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Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model.

Metcalf CS, Huff J, Thomson KE, Johnson K, Edwards SF, Wilcox KS.

Epilepsia Open. 2019 Aug 12;4(3):452-463. doi: 10.1002/epi4.12354. eCollection 2019 Sep.


Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus.

Patel DC, Wallis G, Fujinami RS, Wilcox KS, Smith MD.

Epilepsia Open. 2019 Jul 19;4(3):431-442. doi: 10.1002/epi4.12351. eCollection 2019 Sep.


Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary.

Isom LL, Wilcox KS, Brooks-Kayal A.

Epilepsy Curr. 2019 Jul-Aug;19(4):272-274. doi: 10.1177/1535759719858342. Epub 2019 Jul 7. No abstract available.


Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity.

Loewen JL, Albertini G, Dahle EJ, Sato H, Smolders IJ, Massie A, Wilcox KS.

Exp Neurol. 2019 Aug;318:50-60. doi: 10.1016/j.expneurol.2019.04.010. Epub 2019 Apr 22.


Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.

Umpierre AD, West PJ, White JA, Wilcox KS.

J Neurosci. 2019 Jan 23;39(4):727-742. doi: 10.1523/JNEUROSCI.1148-18.2018. Epub 2018 Nov 30.


Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.

West PJ, Saunders GW, Billingsley P, Smith MD, White HS, Metcalf CS, Wilcox KS.

Epilepsia. 2018 Nov;59(11):2035-2048. doi: 10.1111/epi.14563. Epub 2018 Oct 17.


Novel Targets for Developing Antiseizure and, Potentially, Antiepileptogenic Drugs.

Patel DC, Wilcox KS, Metcalf CS.

Epilepsy Curr. 2017 Sep-Oct;17(5):293-298. doi: 10.5698/1535-7597.17.5.293.


Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research?

Scharfman HE, Kanner AM, Friedman A, Blümcke I, Crocker CE, Cendes F, Diaz-Arrastia R, Förstl H, Fenton AA, Grace AA, Palop J, Morrison J, Nehlig A, Prasad A, Wilcox KS, Jette N, Pohlmann-Eden B.

Epilepsy Behav. 2018 Jan;78:302-312. doi: 10.1016/j.yebeh.2017.09.016. Epub 2017 Oct 31. Review.


Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss.

Remigio GJ, Loewen JL, Heuston S, Helgeson C, White HS, Wilcox KS, West PJ.

Neurobiol Dis. 2017 Sep;105:221-234. doi: 10.1016/j.nbd.2017.06.006. Epub 2017 Jun 15.


Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain.

Smith MD, Woodhead JH, Handy LJ, Pruess TH, Vanegas F, Grussendorf E, Grussendorf J, White K, Bulaj KK, Krumin RK, Hunt M, Wilcox KS.

Neurochem Res. 2017 Jul;42(7):1995-2010. doi: 10.1007/s11064-017-2286-9. Epub 2017 May 15.


Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy.

Patel DC, Wallis G, Dahle EJ, McElroy PB, Thomson KE, Tesi RJ, Szymkowski DE, West PJ, Smeal RM, Patel M, Fujinami RS, White HS, Wilcox KS.

eNeuro. 2017 May 9;4(2). pii: ENEURO.0105-17.2017. doi: 10.1523/ENEURO.0105-17.2017. eCollection 2017 Mar-Apr.


Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH.

Neurochem Res. 2017 Jul;42(7):1939-1948. doi: 10.1007/s11064-017-2287-8. Epub 2017 May 6.


Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.

Metcalf CS, West PJ, Thomson KE, Edwards SF, Smith MD, White HS, Wilcox KS.

Epilepsia. 2017 Jun;58(6):1073-1084. doi: 10.1111/epi.13764. Epub 2017 Apr 27.


Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy.

Barker-Haliski ML, Johnson K, Billingsley P, Huff J, Handy LJ, Khaleel R, Lu Z, Mau MJ, Pruess TH, Rueda C, Saunders G, Underwood TK, Vanegas F, Smith MD, West PJ, Wilcox KS.

Neurochem Res. 2017 Jul;42(7):1904-1918. doi: 10.1007/s11064-017-2227-7. Epub 2017 Mar 16.


Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy.

Barker-Haliski ML, Heck TD, Dahle EJ, Vanegas F, Pruess TH, Wilcox KS, White HS.

Epilepsia. 2016 Dec;57(12):1958-1967. doi: 10.1111/epi.13577. Epub 2016 Oct 14.


NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection.

Libbey JE, Hanak TJ, Doty DJ, Wilcox KS, Fujinami RS.

Exp Neurol. 2016 Jun;280:89-96. doi: 10.1016/j.expneurol.2016.04.010. Epub 2016 Apr 9.


Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy.

Loewen JL, Barker-Haliski ML, Dahle EJ, White HS, Wilcox KS.

J Neuropathol Exp Neurol. 2016 Apr;75(4):366-78. doi: 10.1093/jnen/nlw008. Epub 2016 Mar 4.


Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures.

Umpierre AD, Bennett IV, Nebeker LD, Newell TG, Tian BB, Thomson KE, White HS, White JA, Wilcox KS.

Exp Neurol. 2016 May;279:116-126. doi: 10.1016/j.expneurol.2016.02.014. Epub 2016 Feb 16.


Decrease in CA3 inhibitory network activity during Theiler's virus encephalitis.

Smeal RM, Fujinami R, White HS, Wilcox KS.

Neurosci Lett. 2015 Nov 16;609:210-5. doi: 10.1016/j.neulet.2015.10.032. Epub 2015 Oct 23.


Altered structure and function of astrocytes following status epilepticus.

Wilcox KS, Gee JM, Gibbons MB, Tvrdik P, White JA.

Epilepsy Behav. 2015 Aug;49:17-9. doi: 10.1016/j.yebeh.2015.05.002. Epub 2015 Jul 26. Review.


Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy.

Bhuyan P, Patel DC, Wilcox KS, Patel M.

Exp Neurol. 2015 Sep;271:329-34. doi: 10.1016/j.expneurol.2015.06.012. Epub 2015 Jun 14.


Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation.

Gee JM, Gibbons MB, Taheri M, Palumbos S, Morris SC, Smeal RM, Flynn KF, Economo MN, Cizek CG, Capecchi MR, Tvrdik P, Wilcox KS, White JA.

Front Mol Neurosci. 2015 Apr 15;8:10. doi: 10.3389/fnmol.2015.00010. eCollection 2015.


Could Astrocytes Be Used to Beat Epilepsy? Experiments in dnSNARE Mice Drum Up New Hope.

Gibbons MB, Wilcox KS.

Epilepsy Curr. 2014 Sep;14(5):277-8. doi: 10.5698/1535-7597-14.5.277. No abstract available.


Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse.

Gee JM, Smith NA, Fernandez FR, Economo MN, Brunert D, Rothermel M, Morris SC, Talbot A, Palumbos S, Ichida JM, Shepherd JD, West PJ, Wachowiak M, Capecchi MR, Wilcox KS, White JA, Tvrdik P.

Neuron. 2014 Sep 3;83(5):1058-72. doi: 10.1016/j.neuron.2014.07.024. Epub 2014 Aug 21.


The challenge and promise of anti-epileptic therapy development in animal models.

Simonato M, Brooks-Kayal AR, Engel J Jr, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA.

Lancet Neurol. 2014 Sep;13(9):949-60. doi: 10.1016/S1474-4422(14)70076-6. Epub 2014 Aug 10. Review. Erratum in: Lancet Neurol. 2015 Jul;14(7):677.


Does brain inflammation mediate pathological outcomes in epilepsy?

Wilcox KS, Vezzani A.

Adv Exp Med Biol. 2014;813:169-83. doi: 10.1007/978-94-017-8914-1_14. Review.


Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice.

West PJ, Saunders GW, Remigio GJ, Wilcox KS, White HS.

Epilepsia. 2014 Feb;55(2):214-23. doi: 10.1111/epi.12524. Epub 2014 Jan 21.


Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy.

Umpierre AD, Remigio GJ, Dahle EJ, Bradford K, Alex AB, Smith MD, West PJ, White HS, Wilcox KS.

Neurobiol Dis. 2014 Apr;64:98-106. doi: 10.1016/j.nbd.2013.12.015. Epub 2014 Jan 9.


Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE.

J Med Chem. 2013 Nov 27;56(22):9019-30. doi: 10.1021/jm400894u. Epub 2013 Nov 11.


The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.

Vargas JR, Takahashi DK, Thomson KE, Wilcox KS.

J Neuropathol Exp Neurol. 2013 Oct;72(10):919-32. doi: 10.1097/NEN.0b013e3182a4b266.


Issues related to development of new antiseizure treatments.

Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Moshé SL, Noebels JL, Privitera MD, Rogawski MA.

Epilepsia. 2013 Aug;54 Suppl 4:24-34. doi: 10.1111/epi.12296. Review.


Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy.

Srivastava AK, Alex AB, Wilcox KS, White HS.

Epilepsia. 2013 Jul;54(7):1186-94. doi: 10.1111/epi.12234. Epub 2013 Jun 10.


Contributions of astrocytes to epileptogenesis following status epilepticus: opportunities for preventive therapy?

Gibbons MB, Smeal RM, Takahashi DK, Vargas JR, Wilcox KS.

Neurochem Int. 2013 Dec;63(7):660-9. doi: 10.1016/j.neuint.2012.12.008. Epub 2012 Dec 21. Review.


Potassium Channelopathies of Epilepsy.

Brenner R, Wilcox KS.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.


The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy.

Smeal RM, Stewart KA, Iacob E, Fujinami RS, White HS, Wilcox KS.

J Neurovirol. 2012 Feb;18(1):30-44. doi: 10.1007/s13365-012-0082-5. Epub 2012 Feb 11.


A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M.

Epilepsia. 2012 Jan;53(1):134-46. doi: 10.1111/j.1528-1167.2011.03338.x. Epub 2011 Dec 9. Erratum in: Epilepsia. 2012 Feb;53(2):397.


Altered learning and Arc-regulated consolidation of learning in striatum by methamphetamine-induced neurotoxicity.

Pastuzyn ED, Chapman DE, Wilcox KS, Keefe KA.

Neuropsychopharmacology. 2012 Mar;37(4):885-95. doi: 10.1038/npp.2011.265. Epub 2011 Nov 9.


Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Neurovirol. 2011 Oct;17(5):496-9. doi: 10.1007/s13365-011-0050-5. Epub 2011 Aug 11.


Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2011 Aug;85(16):8149-57. doi: 10.1128/JVI.00730-11. Epub 2011 Jun 15.


cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors.

Simeone TA, Wilcox KS, White HS.

Epilepsy Res. 2011 Sep;96(1-2):176-9. doi: 10.1016/j.eplepsyres.2011.05.009. Epub 2011 Jun 12.


Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection.

Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2011 Jul;85(14):6913-22. doi: 10.1128/JVI.00458-11. Epub 2011 May 4.


Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

Simeone TA, Wilcox KS, White HS.

Pharmacol Res. 2011 Jul;64(1):44-52. doi: 10.1016/j.phrs.2011.03.004. Epub 2011 Mar 21.


CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors.

Alex AB, Saunders GW, Dalpé-Charron A, Reilly CA, Wilcox KS.

Neurotoxicology. 2011 Aug;32(4):392-9. doi: 10.1016/j.neuro.2011.03.002. Epub 2011 Mar 17.


Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice.

Stewart KA, Wilcox KS, Fujinami RS, White HS.

J Neuropathol Exp Neurol. 2010 Dec;69(12):1210-9. doi: 10.1097/NEN.0b013e3181ffc420.


Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus.

Takahashi DK, Vargas JR, Wilcox KS.

Neurobiol Dis. 2010 Dec;40(3):573-85. doi: 10.1016/j.nbd.2010.07.018. Epub 2010 Aug 5.


Role for complement in the development of seizures following acute viral infection.

Libbey JE, Kirkman NJ, Wilcox KS, White HS, Fujinami RS.

J Virol. 2010 Jul;84(13):6452-60. doi: 10.1128/JVI.00422-10. Epub 2010 Apr 28.


Theiler's virus infection chronically alters seizure susceptibility.

Stewart KA, Wilcox KS, Fujinami RS, White HS.

Epilepsia. 2010 Aug;51(8):1418-28. doi: 10.1111/j.1528-1167.2009.02405.x. Epub 2009 Dec 1.


Innate but not adaptive immune responses contribute to behavioral seizures following viral infection.

Kirkman NJ, Libbey JE, Wilcox KS, White HS, Fujinami RS.

Epilepsia. 2010 Mar;51(3):454-64. doi: 10.1111/j.1528-1167.2009.02390.x. Epub 2009 Oct 20.


Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.

Otto JF, Singh NA, Dahle EJ, Leppert MF, Pappas CM, Pruess TH, Wilcox KS, White HS.

Epilepsia. 2009 Jul;50(7):1752-9. doi: 10.1111/j.1528-1167.2009.02100.x. Epub 2009 Apr 27.

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