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Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.

Lee KJ, Tieu W, Blanco-Rodriguez B, Paparella AS, Yu J, Hayes A, Feng J, Marshall AC, Noll B, Milne R, Cini D, Wilce MCJ, Booker GW, Bruning JB, Polyak SW, Abell AD.

ACS Chem Biol. 2019 Aug 21. doi: 10.1021/acschembio.9b00463. [Epub ahead of print]


Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation.

Lang T, Lee JPW, Elgass K, Pinar AA, Tate MD, Aitken EH, Fan H, Creed SJ, Deen NS, Traore DAK, Mueller I, Stanisic D, Baiwog FS, Skene C, Wilce MCJ, Mansell A, Morand EF, Harris J.

Nat Commun. 2018 Jun 8;9(1):2223. doi: 10.1038/s41467-018-04581-2.


Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis.

Shah N, Beckham SA, Wilce JA, Wilce MCJ.

Nucleic Acids Res. 2018 Apr 6;46(6):3169-3186. doi: 10.1093/nar/gkx1307.


Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Paparella AS, Lee KJ, Hayes AJ, Feng J, Feng Z, Cini D, Deshmukh S, Booker GW, Wilce MCJ, Polyak SW, Abell AD.

ACS Infect Dis. 2018 Feb 9;4(2):175-184. doi: 10.1021/acsinfecdis.7b00134. Epub 2017 Nov 16.


Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.

Watson GM, Kulkarni K, Sang J, Ma X, Gunzburg MJ, Perlmutter P, Wilce MCJ, Wilce JA.

J Med Chem. 2017 Nov 22;60(22):9349-9359. doi: 10.1021/acs.jmedchem.7b01320. Epub 2017 Nov 10.


Structural analysis of variant of Helicobacter pylori MotB in its activated form, engineered as chimera of MotB and leucine zipper.

Andrews DA, Nesmelov YE, Wilce MC, Roujeinikova A.

Sci Rep. 2017 Oct 18;7(1):13435. doi: 10.1038/s41598-017-13421-0.


TIA-1 RRM23 binding and recognition of target oligonucleotides.

Waris S, García-Mauriño SM, Sivakumaran A, Beckham SA, Loughlin FE, Gorospe M, Díaz-Moreno I, Wilce MCJ, Wilce JA.

Nucleic Acids Res. 2017 May 5;45(8):4944-4957. doi: 10.1093/nar/gkx102.


Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.

Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA.

Sci Rep. 2016 Jun 3;6:27060. doi: 10.1038/srep27060.


Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.

Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC, Wilce JA.

J Med Chem. 2015 Oct 8;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609. Epub 2015 Sep 23.


Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module.

Selkrig J, Belousoff MJ, Headey SJ, Heinz E, Shiota T, Shen HH, Beckham SA, Bamert RS, Phan MD, Schembri MA, Wilce MC, Scanlon MJ, Strugnell RA, Lithgow T.

Sci Rep. 2015 Aug 5;5:12905. doi: 10.1038/srep12905.


Cooperative interplay of let-7 mimic and HuR with MYC RNA.

Gunzburg MJ, Sivakumaran A, Pendini NR, Yoon JH, Gorospe M, Wilce MC, Wilce JA.

Cell Cycle. 2015;14(17):2729-33. doi: 10.1080/15384101.2015.1069930. Epub 2015 Jul 15.


X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein.

Don Paul C, Traore DA, Olsen S, Devenish RJ, Close DW, Bell TD, Bradbury A, Wilce MC, Prescott M.

PLoS One. 2015 Apr 29;10(4):e0123338. doi: 10.1371/journal.pone.0123338. eCollection 2015.


Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.

Salaemae W, Yap MY, Wegener KL, Booker GW, Wilce MC, Polyak SW.

Tuberculosis (Edinb). 2015 May;95(3):259-66. doi: 10.1016/ Epub 2015 Mar 6.


The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4.

Moradi S, Berry R, Pymm P, Hitchen C, Beckham SA, Wilce MC, Walpole NG, Clements CS, Reid HH, Perugini MA, Brooks AG, Rossjohn J, Vivian JP.

J Biol Chem. 2015 Apr 17;290(16):10460-71. doi: 10.1074/jbc.M114.612291. Epub 2015 Mar 10.


Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX.

Headey SJ, Sivakumaran A, Adams V, Lyras D, Rood JI, Scanlon MJ, Wilce MC.

J Mol Recognit. 2015 May;28(5):316-24. doi: 10.1002/jmr.2446. Epub 2015 Feb 26.


Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.

Tieu W, Polyak SW, Paparella AS, Yap MY, Soares da Costa TP, Ng B, Wang G, Lumb R, Bell JM, Turnidge JD, Wilce MC, Booker GW, Abell AD.

ACS Med Chem Lett. 2014 Dec 11;6(2):216-20. doi: 10.1021/ml500475n. eCollection 2015 Feb 12.


RNA recognition and stress granule formation by TIA proteins.

Waris S, Wilce MC, Wilce JA.

Int J Mol Sci. 2014 Dec 16;15(12):23377-88. doi: 10.3390/ijms151223377. Review.


Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering.

Close DW, Paul CD, Langan PS, Wilce MC, Traore DA, Halfmann R, Rocha RC, Waldo GS, Payne RJ, Rucker JB, Prescott M, Bradbury AR.

Proteins. 2015 Jul;83(7):1225-37. doi: 10.1002/prot.24699. Epub 2015 May 8.


Spontaneous redox synthesis and characterization of the tetrathiafulvalene-vanadium-substituted polyoxometalate charge-transfer material TTF4[SVW11O40]: comparison with the Mo analogue.

Li Q, Lu J, Boas JF, Traore DA, Wilce MC, Martin LL, Ueda T, Bond AM.

Inorg Chem. 2014 Oct 20;53(20):10996-1006. doi: 10.1021/ic501431c. Epub 2014 Oct 1.


Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.

Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC, Wilce JA.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):182-6. doi: 10.1107/S2053230X13033414. Epub 2014 Jan 21.


Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus.

Soares da Costa TP, Yap MY, Perugini MA, Wallace JC, Abell AD, Wilce MC, Polyak SW, Booker GW.

Mol Microbiol. 2014 Jan;91(1):110-20. doi: 10.1111/mmi.12446. Epub 2013 Nov 21.


Structure guided design of biotin protein ligase inhibitors for antibiotic discovery.

Paparella AS, Soares da Costa TP, Yap MY, Tieu W, Wilce MC, Booker GW, Abell AD, Polyak SW.

Curr Top Med Chem. 2014;14(1):4-20. Review.


Quinine binding by the cocaine-binding aptamer. Thermodynamic and hydrodynamic analysis of high-affinity binding of an off-target ligand.

Reinstein O, Yoo M, Han C, Palmo T, Beckham SA, Wilce MC, Johnson PE.

Biochemistry. 2013 Dec 3;52(48):8652-62. doi: 10.1021/bi4010039. Epub 2013 Nov 14.


Phanta: a non-fluorescent photochromic acceptor for pcFRET.

Don Paul C, Kiss C, Traore DA, Gong L, Wilce MC, Devenish RJ, Bradbury A, Prescott M.

PLoS One. 2013 Sep 30;8(9):e75835. doi: 10.1371/journal.pone.0075835. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/b83e925b-2f2a-47b9-b939-0a1eeab18324.


Supramolecular self-assembly of N-acetyl-capped β-peptides leads to nano- to macroscale fiber formation.

Del Borgo MP, Mechler AI, Traore D, Forsyth C, Wilce JA, Wilce MC, Aguilar MI, Perlmutter P.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8266-70. doi: 10.1002/anie.201303175. Epub 2013 Jun 19. No abstract available.


Distinct binding properties of TIAR RRMs and linker region.

Kim HS, Headey SJ, Yoga YM, Scanlon MJ, Gorospe M, Wilce MC, Wilce JA.

RNA Biol. 2013 Apr;10(4):579-89. doi: 10.4161/rna.24341. Epub 2013 Apr 1.


Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target.

Pendini NR, Yap MY, Traore DA, Polyak SW, Cowieson NP, Abell A, Booker GW, Wallace JC, Wilce JA, Wilce MC.

Protein Sci. 2013 Jun;22(6):762-73. doi: 10.1002/pro.2262. Erratum in: Protein Sci. 2014 Jan;23(1):121. Traore, D A K [added].


The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA.

ChemMedChem. 2013 Feb;8(2):280-8. doi: 10.1002/cmdc.201200400. Epub 2012 Dec 17.


Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly.

Beckham SA, Brouwer J, Roth A, Wang D, Sadler AJ, John M, Jahn-Hofmann K, Williams BR, Wilce JA, Wilce MC.

Nucleic Acids Res. 2013 Mar 1;41(5):3436-45. doi: 10.1093/nar/gks1477. Epub 2013 Jan 15.


Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studies.

Andrews DA, Xie M, Hughes V, Wilce MC, Roujeinikova A.

J R Soc Interface. 2013 Feb;10(79):20120717. doi: 10.1098/rsif.2012.0717.


Spontaneous redox synthesis of the charge transfer material TTF4[SVMo11O40].

Li Q, Lu J, Boas JF, Traore DA, Wilce MC, Huang F, Martin LL, Ueda T, Bond AM.

Inorg Chem. 2012 Dec 3;51(23):12929-37. doi: 10.1021/ic302045m. Epub 2012 Nov 12.


A green fluorescent protein containing a QFG tri-peptide chromophore: optical properties and X-ray crystal structure.

Battad JM, Traore DA, Byres E, Rossjohn J, Devenish RJ, Olsen S, Wilce MC, Prescott M.

PLoS One. 2012;7(10):e47331. doi: 10.1371/journal.pone.0047331. Epub 2012 Oct 10.


Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase.

Soares da Costa TP, Tieu W, Yap MY, Zvarec O, Bell JM, Turnidge JD, Wallace JC, Booker GW, Wilce MC, Abell AD, Polyak SW.

ACS Med Chem Lett. 2012 May 23;3(6):509-14. doi: 10.1021/ml300106p. eCollection 2012 Jun 14.


Synthesis and conformation of fluorinated β-peptidic compounds.

Peddie V, Butcher RJ, Robinson WT, Wilce MC, Traore DA, Abell AD.

Chemistry. 2012 May 21;18(21):6655-62. doi: 10.1002/chem.201200313. Epub 2012 Apr 19.


Selective inhibition of biotin protein ligase from Staphylococcus aureus.

Soares da Costa TP, Tieu W, Yap MY, Pendini NR, Polyak SW, Sejer Pedersen D, Morona R, Turnidge JD, Wallace JC, Wilce MC, Booker GW, Abell AD.

J Biol Chem. 2012 May 18;287(21):17823-32. doi: 10.1074/jbc.M112.356576. Epub 2012 Mar 21.


Sequence requirements for RNA binding by HuR and AUF1.

Barker A, Epis MR, Porter CJ, Hopkins BR, Wilce MC, Wilce JA, Giles KM, Leedman PJ.

J Biochem. 2012 Apr;151(4):423-37. doi: 10.1093/jb/mvs010. Epub 2012 Feb 25.


Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides.

Yoga YM, Traore DA, Sidiqi M, Szeto C, Pendini NR, Barker A, Leedman PJ, Wilce JA, Wilce MC.

Nucleic Acids Res. 2012 Jun;40(11):5101-14. doi: 10.1093/nar/gks058. Epub 2012 Feb 16.


Conformational stability studies of a stapled hexa-β3-peptide library.

Gopalan RD, Del Borgo MP, Bergman YE, Unabia S, Mulder RJ, Wilce MC, Wilce JA, Aguilar MI, Perlmutter P.

Org Biomol Chem. 2012 Mar 7;10(9):1802-6. doi: 10.1039/c2ob06617c. Epub 2012 Jan 18.


Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.

Gunzburg MJ, Ambaye ND, Del Borgo MP, Pero SC, Krag DN, Wilce MC, Wilce JA.

J Mol Recognit. 2012 Jan;25(1):57-67. doi: 10.1002/jmr.2148.


Structure, function and selective inhibition of bacterial acetyl-coa carboxylase.

Polyak SW, Abell AD, Wilce MC, Zhang L, Booker GW.

Appl Microbiol Biotechnol. 2012 Feb;93(3):983-92. doi: 10.1007/s00253-011-3796-z. Epub 2011 Dec 20. Review.


Expression, purification, crystallization and preliminary X-ray analysis of eCGP123, an extremely stable monomeric green fluorescent protein with reversible photoswitching properties.

Don Paul C, Traore DA, Byres E, Rossjohn J, Devenish RJ, Kiss C, Bradbury A, Wilce MC, Prescott M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1266-8. doi: 10.1107/S1744309111028156. Epub 2011 Sep 30.


Mutation and crystallization of the first KH domain of human polycytosine-binding protein 1 (PCBP1) in complex with DNA.

Yoga YM, Traore DA, Wilce JA, Wilce MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1257-61. doi: 10.1107/S1744309111028004. Epub 2011 Sep 30.


Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism.

Reinstein O, Neves MA, Saad M, Boodram SN, Lombardo S, Beckham SA, Brouwer J, Audette GF, Groves P, Wilce MC, Johnson PE.

Biochemistry. 2011 Nov 1;50(43):9368-76. doi: 10.1021/bi201361v. Epub 2011 Oct 10.


Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.

Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA.

J Mol Biol. 2011 Sep 23;412(3):397-411. doi: 10.1016/j.jmb.2011.07.030. Epub 2011 Jul 23.


Identification of an mRNP complex regulating tumorigenesis at the translational elongation step.

Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, Merrick WC, Howe PH.

Mol Cell. 2011 Feb 18;41(4):419-31. doi: 10.1016/j.molcel.2011.02.003.


Different modes of interaction by TIAR and HuR with target RNA and DNA.

Kim HS, Wilce MC, Yoga YM, Pendini NR, Gunzburg MJ, Cowieson NP, Wilson GM, Williams BR, Gorospe M, Wilce JA.

Nucleic Acids Res. 2011 Feb;39(3):1117-30. doi: 10.1093/nar/gkq837. Epub 2011 Jan 13.


Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide.

Yap MY, Wilce MC, Clayton DJ, Perlmutter P, Aguilar MI, Wilce JA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1640-3. doi: 10.1107/S1744309110041850. Epub 2010 Nov 26.


Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA.

Bioorg Med Chem. 2011 Jan 1;19(1):693-701. doi: 10.1016/j.bmc.2010.10.030. Epub 2010 Oct 19.


The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.

Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF, Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T, Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J, Rossjohn J.

Nature. 2010 Oct 14;467(7317):844-8. doi: 10.1038/nature09448.


Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.

Klaver DW, Wilce MC, Cui H, Hung AC, Gasperini R, Foa L, Small DH.

Biol Chem. 2010 Aug;391(8):849-59. doi: 10.1515/BC.2010.089. Review.


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