophthalmology. 2016 Apr;123(4):841-9. doi: 10.1016/j.ophtha.2015.11.021. Epub 2016 Feb 10.


Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen.

Flamendorf J, Agrón E, Wong WT, Thompson D, Wiley HE, Doss EL, Al-Holou S, Ferris FL 3rd, Chew EY, Cukras C.

Ophthalmology. 2015 Oct;122(10):2053-62. doi: 10.1016/j.ophtha.2015.06.023. Epub 2015 Aug 4.


Sensitive targeted quantification of ERK phosphorylation dynamics and stoichiometry in human cells without affinity enrichment.

Shi T, Gao Y, Gaffrey MJ, Nicora CD, Fillmore TL, Chrisler WB, Gritsenko MA, Wu C, He J, Bloodsworth KJ, Zhao R, Camp DG 2nd, Liu T, Rodland KD, Smith RD, Wiley HS, Qian WJ.

Anal Chem. 2015 Jan 20;87(2):1103-10. doi: 10.1021/ac503797x. Epub 2014 Dec 31.


Open questions: the disrupted circuitry of the cancer cell.

Wiley HS.

BMC Biol. 2014 Oct 18;12:88. doi: 10.1186/s12915-014-0088-y. No abstract available.


Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits.

Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA.

Hum Gene Ther Clin Dev. 2014 Dec;25(4):202-11. doi: 10.1089/humc.2014.067.


CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function.

Zein WM, Jeffrey BG, Wiley HE, Turriff AE, Tumminia SJ, Tao W, Bush RA, Marangoni D, Wen R, Wei LL, Sieving PA.

Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6301-8. doi: 10.1167/iovs.14-14860.


Effect of ranibizumab on high-speed indocyanine green angiography and minimum intensity projection optical coherence tomography findings in neovascular age-related macular degeneration.

Nicholson BP, Nigam D, Toy B, Stetson PF, Agrón E, Jacobs-El N, Cunningham D, Cukras C, Wong W, Wiley H, Chew E, Ferris F, Meyerle CB.

Retina. 2015 Jan;35(1):58-68. doi: 10.1097/IAE.0000000000000260.


Epidemiology of epiretinal membrane in a large cohort of patients with uveitis.

Nicholson BP, Zhou M, Rostamizadeh M, Mehta P, Agrón E, Wong W, Wiley H, Nussenblatt R, Sen HN.

Ophthalmology. 2014 Dec;121(12):2393-8. doi: 10.1016/j.ophtha.2014.06.015. Epub 2014 Jul 23.


Inference of interactions in cyanobacterial-heterotrophic co-cultures via transcriptome sequencing.

Beliaev AS, Romine MF, Serres M, Bernstein HC, Linggi BE, Markillie LM, Isern NG, Chrisler WB, Kucek LA, Hill EA, Pinchuk GE, Bryant DA, Wiley HS, Fredrickson JK, Konopka A.

ISME J. 2014 Nov;8(11):2243-55. doi: 10.1038/ismej.2014.69. Epub 2014 Apr 29.


Changes in translational efficiency is a dominant regulatory mechanism in the environmental response of bacteria.

Taylor RC, Webb Robertson BJ, Markillie LM, Serres MH, Linggi BE, Aldrich JT, Hill EA, Romine MF, Lipton MS, Wiley HS.

Integr Biol (Camb). 2013 Nov;5(11):1393-406. doi: 10.1039/c3ib40120k. Epub 2013 Sep 30.


Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo.

Zhou ZN, Sharma VP, Beaty BT, Roh-Johnson M, Peterson EA, Van Rooijen N, Kenny PA, Wiley HS, Condeelis JS, Segall JE.

Oncogene. 2014 Jul 17;33(29):3784-93. doi: 10.1038/onc.2013.363. Epub 2013 Sep 9.


Intraocular (vitreoretinal) lymphoma following primary testicular lymphoma.

Grange LK, Jacobs-El N, Wiley HE, Kurup S, Chan CC, Sen HN.

Can J Ophthalmol. 2013 Aug;48(4):e95-7. doi: 10.1016/j.jcjo.2013.03.024. No abstract available.


Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics.

Hess BM, Xue J, Markillie LM, Taylor RC, Wiley HS, Ahring BK, Linggi B.

PLoS One. 2013 Jun 19;8(6):e66104. doi: 10.1371/journal.pone.0066104. Print 2013.


Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis.

Sampaio EP, Hsu AP, Pechacek J, Bax HI, Dias DL, Paulson ML, Chandrasekaran P, Rosen LB, Carvalho DS, Ding L, Vinh DC, Browne SK, Datta S, Milner JD, Kuhns DB, Long Priel DA, Sadat MA, Shiloh M, De Marco B, Alvares M, Gillman JW, Ramarathnam V, de la Morena M, Bezrodnik L, Moreira I, Uzel G, Johnson D, Spalding C, Zerbe CS, Wiley H, Greenberg DE, Hoover SE, Rosenzweig SD, Galgiani JN, Holland SM.

J Allergy Clin Immunol. 2013 Jun;131(6):1624-34. doi: 10.1016/j.jaci.2013.01.052. Epub 2013 Mar 28.


Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.

Shankaran H, Zhang Y, Chrisler WB, Ewald JA, Wiley HS, Resat H.

Mol Biosyst. 2012 Nov;8(11):2868-82. doi: 10.1039/c2mb25190f. Epub 2012 Sep 5.


Improving RNA-Seq Precision with MapAl.

Labaj PP, Linggi BE, Wiley HS, Kreil DP.

Front Genet. 2012 Apr 2;3:28. doi: 10.3389/fgene.2012.00028. eCollection 2012.


Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data.

Waters KM, Liu T, Quesenberry RD, Willse AR, Bandyopadhyay S, Kathmann LE, Weber TJ, Smith RD, Wiley HS, Thrall BD.

PLoS One. 2012;7(3):e34515. doi: 10.1371/journal.pone.0034515. Epub 2012 Mar 29.


Cytomegalovirus retinitis successfully treated with ganciclovir implant in a patient with blood ganciclovir resistance and ocular ganciclovir sensitivity.

Bakshi NK, Fahle GA, Sereti I, Wiley H, Nussenblatt RB, Sen HN.

Eye (Lond). 2012 May;26(5):759-60. doi: 10.1038/eye.2012.17. Epub 2012 Feb 10. No abstract available.


Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling.

Łabaj PP, Leparc GG, Linggi BE, Markillie LM, Wiley HS, Kreil DP.

Bioinformatics. 2011 Jul 1;27(13):i383-91. doi: 10.1093/bioinformatics/btr247.


Integrating multiple types of data for signaling research: challenges and opportunities.

Wiley HS.

Sci Signal. 2011 Feb 15;4(160):pe9. doi: 10.1126/scisignal.2001826.


Oscillatory dynamics of the extracellular signal-regulated kinase pathway.

Shankaran H, Wiley HS.

Curr Opin Genet Dev. 2010 Dec;20(6):650-5. doi: 10.1016/j.gde.2010.08.002. Review.


The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

Prince RN, Schreiter ER, Zou P, Wiley HS, Ting AY, Lee RT, Lauffenburger DA.

J Cell Sci. 2010 Jul 1;123(Pt 13):2308-18. doi: 10.1242/jcs.058321. Epub 2010 Jun 8.


Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context.

Joslin EJ, Shankaran H, Opresko LK, Bollinger N, Lauffenburger DA, Wiley HS.

Mol Biosyst. 2010 Jul;6(7):1293-306. doi: 10.1039/c003921g. Epub 2010 May 10.


An analysis pipeline for the inference of protein-protein interaction networks.

Taylor RC, Singhal M, Daly DS, Gilmore J, Cannon WR, Domico K, White AM, Auberry DL, Auberry KJ, Hooker BS, Hurst G, McDermott JE, McDonald WH, Pelletier DA, Schmoyer D, Wiley HS.

Int J Data Min Bioinform. 2009;3(4):409-30.


Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.

Weber TJ, Shankaran H, Wiley HS, Opresko LK, Chrisler WB, Quesenberry RD.

J Invest Dermatol. 2010 May;130(5):1444-56. doi: 10.1038/jid.2009.383. Epub 2009 Dec 17.


Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.

Shankaran H, Ippolito DL, Chrisler WB, Resat H, Bollinger N, Opresko LK, Wiley HS.

Mol Syst Biol. 2009;5:332. doi: 10.1038/msb.2009.90. Epub 2009 Dec 1.


HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells.

Zhang Y, Opresko L, Shankaran H, Chrisler WB, Wiley HS, Resat H.

BMC Cell Biol. 2009 Oct 31;10:78. doi: 10.1186/1471-2121-10-78.


An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.

Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG 2nd, Smith RD, Wiley HS, Qian WJ.

J Proteome Res. 2009 Aug;8(8):3852-61. doi: 10.1021/pr900044c.


Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models.

Rogers S, Girolami M, Kolch W, Waters KM, Liu T, Thrall B, Wiley HS.

Bioinformatics. 2008 Dec 15;24(24):2894-900. doi: 10.1093/bioinformatics/btn553. Epub 2008 Oct 30.


Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.

Rodland KD, Bollinger N, Ippolito D, Opresko LK, Coffey RJ, Zangar R, Wiley HS.

J Biol Chem. 2008 Nov 14;283(46):31477-87. doi: 10.1074/jbc.M800456200. Epub 2008 Sep 9.

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