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C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.

Wilcock BC, Endo MM, Uno BE, Burke MD.

J Am Chem Soc. 2013 Jun 12;135(23):8488-91. doi: 10.1021/ja403255s. Epub 2013 Jun 3.


Electronic tuning of site-selectivity.

Wilcock BC, Uno BE, Bromann GL, Clark MJ, Anderson TM, Burke MD.

Nat Chem. 2012 Dec;4(12):996-1003.


Amphotericin primarily kills yeast by simply binding ergosterol.

Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17.


Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities.

Palacios DS, Dailey I, Siebert DM, Wilcock BC, Burke MD.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6733-8. doi: 10.1073/pnas.1015023108. Epub 2011 Feb 28.

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