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A review on anti-tuberculosis peptides: Impact of peptide structure on anti-tuberculosis activity.

Yathursan S, Wiles S, Read H, Sarojini V.

J Pept Sci. 2019 Sep 12:e3213. doi: 10.1002/psc.3213. [Epub ahead of print] Review.


Gr1int/high Cells Dominate the Early Phagocyte Response to Mycobacterial Lung Infection in Mice.

Ryder BM, Sandford SK, Manners KM, Dalton JP, Wiles S, Kirman JR.

Front Microbiol. 2019 Mar 8;10:402. doi: 10.3389/fmicb.2019.00402. eCollection 2019.


A paraneoplastic potassium and acid-base disturbance.

Wiles SP, Kiczek M, Rutecki GW.

Cleve Clin J Med. 2019 Mar;86(3):187-197. doi: 10.3949/ccjm.86a.18014. No abstract available.


Non-invasive positive pressure ventilation in lung transplant recipients with acute respiratory failure: Beyond the perioperative period.

Wiles SP, Lane CR, Ataya A, Senussi MH, Sasidhar M, Wang X, Hanane T.

J Crit Care. 2018 Oct;47:287-294. doi: 10.1016/j.jcrc.2018.07.028. Epub 2018 Aug 1.


Modelling invasive group A streptococcal disease using bioluminescence.

Lamb LE, Zhi X, Alam F, Pyzio M, Scudamore CL, Wiles S, Sriskandan S.

BMC Microbiol. 2018 Jun 19;18(1):60. doi: 10.1186/s12866-018-1200-1.


Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus.

Sun Y, Emolo C, Holtfreter S, Wiles S, Kreiswirth B, Missiakas D, Schneewind O.

J Bacteriol. 2018 Apr 9;200(9). pii: e00735-17. doi: 10.1128/JB.00735-17. Print 2018 May 1.


Global spread of mouse-adapted Staphylococcus aureus lineages CC1, CC15, and CC88 among mouse breeding facilities.

Mrochen DM, Grumann D, Schulz D, Gumz J, Trübe P, Pritchett-Corning K, Johnson S, Nicklas W, Kirsch P, Martelet K, Brandt JVD, Berg S, Bröker BM, Wiles S, Holtfreter S.

Int J Med Microbiol. 2018 Aug;308(6):598-606. doi: 10.1016/j.ijmm.2017.11.006. Epub 2017 Nov 20.


Do surgical helmet systems affect intraoperative wound contamination? A randomised controlled trial.

Shirley OC, Bayan A, Zhu M, Dalton JP, Wiles S, Young SW.

Arch Orthop Trauma Surg. 2017 Nov;137(11):1565-1569. doi: 10.1007/s00402-017-2795-7. Epub 2017 Sep 16.


Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response-Note of Caution for In vivo Infection Experiments.

Schulz D, Grumann D, Trübe P, Pritchett-Corning K, Johnson S, Reppschläger K, Gumz J, Sundaramoorthy N, Michalik S, Berg S, van den Brandt J, Fister R, Monecke S, Uy B, Schmidt F, Bröker BM, Wiles S, Holtfreter S.

Front Cell Infect Microbiol. 2017 May 2;7:152. doi: 10.3389/fcimb.2017.00152. eCollection 2017.


A Novel Restraint Device for Injection of Galleria mellonella Larvae that Minimizes the Risk of Accidental Operator Needle Stick Injury.

Dalton JP, Uy B, Swift S, Wiles S.

Front Cell Infect Microbiol. 2017 Mar 28;7:99. doi: 10.3389/fcimb.2017.00099. eCollection 2017.


Interhospital transfers of the critically ill: Time spent at referring institutions influences survival.

Hanane T, Wiles S, Senussi MH, Han X, Wang XF, Hite RD, Guzman JA.

J Crit Care. 2017 Jun;39:1-5. doi: 10.1016/j.jcrc.2016.12.016. Epub 2016 Dec 24.


The tuberculocidal activity of polyaniline and functionalised polyanilines.

Robertson J, Dalton J, Wiles S, Gizdavic-Nikolaidis M, Swift S.

PeerJ. 2016 Dec 20;4:e2795. doi: 10.7717/peerj.2795. eCollection 2016.


Effect of common and experimental anti-tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms.

Dalton JP, Uy B, Phummarin N, Copp BR, Denny WA, Swift S, Wiles S.

PeerJ. 2016 Nov 22;4:e2717. eCollection 2016.


Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model.

Dalton JP, Uy B, Okuda KS, Hall CJ, Denny WA, Crosier PS, Swift S, Wiles S.

J Antimicrob Chemother. 2017 Feb;72(2):421-427. doi: 10.1093/jac/dkw421. Epub 2016 Oct 24.


The in vitro and in vivo effects of constitutive light expression on a bioluminescent strain of the mouse enteropathogen Citrobacter rodentium.

Read HM, Mills G, Johnson S, Tsai P, Dalton J, Barquist L, Print CG, Patrick WM, Wiles S.

PeerJ. 2016 Jun 22;4:e2130. doi: 10.7717/peerj.2130. eCollection 2016.


SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors.

Phummarin N, Boshoff HI, Tsang PS, Dalton J, Wiles S, Barry Rd CE, Copp BR.

Medchemcomm. 2016 Nov 1;7(11):2122-2127. doi: 10.1039/c6md00236f. Epub 2016 Aug 22.


Biologically Active Acetylenic Amino Alcohol and N-Hydroxylated 1,2,3,4-Tetrahydro-β-carboline Constituents of the New Zealand Ascidian Pseudodistoma opacum.

Wang J, Pearce AN, Chan ST, Taylor RB, Page MJ, Valentin A, Bourguet-Kondracki ML, Dalton JP, Wiles S, Copp BR.

J Nat Prod. 2016 Mar 25;79(3):607-10. doi: 10.1021/acs.jnatprod.5b00770. Epub 2015 Dec 15.


All models are wrong, but some are useful: Averting the 'microbial apocalypse'.

Wiles S.

Virulence. 2015;6(8):730-2. doi: 10.1080/21505594.2014.1001238. No abstract available.


Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA.

Young SW, Roberts T, Johnson S, Dalton JP, Coleman B, Wiles S.

Clin Orthop Relat Res. 2015 Nov;473(11):3573-84. doi: 10.1007/s11999-015-4464-x. Epub 2015 Jul 30.


Low-dose irradiation affects the functional behavior of oral microbiota in the context of mucositis.

Vanhoecke BW, De Ryck TR, De boel K, Wiles S, Boterberg T, Van de Wiele T, Swift S.

Exp Biol Med (Maywood). 2016 Jan;241(1):60-70. doi: 10.1177/1535370215595467. Epub 2015 Jul 22.


In vivo correlates of molecularly inferred virulence among extraintestinal pathogenic Escherichia coli (ExPEC) in the wax moth Galleria mellonella model system.

Williamson DA, Mills G, Johnson JR, Porter S, Wiles S.

Virulence. 2014 Apr 1;5(3):388-93. doi: 10.4161/viru.27912. Epub 2014 Feb 11.


Engagement and skill development in biology students through analysis of art.

Milkova L, Crossman C, Wiles S, Allen T.

CBE Life Sci Educ. 2013 Winter;12(4):687-700. doi: 10.1187/cbe.12-08-0114.


Non-invasive monitoring of Streptococcus pyogenes vaccine efficacy using biophotonic imaging.

Alam FM, Bateman C, Turner CE, Wiles S, Sriskandan S.

PLoS One. 2013 Nov 20;8(11):e82123. doi: 10.1371/journal.pone.0082123. eCollection 2013.


Effects of ascent to high altitude on human antimycobacterial immunity.

Eisen S, Pealing L, Aldridge RW, Siedner MJ, Necochea A, Leybell I, Valencia T, Herrera B, Wiles S, Friedland JS, Gilman RH, Evans CA.

PLoS One. 2013 Sep 13;8(9):e74220. doi: 10.1371/journal.pone.0074220. eCollection 2013.


Study in pink...rash!

Bannaga AS, Wiles S, Rahama O, Thaker H.

BMJ Case Rep. 2013 Sep 19;2013. pii: bcr2013201319. doi: 10.1136/bcr-2013-201319. No abstract available.


Characterization of a mouse-adapted Staphylococcus aureus strain.

Holtfreter S, Radcliff FJ, Grumann D, Read H, Johnson S, Monecke S, Ritchie S, Clow F, Goerke C, Bröker BM, Fraser JD, Wiles S.

PLoS One. 2013 Sep 2;8(9):e71142. doi: 10.1371/journal.pone.0071142. eCollection 2013.


Clinical and molecular correlates of virulence in Escherichia coli causing bloodstream infection following transrectal ultrasound-guided (TRUS) prostate biopsy.

Williamson DA, Freeman JT, Porter S, Roberts S, Wiles S, Paterson DL, Johnson JR.

J Antimicrob Chemother. 2013 Dec;68(12):2898-906. doi: 10.1093/jac/dkt276. Epub 2013 Jul 5.


Galleria mellonella larvae as an infection model for group A streptococcus.

Loh JM, Adenwalla N, Wiles S, Proft T.

Virulence. 2013 Jul 1;4(5):419-28. doi: 10.4161/viru.24930. Epub 2013 May 7.


Inactivation of the CovR/S virulence regulator impairs infection in an improved murine model of Streptococcus pyogenes naso-pharyngeal infection.

Alam FM, Turner CE, Smith K, Wiles S, Sriskandan S.

PLoS One. 2013 Apr 25;8(4):e61655. doi: 10.1371/journal.pone.0061655. Print 2013. Erratum in: PLoS One. 2013;8(9):doi/10.1371/annotation/1144e132-9e69-47bb-8e65-1414dbb01db7.


Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase.

Andreu N, Zelmer A, Sampson SL, Ikeh M, Bancroft GJ, Schaible UE, Wiles S, Robertson BD.

J Antimicrob Chemother. 2013 Sep;68(9):2118-27. doi: 10.1093/jac/dkt155. Epub 2013 Apr 30.


Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs.

Montrose K, Yang Y, Sun X, Wiles S, Krissansen GW.

Sci Rep. 2013;3:1661. doi: 10.1038/srep01661.


Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria.

Arafah S, Kicka S, Trofimov V, Hagedorn M, Andreu N, Wiles S, Robertson B, Soldati T.

Methods Mol Biol. 2013;983:403-17. doi: 10.1007/978-1-62703-302-2_22.


A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging.

Zelmer A, Carroll P, Andreu N, Hagens K, Mahlo J, Redinger N, Robertson BD, Wiles S, Ward TH, Parish T, Ripoll J, Bancroft GJ, Schaible UE.

J Antimicrob Chemother. 2012 Aug;67(8):1948-60. doi: 10.1093/jac/dks161. Epub 2012 May 25.


Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence.

Andreu N, Fletcher T, Krishnan N, Wiles S, Robertson BD.

J Antimicrob Chemother. 2012 Feb;67(2):404-14. doi: 10.1093/jac/dkr472. Epub 2011 Nov 17.


Treatments no better than placebos.

Wiles S.

Nurs N Z. 2011 Apr;17(3):4; author reply 5. No abstract available.


Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux.

Petty NK, Feltwell T, Pickard D, Clare S, Toribio AL, Fookes M, Roberts K, Monson R, Nair S, Kingsley RA, Bulgin R, Wiles S, Goulding D, Keane T, Corton C, Lennard N, Harris D, Willey D, Rance R, Yu L, Choudhary JS, Churcher C, Quail MA, Parkhill J, Frankel G, Dougan G, Salmond GP, Thomson NR.

PLoS Pathog. 2011 Apr;7(4):e1002018. doi: 10.1371/journal.ppat.1002018. Epub 2011 Apr 7.


Noninvasive biophotonic imaging for studies of infectious disease.

Andreu N, Zelmer A, Wiles S.

FEMS Microbiol Rev. 2011 Mar;35(2):360-94. doi: 10.1111/j.1574-6976.2010.00252.x. Epub 2010 Oct 19. Review.


Optimisation of bioluminescent reporters for use with mycobacteria.

Andreu N, Zelmer A, Fletcher T, Elkington PT, Ward TH, Ripoll J, Parish T, Bancroft GJ, Schaible U, Robertson BD, Wiles S.

PLoS One. 2010 May 24;5(5):e10777. doi: 10.1371/journal.pone.0010777.


Sensitive detection of gene expression in mycobacteria under replicating and non-replicating conditions using optimized far-red reporters.

Carroll P, Schreuder LJ, Muwanguzi-Karugaba J, Wiles S, Robertson BD, Ripoll J, Ward TH, Bancroft GJ, Schaible UE, Parish T.

PLoS One. 2010 Mar 23;5(3):e9823. doi: 10.1371/journal.pone.0009823.


Bioluminescent monitoring of in vivo colonization and clearance dynamics by light-emitting bacteria.

Wiles S, Robertson BD, Frankel G, Kerton A.

Methods Mol Biol. 2009;574:137-53. doi: 10.1007/978-1-60327-321-3_12.


Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi.

Turner CE, Kurupati P, Wiles S, Edwards RJ, Sriskandan S.

Vaccine. 2009 Aug 6;27(36):4923-9. doi: 10.1016/j.vaccine.2009.06.042. Epub 2009 Jun 27.


Role of NleH, a type III secreted effector from attaching and effacing pathogens, in colonization of the bovine, ovine, and murine gut.

Hemrajani C, Marches O, Wiles S, Girard F, Dennis A, Dziva F, Best A, Phillips AD, Berger CN, Mousnier A, Crepin VF, Kruidenier L, Woodward MJ, Stevens MP, La Ragione RM, MacDonald TT, Frankel G.

Infect Immun. 2008 Nov;76(11):4804-13. doi: 10.1128/IAI.00742-08. Epub 2008 Aug 25.


The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter rodentium.

Dennis A, Kudo T, Kruidenier L, Girard F, Crepin VF, MacDonald TT, Frankel G, Wiles S.

Infect Immun. 2008 Nov;76(11):4978-88. doi: 10.1128/IAI.00736-08. Epub 2008 Aug 11.


The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom.

Yesudian PD, Berry JL, Wiles S, Hoyle S, Young DB, Haylett AK, Rhodes LE, Davies P.

Photodermatol Photoimmunol Photomed. 2008 Apr;24(2):97-8. doi: 10.1111/j.1600-0781.2008.00339.x.


In vivo imaging of gene transfer to the respiratory tract.

Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van der Hoeven P, Sinn PL, McCray PB Jr, Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EW.

Biomaterials. 2008 Apr;29(10):1533-40. Epub 2007 Dec 21.


Cell attachment properties and infectivity of host-adapted and environmentally adapted Citrobacter rodentium.

Bishop AL, Wiles S, Dougan G, Frankel G.

Microbes Infect. 2007 Sep;9(11):1316-24. Epub 2007 Jun 30.


Use of biophotonic imaging as a training aid for administration of substances in laboratory rodents.

Wiles S, Crepin VF, Childs G, Frankel G, Kerton A.

Lab Anim. 2007 Jul;41(3):321-8.


In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium.

Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G.

Infect Immun. 2006 Sep;74(9):5391-6.


Essential role of the type III secretion system effector NleB in colonization of mice by Citrobacter rodentium.

Kelly M, Hart E, Mundy R, Marchès O, Wiles S, Badea L, Luck S, Tauschek M, Frankel G, Robins-Browne RM, Hartland EL.

Infect Immun. 2006 Apr;74(4):2328-37.

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