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Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.

de Groot T, Ebert LK, Christensen BM, Andralojc K, Cheval L, Doucet A, Mao C, Baumgarten R, Low BE, Sandhoff R, Wiles MV, Deen PMT, Korstanje R.

J Am Soc Nephrol. 2019 Sep 26. pii: ASN.2018050549. doi: 10.1681/ASN.2018050549. [Epub ahead of print]


Quantitative Trait Locus and Integrative Genomics Revealed Candidate Modifier Genes for Ectopic Mineralization in Mouse Models of Pseudoxanthoma Elasticum.

Li Q, Philip VM, Stearns TM, Bubier JA, King BL, Low BE, Wiles MV, Saeidian AH, Sundberg BA, Uitto J, Sundberg JP.

J Invest Dermatol. 2019 Jun 15. pii: S0022-202X(19)31761-0. doi: 10.1016/j.jid.2019.04.023. [Epub ahead of print]


The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain.

Sarsani VK, Raghupathy N, Fiddes IT, Armstrong J, Thibaud-Nissen F, Zinder O, Bolisetty M, Howe K, Hinerfeld D, Ruan X, Rowe L, Barter M, Ananda G, Paten B, Weinstock GM, Churchill GA, Wiles MV, Schneider VA, Srivastava A, Reinholdt LG.

G3 (Bethesda). 2019 Jun 5;9(6):1795-1805. doi: 10.1534/g3.119.400071.


Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique.

Pernold K, Iannello F, Low BE, Rigamonti M, Rosati G, Scavizzi F, Wang J, Raspa M, Wiles MV, Ulfhake B.

PLoS One. 2019 Feb 4;14(2):e0211063. doi: 10.1371/journal.pone.0211063. eCollection 2019.


Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.

Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD.

FASEB J. 2019 Mar;33(3):3137-3151. doi: 10.1096/fj.201800636R. Epub 2018 Nov 1.


Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3, Is Dependent on the Crb1rd8 Allele.

Chang B, FitzMaurice B, Wang J, Low BE, Wiles MV, Nishina PM.

Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):5127-5139. doi: 10.1167/iovs.18-25046.


RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?

Hosur V, Farley ML, Low BE, Burzenski LM, Shultz LD, Wiles MV.

Front Genet. 2018 Jul 4;9:233. doi: 10.3389/fgene.2018.00233. eCollection 2018.


Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection.

Winer BY, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low BE, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais MA, Frankel AS, Chiriboga L, Cullen J, Nahass RG, Lutgehetmann M, Toettcher JE, Wiles MV, Schwartz RE, Ploss A.

Sci Transl Med. 2018 Jun 27;10(447). pii: eaap9328. doi: 10.1126/scitranslmed.aap9328.


ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin.

Hosur V, Farley ML, Burzenski LM, Shultz LD, Wiles MV.

FEBS Open Bio. 2018 Mar 12;8(4):702-710. doi: 10.1002/2211-5463.12407. eCollection 2018 Apr.


Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates.

Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I, Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV, Mao C.

FASEB J. 2018 Jun;32(6):3058-3069. doi: 10.1096/fj.201700445RR. Epub 2018 Jan 22.


Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.

Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE.

Genetics. 2018 Mar;208(3):1165-1179. doi: 10.1534/genetics.117.300447. Epub 2018 Jan 3.


Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis.

Hosur V, Low BE, Shultz LD, Wiles MV.

Biol Open. 2017 Aug 15;6(8):1174-1179. doi: 10.1242/bio.026260.


Development of Humanized Mice in the Age of Genome Editing.

Hosur V, Low BE, Avery C, Shultz LD, Wiles MV.

J Cell Biochem. 2017 Oct;118(10):3043-3048. doi: 10.1002/jcb.26002. Epub 2017 May 15.


Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.

Hosur V, Burzenski LM, Stearns TM, Farley ML, Sundberg JP, Wiles MV, Shultz LD.

Exp Mol Pathol. 2017 Apr;102(2):337-346. doi: 10.1016/j.yexmp.2017.03.003. Epub 2017 Mar 6.


Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection.

Winer BY, Huang T, Low BE, Avery C, Pais MA, Hrebikova G, Siu E, Chiriboga L, Wiles MV, Ploss A.

Virology. 2017 Feb;502:63-72. doi: 10.1016/j.virol.2016.12.017. Epub 2016 Dec 19.


A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics.

Low BE, Wiles MV.

Methods Mol Biol. 2016;1438:115-22. doi: 10.1007/978-1-4939-3661-8_7. Review.


Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice.

Low BE, Taft RA, Wiles MV.

Methods Mol Biol. 2016;1438:55-66. doi: 10.1007/978-1-4939-3661-8_3.


Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods.

Low BE, Kutny PM, Wiles MV.

Methods Mol Biol. 2016;1438:19-53. doi: 10.1007/978-1-4939-3661-8_2. Review.


Excavating the Genome: Large-Scale Mutagenesis Screening for the Discovery of New Mouse Models.

Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Murray SA, Denegre JM, Schofield PN, King LE Jr, Wiles MV, Pratt CH.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):27-9. doi: 10.1038/jidsymp.2015.36. Review.


CRISPR-Cas9-mediated genome editing and guide RNA design.

Wiles MV, Qin W, Cheng AW, Wang H.

Mamm Genome. 2015 Oct;26(9-10):501-10. doi: 10.1007/s00335-015-9565-z. Epub 2015 May 20. Review.


Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs.

Roopenian DC, Low BE, Christianson GJ, Proetzel G, Sproule TJ, Wiles MV.

MAbs. 2015;7(2):344-51. doi: 10.1080/19420862.2015.1008345.


Generation of improved humanized mouse models for human infectious diseases.

Brehm MA, Wiles MV, Greiner DL, Shultz LD.

J Immunol Methods. 2014 Aug;410:3-17. doi: 10.1016/j.jim.2014.02.011. Epub 2014 Mar 4. Review.


Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

Low BE, Krebs MP, Joung JK, Tsai SQ, Nishina PM, Wiles MV.

Invest Ophthalmol Vis Sci. 2014 Jan 20;55(1):387-95. doi: 10.1167/iovs.13-13278.


Genetically engineered humanized mouse models for preclinical antibody studies.

Proetzel G, Wiles MV, Roopenian DC.

BioDrugs. 2014 Apr;28(2):171-80. doi: 10.1007/s40259-013-0071-0. Review.


The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells.

Taft RA, Low BE, Byers SL, Murray SA, Kutny P, Wiles MV.

PLoS One. 2013 Jul 2;8(7):e67826. doi: 10.1371/journal.pone.0067826. Print 2013.


Mouse estrous cycle identification tool and images.

Byers SL, Wiles MV, Dunn SL, Taft RA.

PLoS One. 2012;7(4):e35538. doi: 10.1371/journal.pone.0035538. Epub 2012 Apr 13.


The sophisticated mouse: protecting a precious reagent.

Wiles MV, Taft RA.

Methods Mol Biol. 2010;602:23-36. doi: 10.1007/978-1-60761-058-8_2.


The response of C57BL/6J and BALB/cJ mice to increased housing density.

Nicholson A, Malcolm RD, Russ PL, Cough K, Touma C, Palme R, Wiles MV.

J Am Assoc Lab Anim Sci. 2009 Nov;48(6):740-53.


Surgical oocyte retrieval (SOR): a method for collecting mature mouse oocytes without euthanasia.

Byers SL, Wiles MV, Taft RA.

J Am Assoc Lab Anim Sci. 2009 Jan;48(1):44-51.


Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation.

Ostermeier GC, Wiles MV, Farley JS, Taft RA.

PLoS One. 2008 Jul 30;3(7):e2792. doi: 10.1371/journal.pone.0002792.


Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens.

Shaw I, Powell TJ, Marston DA, Baker K, van Hateren A, Riegert P, Wiles MV, Milne S, Beck S, Kaufman J.

J Immunol. 2007 May 1;178(9):5744-52.


Know thy mouse.

Taft RA, Davisson M, Wiles MV.

Trends Genet. 2006 Dec;22(12):649-53. Epub 2006 Sep 26. Review.


Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens.

Wallny HJ, Avila D, Hunt LG, Powell TJ, Riegert P, Salomonsen J, Skjødt K, Vainio O, Vilbois F, Wiles MV, Kaufman J.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1434-9. Epub 2006 Jan 23.


An efficient SNP system for mouse genome scanning and elucidating strain relationships.

Petkov PM, Ding Y, Cassell MA, Zhang W, Wagner G, Sargent EE, Asquith S, Crew V, Johnson KA, Robinson P, Scott VE, Wiles MV.

Genome Res. 2004 Sep;14(9):1806-11.


Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.

Petkov PM, Cassell MA, Sargent EE, Donnelly CJ, Robinson P, Crew V, Asquith S, Haar RV, Wiles MV.

Genomics. 2004 May;83(5):902-11.


The properties of the single chicken MHC classical class II alpha chain ( B-LA) gene indicate an ancient origin for the DR/E-like isotype of class II molecules.

Salomonsen J, Marston D, Avila D, Bumstead N, Johansson B, Juul-Madsen H, Olesen GD, Riegert P, Skjødt K, Vainio O, Wiles MV, Kaufman J.

Immunogenetics. 2003 Dec;55(9):605-14. Epub 2003 Nov 8.


The use of a chemically defined media for the analyses of early development in ES cells and mouse embryos.

Proetzel G, Wiles MV.

Methods Mol Biol. 2002;185:17-26. Review. No abstract available.


A radiation hybrid transcript map of the mouse genome.

Avner P, Bruls T, Poras I, Eley L, Gas S, Ruiz P, Wiles MV, Sousa-Nunes R, Kettleborough R, Rana A, Morissette J, Bentley L, Goldsworthy M, Haynes A, Herbert E, Southam L, Lehrach H, Weissenbach J, Manenti G, Rodriguez-Tome P, Beddington R, Dunwoodie S, Cox RD.

Nat Genet. 2001 Oct;29(2):194-200.


Establishment of a gene-trap sequence tag library to generate mutant mice from embryonic stem cells.

Wiles MV, Vauti F, Otte J, Füchtbauer EM, Ruiz P, Füchtbauer A, Arnold HH, Lehrach H, Metz T, von Melchner H, Wurst W.

Nat Genet. 2000 Jan;24(1):13-4. No abstract available.


Embryonic stem cell development in a chemically defined medium.

Wiles MV, Johansson BM.

Exp Cell Res. 1999 Feb 25;247(1):241-8.


Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component.

Kopf M, Herren S, Wiles MV, Pepys MB, Kosco-Vilbois MH.

J Exp Med. 1998 Nov 16;188(10):1895-906.


Transforming growth factor-beta 3 is required for secondary palate fusion.

Proetzel G, Pawlowski SA, Wiles MV, Yin M, Boivin GP, Howles PN, Ding J, Ferguson MW, Doetschman T.

Nat Genet. 1995 Dec;11(4):409-14.


A new approach to the study of haematopoietic development in the yolk sac and embryoid bodies.

Guimarães MJ, Bazan JF, Zlotnik A, Wiles MV, Grimaldi JC, Lee F, McClanahan T.

Development. 1995 Oct;121(10):3335-46.


Alpha 6 integrins participate in pro-T cell homing to the thymus.

Ruiz P, Wiles MV, Imhof BA.

Eur J Immunol. 1995 Jul;25(7):2034-41.


An in vitro differentiation system for the examination of transgene activation in mouse macrophages.

Faust N, Bonifer C, Wiles MV, Sippel AE.

DNA Cell Biol. 1994 Sep;13(9):901-7.


Hematopoietic commitment during embryonic stem cell differentiation in culture.

Keller G, Kennedy M, Papayannopoulou T, Wiles MV.

Mol Cell Biol. 1993 Jan;13(1):473-86.


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